{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:56:20Z","timestamp":1785412580233,"version":"3.56.0"},"reference-count":224,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRB JPND-Cofund-2025-3"],"award-info":[{"award-number":["HRB JPND-Cofund-2025-3"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"award":["HRB JPND-Cofund-2025-3"],"award-info":[{"award-number":["HRB JPND-Cofund-2025-3"]}],"id":[{"id":"https:\/\/ror.org\/003hb2249","id-type":"ROR","asserted-by":"publisher"}]},{"name":"EU Joint Programme\u2014Neurodegenerative Disease Research","award":["JPND\u20142025 \u201cQual-Bulb-MND\u201d"],"award-info":[{"award-number":["JPND\u20142025 \u201cQual-Bulb-MND\u201d"]}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI SP20\/SP\/8953"],"award-info":[{"award-number":["SFI SP20\/SP\/8953"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Motor neuron diseases (MNDs) encompass a clinically heterogeneous group of neurodegenerative conditions with varying impact on dexterity, mobility, decision making, respiratory and bulbar dysfunction. While consensus best-practice recommendations exist for genetic screening, diagnostic work-up, pharmacological and respiratory management, disease-specific facets of driving safety, assessment approaches and intervention strategies to support patients for safe driving have not been comprehensively reviewed. MNDs have unique, phenotype-specific clinical features, which are distinct form other neuromuscular conditions which necessitate a careful and systematic approach to evaluate driving safety. While MNDs are primarily associated with progressive motor impairment, extrapyramidal, cerebellar, cognitive, behavioural, and respiratory manifestations of the disease also affect driving safety and necessitate comprehensive driving assessments and individualised strategies to enable patients to continue to drive. The majority of existing papers focus on amyotrophic lateral sclerosis, and low-incidence MND phenotypes, such as PLS, SBMA, PPS, are glaringly understudied from a driving safety perspective despite the relatively slower progression of these conditions. Beyond the review of specific aspects of driving in MNDs, the main objective of this review paper is to raise awareness of non-motor aspects of MNDs with regard to driving safety and to explore viable strategies to support patients to maintain their independence. Despite the considerable differences in driving regulations around the globe, there are core, disease-specific aspects of MND which are universal. The careful consideration of these clinical factors, comprehensive domain-by-domain assessments, and the implementation of practical, individualised adaptations may enable patients to continue driving safely, maintain their independence and enhance their quality of life.<\/jats:p>","DOI":"10.3390\/brainsci16040408","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:58:22Z","timestamp":1775829502000},"page":"408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Driving with Motor Neuron Disease: Disease-Specific Considerations, Multi-Domain Assessments and Support Strategies"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-8516","authenticated-orcid":false,"given":"Jana","family":"Kleinerova","sequence":"first","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Tully","sequence":"additional","affiliation":[{"name":"Department of Neurology, St James\u2019s Hospital, D08 NHY1 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Lope","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Toomey","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"We Fong","family":"Siah","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bede","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"},{"name":"Department of Neurology, St James\u2019s Hospital, D08 NHY1 Dublin, Ireland"},{"name":"The Irish FTD\/FTLD Network, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/21678421.2016.1265565","article-title":"Comparison of the King\u2019s and MiToS staging systems for ALS","volume":"18","author":"Fang","year":"2017","journal-title":"Amyotroph. 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