{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:30:44Z","timestamp":1792765844403,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Treatment of severe traumatic brain injury (TBI) remains a major challenge in neurocritical care. The functional state of the brain largely depends on the applied ventilation strategy. Many patients develop acute respiratory distress syndrome (ARDS), for which lung-protective ventilation is recommended. However, its effect on outcomes in severe TBI remains unclear. This study aimed to assess whether a lung-protective ventilation strategy improves short-term outcomes in patients with severe TBI complicated by ARDS. Methods: This multicenter retrospective study included patients with severe TBI and ARDS treated in three Ukrainian tertiary hospitals. Lung-protective ventilation was defined as the use of a low tidal volume and moderate positive end-expiratory pressure (PEEP). The primary endpoint was 28-day mortality; secondary endpoints included the Glasgow Coma Scale (GCS) score and intracranial pressure (ICP) on day 28. Univariate and multivariate logistic regression analyses identified factors associated with mortality. Results: Mortality did not depend on arterial PaO2 (p = 0.173) but correlated with lower GCS (p &lt; 0.001), reduced PaO2\/FiO2 ratio (p &lt; 0.001), higher tidal volume (p &lt; 0.001), and lower PEEP (p &lt; 0.001). Lung-protective ventilation reduced mortality from 78.6% to 31.4%. Conclusions: Lung-protective ventilation is safe and effective in severe TBI with ARDS, significantly improving short-term survival without compromising cerebral outcomes.<\/jats:p>","DOI":"10.3390\/brainsci15111151","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:16:07Z","timestamp":1761642967000},"page":"1151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficiency of a Protective Mode of Mechanical Ventilation in Patients with Severe Traumatic Brain Injury Complicated by Acute Respiratory Distress Syndrome"],"prefix":"10.3390","volume":"15","author":[{"given":"Marta","family":"Rachel","sequence":"first","affiliation":[{"name":"Department of Allergology and Cystic Fibrosis, Rzeszow University, 35-315 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svitlana","family":"Yaroslavska","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstiantyn","family":"Krenov","sequence":"additional","affiliation":[{"name":"Department of Surgery with a Course in the Basics of Dentistry, Faculty of Postgraduate Education, Vinnytsia National Medical University Named After M. I. Pirogov, Pilotna St. 1, 29000 Khmelnytski, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Mamonowa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Dobrorodniy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Ternopil National Medical University, 46000 Ternopil, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2886-7741","authenticated-orcid":false,"given":"Oleksandr","family":"Oliynyk","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: Integrated approaches to improve prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.21037\/jtd-23-425","article-title":"Incidence rate and risk factors of ventilator-associated pneumonia in patients with traumatic brain injury: A systematic review and meta-analysis of observational studies","volume":"15","author":"Chen","year":"2023","journal-title":"J. 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