{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:45Z","timestamp":1787027805923,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["TZ 100\/2-1"],"award-info":[{"award-number":["TZ 100\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["510395418"],"award-info":[{"award-number":["510395418"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Tinnitus treatment is often based on coping strategies, as, still, no causal treatment is available. Based on our \u201cErlangen model\u201d of tinnitus development, we treated tinnitus patients with individualized, non-masking low-intensity noise (LIN) to reduce the tinnitus loudness. Methods: A total of 72 adult patients with a tinnitus severity index below IV (tinnitus health questionnaire, THQ), a hearing loss not exceeding 40 dB up to 6 kHz, and without experience in hearing aid (HA) usage were included in this study. Their audiograms, tinnitus parameters, THQ scores, and optimal LIN were determined individually. Patients were double-blinded, assigned to a treatment-only (TO) or placebo-and-treatment (PT) group. The TO patients received treatment for four weeks while the PT patients initially received a placebo (low-intensity white noise) stimulation for two weeks and, hereinafter, treatment for four weeks. Every two weeks, the measurements listed above were repeated. The long-term effects on THQ were assessed four weeks after the end of treatment. The data were analyzed by parametric and nonparametric statistics. Results: We identified a significant decrease in the THQ score already after two (\u03b72 = 0.14) and four weeks of treatment (\u03b72 = 0.43), that was still present four weeks after the end of treatment (\u03b72 = 0.15) in the TO group. Subjective individual patient reports hint at a possible complete suppression of the percept by LINTS. The PT group profited much less, as the initial placebo treatment seemed to counteract the LIN effects. Conclusions: Individually fitted LIN treatment seems to be able to suppress tinnitus, in some cases completely. The optimal fitting of the LIN is crucial for treatment success.<\/jats:p>","DOI":"10.3390\/brainsci15111222","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:06:36Z","timestamp":1763111196000},"page":"1222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phase II Clinical Study on Low-Intensity-Noise Tinnitus Suppression (LINTS) for Tinnitus Treatment"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-9249","authenticated-orcid":false,"given":"Konstantin","family":"Tziridis","sequence":"first","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Heep","sequence":"additional","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Piwonski","sequence":"additional","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Nguyen","sequence":"additional","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"K\u00f6lbl","sequence":"additional","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Schilling","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation and Neuroprosthetics, University Hospital Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"},{"name":"BG Clinic Ludwigshafen, Ludwig-Guttmann-Stra\u00dfe 13, 67071 Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-4541","authenticated-orcid":false,"given":"Holger","family":"Schulze","sequence":"additional","affiliation":[{"name":"ENT Clinic Head and Neck Surgery, Experimental Otolaryngology, University Hospital Erlangen, Waldstrasse 1, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Di Stadio, A., Dipietro, L., Ricci, G., Della Volpe, A., Minni, A., Greco, A., De Vincentiis, M., and Ralli, M. 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