{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:14:24Z","timestamp":1766139264379,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"],"award-info":[{"award-number":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"],"award-info":[{"award-number":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Clinical Research Center for Neurological Diseases","award":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"],"award-info":[{"award-number":["2023ZD0504800","2023ZD0504802","2023A1515010169","LCYSSQ20220823091204009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Intracranial atherosclerosis disease (ICAD) represents a significant etiology of stroke. This study aimed to evaluate correlations between intracranial atherosclerotic burden and risk of ischemic events. Methods: In this prospective observational study, all enrolled patients underwent High-Resolution Magnetic Resonance vessel wall Imaging (HR MR-VMI) within two weeks of onset, or of enrollment. Baseline assessments included modified American Heart Association plaque type, stenosis degree, intra-plaque hemorrhage (IPH), plaque thickness, plaque length, and vessel wall enhancement. Modified Rankin Scale (mRS) was followed with one-year treatment in adherence to the guidelines. Comparative analyses were conducted between symptomatic and asymptomatic groups, culprit versus non-culprit plaques, and favorable versus poor prognosis groups. Results: The study included 129 symptomatic and 42 asymptomatic patients. Hypertension, diabetes, and smoking were more prevalent in patients in the symptomatic group. Vulnerable plaque (97.7% vs. 64.3%, p = 0.003), IPH (17.8% vs. 4.8%, p = 0.022) and higher stenosis degree (\u03c72 = 2.675, p = 0.008) were significantly more prevalent in the symptomatic group. Culprit plaques were predominantly located in the superior wall of the middle cerebral artery (MCA) (\u03c72 = 15.561, p = 0.001) and the left wall of the basilar artery (\u03c72 = 34.138, p = 0.008). Factors associated with poor prognosis included older age (63.63 \u00b1 8.19 vs. 55.63 \u00b1 13.15, p = 0.001), presence of IPH (31.82% vs. 14.29%, p = 0.037), and elevated D-dimer levels (0.77 \u00b1 0.60 vs. 0.40 \u00b1 0.36, p = 0.022). Conclusions: Vulnerable plaque, specific lesion locations, and higher stenosis degree are significantly associated with ischemic events in ICAD. While plaque enhancement and stenosis correlate with stroke occurrence, they show no clear association with prognosis. Neither the length nor the thickness of plaques manifests a significant correlation with either stroke events or the prognostic outcomes.<\/jats:p>","DOI":"10.3390\/brainsci15091009","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T09:32:32Z","timestamp":1758187952000},"page":"1009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative Analysis of Intracranial Atherosclerosis and Its Correlation with Ischemic Cerebrovascular Disease and Prognosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Jingjing","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Neurology, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Neurology, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6510-5470","authenticated-orcid":false,"given":"Sizhan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-0341","authenticated-orcid":false,"given":"Gelin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Neurology, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/STROKEAHA.113.003508","article-title":"Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: The Chinese Intracranial Atherosclerosis (CICAS) Study","volume":"45","author":"Wang","year":"2014","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1474-4422(13)70195-9","article-title":"Atherosclerotic intracranial arterial stenosis: Risk factors, diagnosis, and treatment","volume":"12","author":"Holmstedt","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1212\/01.wnl.0000208404.94585.b2","article-title":"Prospective study of symptomatic atherothrombotic intracranial stenoses: The GESICA study","volume":"66","author":"Mazighi","year":"2006","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000475","article-title":"2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association\/American Stroke Association","volume":"55","author":"Bushnell","year":"2024","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/STROKEAHA.124.050336","article-title":"ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease","volume":"56","author":"Tjoumakaris","year":"2025","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/STROKEAHA.123.043630","article-title":"Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease","volume":"55","author":"Chen","year":"2024","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1161\/STROKEAHA.123.035675","article-title":"Symptomatic Nonstenotic Carotids: A Topical Review","volume":"55","author":"Savastano","year":"2024","journal-title":"Stroke"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/STROKEAHA.123.045513","article-title":"Focused Update on Intracranial Atherosclerosis: Introduction, Highlights, and Knowledge Gaps","volume":"55","author":"Hoh","year":"2024","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00234-022-03093-7","article-title":"Utility of high-resolution magnetic resonance vessel wall imaging in differentiating between atherosclerotic plaques, vasculitis, and arterial dissection","volume":"65","author":"Tritanon","year":"2023","journal-title":"Neuroradiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00330-024-10968-1","article-title":"Application of high-resolution MRI in evaluating statin efficacy on symptomatic intracranial atherosclerosis","volume":"35","author":"Huang","year":"2025","journal-title":"Eur. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/17474930231189946","article-title":"Magnetic resonance imaging for diagnostic workup of embolic stroke of undetermined source: A systematic review","volume":"19","author":"Khenkina","year":"2024","journal-title":"Int. J. Stroke Off. J. Int. Stroke Soc."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mazzacane, F., Mazzoleni, V., Scola, E., Mancini, S., Lombardo, I., Busto, G., Rognone, E., Pichiecchio, A., Padovani, A., and Morotti, A. (2022). Vessel Wall Magnetic Resonance Imaging in Cerebrovascular Diseases. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020258"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nic.2021.01.005","article-title":"High-Resolution Magnetic Resonance Vessel Wall Imaging for the Evaluation of Intracranial Vascular Pathology","volume":"31","author":"Vranic","year":"2021","journal-title":"Neuroimaging Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.atherosclerosis.2014.10.007","article-title":"Intracranial atherosclerosis: Correlation between in-vivo 3T high resolution MRI and pathology","volume":"237","author":"Turan","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.23736\/S0390-5616.19.04820-3","article-title":"Correlation of MRI-detected vulnerable carotid plaques with clinical presentation: A systematic review and meta-analysis","volume":"64","author":"Seyedsaadat","year":"2020","journal-title":"J. Neurosurg. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(21)00376-8","article-title":"Intracranial atherosclerotic stenosis: Risk factors, diagnosis, and treatment","volume":"21","author":"Gutierrez","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"North American Symptomatic Carotid Endarterectomy Trial Collaborators, Barnett, H.J.M., Taylor, D.W., Haynes, R.B., Sackett, D.L., Peerless, S.J., Ferguson, G.G., Fox, A.J., Rankin, R.N., and Hachinski, V.C. (1991). Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N. Engl. J. Med., 325, 445\u2013453.","DOI":"10.1056\/NEJM199108153250701"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20180950","DOI":"10.1259\/bjr.20180950","article-title":"Intracranial aneurysms at higher clinical risk for rupture demonstrate increased wall enhancement and thinning on multicontrast 3D vessel wall MRI","volume":"92","author":"Hartman","year":"2019","journal-title":"Br. J. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.CIR.0000028591.44554.F9","article-title":"Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging","volume":"106","author":"Cai","year":"2002","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(23)00575-5","article-title":"Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: A multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial","volume":"401","author":"Olthuis","year":"2023","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1177\/17474930211066427","article-title":"Intracranial atherosclerosis: Review of imaging features and advances in diagnostics","volume":"17","author":"Kim","year":"2022","journal-title":"Int. J. Stroke Off. J. Int. Stroke Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/STROKEAHA.110.577973","article-title":"Treating arteries instead of risk factors: A paradigm change in management of atherosclerosis","volume":"41","author":"Spence","year":"2010","journal-title":"Stroke"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa1910355","article-title":"A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke","volume":"382","author":"Amarenco","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11883-024-01194-7","article-title":"European Lipid Guidelines and Cardiovascular Risk Estimation: Current Status and Future Challenges","volume":"26","author":"Pirillo","year":"2024","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mrm.21786","article-title":"Imaging and analysis of lenticulostriate arteries using 7.0-Tesla magnetic resonance angiography","volume":"61","author":"Kang","year":"2009","journal-title":"Magn. Reason. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ca.1032","article-title":"Anatomic and clinical correlations of the lenticulostriate arteries","volume":"14","author":"Marinkovic","year":"2001","journal-title":"Clin. Anat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5853\/jos.2017.00829","article-title":"Basilar Artery Plaque and Pontine Infarction Location and Vascular Geometry","volume":"20","author":"Kim","year":"2018","journal-title":"J. Stroke"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1007\/s00330-024-11248-8","article-title":"Atherosclerotic plaque evolution predicts cerebral ischemic events in patients with intracranial atherosclerosis: A multicentre longitudinal study using high-resolution MRI","volume":"35","author":"Yao","year":"2025","journal-title":"Eur. Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.atherosclerosis.2012.06.015","article-title":"Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage","volume":"223","author":"Teng","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1161\/STROKEAHA.112.662692","article-title":"Clinical and histological significance of gadolinium enhancement in carotid atherosclerotic plaque","volume":"43","author":"Millon","year":"2012","journal-title":"Stroke"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1177\/17474930241228203","article-title":"Association between high-resolution magnetic resonance vessel wall imaging characteristics and recurrent stroke in patients with intracranial atherosclerotic steno-occlusive disease: A prospective multicenter study","volume":"19","author":"Yuan","year":"2024","journal-title":"Int. J. Stroke Off. J. Int. Stroke Soc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107616","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107616","article-title":"Differences in intracranial atherosclerosis plaque between posterior circulation and anterior circulation on high-resolution magnetic resonance imaging: A systematic review and meta-analysis","volume":"33","author":"Yan","year":"2024","journal-title":"J. Stroke Cerebrovasc. Dis. Off. J. Natl. Stroke Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/STROKEAHA.115.009955","article-title":"Patterns and Implications of Intracranial Arterial Remodeling in Stroke Patients","volume":"47","author":"Qiao","year":"2016","journal-title":"Stroke"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111300","DOI":"10.1016\/j.ejrad.2024.111300","article-title":"Carotid atherosclerotic plaque predicts progression of intracranial artery atherosclerosis: A MR imaging-based community cohort study","volume":"172","author":"Yu","year":"2024","journal-title":"Eur. J. Radiol."},{"key":"ref_36","first-page":"40","article-title":"Artificial intelligence and stroke imaging","volume":"38","author":"Rondina","year":"2025","journal-title":"Curr. Opin. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1109\/JBHI.2024.3448238","article-title":"Multimodal Machine Learning for Stroke Prognosis and Diagnosis: A Systematic Review","volume":"28","author":"Shurrab","year":"2024","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/STROKEAHA.118.024293","article-title":"Machine Learning-Based Model for Prediction of Outcomes in Acute Stroke","volume":"50","author":"Heo","year":"2019","journal-title":"Stroke"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Al-Janabi, O.M., El Refaei, A., Elgazzar, T., Mahmood, Y.M., Bakir, D., Gajjar, A., Alateya, A., Jha, S.K., Ghozy, S., and Kallmes, D.F. (2024). Current Stroke Solutions Using Artificial Intelligence: A Review of the Literature. Brain Sci., 14.","DOI":"10.3390\/brainsci14121182"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1177\/23969873241275863","article-title":"Artificial intelligence, machine learning, and reproducibility in stroke research","volume":"9","author":"Romoli","year":"2024","journal-title":"Eur. Stroke J."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/9\/1009\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:42Z","timestamp":1760035662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/9\/1009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["brainsci15091009"],"URL":"https:\/\/doi.org\/10.3390\/brainsci15091009","relation":{},"ISSN":["2076-3425"],"issn-type":[{"type":"electronic","value":"2076-3425"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}