{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:38:57Z","timestamp":1793320737010,"version":"4.5.0"},"reference-count":137,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TaiShan Scholars","award":["tstp20250540"],"award-info":[{"award-number":["tstp20250540"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0531803"],"award-info":[{"award-number":["2024ZD0531803"]}]},{"name":"Shandong Provincial Sports and Fitness Technology Innovation Center","award":["SJSCXZX2025003"],"award-info":[{"award-number":["SJSCXZX2025003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is characterized by progressive degeneration of the nigrostriatal dopaminergic system and \u03b1-synuclein (\u03b1-syn) pathology, with disease progression driven by convergent mechanisms including neuroinflammation, mitochondrial injury, oxidative stress, and regulated cell-death programs such as ferroptosis. Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) constitute a key signaling system in the central nervous system, influencing not only neuronal survival and glial states but also intersecting with networks governing redox homeostasis and iron metabolism. Accumulating evidence indicates that, beyond classical neurotrophic actions, FGF\u2013FGFR signaling can modulate mitochondrial quality control, glial inflammatory activation, and lipid peroxidation-related processes, thereby reshaping cellular susceptibility to ferroptotic injury. This review summarizes current advances in understanding FGF signaling networks in Parkinson\u2019s disease, synthesizes their potential mechanistic links to the interplay among neuroinflammation, mitochondrial dysfunction, and redox imbalance as well as to ferroptosis regulation, and discusses the experimental basis and translational challenges of targeting the FGF pathway as a disease-modifying therapeutic strategy.<\/jats:p>","DOI":"10.3390\/brainsci16020151","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:56:34Z","timestamp":1769684194000},"page":"151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["FGF\u2013FGFR Signaling in Parkinson\u2019s Disease: Mechanistic Links to Ferroptosis and Neuroprotection"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0833-5019","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Academy of Sports Sciences, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wen","sequence":"additional","affiliation":[{"name":"Academy of Sports Sciences, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[{"name":"Academy of Sports Sciences, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-2678","authenticated-orcid":false,"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Sports Sciences, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Mao","sequence":"additional","affiliation":[{"name":"Physical Education Unit, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-4554","authenticated-orcid":false,"given":"Xuewen","family":"Tian","sequence":"additional","affiliation":[{"name":"Academy of Sports Sciences, Shandong Sport University, Jinan 250102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","first-page":"101078","article-title":"Disease burden of Parkinson\u2019s disease in China and its provinces from 1990 to 2021: Findings from the global burden of disease study 2021","volume":"46","author":"Xu","year":"2024","journal-title":"Lancet Reg. 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