{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:35:08Z","timestamp":1787027708886,"version":"build-2736575974"},"reference-count":95,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: The anterior cerebral artery (ACA), as one of the terminal branches of the internal carotid artery, supplies the medial and superior portions of the frontal lobes as well as the anterior portions of the parietal lobes. The present meta-analysis aims to consolidate current knowledge regarding the anatomy and variations in the ACA, providing a comprehensive resource for physicians. Methods: To conduct this meta-analysis, we systematically searched prominent online medical databases, including PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar, to identify all studies that investigated the anatomy of the ACA. Results: The results of the present study were based on a total of 73 articles. In the aforementioned studies, a total of 24,015 patients were evaluated. The pooled mean total length of the A1 segment of the ACA, based on all evaluated cases, was 14.47 mm (SE = 0.28). The pooled mean total diameter of the A1 segment measured 2.00 mm on average (SE = 0.07). The overall pooled prevalence of the median ACA was 2.65% (95% CI: 1.57\u20133.99%). Conclusions: This systematic review and meta-analysis provide valuable insights into the anatomy and variations in the ACA. The current data may support clinicians and neurosurgeons in the management of cerebrovascular diseases and associated procedures, potentially enhancing procedural safety and therapeutic outcomes.<\/jats:p>","DOI":"10.3390\/brainsci15121277","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:26:57Z","timestamp":1764318417000},"page":"1277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anatomical Variations and Morphometric Features of the Anterior Cerebral Artery: A Systematic Review and Meta-Analysis of 24,015 Cases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-165X","authenticated-orcid":false,"given":"Micha\u0142","family":"Bonczar","sequence":"first","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Mo\u017cd\u017ce\u0144","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Murawska","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Toppich","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-9471","authenticated-orcid":false,"given":"Patryk","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elsaftawy","sequence":"additional","affiliation":[{"name":"Department of Plastic and Hand Surgery, St. Jadwiga \u015al\u0105ska Hospital, 55-100 Trzebnica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Yevstifeieva","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Koziej","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagiellonian University Medical College, 31-034 Krak\u00f3w, Poland"},{"name":"Youthoria, Youth Research Organization, 31-034 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-5380","authenticated-orcid":false,"given":"Magdalena","family":"Grzonkowska","sequence":"additional","affiliation":[{"name":"Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Orkisz","sequence":"additional","affiliation":[{"name":"Department of Normal and Clinical Anatomy, Faculty of Medicine, University of Social Sciences in Lodz, 90-113 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-3686","authenticated-orcid":false,"given":"Andrzej","family":"\u017bytkowski","sequence":"additional","affiliation":[{"name":"Department of Normal and Clinical Anatomy, Faculty of Medicine, University of Social Sciences in Lodz, 90-113 \u0141\u00f3d\u017a, Poland"},{"name":"Norbert Barlicki Memorial Teaching Hospital No. 1 of the Medical University of Lodz, 90-153 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical University of Lodz, 90-419 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-4998","authenticated-orcid":false,"given":"Micha\u0142","family":"Polguj","sequence":"additional","affiliation":[{"name":"Department of Normal and Clinical Anatomy, Chair of Anatomy and Histology, Medical University of Lodz, 90-752 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-2295","authenticated-orcid":false,"given":"Grzegorz","family":"Wysiadecki","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroanatomy, Department of Normal and Clinical Anatomy, Chair of Anatomy and Histology, Medical University of Lodz, 90-752 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","unstructured":"Moore, K.L., Dalley, A.F., and Agur, A. (2017). Clinically Oriented Anatomy, Lippincott Williams and Wilkins. [8th ed.]."},{"key":"ref_2","unstructured":"Haines, D.E., Gregory, A., and Mihailoff, G.A. (2018). Fundamental Neuroscience for Basic and Clinical Applications, Elsevier."},{"key":"ref_3","first-page":"100161","article-title":"Early Bifurcation of the Middle Cerebral Artery\u2014A Case Report with Commentaries on the Clinical Significance","volume":"26","author":"Clarke","year":"2022","journal-title":"Transl. Res. Anat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aanat.2016.04.036","article-title":"Detailed Description of the Anterior Cerebral Artery Anomalies Observed in a Cadaver Population","volume":"208","author":"Cilliers","year":"2016","journal-title":"Ann. Anat.\u2014Anat. Anz."},{"key":"ref_5","first-page":"e58808","article-title":"Anterior Interhemispheric Approach for the Surgical Treatment of Azygos Anterior Cerebral Artery Aneurysms: A Case Series","volume":"16","year":"2024","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.5797\/jnet.cr.2020-0181","article-title":"Mechanical Thrombectomy for Azygos Anterior Cerebral Artery Occlusion: A Case Report and Literature Review","volume":"15","author":"Asai","year":"2021","journal-title":"J. Neuroendovascular Ther."},{"key":"ref_7","unstructured":"Anetsberger, S., Gonzalez-Lopez, P., Elsawaf, Y., Giotta Lucifero, A., Luzzi, S., and Elbabaa, S. (2022). Interhemispheric Approach. Acta Biomed., 92."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1016\/j.wneu.2019.09.003","article-title":"Morphological Characteristics of Pericallosal Artery Aneurysms and Their High Propensity for Rupture","volume":"133","author":"Zhai","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_9","first-page":"100197","article-title":"Atypical Formation of Pericallosal Artery A4 Segment Altering the Corpus Callosum\u2014Anatomical Case Report","volume":"27","author":"Mazurek","year":"2022","journal-title":"Transl. Res. Anat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ca.23833","article-title":"The Critical Appraisal Tool for Anatomical Meta-analysis: A Framework for Critically Appraising Anatomical Meta-analyses","volume":"35","author":"Tubbs","year":"2022","journal-title":"Clin. Anat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ca.22799","article-title":"Development of the Anatomical Quality Assessment (AQUA) Tool for the Quality Assessment of Anatomical Studies Included in Meta-Analyses and Systematic Reviews","volume":"30","author":"Henry","year":"2017","journal-title":"Clin. Anat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ca.23069","article-title":"Consensus Guidelines for the Uniform Reporting of Study Ethics in Anatomical Research within the Framework of the Anatomical Quality Assurance (AQUA) Checklist","volume":"31","author":"Henry","year":"2018","journal-title":"Clin. Anat."},{"key":"ref_13","first-page":"289","article-title":"The Arteries Forming the Circle of Willis","volume":"22","author":"Windle","year":"1888","journal-title":"J. Anat. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1212\/WNL.13.10.825","article-title":"Studies on the Arteries of the Brain","volume":"13","author":"Baptista","year":"1963","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3171\/jns.1964.21.1.0026","article-title":"Dimensions of the Circle of Willis and Dynamic Studies Using Electrical Analogy","volume":"21","author":"Murray","year":"1964","journal-title":"J. Neurosurg."},{"key":"ref_16","first-page":"134","article-title":"Some Observations On The Anatomy of The Middle Cerebral Artery","volume":"7","author":"Jain","year":"1964","journal-title":"Can. J. Surg."},{"key":"ref_17","first-page":"99","article-title":"The Circle of Willis: Anatomical Variations","volume":"2","author":"Fisher","year":"1965","journal-title":"Vasc. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2214\/ajr.98.3.602","article-title":"The Clinical Significance of The Azygos Anterior Cerebral Artery (A.C.A.)","volume":"98","author":"Lemay","year":"1966","journal-title":"Am. J. Roentgenol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2214\/ajr.101.1.68","article-title":"Experience and Result With Postmortem Cerebral Angiography Performed As Routine Procedure of The Autopsy","volume":"101","author":"Wollschlaeger","year":"1967","journal-title":"Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2214\/ajr.104.1.109","article-title":"Roentgenographic Anatomy of The Pericallosal Arteries","volume":"104","author":"Ring","year":"1968","journal-title":"Am. J. Roentgenol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3171\/jns.1976.44.3.0359","article-title":"Surgical Anatomy of the Proximal Anterior Cerebral Artery","volume":"44","author":"Dunker","year":"1976","journal-title":"J. Neurosurg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3171\/jns.1976.45.3.0259","article-title":"Microsurgical Anatomy of the Anterior Cerebral-Anterior Communicating-Recurrent Artery Complex","volume":"45","author":"Perlmutter","year":"1976","journal-title":"J. Neurosurg."},{"key":"ref_23","first-page":"3","article-title":"Anatomical Variations of the Arterial System of the Base of the Brain","volume":"46","author":"Ozaki","year":"1977","journal-title":"Nihon Geka Hokan"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0303-8467(78)80038-9","article-title":"A Study of the Anatomy of the Anterior Communicating Artery with the Aid of the Operating Microscope","volume":"80","author":"Tulleken","year":"1978","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3171\/jns.1978.49.2.0204","article-title":"Microsurgical Anatomy of the Distal Anterior Cerebral Artery","volume":"49","author":"Perlmutter","year":"1978","journal-title":"J. Neurosurg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00342389","article-title":"Incidence of Berry Aneurysms of the Unpaired Pericallosal Artery: Angiographic Study","volume":"19","author":"Huber","year":"1980","journal-title":"Neuroradiology"},{"key":"ref_27","first-page":"419","article-title":"Observations on the Length and Diameter of Vessels Forming the Circle of Willis","volume":"133","author":"Kamath","year":"1981","journal-title":"J. Anat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000146042","article-title":"Blood Vessel Size of Circulus Arteriosus Cerebri (Circle of Willis): A Statistical Research on 100 Human Subjects","volume":"123","author":"Orlandini","year":"1985","journal-title":"Cells Tissues Organs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0090-3019(86)90365-4","article-title":"Microanatomy of the Anterior Cerebral Artery","volume":"26","author":"Gomes","year":"1986","journal-title":"Surg. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1148\/radiology.207.1.9530305","article-title":"Circle of Willis: Morphologic Variation on Three-Dimensional Time-of-Flight MR Angiograms","volume":"207","author":"Algra","year":"1998","journal-title":"Radiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3171\/jns.1992.77.6.0927","article-title":"Variability of the Territories of the Major Cerebral Arteries","volume":"77","author":"Hillen","year":"1992","journal-title":"J. Neurosurg."},{"key":"ref_32","first-page":"675","article-title":"Fenestration of Intracranial Arteries with Special Attention to Associated Aneurysms and Other Anomalies","volume":"14","author":"Sanders","year":"1993","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0301-5629(93)90109-2","article-title":"Morphometry of Intraluminal Side-to-Side Differences in Human Basal Cerebral Arteries","volume":"19","author":"Piepgras","year":"1993","journal-title":"Ultrasound Med. Biol."},{"key":"ref_34","first-page":"115","article-title":"Magnetic Resonance Angiographic Evaluation of Circulus Arteriosus Cerebri (Circle of Willis): A Morphologic Study in 100 Human Healthy Subjects","volume":"101","author":"Macchi","year":"1996","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/00006123-199706000-00019","article-title":"Microsurgical Anatomy and Clinical Significance of the Anterior Communicating Artery and Its Perforating Branches","volume":"40","author":"Serizawa","year":"1997","journal-title":"Neurosurgery"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/1098-2353(2000)13:4<231::AID-CA1>3.0.CO;2-T","article-title":"Anatomic Variations of Anterior Cerebral Artery Cortical Branches","volume":"13","author":"Stefani","year":"2000","journal-title":"Clin. Anat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0303-8467(01)00103-2","article-title":"Perforating Branches of the Anomalous Anterior Communicating Complex","volume":"103","author":"Avci","year":"2001","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_38","first-page":"3","article-title":"[Variation in the Flow and Branching of the Anterior and Middle Cerebral Arteries]","volume":"57","author":"Ovcina","year":"2003","journal-title":"Med. Arh."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.surneu.2005.07.049","article-title":"Arterial Vascularization of Primary Motor Cortex (Precentral Gyrus)","volume":"64","author":"Ugur","year":"2005","journal-title":"Surg. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/0028-3886.16406","article-title":"Microsurgical Anatomy of the Middle Cerebral Artery","volume":"53","author":"Pai","year":"2005","journal-title":"Neurol. India"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3171\/jns.2006.104.2.278","article-title":"A Neurosurgical View of Anatomical Variations of the Distal Anterior Cerebral Artery: An Anatomical Study","volume":"104","author":"Ugur","year":"2006","journal-title":"J. Neurosurg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.surneu.2005.05.027","article-title":"Microsurgical Anatomy of the Anterior Communicating Artery Complex in Adult Chinese Heads","volume":"65","author":"Tao","year":"2006","journal-title":"Surg. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4067\/S0717-95022007000400038","article-title":"Biometrical Aspects of the Anterior Cerebral Artery in Its Proximal Segment (A1) and Internal Carotid Artery","volume":"25","author":"Mandiola","year":"2007","journal-title":"Int. J. Morphol."},{"key":"ref_44","first-page":"97","article-title":"Variant Anatomy of The Anterior Cerebral Artery In Adult Brains","volume":"27","author":"Saidi","year":"2008","journal-title":"Afr. J. Neurol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.surneu.2008.03.008","article-title":"Microneurosurgical Management of Aneurysms at the A2 Segment of Anterior Cerebral Artery (Proximal Pericallosal Artery) and Its Frontobasal Branches","volume":"70","author":"Lehecka","year":"2008","journal-title":"Surg. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1447-073X.2007.00216.x","article-title":"Variations in the Configuration of the Circle of Willis","volume":"83","author":"Kapoor","year":"2008","journal-title":"Anat. Sci. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ca.20647","article-title":"Callosal Branches of the Anterior Cerebral Artery: An Anatomical Report","volume":"21","author":"Kahilogullari","year":"2008","journal-title":"Clin. Anat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-2007-1004588","article-title":"Changing Diameters of Cerebral Vessels with Age in Human Autopsy Specimens: Possible Relationships to Atherosclerotic Changes","volume":"69","author":"Ozdogmus","year":"2008","journal-title":"Zentralblatt Neurochir.\u2014Cent. Eur. Neurosurg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ca.21036","article-title":"Three-dimensional Morphometry of the A2 Segment of the Anterior Cerebral Artery with Neurosurgical Relevance","volume":"23","author":"Gielecki","year":"2010","journal-title":"Clin. Anat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ejrnm.2011.09.001","article-title":"Three Dimensional Magnetic Resonance Angiography of the Circle of Willis: Anatomical Variations in General Egyptian Population","volume":"42","author":"Maaly","year":"2011","journal-title":"Egypt. J. Radiol. Nucl. Med."},{"key":"ref_51","first-page":"243","article-title":"Variations in the Brain Circulation\u2014The Circle of Willis","volume":"29","author":"Nordon","year":"2012","journal-title":"J. Morphol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1552-6569.2012.00769.x","article-title":"Azygous Anterior Cerebral Artery and Associated Aneurysms: Detection and Identification Using 3-Dimensional Time-of-Flight Magnetic Resonance Angiography","volume":"24","author":"Shi","year":"2014","journal-title":"J. Neuroimaging"},{"key":"ref_53","first-page":"046","article-title":"Anatomic Features of Distal Anterior Cerebral Artery Supply on Corpus Callosum: A Detailed Study on 140 Cerebral Hemispheres","volume":"29","author":"Swetha","year":"2012","journal-title":"J. Neurol. Sci. Turk."},{"key":"ref_54","first-page":"764","article-title":"Length of the Anterior Cerebral Artery (ACA) on MRI Angiograms","volume":"6","author":"Aggarwal","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/S1516-89132013000100006","article-title":"Influence of the Gender on Cerebral Vascular Diameters Observed during the Magnetic Resonance Angiographic Examination of Willis Circle","volume":"56","author":"Stefani","year":"2013","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/0028-3886.111113","article-title":"Microsurgical Anatomy of the Anterior Cerebral Artery in Indian Cadavers","volume":"61","author":"Kedia","year":"2013","journal-title":"Neurol. India"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00276-013-1082-8","article-title":"Display with 64-Detector MDCT Angiography of Cerebral Vascular Variations","volume":"35","author":"Hamidi","year":"2013","journal-title":"Surg. Radiol. Anat."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1227\/NEU.0000000000000125","article-title":"The A1-A2 Diameter Ratio May Influence Formation and Rupture Potential of Anterior Communicating Artery Aneurysms","volume":"73","author":"Flores","year":"2013","journal-title":"Neurosurgery"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"687281","DOI":"10.1155\/2014\/687281","article-title":"Anatomical Variations of the Circulus Arteriosus in Cadaveric Human Brains","volume":"2014","author":"Gunnal","year":"2014","journal-title":"Neurol. Res. Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.12659\/MSM.894322","article-title":"Assessment of the Circle of Willis with Cranial Tomography Angiography","volume":"21","author":"Karatas","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12565-015-0301-2","article-title":"A Multitude of Variations in the Configuration of the Circle of Willis: An Autopsy Study","volume":"91","author":"Rybicka","year":"2016","journal-title":"Anat. Sci. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00701-015-2497-2","article-title":"The Extended Endoscopic Endonasal Transplanum Transtuberculum Approach to the Anterior Communicating Artery Complex: Anatomic Study","volume":"157","author":"Berenguer","year":"2015","journal-title":"Acta Neurochir."},{"key":"ref_63","first-page":"608","article-title":"Angiographic Morphometry of Internal Carotid Circulation in Turkish Children","volume":"25","author":"Arat","year":"2015","journal-title":"Turk. Neurosurg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.16965\/ijar.2016.189","article-title":"Diameter of Anterior Cerebral Artery On Mri Angiograms","volume":"4","author":"Aggarwal","year":"2016","journal-title":"Int. J. Anat. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.16965\/ijar.2016.193","article-title":"Anatomical Variations In Anterior Cerebral Artery In Human Cadavers","volume":"4","author":"Shinde","year":"2016","journal-title":"Int. J. Anat. Res."},{"key":"ref_66","first-page":"54","article-title":"The Anatomy of Circulus Arteriosus Cerebri (Circle of Willis): A Study in Turkish Population","volume":"26","author":"Karatas","year":"2015","journal-title":"Turk. Neurosurg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clineuro.2016.11.024","article-title":"Description of the Anterior Cerebral Artery and Its Cortical Branches: Variation in Presence, Origin, and Size","volume":"152","author":"Cilliers","year":"2017","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3889\/oamjms.2017.160","article-title":"Influence of Gender and Age on Average Dimensions of Arteries Forming the Circle of Willis Study by Magnetic Resonance Angiography on Kosovo\u2019s Population","volume":"5","author":"Shatri","year":"2017","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.wneu.2017.09.048","article-title":"Monolateral Pterional Keyhole Approaches to Bilateral Cerebral Aneurysms: Anatomy and Clinical Application","volume":"108","author":"Yu","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_70","first-page":"37","article-title":"Morphological Changes of Anterior Cerebral Artery (ACA) in Hydrocephalic Pediatric Patients","volume":"11","author":"Ozturk","year":"2017","journal-title":"Iran. J. Child. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4067\/S0717-95022017000300049","article-title":"Anatomical Variants of Anterior Cerebral Arterial Circle: A Study by Multidetector Computerized 3D Tomographic Angiography","volume":"35","year":"2017","journal-title":"Int. J. Morphol."},{"key":"ref_72","first-page":"56","article-title":"Morphometric Analysis of the Arteries of Willis Polygon","volume":"32","author":"Canaz","year":"2018","journal-title":"Rom. Neurosurg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5603\/FM.a2018.0095","article-title":"Anatomical Variations and Dimensions of Arteries in the Anterior Part of the Circle of Willis","volume":"78","author":"Shatri","year":"2019","journal-title":"Folia Morphol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.16965\/ijar.2019.156","article-title":"Anatomic Variants of The Anterior Part of The Cerebral Arterial Circle: A Cadaveric Study","volume":"7","author":"Thenmozhi","year":"2019","journal-title":"Int. J. Anat. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"703","DOI":"10.5603\/FM.a2019.0015","article-title":"Configuration of the Circle of Willis and Its Two Parts among Egyptian: A Magnetic Resonance Angiographic Study","volume":"78","author":"Zaki","year":"2019","journal-title":"Folia Morphol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.morpho.2019.07.001","article-title":"Morphometric Evaluation of Anterior Cerebral Artery (on Digital Subtraction Angiography)\u2013Potential Implications","volume":"104","author":"Sharma","year":"2020","journal-title":"Morphologie"},{"key":"ref_77","first-page":"121","article-title":"Variantes anat\u00f3micas del c\u00edrculo arterial cerebral en un anfiteatro universitario en Bogot\u00e1 (Colombia)","volume":"18","author":"Blanco","year":"2020","journal-title":"Rev. Cienc. de la Salud"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00276-020-02509-4","article-title":"Radiological Classification of Azygos Anterior Cerebral Artery and Evaluation of the Accompanying Vascular Anomalies","volume":"42","author":"Beyhan","year":"2020","journal-title":"Surg. Radiol. Anat."},{"key":"ref_79","unstructured":"Giotta Lucifero, A., Baldoncini, M., Bruno, N., Tartaglia, N., Ambrosi, A., Marseglia, G.L., Galzio, R., Campero, A., Hernesniemi, J., and Luzzi, S. (2021). Microsurgical Neurovascular Anatomy of the Brain: The Anterior Circulation (Part I). Acta Biomed., 92."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4067\/S0717-95022022000300632","article-title":"Variations of the Cerebral Arterial Circle. Morphological and Clinical Analysis","volume":"40","author":"Riveros","year":"2022","journal-title":"Int. J. Morphol."},{"key":"ref_81","first-page":"100200","article-title":"A Clinical Investigation of the Anatomy of the Proximal Anterior Cerebral Artery and Its Association with Anterior Communicating Artery Aneurysm","volume":"27","author":"Luckrajh","year":"2022","journal-title":"Transl. Res. Anat."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"469","DOI":"10.5115\/acb.23.162","article-title":"Magnetic Resonance Angiography in Assessment of Anomalies of Anterior Cerebral Artery in Adults","volume":"56","author":"Madkour","year":"2023","journal-title":"Anat. Cell Biol."},{"key":"ref_83","unstructured":"Forero, P. (2006). Variaciones Del C\u00edrculo Arterial Cerebral (Willis) y de Las Arterias Cere-Brales: Un Estudio Anat\u00f3mico Directo. [Master\u2019s Thesis, Escuela de Medicina, Universidad Industrial de Santander]."},{"key":"ref_84","first-page":"15","article-title":"Variations of the Anterior Cerebral Artery in Human Cadavers: A Dissection Study","volume":"53","author":"Paul","year":"2004","journal-title":"J. Anat. Soc. India"},{"key":"ref_85","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2024). Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Available online: www.cochrane.org\/handbook."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aanat.2015.12.002","article-title":"Methods of Evidence-Based Anatomy: A Guide to Conducting Systematic Reviews and Meta-Analysis of Anatomical Studies","volume":"205","author":"Henry","year":"2016","journal-title":"Ann. Anat.\u2014Anat. Anz."},{"key":"ref_87","first-page":"653","article-title":"Review of the Anatomy of the Distal Anterior Cerebral Artery and Its Anomalies","volume":"26","author":"Cilliers","year":"2015","journal-title":"Turk. Neurosurg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neurad.2018.12.001","article-title":"Endovascular Treatment of Distal Anterior Cerebral Artery Aneurysms: Long-Term Results","volume":"47","author":"Liao","year":"2020","journal-title":"J. Neuroradiol."},{"key":"ref_89","first-page":"157","article-title":"Single-Lane Clipping Technique for a Ruptured Aneurysm of A1 Fenestration of the Anterior Cerebral Artery: A Case Report and Literature Review","volume":"85","author":"Kubota","year":"2023","journal-title":"Nagoya J. Med. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.surneu.2008.03.012","article-title":"Surgery for Distal Anterior Cerebral Artery Aneurysms","volume":"70","author":"Lee","year":"2008","journal-title":"Surg. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5797\/jnet.cr.2021-0026","article-title":"A Case of a Ruptured Aneurysm at the Supracallosal Portion (A4\u2013A5) of the Bihemispheric Anterior Cerebral Artery Treated with Endovascular Surgery","volume":"16","author":"Uchino","year":"2022","journal-title":"J. Neuroendovascular Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1097\/SCS.0000000000009403","article-title":"Bihemispheric Right Anterior Cerebral Artery, Fenestrated Origin of the Left Pericallosal Artery, Fenestrated Basilar Artery, Double Right Posterior Cerebral Artery","volume":"34","author":"Rusu","year":"2023","journal-title":"J. Craniofacial Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"ons65","DOI":"10.1227\/01.NEU.0000365550.84124.BB","article-title":"Anterior Interhemispheric Approach for 100 Tumors in and Around the Anterior Third Ventricle","volume":"66","author":"Hori","year":"2010","journal-title":"Oper. Neurosurg."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3171\/2014.12.JNS141732","article-title":"Posterior Callosotomy Using a Parietooccipital Interhemispheric Approach in the Semi-Prone Park-Bench Position","volume":"123","author":"Ito","year":"2015","journal-title":"J. Neurosurg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1161\/STROKEAHA.120.032867","article-title":"Anterior Cerebral Artery Stroke: Role of Collateral Systems on Infarct Topography","volume":"52","author":"Thirugnanachandran","year":"2021","journal-title":"Stroke"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/12\/1277\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:50:26Z","timestamp":1764319826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/12\/1277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":95,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["brainsci15121277"],"URL":"https:\/\/doi.org\/10.3390\/brainsci15121277","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]}}}