{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:42:41Z","timestamp":1763113361945,"version":"3.45.0"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Socio-cognitive disorders constitute the early-stage disabling dimension of non-motor symptoms of Parkinson\u2019s disease (PD) and affect social functioning and interpersonal adjustment. However, current assessment tools do not adequately reveal the nature of these disorders. The Edinburgh Social Cognition Test (ESCoT) has recently been validated as a multifaceted, sensitive instrument for detecting this dysfunction in various neurological disorders. This study aimed to systematically examine socio-cognitive changes in early-stage PD using the ESCoT and their relationship with executive functions. Methods: This prospective case\u2013control study included 27 early-stage idiopathic PD patients without cognitive impairment and 46 healthy controls. Social cognitive abilities were assessed using the ESCoT, and executive functions via the Frontal Assessment Battery (FAB). Group differences and inter-variable linear associations were evaluated using parametric inferential statistics. The independent predictive contribution of FAB to ESCoT performance was modeled through multiple linear regression. Results: Groups did not differ in age, sex, or education (p &gt; 0.05). PD patients had significantly lower ESCoT total scores (45.67 \u00b1 0.85 vs. 55.52 \u00b1 0.63) and reduced performance across all subscales: Cognitive Theory of Mind (ToM), affective ToM, interpersonal, and intrapersonal norms (p &lt; 0.001). In the PD cohort, FAB correlated strongly with ESCoT (r &gt; 0.40, p &lt; 0.05) and significantly predicted ESCoT total (R2 = 0.247, p = 0.008), affective ToM (\u03b2 = 0.221, p = 0.034), and interpersonal norms (\u03b2 = 0.447, p = 0.019). Conclusions: This study demonstrates, for the first time, that ESCoT can sensitively capture multidimensional social cognitive deficits in PD, even in preserved global cognitive function. The observed link with executive dysfunction underlines the need for a more integrative approach to cognitive symptoms in PD.<\/jats:p>","DOI":"10.3390\/brainsci15111223","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:06:36Z","timestamp":1763111196000},"page":"1223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional Phenotyping and Predictive Neuropsychological Modeling of Socio-Cognitive Endophenotypes in Early Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-9619","authenticated-orcid":false,"given":"Esra","family":"Demir \u00dcnal","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melih","family":"\u00c7amc\u0131","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-3318","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Institute of Health Sciences, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06800, Turkey"},{"name":"Department of Biophysics, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jnp.12028","article-title":"Executive dysfunction in Parkinson\u2019s disease: A review","volume":"7","author":"Dirnberger","year":"2013","journal-title":"J. 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