{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:52:37Z","timestamp":1779900757729,"version":"3.53.1"},"reference-count":74,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Graduate Studies and Scientific Research at Qassim University","award":["QU-APC-2025"],"award-info":[{"award-number":["QU-APC-2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Obsessive\u2013Compulsive Disorder (OCD) is a chronic mental health condition characterized by intrusive thoughts and repetitive behaviors. Traditional diagnostic methods rely on subjective clinical assessments, delaying effective intervention. This review examines how advanced neuroimaging techniques, such as Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI), integrated with machine learning (ML), can improve OCD diagnostics by identifying structural and functional brain abnormalities, particularly in the cortico-striato-thalamo-cortical (CSTC) circuit. Methods: Findings from studies using MRI and DTI to identify OCD-related neurobiological markers are synthesized. Machine learning algorithms like Convolutional Neural Networks (CNNs) and Support Vector Machines (SVMs) are evaluated for their ability to analyze neuroimaging data. The role of transfer learning in overcoming dataset limitations and heterogeneity is also explored. Results: ML algorithms have achieved diagnostic accuracies exceeding 80%, revealing subtle neurobiological markers linked to OCD. Abnormalities in the CSTC circuit are consistently identified. Transfer learning shows promise in enhancing predictive modeling and enabling personalized treatment strategies, especially in resource-constrained settings. Conclusions: The integration of neuroimaging and ML represents a transformative approach to OCD diagnostics, offering improved accuracy and biologically informed insights. Future research should focus on optimizing multimodal imaging techniques, increasing data generalizability, and addressing interpretability challenges to enhance clinical applicability. These innovations have the potential to advance precision diagnostics and support more targeted therapeutic interventions, ultimately improving outcomes for individuals with OCD.<\/jats:p>","DOI":"10.3390\/brainsci15101106","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:06:32Z","timestamp":1760508392000},"page":"1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6593-8956","authenticated-orcid":false,"given":"Norah A.","family":"Alturaiqi","sequence":"first","affiliation":[{"name":"Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2809-7880","authenticated-orcid":false,"given":"Wijdan S.","family":"Aljebreen","sequence":"additional","affiliation":[{"name":"Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-9020","authenticated-orcid":false,"given":"Wedad","family":"Alawad","sequence":"additional","affiliation":[{"name":"Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-0296","authenticated-orcid":false,"given":"Shuaa S.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-2826","authenticated-orcid":false,"given":"Haifa F.","family":"Alhasson","sequence":"additional","affiliation":[{"name":"Department of Information Technology, College of Computer, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). 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