{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:54:04Z","timestamp":1766490844904,"version":"3.48.0"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Introduction: Syringomyelia is a rare disease of the spinal cord, and postoperative syringomyelia is an extremely rare complication. There are very few scientific reports on this subject in the literature, which is why we decided to review them and report our case of a patient after resection of a meningioma of the foramen magnum; we diagnosed syringomyelia in the course of postoperative complications. Methods: PubMed MEDLINE, Scopus, and Web of Science were searched. The PRISMA checklist was followed for a systematic structure. We paid special attention to publications describing syringomyelia only as a complication of invasive procedures and not as a pathology co-occurring with other diseases. In addition, our studies were based exclusively on the adult population. Results: As a result of the literature analysis, we selected 5 papers that met the established criteria, which are case studies describing the 5 patients. In each of them, syringomyelia was diagnosed after a procedure on the central nervous system (or spine). In three papers, it was decided to treat the syringomyelia that developed in this way surgically, and in the remaining two, conservative treatment and adjustment of the already inserted ventriculoperitoneal shunt were performed. The case of a patient described by us after resection of a meningioma of the foramen magnum required surgical treatment of syringomyelia after two years due to significant progression of the syrinx and the occurrence of troublesome clinical symptoms. In all cases described (including ours), significant clinical improvement was ultimately achieved, allowing patients to return to their daily activities. Conclusions: Iatrogenic syringomyelia is an extremely rare complication that is poorly described in the literature. The large heterogeneity and small number of reported cases make it difficult to draw clear conclusions. Further studies and analyses describing this topic are necessary, and will allow for a better understanding of the mechanism and standardized treatment. However, based on our work, we suggest that interventions on the ventricular system in particular may increase the probability of postoperative syringomyelia.<\/jats:p>","DOI":"10.3390\/brainsci16010014","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:30:18Z","timestamp":1766489418000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Syringomyelia\u00a0in the Course of Resection of Foramen Magnum Pathology: A Case Report with an Intriguing Therapeutic Solution and Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2868-4549","authenticated-orcid":false,"given":"Rafal","family":"Rajski","sequence":"first","affiliation":[{"name":"Doctoral School, University of Opole, 45-060 Opole, Poland"},{"name":"Department of Neurosurgery, University Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Kolodziej","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Sobolewski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kandziora","sequence":"additional","affiliation":[{"name":"Helimed\u2014Imaging Diagnostics, St. Hedwig\u2019s Regional Specialist Hospital, 45-221 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-2094","authenticated-orcid":false,"given":"Tomasz","family":"Klepinowski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Latka","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Hedwig\u2019s Regional Specialist Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Labuz-Roszak","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Hedwig\u2019s Regional Specialist Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-2477","authenticated-orcid":false,"given":"Dariusz","family":"Latka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-4489","authenticated-orcid":false,"given":"Kajetan","family":"Latka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland"},{"name":"Department of Neurosurgery, St. Hedwig\u2019s Regional Specialist Hospital, 45-221 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/practneurol-2021-002994","article-title":"Syringomyelia: Diagnosis and management","volume":"21","author":"Flint","year":"2021","journal-title":"Pract. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/neurosurgery\/6.CN_suppl_1.131","article-title":"The mechanism of syringomyelia and its surgical correction","volume":"6","author":"Gardner","year":"1958","journal-title":"Clin. Neurosurg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/014107688007301109","article-title":"On the pathogenesis of syringomyelia: A review","volume":"73","author":"Williams","year":"1980","journal-title":"J. R. Soc. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0140-6736(72)92152-6","article-title":"Pathogenesis of syringomyelia","volume":"14","author":"Ball","year":"1972","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3171\/jns.1994.80.1.0003","article-title":"Pathophysiology of syringomyelia associated with Chiari I malformation of the cerebellar tonsils. Implications for diagnosis and treatment","volume":"80","author":"Oldfield","year":"1994","journal-title":"J. Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10143-010-0266-5","article-title":"Pathogenesis of syringomyelia associated with Chiari type 1 malformation: Review of evidences and proposal of a new hypothesis","volume":"33","author":"Koyanagi","year":"2010","journal-title":"Neurosurg. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nrl.2016.09.010","article-title":"Update on the pathophysiology and management of syringomyelia unrelated to Chiari malformation","volume":"34","author":"Giner","year":"2019","journal-title":"Neurologia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"246714","DOI":"10.1136\/bcr-2021-246714","article-title":"Delayed presentation of syringomyelia after retrosigmoid craniectomy and resection of vestibular schwannoma: Discussion of mechanisms","volume":"14","author":"Egu","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Aromataris, E., and Munn, Z. (2020). Chapter 7: Systematic reviews of etiology and risk. JBI Manual for Evidence Synthesis, JBI.","DOI":"10.46658\/JBIRM-17-01"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1590\/S0004-282X2004000500029","article-title":"Syringohydromyelia associated to therapeutic procedures for severe forms of neurocysticercoses: Case report","volume":"62","author":"Honorato","year":"2004","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00381-008-0739-9","article-title":"Decompensated hydrocephalus causing syringomyelia and tetraparesis: A case report","volume":"25","author":"Peraud","year":"2009","journal-title":"Childs Nerv. Syst."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/BRS.0b013e3181cf7621","article-title":"Cervical epidural injection complicated by syrinx formation: A case report","volume":"35","author":"Khan","year":"2010","journal-title":"Spine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/02688697.2017.1297369","article-title":"Iatrogenic syringomyelia secondary to lumboperitoneal shunt altered by the raised intra-abdominal pressure of pregnancy","volume":"32","author":"Kersey","year":"2017","journal-title":"Br. J. Neurosurg."},{"key":"ref_14","first-page":"29126","article-title":"Novelty in Impact of Neurorehabilitation in a Classic Case of Syringomyelia","volume":"14","author":"Gade","year":"2022","journal-title":"Cureus"},{"key":"ref_15","first-page":"48","article-title":"Syringomyelia and Chiari Syndrome Registry: Advances in epidemiology, clinical phenotypes and natural history based on a North Western Italy cohort","volume":"56","author":"Ciaramitaro","year":"2020","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1179\/016164111X12962202723760","article-title":"Defining the signs and symptoms of Chiari malformation type I with and without syringomyelia","volume":"33","author":"George","year":"2011","journal-title":"Neurol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/088307389400900103","article-title":"Pediatric syringomyelia","volume":"9","author":"Gower","year":"1994","journal-title":"J. Child. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.asjsur.2022.06.150","article-title":"Outcome predictors and clinical presentation of syringomyelia","volume":"46","author":"Zheng","year":"2023","journal-title":"Asian J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3171\/2014.10.PEDS14295","article-title":"Pediatric and adult Chiari malformation Type I surgical series 1965-2013: A review of demographics, operative treatment, and outcomes","volume":"15","author":"Arnautovic","year":"2015","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01428512","article-title":"Magnetic resonance imaging (MRI) in syringomyelia","volume":"134","author":"Tanghe","year":"1995","journal-title":"Acta Neurochir."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3174\/ajnr.A5328","article-title":"Syringomyelia Fluid Dynamics and Cord Motion Revealed by Serendipitous Null Point Artifacts during Cine MRI","volume":"38","author":"Honey","year":"2017","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1227\/01.NEU.0000334411.93870.45","article-title":"Cardiac-gated phase-contrast magnetic resonance imaging of cerebrospinal fluid flow in the diagnosis of idiopathic syringomyelia","volume":"63","author":"Mauer","year":"2008","journal-title":"Neurosurgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jns.2018.09.034","article-title":"Posttubercular syringomyelia in HIV-infected patients: A report of 10 cases and literature review","volume":"395","author":"Marais","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/jnnp.53.2.106","article-title":"Syringomyelia and arachnoiditis","volume":"53","author":"Caplan","year":"1990","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/10790268.2020.1743086","article-title":"Radiographic assessment of surgical treatment of post-traumatic syringomyelia","volume":"44","author":"Li","year":"2021","journal-title":"J. Spinal Cord. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2176\/nmc.51.157","article-title":"Syringomyelia due to thoracic spinal stenosis with ossified ligamentum flavum\u2014Case report","volume":"51","author":"Arai","year":"2011","journal-title":"Neurol. Med. Chir."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.wneu.2016.11.080","article-title":"Acquired Chiari Malformation and Syringomyelia Secondary to Space-Occupying Lesions: A Systematic Review","volume":"98","author":"Wang","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3171\/2019.12.PEDS19427","article-title":"CSF goes astray no matter what is in the way: Occipital intradiploic pseudomeningocele and de novo syringomyelia following foramen magnum decompression for Chiari I malformation in a pediatric patient","volume":"25","author":"Kurzbuch","year":"2020","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.wneu.2023.02.134","article-title":"Low versus High Intracranial Compliance in Adult Patients with Chiari Malformation Type 1-Comparison of Long-Term Outcome After Tailored Treatment","volume":"173","author":"Ringstad","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10143-023-01972-y","article-title":"Fourth ventricle to spinal subarachnoid space stenting in pediatric patients with refractory syringomyelia: Case series and systematic review","volume":"46","author":"Spennato","year":"2023","journal-title":"Neurosurg. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.wneu.2020.08.068","article-title":"Intradural Pathology Causing Cerebrospinal Fluid Obstruction in Syringomyelia and Effectiveness of Foramen Magnum and Foramen of Magendie Dredging Treatment","volume":"144","author":"Guan","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3171\/jns.1989.71.2.0159","article-title":"Symptomatic Chiari malformations. An analysis of presentation, management, and long-term outcome","volume":"71","author":"Dyste","year":"1989","journal-title":"J. Neurosurg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/21925682211009175","article-title":"An Effective Surgical Method for Terminal Syringomyelia: Terminal Ventriculostomy-Associated \u201cV\u201d-Type Ostomy","volume":"13","author":"Sun","year":"2023","journal-title":"Glob. Spine J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/jnnp.44.4.273","article-title":"Syringomyelia and its surgical treatment\u2014An analysis of 75 patients","volume":"44","author":"Logue","year":"1981","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41598-023-38565-0","article-title":"Spinal cord tethering and syringomyelia after trauma: Impact of age and surgical outcome","volume":"13","author":"Bratelj","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1227\/01.NEU.0000279971.87437.1F","article-title":"Observations on spine deformity and syringomyelia","volume":"61","author":"Batzdorf","year":"2007","journal-title":"Neurosurgery"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1227\/00006123-199510000-00010","article-title":"Surgical indication and results of foramen magnum decompression versus syringosubarachnoid shunting for syringomyelia associated with Chiari I malformation","volume":"37","author":"Hida","year":"1995","journal-title":"Neurosurgery"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1007\/s00381-021-05268-8","article-title":"Iatrogenic syringomyelia postcranial surgery in pediatric patients: Systematic review and illustrative case","volume":"37","author":"Kurzbuch","year":"2021","journal-title":"Childs Nerv. Syst."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/1\/14\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:51:54Z","timestamp":1766490714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/1\/14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["brainsci16010014"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16010014","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}