{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:50:35Z","timestamp":1774079435159,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00393"],"award-info":[{"award-number":["PI23\/00393"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The qEEG findings of subjects with Down syndrome (DS) have not been described in the context of bipolar montage. Resting-state EEG (rsEEG) with a bipolar montage was performed in 22 young adults (26.0 \u00b1 1.2 years) with DS but without psychiatric or neurological pathology and matched control subjects of the same sex and age, and the results were conventionally and numerically analyzed. Channels were grouped into frontal, parieto-occipital, and temporal lobes. For every channel, the power spectrum was calculated and used to compute the area for the delta, theta, alpha and beta bands and was log-transformed. Shannon\u2019s spectral entropy (SSE) and coherence by bands were computed. Finally, we also calculated the peak frequency distribution of the alpha band. qEEG revealed alterations in the rsEEG that were not detected visually. Subjects with DS showed a significant generalized increase in the power of the delta and theta bands, along with a decrease in the power of the alpha band in the posterior half of the scalp. This alpha activity also exhibited features corresponding to older euploid subjects, showing interhemispheric asynchrony in one-third of the individuals. The beta band power was significantly increased in the frontal lobes and adjacent regions, such as the parietal and mid-temporal regions. Individuals with DS showed a generalized decrease in parieto-occipital synchronization associated with intelligence quotient. Left temporal synchronization was also lower. The synchronization of specific channel pairs was greater in subjects with DS in the frontal lobe and much lower in the occipital and temporal regions. These results indicate that alterations in band structure and synchronization in subjects with DS are highly specific and can aid in the clinical evaluation of these individuals.<\/jats:p>","DOI":"10.3390\/brainsci16030328","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:50:36Z","timestamp":1773921036000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Resting-State EEG and Synchronization Between Young Adults with Down Syndrome and Controls in Bipolar Montage"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-8409","authenticated-orcid":false,"given":"Jes\u00fas","family":"Pastor","sequence":"first","affiliation":[{"name":"Clinical Neurophysiology and Instituto de Investigaci\u00f3n Biom\u00e9dica, Hospital Universitario de La Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-2234","authenticated-orcid":false,"given":"Lorena","family":"Vega-Zelaya","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology and Instituto de Investigaci\u00f3n Biom\u00e9dica, Hospital Universitario de La Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Real de As\u00faa","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna and Instituto de Investigaci\u00f3n Biom\u00e9dica, Hospital Universitario de La Princesa, C\/Diego de Le\u00f3n 62, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mrdd.20157","article-title":"Epidemiology of Down syndrome","volume":"13","author":"Sherman","year":"2007","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/ajmg.a.38465","article-title":"Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date","volume":"173","author":"Hart","year":"2017","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_3","first-page":"Cd011546","article-title":"Pharmacological interventions for cognitive decline in people with Down syndrome","volume":"2015","author":"Livingstone","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1474-4422(10)70112-5","article-title":"Cognitive deficits and associated neurological complications in individuals with Down\u2019s syndrome","volume":"9","author":"Lott","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hasina, Z., Wang, N., and Wang, C.C. (2022). Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.877711"},{"key":"ref_6","unstructured":"Nakano, H. (2021). Necessity of quantitative EEG in daily clinical practice. Electroencephalography, InTech."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fingelkurts, A.A., and Fingelkurts, A.A. (2022). Quantitative Electroencephalogram (qEEG) as a Natural and Non-Invasive Window into Living Brain and Mind in the Functional Continuum of Healthy and Pathological Conditions. Appl. Sci., 12.","DOI":"10.3390\/app12199560"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chmiel, J., Rybakowski, F., and Leszek, J. (2024). EEG in Down Syndrome. A Review and Insights into Potential Neural Mechanisms. Brain Sci., 14.","DOI":"10.3390\/brainsci14020136"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S1474-4422(21)00245-3","article-title":"Alzheimer\u2019s disease associated with Down syndrome: Genetic form of dementia","volume":"20","author":"Fortea","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(02)00142-X","article-title":"The neurophysics of consciousness","volume":"39","author":"John","year":"2002","journal-title":"Brain Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pastor, J. (2025). Introduction to Electroencephalography. Quantitative EEG Practical Guide, Springer Nature.","DOI":"10.1007\/978-3-032-05457-9"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pastor, J., and Vega-Zelaya, L. (2023). Normative Structure of Resting-State EEG in Bipolar Derivations for Daily Clinical Practice: A Pilot Study. Brain Sci., 13.","DOI":"10.3390\/brainsci13020167"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pastor, J. (2025). Measurements of Synchronization. Quantitative EEG Practical Guide, Springer Nature.","DOI":"10.1007\/978-3-032-05457-9"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.clinph.2013.03.004","article-title":"Disrupted small-world brain network in children with Down Syndrome","volume":"124","author":"Ahmadlou","year":"2013","journal-title":"Clin. Neurophysiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0013-4694(92)90024-C","article-title":"Comparative coherence studies in healthy volunteers and Down\u2019s syndrome patients from childhood to adult age","volume":"83","author":"Schmid","year":"1992","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.clinph.2009.06.017","article-title":"Inter-hemispheric functional coupling of eyes-closed resting EEG rhythms in adolescents with Down syndrome","volume":"120","author":"Babiloni","year":"2009","journal-title":"Clin. Neurophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pastor, J., Vega-Zelaya, L., and Martin, A.E. (2020). Specific EEG encephalopathic pattern in SARS-CoV-2 patients. J. Clin. Med., 91.","DOI":"10.3390\/jcm9051545"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pastor, J. (2025). A Proposal for an Analytic System: CRANE. Quantitative EEG Practical Guide, Springer Nature.","DOI":"10.1007\/978-3-032-05457-9"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1111\/ejn.13854","article-title":"Single-trial log transformation is optimal in frequency analysis of resting EEG alpha","volume":"48","author":"Smulders","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"ref_20","unstructured":"Shomer, D.L., and Lopes da Silva, F. (2018). Normal EEG in wakefulness and sleep: Adults and elederly. Niedermeyer\u2019s Electroencephalography: Basic Principles, Clinical Applications and Related Fields, Oxford University Press. [7th ed.]. 49."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNP.0000000000000806","article-title":"American Clinical Neurophysiology Society\u2019s Standardized Critical Care EEG Terminology: 2021 Version","volume":"38","author":"Hirsch","year":"2021","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/archneur.1990.00530010072022","article-title":"Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down\u2019s syndrome: Age-specific changes","volume":"47","author":"Devinsky","year":"1990","journal-title":"Arch. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1600-0404.1996.tb07059.x","article-title":"EEG reactivity correlates with neuropsychological test scores in down\u2019s syndrome","volume":"94","author":"Partanen","year":"1996","journal-title":"Acta Neurol. Scand."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.7434026","article-title":"Developmental equations for the electroencephalogram","volume":"210","author":"John","year":"1980","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.tics.2012.10.007","article-title":"Alpha-band oscillations, attention, and controlled access to stored information","volume":"16","author":"Klimesch","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.tics.2016.09.004","article-title":"Brain networks and \u03b1-oscillations: Structural and functional foundations of cognitive control","volume":"20","author":"Sadaghiani","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hbm.21061","article-title":"Cognitive impairment and EEG background activity in adults with Down\u2019s syndrome: A topographic study","volume":"32","author":"Velikova","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"ref_28","first-page":"659","article-title":"Age-related changes in occipital alpha rhythm of adults with Down syndrome","volume":"46","author":"Ono","year":"1992","journal-title":"Jpn. J. Psychiatry Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuroimage.2012.12.018","article-title":"Thalamo-cortical mechanisms underlying changes in amplitude and frequency of human alpha oscillations","volume":"70","author":"Hindriks","year":"2013","journal-title":"Neuroimage"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuroimage.2016.05.049","article-title":"Acetylcholine modulates human working memory and subsequent familiarity based recognition via alpha oscillations","volume":"137","author":"Eckart","year":"2016","journal-title":"Neuroimage"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1523\/JNEUROSCI.4468-07.2008","article-title":"Cellular dynamics of cholinergically induced \u03b1 (8\u201313 Hz) rhythms in sensory thalamic nuclei In Vitro","volume":"28","author":"Crunelli","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"18553","DOI":"10.1073\/pnas.1215385109","article-title":"Thalamic model of awake alpha oscillations and implications for stimulus processing","volume":"109","author":"Vijayan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1744629506067615","article-title":"The cholinergic system in Down\u2019s syndrome","volume":"10","author":"Fodale","year":"2006","journal-title":"J. Intellect. Disabil."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0006-3223(94)90010-8","article-title":"Quantitative EEG study on premature aging in adult down\u2019s syndrome","volume":"35","author":"Murata","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s11689-021-09392-z","article-title":"Comparison of resting-state EEG between adults with Down syndrome and typically developing controls","volume":"13","author":"Hamburg","year":"2021","journal-title":"J. Neurodev. Disord."},{"key":"ref_36","first-page":"50","article-title":"Neurometric evaluation in Down syndrome individuals: Possible implications for dual diagnosis","volume":"3","author":"Salamy","year":"1990","journal-title":"Brain Dysfunct."},{"key":"ref_37","first-page":"215","article-title":"Quantified electroencephalogram in adult patients with Down\u2019s syndrome","volume":"9","author":"Locatelli","year":"1996","journal-title":"Dev. Brain Dysfunct."},{"key":"ref_38","first-page":"48","article-title":"P300 and EEG mapping in Down\u2019s syndrome","volume":"11","author":"Medaglini","year":"1997","journal-title":"J. Psychophysiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainresbull.2022.06.006","article-title":"Circuits and components of delta wave regulation","volume":"188","author":"Uygun","year":"2022","journal-title":"Brain Res. Bull."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12253","DOI":"10.1523\/JNEUROSCI.0618-14.2014","article-title":"Thalamic \u03b4-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo","volume":"34","author":"Orser","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/revneuro-2022-0067","article-title":"Brain circuit pathology in Down syndrome: From neurons to neural networks","volume":"34","author":"Bartesaghi","year":"2022","journal-title":"Rev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Contestabile, A., Magara, S., and Cancedda, L. (2017). The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. Front. Cell. Neurosci., 11.","DOI":"10.3389\/fncel.2017.00054"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Klein, J.A., and Haydar, T.F. (2022). Neurodevelopment in Down syndrome: Concordance in humans and models. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.941855"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nu\u00f1ez, A., and Bu\u00f1o, W. (2021). The Theta Rhythm of the Hippocampus: From Neuronal and Circuit Mechanisms to Behavior. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.649262"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/ejn.12091","article-title":"The generation of theta rhythm in hippocampal formation maintained in vitro","volume":"37","author":"Kowalczyk","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.5604\/17322693.1058537","article-title":"Theta rhythm recorded in the hippocampal formation in vitro","volume":"15","author":"Kowalczyk","year":"2013","journal-title":"Postep. Hig. Med. Dosw."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0173(98)00056-3","article-title":"EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis","volume":"29","author":"Klimesch","year":"1999","journal-title":"Brain Res. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ajmg.c.31439","article-title":"Down syndrome: Cognitive and behavioral functioning across the lifespan","volume":"169","author":"Grieco","year":"2015","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.clinph.2010.02.155","article-title":"Cortical sources of EEG rhythms are abnormal in down syndrome","volume":"121","author":"Babiloni","year":"2010","journal-title":"Clin. Neurophysiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0306-4522(93)90284-M","article-title":"Age related cognitive decline and electroencephalogram slowing in down\u2019s syndrome as a model of Alzheimer\u2019s disease","volume":"53","author":"Soininen","year":"1993","journal-title":"Neuroscience"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1055\/s-2008-1059540","article-title":"Z-transformed EEG power spectra of children with down syndrome vs a control group","volume":"16","author":"Schmid","year":"1985","journal-title":"Neuropediatrics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainresbull.2022.01.012","article-title":"Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson\u2019s disease","volume":"181","author":"Wang","year":"2022","journal-title":"Brain Res. Bull."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1523\/JNEUROSCI.1163-19.2019","article-title":"Beta Oscillations inWorking Memory, Executive Control of Movement and Thought, and Sensorimotor Function","volume":"39","author":"Schmidt","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.17712\/nsj.2022.4.20220025","article-title":"Review of electroencephalography signals approaches for mental stress assessment","volume":"27","author":"Attar","year":"2022","journal-title":"Neurosciences"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13054-018-2104-z","article-title":"Value and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness: A systematic review","volume":"22","author":"Azabou","year":"2018","journal-title":"Crit. Care"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00001756-200403010-00028","article-title":"Cortical activity associated with auditory hallucinations","volume":"15","author":"Ropohl","year":"2004","journal-title":"NeuroReport"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e209451","DOI":"10.1212\/WNL.0000000000209451","article-title":"EEG ictal power dynamics, function-structure associations, and epilepsy surgical outcomes","volume":"102","author":"Gong","year":"2024","journal-title":"Neurology"},{"key":"ref_58","first-page":"69","article-title":"Cognition-related EEG abnormalities in nondemented Down syndrome subjects","volume":"7","author":"Politoff","year":"1996","journal-title":"Dementia"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/WNP.0000000000000308","article-title":"American Clinical Neurophysiology Society Guideline 1: Minimum Technical Requirements for Performing Clinical Electroencephalography","volume":"33","author":"Sinha","year":"2016","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Gabbiani, F., and Cox, S.J. (2010). Power and Cross Spectra. Mathematics for Neuroscientist, Academic Press.","DOI":"10.1016\/B978-0-12-374882-9.00018-6"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0013-4694(88)90171-X","article-title":"Common reference coherence data are confounded by power and phase effects","volume":"69","author":"Fein","year":"1988","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0168-5597(85)90058-9","article-title":"A theoretical justification of the average reference in topographic evoked potential studies","volume":"62","author":"Bertrand","year":"1985","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Qin, Y., Xin, X., Zhu, H., Li, F., Xiong, H., Zhang, T., and Lai, Y. (2017). A Comparative Study on the Dynamic EEG Center of Mass with Different References. Front. Neurosci., 11.","DOI":"10.3389\/fnins.2017.00509"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/3\/328\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:24:07Z","timestamp":1774070647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/3\/328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["brainsci16030328"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16030328","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]}}}