{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:02:56Z","timestamp":1780912976692,"version":"3.54.1"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Oral health is increasingly recognized as a potentially modifiable factor in Alzheimer\u2019s disease (AD), although its influence on cognitive outcomes remains uncertain. Methods: This scoping review followed the Arksey and O\u2019Malley framework and was reported in accordance with PRISMA-ScR guidelines. Searches were conducted in PubMed, Scopus, and Web of Science through August 2025. Eleven studies met the inclusion criteria: one randomized controlled trial, one nonrandomized trial, and nine observational studies. Results: Poor oral health, including tooth loss, periodontal disease, and impaired mastication, was consistently associated with worse cognitive and dementia-related outcomes. Interventions improved oral and functional measures but yielded limited and inconsistent evidence of cognitive benefit. Proposed mechanisms, including systemic inflammation and microbiome alterations, were infrequently evaluated directly. Conclusions: Overall, oral health correlates with cognitive status in AD, but the causal impact of interventions remains uncertain, highlighting the need for rigorous trials with standardized cognitive and mechanistic outcomes.<\/jats:p>","DOI":"10.3390\/brainsci16060615","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:43:02Z","timestamp":1780904582000},"page":"615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Evidence on Oral Health Interventions and Cognitive Status in Alzheimer\u2019s Disease: A Scoping Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-3740","authenticated-orcid":false,"given":"Man","family":"Hung","sequence":"first","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"},{"name":"Department of Family Medicine and Public Health, University of Utah, Salt Lake City, UT 84108, USA"},{"name":"College of Education, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"VA Salt Lake City Health Care, Salt Lake City, UT 84148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Chriss","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Nelson","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaki","family":"O\u2019Callaghan","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9947-2920","authenticated-orcid":false,"given":"Corban","family":"Ward","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7862-1904","authenticated-orcid":false,"given":"Alicia","family":"Parry","sequence":"additional","affiliation":[{"name":"Library, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2858-1429","authenticated-orcid":false,"given":"Jacob","family":"Marx","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Lipsky","sequence":"additional","affiliation":[{"name":"College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA"},{"name":"Institute on Aging, Portland State University, Portland, OR 97207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rostagno, A.A. (2023). Pathogenesis of Alzheimer\u2019s disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010107"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3233\/JAD-190587","article-title":"Analysis of salivary microbiome in patients with Alzheimer\u2019s disease","volume":"72","author":"Liu","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000458411","article-title":"Is periodontal disease associated with Alzheimer\u2019s disease? A systematic review with meta-analysis","volume":"48","author":"Leira","year":"2017","journal-title":"Neuroepidemiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-017-0282-6","article-title":"Association between chronic periodontitis and the risk of Alzheimer\u2019s disease: A retrospective, population-based, matched cohort study","volume":"9","author":"Chen","year":"2017","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1007\/s00784-018-2396-z","article-title":"Oral health in Alzheimer\u2019s disease: A multicenter case-control study","volume":"22","author":"Montero","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104267","DOI":"10.1016\/j.archger.2020.104267","article-title":"Effect of oral health intervention on cognitive decline in community-dwelling older adults: A randomized controlled trial","volume":"92","author":"Matsubara","year":"2021","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Guo, H., Wang, Z., Chu, C.H., Chan, A.K.Y., Lo, E.C.M., and Jiang, C.M. (2024). Effects of oral health interventions on cognition of people with dementia: A systematic review with meta-analysis. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04750-4"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-V\u00e1squez, A., Barrenechea-Pulache, A., Aguirre-Ipenza, R., Comand\u00e9, D., and Aza\u00f1edo, D. (2022). Interventions to improve the oral hygiene of individuals with Alzheimer\u2019s disease: A systematic review. Dent. J., 10.","DOI":"10.3390\/dj10050092"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/00220345251377014","article-title":"Oral health and dementia: Causal inference and theoretical mechanisms","volume":"105","author":"Aida","year":"2026","journal-title":"J. Dent. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kulkarni, M.S., Miller, B.C., Mahani, M., Mhaskar, R., Tsalatsanis, A., Jain, S., and Yadav, H. (2023). Poor oral health linked with higher risk of Alzheimer\u2019s disease. Brain Sci., 13.","DOI":"10.3390\/brainsci13111555"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sherbaf, R.A., Kaposv\u00e1ri, G.M., Nagy, K., Pak\u00e1ski, M., Gajd\u00e1cs, M., Matusovits, D., and Bar\u00e1th, Z. (2025). Oral health status and factors associated with oral health in patients with Alzheimer\u2019s disease: A matched case-control observational study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14051412"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.prosdent.2017.07.010","article-title":"Mastication and oral health-related quality of life in removable denture wearers with Alzheimer disease","volume":"119","author":"Campos","year":"2018","journal-title":"J. Prosthet. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.gerinurse.2022.09.005","article-title":"Effects of oral health intervention strategies on cognition and microbiota alterations in patients with mild Alzheimer\u2019s disease: A randomized controlled trial","volume":"48","author":"Chen","year":"2022","journal-title":"Geriatr. Nurs."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/1981-863720160001000022854","article-title":"Evaluation of oral conditions in patients with neurodegenerative diseases treated in geriatric centers","volume":"64","author":"Frota","year":"2016","journal-title":"Rev. Gaucha Odontol."},{"key":"ref_18","first-page":"255","article-title":"Oral and periodontal health in patients with Alzheimer\u2019s disease and other forms of dementia: A cross-sectional pilot study","volume":"19","author":"Laugisch","year":"2021","journal-title":"Oral Health Prev. Dent."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Shirobe, M., Edahiro, A., Motokawa, K., Morishita, S., Ohara, Y., Motohashi, Y., Iwasaki, M., Watanabe, Y., and Hirano, H. (2023). Association between dementia severity and oral hygiene management issues in older adults with Alzheimer\u2019s disease: A cross-sectional study. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20053841"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105862","DOI":"10.1016\/j.jdent.2025.105862","article-title":"Oral health variables associated with factors across the Alzheimer\u2019s disease continuum: From subjective cognitive decline to dementia","volume":"160","author":"Wu","year":"2025","journal-title":"J. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yang, B., Tao, B., Yin, Q., Chai, Z., Xu, L., Zhao, Q., and Wang, J. (2021). Associations between oral health status, perceived stress, and neuropsychiatric symptoms among community individuals with Alzheimer\u2019s disease: A mediation analysis. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.801209"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jdsr.2025.11.003","article-title":"Oral diseases as emerging risk factors for alzheimer\u2019s disease: A scoping review","volume":"61","author":"Yi","year":"2025","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Felicetti, A., Azzolino, D., Piro, P.P., Lopes, G.C.D., Rezaeinezhad, N., Lovero, R., Bocchio-Chiavetto, L., Colella, M., and Passarelli, P.C. (2025). The oral-brain axis in alzheimer\u2019s disease: From microbial dysbiosis to neurodegeneration. 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