{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:28:16Z","timestamp":1788985696593,"version":"build-2803163510"},"reference-count":112,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ono Academic College"},{"id":[{"id":"https:\/\/ror.org\/02td5wn81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Extensive explorations in neuroscience, psychology, and psychotherapy increasingly recognized the embodied and relational foundations of selfhood, underscoring the need for an integrated framework spanning development, psychopathology, and therapeutic change. This narrative review synthesizes empirical and theoretical literature across neuroscience, embodiment research, predictive processing, developmental science, phenomenology, and psychodynamic theory, proposing a multidimensional neuropsychodynamic framework of embodied selfhood and its clinical implications. A central contribution is the positioning of Peripersonal Space (PPS) as an embodied action-oriented interface that functions as a primary developmental scaffold for bodily self-consciousness, self-other relations, affect regulation and temporal continuity. PPS is proposed as a dynamic matrix linking embodied predictive self-processes with relational experience, thereby shaping subjective temporality and autobiographical processes. Within this framework, subjective time emerges through bodily rhythms, interpersonal synchronization, and predictive engagement with environmental affordances. These embodied temporal processes gradually extend toward autobiographical continuity and mentalizing capacities, supported by coordinated interactions among large-scale brain networks. Psychodynamic concepts including holding, containment, dimensionality, and symbolic transformation are revisited in dialogue with contemporary embodied and relational neuroscience. Clinically, disturbances of selfhood across psychopathological conditions are discussed in relation to altered PPS organization, disturbances in self-evidencing, and embodied temporal continuity. Psychotherapeutic change is conceptualized as involving gradual reorganization across embodied, affective, and reflective dimensions through co-regulation, interpersonal attunement, and temporally extended relational engagement. Overall, this perspective advances a process-oriented and interdisciplinary framework linking embodiment, temporality, autobiographical integration, and psychotherapy, while highlighting directions for future interdisciplinary research at the interface of neuroscience, embodiment and psychodynamics.<\/jats:p>","DOI":"10.3390\/brainsci16060627","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:49:51Z","timestamp":1781257791000},"page":"627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Embodied Neuropsychodynamics of the Relational Self Across Space and Time: An Integrative Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-2243","authenticated-orcid":false,"given":"Sharon","family":"Vaisvaser","sequence":"first","affiliation":[{"name":"School of Society and the Arts, Faculty of Humanities and Social Sciences, Ono Academic College, 1 Academic Avenue, Kiryat Ono 5560614, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dary, Z., and Lopez, C. (2023). Understanding the Neural Bases of Bodily Self-Consciousness: Recent Achievements and Main Challenges. Front. Integr. Neurosci., 17.","DOI":"10.3389\/fnint.2023.1145924"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vaisvaser, S. (2025). Minding the Moving Self: The Centrality of Body Movement in the Neurodynamics of the Self and Psychotherapeutic Implications. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1726099"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"105864","DOI":"10.1016\/j.neubiorev.2024.105864","article-title":"Interoception, Network Physiology and the Emergence of Bodily Self-Awareness","volume":"165","author":"Engelen","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103634","DOI":"10.1016\/j.concog.2024.103634","article-title":"The State-Trait Sense of Self Inventory: A Psychometric Study of Self-Experience and Its Relation to Psychosis-like Manifestations","volume":"118","author":"Ebisch","year":"2024","journal-title":"Conscious. Cogn."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"116284","DOI":"10.1016\/j.neuroimage.2019.116284","article-title":"I Am Me: Brain Systems Integrate and Segregate to Establish a Multidimensional Sense of Self","volume":"205","author":"Perrucci","year":"2020","journal-title":"Neuroimage"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101083","DOI":"10.1016\/j.newideapsych.2024.101083","article-title":"Embodiment as a Synthesis of Having a Body and Being a Body, and Its Role in Self-Identity and Mental Health","volume":"74","author":"Lundh","year":"2024","journal-title":"New Ideas Psychol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105141","DOI":"10.1016\/j.neubiorev.2023.105141","article-title":"Relating Different Dimensions of Bodily Experiences: Review and Proposition of an Integrative Model Relying on Phenomenology, Predictive Brain and Neuroscience of the Self","volume":"148","author":"Raoul","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vaisvaser, S. (2024). Meeting the Multidimensional Self: Fostering Selfhood at the Interface of Creative Arts Therapies and Neuroscience. Front. Psychol., 15.","DOI":"10.3389\/fpsyg.2024.1417035"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cieri, F., and Esposito, R. (2019). Psychoanalysis and Neuroscience: The Bridge Between Mind and Brain. Front. Psychol., 10.","DOI":"10.3389\/fpsyg.2019.01983"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1192\/bja.2020.63","article-title":"Relational and Affective Neuroscience: A Quiet Revolution in Psychiatric and Psychotherapeutic Practice","volume":"26","author":"Mizen","year":"2020","journal-title":"BJPsych Adv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrn2787","article-title":"The Free-Energy Principle: A Unified Brain Theory?","volume":"11","author":"Friston","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"20170792","DOI":"10.1098\/rsif.2017.0792","article-title":"The Markov Blankets of Life: Autonomy, Active Inference and the Free Energy Principle","volume":"15","author":"Kirchhoff","year":"2018","journal-title":"J. R. Soc. Interface"},{"key":"ref_13","first-page":"202","article-title":"How and Why Consciousness Arises: Some Considerations from Physics and Physiology","volume":"25","author":"Solms","year":"2018","journal-title":"J. Conscious. Stud."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/nous.12062","article-title":"The Self-Evidencing Brain","volume":"50","author":"Hohwy","year":"2016","journal-title":"Nous"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Limanowski, J., and Blankenburg, F. (2013). Minimal Self-Models and the Free Energy Principle. Front. Hum. Neurosci., 7.","DOI":"10.3389\/fnhum.2013.00547"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"niab024","DOI":"10.1093\/nc\/niab024","article-title":"Consciousness in Active Inference: Deep Self-Models, Other Minds, and the Challenge of Psychedelic-Induced Ego-Dissolution","volume":"2021","author":"Deane","year":"2021","journal-title":"Neurosci. Conscious."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tics.2013.09.007","article-title":"Interoceptive Inference, Emotion, and the Embodied Self","volume":"17","author":"Seth","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrn3292","article-title":"Multisensory Brain Mechanisms of Bodily Self-Consciousness","volume":"13","author":"Blanke","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Solms, M. (2021). The Hidden Spring: A Journey to the Source of Consciousness, Norton & Company.","DOI":"10.53765\/20512201.28.11.153"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Miller, E., Weightman, M., Amos, A., Yeates, S., and Wilkes, F. (2026). Integrating Neuropsychoanalytic and Neuropsychiatric Perspectives into Psychiatric Clinical Neuroscience Curricula: A Conceptual Overview. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1712622"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/scan\/nsx060","article-title":"The Theory of Constructed Emotion: An Active Inference Account of Interoception and Categorization","volume":"12","author":"Barrett","year":"2017","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tics.2024.01.009","article-title":"The Neurobiology of Interoception and Affect","volume":"28","author":"Feldman","year":"2024","journal-title":"Trends Cogn. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/mila.12281","article-title":"New Directions in Predictive Processing","volume":"35","author":"Hohwy","year":"2020","journal-title":"Mind Lang."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/10892680231224399","article-title":"The Future of Psychotherapy Research and Neuroscience: Introducing the 4E\/MoBI Approach to the Study of Patient\u2013Therapist Interaction","volume":"28","author":"Parada","year":"2024","journal-title":"Rev. General. Psychol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Eshel, O. (2019). The Emergence of Analytic Oneness: Into the Heart of Psychoanalysis. The Emergence of Analytic Oneness, Routledge.","DOI":"10.4324\/9781315212531"},{"key":"ref_26","unstructured":"Bion, W. (1965). Transformations, Heinemann."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neubiorev.2019.01.016","article-title":"Peripersonal Space (PPS) as a Multisensory Interface between the Individual and the Environment, Defining the Space of the Self","volume":"99","author":"Serino","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/nyas.13867","article-title":"From Multisensory Integration in Peripersonal Space to Bodily Self-Consciousness: From Statistical Regularities to Statistical Inference","volume":"1426","author":"Noel","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cortex.2021.05.005","article-title":"The Peripersonal Space in a Social World","volume":"142","author":"Bogdanova","year":"2021","journal-title":"Cortex"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e36487","DOI":"10.1016\/j.heliyon.2024.e36487","article-title":"The Space between Us: The Effect of Perceived Threat on Discomfort Distance and Perceived Pleasantness of Interpersonal Vicarious Touch","volume":"10","author":"Abra","year":"2024","journal-title":"Heliyon"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00429-024-02781-9","article-title":"Neuroanatomical Correlates of Peripersonal Space: Bridging the Gap between Perception, Action, Emotion and Social Cognition","volume":"229","author":"Basile","year":"2024","journal-title":"Brain Struct. Funct."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Coello, Y., and Cartaud, A. (2021). The Interrelation Between Peripersonal Action Space and Interpersonal Social Space: Psychophysiological Evidence and Clinical Implications. Front. Hum. Neurosci., 15.","DOI":"10.3389\/fnhum.2021.636124"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.tics.2018.09.004","article-title":"An Action Field Theory of Peripersonal Space","volume":"22","author":"Bufacchi","year":"2018","journal-title":"Trends Cogn. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Straka, Z., Noel, J.P., and Hoffmann, M. (2022). A Normative Model of Peripersonal Space Encoding as Performing Impact Prediction. PLoS Comput. Biol., 18.","DOI":"10.1371\/journal.pcbi.1010464"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Fagard, J., Esseily, R., Jacquey, L., O\u2019Regan, K., and Somogyi, E. (2018). Fetal Origin of Sensorimotor Behavior. Front. Neurorobot., 12.","DOI":"10.3389\/fnbot.2018.00023"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"106491","DOI":"10.1016\/j.neubiorev.2025.106491","article-title":"Maternal Activity and Fetal Movement: A Scoping Review","volume":"180","author":"Nemoto","year":"2026","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"27893","DOI":"10.1038\/srep27893","article-title":"An Embodied Brain Model of the Human Foetus","volume":"6","author":"Yamada","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neubiorev.2020.03.003","article-title":"The Body Comes First. Embodied Reparation and the Co-Creation of Infant Bodily-Self","volume":"113","author":"Montirosso","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Carozza, S., and Leong, V. (2021). The Role of Affectionate Caregiver Touch in Early Neurodevelopment and Parent\u2013Infant Interactional Synchrony. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.613378"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20210070","DOI":"10.1098\/rspb.2021.0070","article-title":"The Development of Body Representations: An Associative Learning Account","volume":"288","author":"Filippetti","year":"2021","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_41","unstructured":"Turner, C. (1989). The Skin Ego: A Psychoanalytic Approach to the Self, Yale University Press. First published 1985."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mellier, D. (2014). The Psychic Envelopes in Psychoanalytic Theories of Infancy. Front. Psychol., 5.","DOI":"10.3389\/fpsyg.2014.00734"},{"key":"ref_43","first-page":"585","article-title":"The Theory of the Parent-Infant Relationship","volume":"41","author":"Winnicott","year":"1960","journal-title":"Int. J. Psychoanal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"20130177","DOI":"10.1098\/rstb.2013.0177","article-title":"Bodily Selves in Relation: Embodied Simulation as Second-Person Perspective on Intersubjectivity","volume":"369","author":"Gallese","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20130289","DOI":"10.1098\/rstb.2013.0289","article-title":"The Mirror Neuron System as Revealed through Neonatal Imitation: Presence from Birth, Predictive Power and Evidence of Plasticity","volume":"369","author":"Simpson","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fanghella, M., Era, V., and Candidi, M. (2021). Interpersonal Motor Interactions Shape Multisensory Representations of the Peripersonal Space. Brain Sci., 11.","DOI":"10.3390\/brainsci11020255"},{"key":"ref_47","first-page":"484","article-title":"The Experience of the Skin in Early Object Relations","volume":"49","author":"Bick","year":"1968","journal-title":"Int. J. Psychoanal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.schres.2016.09.021","article-title":"The Spatial Self in Schizophrenia and Autism Spectrum Disorder","volume":"179","author":"Noel","year":"2017","journal-title":"Schizophr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40489-019-00173-y","article-title":"Modelling Me, Modelling You: The Autistic Self","volume":"7","author":"Perrykkad","year":"2020","journal-title":"Rev. J. Autism Dev. Disord."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biopsych.2022.09.029","article-title":"Integrative Brain Network and Salience Models of Psychopathology and Cognitive Dysfunction in Schizophrenia","volume":"94","author":"Menon","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/schbul\/sbab024","article-title":"Altered Peripersonal Space and the Bodily Self in Schizophrenia: A Virtual Reality Study","volume":"47","author":"Lee","year":"2021","journal-title":"Schizophr. Bull."},{"key":"ref_52","unstructured":"Meltzer, D. (1992). The Claustrum: An Investigation of Claustrophobic Phenomena, The Clunie Press."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Rabellino, D., Frewen, P.A., McKinnon, M.C., and Lanius, R.A. (2020). Peripersonal Space and Bodily Self-Consciousness: Implications for Psychological Trauma-Related Disorders. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.586605"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"111683","DOI":"10.1016\/j.isci.2024.111683","article-title":"Your Space or Mine: Trait Anxiety Affects the Peripersonal Space Plasticity in a Social Context","volume":"28","author":"Ferroni","year":"2025","journal-title":"iScience"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Di Plinio, S., and Etxebarria-Perez-De-Nanclares, O. (2025). Sex and Gender Identities Are Emergent Properties of Neural Complexity. Behav. Sci., 15.","DOI":"10.3390\/bs15121599"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41593-025-01958-7","article-title":"Egocentric Value Maps of the Near-Body Environment","volume":"28","author":"Bufacchi","year":"2025","journal-title":"Nat. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/17456916231188000","article-title":"An Active-Inference Approach to Second-Person Neuroscience","volume":"19","author":"Lehmann","year":"2023","journal-title":"Perspect. Psychol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1146\/annurev-psych-080123-101149","article-title":"Synchrony Across Brains","volume":"76","author":"Schilbach","year":"2024","journal-title":"Annu. Rev. Psychol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"niaa010","DOI":"10.1093\/nc\/niaa010","article-title":"What Binds Us? Inter-Brain Neural Synchronization and Its Implications for Theories of Human Consciousness","volume":"2020","author":"Valencia","year":"2020","journal-title":"Neurosci. Conscious."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tics.2016.11.007","article-title":"The Neurobiology of Human Attachments","volume":"21","author":"Feldman","year":"2017","journal-title":"Trends Cogn. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11065-023-09588-1","article-title":"Embodying Time in the Brain: A Multi-Dimensional Neuroimaging Meta-Analysis of 95 Duration Processing Studies","volume":"34","author":"Naghibi","year":"2023","journal-title":"Neuropsychol. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"106416","DOI":"10.1016\/j.neubiorev.2025.106416","article-title":"How the Body and Brain Process Time","volume":"179","author":"Teghil","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"105430","DOI":"10.1016\/j.neubiorev.2023.105430","article-title":"Time Processing in Neurological and Psychiatric Conditions","volume":"154","author":"Hinault","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41380-022-01891-2","article-title":"Taking Subjectivity Seriously: Towards a Unification of Phenomenology, Psychiatry, and Neuroscience","volume":"28","author":"Kyzar","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Friston, K. (2018). Am i Self-Conscious? (Or Does Self-Organization Entail Self-Consciousness?). Front. Psychol., 9.","DOI":"10.3389\/fpsyg.2018.00579"},{"key":"ref_66","first-page":"91","article-title":"The Past, Present and Future of Time-Consciousness: From Husserl to Varela and Beyond","volume":"13","author":"Gallagher","year":"2017","journal-title":"Constr. Found."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Winnicott, D.W. (1954). Mind and Its Relation to the Psyche-Soma. Through Paediatrics to Psycho-Analysis, Hogarth Press and the Institute of Psycho-Analysis.","DOI":"10.1111\/j.2044-8341.1954.tb00864.x"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1162\/neco_a_00999","article-title":"Active Inference, Curiosity and Insight","volume":"29","author":"Friston","year":"2017","journal-title":"Neural Comput."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Schwartenbeck, P., FitzGerald, T., Dolan, R.J., and Friston, K. (2013). Exploration, Novelty, Surprise, and Free Energy Minimization. Front. Psychol., 4.","DOI":"10.3389\/fpsyg.2013.00710"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tics.2018.01.009","article-title":"Hierarchical Active Inference: A Theory of Motivated Control","volume":"22","author":"Pezzulo","year":"2018","journal-title":"Trends Cogn. Sci."},{"key":"ref_71","unstructured":"Freud, S. (1920). Beyond the Pleasure Principle, Hogarth."},{"key":"ref_72","unstructured":"Bion, W.R. (1962). Learning from Experience, Heinemann."},{"key":"ref_73","first-page":"103","article-title":"Fear of Breakdown","volume":"1","author":"Winnicott","year":"1974","journal-title":"Int. Rev. Psycho-Anal."},{"key":"ref_74","first-page":"243","article-title":"The Development of Time Sense: From Birth to Object Constancy","volume":"60","author":"Colarusso","year":"1979","journal-title":"Int. J. Psychoanal."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/000306518603400301","article-title":"Psychoanalysis and Time","volume":"34","author":"Arlow","year":"1986","journal-title":"J. Am. Psychoanal. Assoc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/bjp.12284","article-title":"When Time Stood Still: Thoughts about Time in Primitive Mental States","volume":"33","author":"Schellekes","year":"2017","journal-title":"Br. J. Psychother."},{"key":"ref_77","unstructured":"Damasio, A.R. (2010). Self Comes to Mind: Constructing the Conscious Brain, Heinemann."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1364-6613(99)01417-5","article-title":"Philosophical Conceptions of the Self: Implications for Cognitive Science","volume":"4","author":"Gallagher","year":"2000","journal-title":"Trends Cogn. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neubiorev.2020.05.004","article-title":"Linking Bodily, Environmental and Mental States in the Self\u2014A Three-Level Model Based on a Meta-Analysis","volume":"115","author":"Qin","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"16800","DOI":"10.1073\/pnas.1210627109","article-title":"Mental Time Travel and Default-Mode Network Functional Connectivity in the Developing Brain","volume":"109","author":"Walhovd","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1162\/neco_a_01514","article-title":"A Predictive Processing Model of Episodic Memory and Time Perception","volume":"34","author":"Fountas","year":"2022","journal-title":"Neural Comput."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/s42003-024-06757-7","article-title":"Embodiment in Episodic Memory through Premotor-Hippocampal Coupling","volume":"2024","author":"Meyer","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41583-020-00420-w","article-title":"The Default Mode Network: Where the Idiosyncratic Self Meets the Shared Social World","volume":"22","author":"Yeshurun","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.neuron.2023.04.023","article-title":"20 Years of the Default Mode Network: A Review and Synthesis","volume":"111","author":"Menon","year":"2023","journal-title":"Neuron"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"101607","DOI":"10.1016\/j.cobeha.2025.101607","article-title":"Embodying the Default Mode Network: Self-Related Processing from an Embodied Perspective","volume":"66","author":"Kim","year":"2025","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-Scale Brain Networks and Psychopathology: A Unifying Triple Network Model","volume":"15","author":"Menon","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"109385","DOI":"10.1016\/j.mehy.2019.109385","article-title":"Towards a New Model of Understanding\u2014The Triple Network, Psychopathology and the Structure of the Mind","volume":"133","author":"Menon","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1162\/jocn.2009.21287","article-title":"Shared Neural Circuits for Mentalizing about the Self and Others","volume":"22","author":"Lombardo","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Harris, H.W. (2025). Active Inference and Psychodynamics: A Novel Integration with Applications to Depression and Stress Disorders. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1630858"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41562-018-0384-6","article-title":"Growing a Social Brain","volume":"2","author":"Atzil","year":"2018","journal-title":"Nat. Hum. Behav."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/scan\/nsab132","article-title":"Neural Representation of the Parent\u2013Child Attachment from Infancy to Adulthood","volume":"17","author":"Waidergoren","year":"2022","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e2012900118","DOI":"10.1073\/pnas.2012900118","article-title":"Synchronous Caregiving from Birth to Adulthood Tunes Humans\u2019 Social Brain","volume":"118","author":"Yaniv","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Scalabrini, A., Mucci, C., and Northoff, G. (2022). The Nested Hierarchy of Self and Its Trauma: In Search for a Synchronic Dynamic and Topographical Re-Organization. Front. Hum. Neurosci., 16.","DOI":"10.3389\/fnhum.2022.980353"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/00207578.2023.2194364","article-title":"Winnicott and the (Un)Integrated Self","volume":"104","author":"Taipale","year":"2023","journal-title":"Int. J. Psychoanal."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Alcaro, A., and Carta, S. (2019). The \u201cInstinct\u201d of Imagination. A Neuro-Ethological Approach to the Evolution of the Reflective Mind and Its Application to Psychotherapy. Front. Hum. Neurosci., 12.","DOI":"10.3389\/fnhum.2018.00522"},{"key":"ref_96","unstructured":"Winnicott, D.W. (1965). The Capacity to Be Alone. The Maturational Processes and the Facilitating Environment, International Universities Press. First published 1958."},{"key":"ref_97","unstructured":"Meltzer, D., and Williams, M.H. (1988). Aesthetic Conflict: Its Place in the Developmental Process. The Apprehension of Beauty: The Role of Aesthetic Conflict in Development, Art, and Violence, The Harris Meltzer Trust."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"niad015","DOI":"10.1093\/nc\/niad015","article-title":"The Self-Simulational Theory of Temporal Extension","volume":"2023","author":"Bellingrath","year":"2023","journal-title":"Neurosci. Conscious."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/1745-8315.12617","article-title":"The Hippocampus Facilitates Integration within a Symbolic Field","volume":"98","author":"Cornelius","year":"2017","journal-title":"Int. J. Psychoanal."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cieri, F. (2022). Memory for the Future: Psychodynamic Approach to Time and Self Through the Default Network. Front. Hum. Neurosci., 16.","DOI":"10.3389\/fnhum.2022.885315"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Wilkinson, S., Dodgson, G., and Meares, K. (2017). Predictive Processing and the Varieties of Psychological Trauma. Front. Psychol., 8.","DOI":"10.3389\/fpsyg.2017.01840"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/13546805.2019.1665994","article-title":"Reframing PTSD for Computational Psychiatry with the Active Inference Framework","volume":"24","author":"Linson","year":"2019","journal-title":"Cogn. Neuropsychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Krupnik, V. (2020). Trauma or Drama: A Predictive Processing Perspective on the Continuum of Stress. Front. Psychol., 11.","DOI":"10.3389\/fpsyg.2020.01248"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bpsgos.2023.05.006","article-title":"Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium","volume":"4","author":"Lazarov","year":"2024","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1038\/s41380-024-02520-w","article-title":"The Nested Hierarchical Model of Self and Its Non-Relational vs Relational Posttraumatic Manifestation: An FMRI Meta-Analysis of Emotional Processing","volume":"29","author":"Scalabrini","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"106139","DOI":"10.1016\/j.neubiorev.2025.106139","article-title":"Bridging the Gap of Brain and Experience\u2014Converging Neurophenomenology with Spatiotemporal Neuroscience","volume":"173","author":"Northoff","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/jnr.24674","article-title":"Multimodal Neuroimaging in Anorexia Nervosa","volume":"98","author":"Alfano","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_108","first-page":"3","article-title":"The Analytical Third: Working with Intersubjective Clinical Facts","volume":"75","author":"Ogden","year":"1994","journal-title":"Int. J. Psycho-Anal."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1027\/1618-3169\/a000350","article-title":"Individual Differences in the Flexibility of Peripersonal Space","volume":"64","author":"Hunley","year":"2017","journal-title":"Exp. Psychol."},{"key":"ref_110","first-page":"20552076221129096","article-title":"Movement-Based Patient-Therapist Attunement in Psychological Therapy and Its Association with Early Change","volume":"8","author":"Schwartz","year":"2022","journal-title":"Digit. Health"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/17470919.2024.2409758","article-title":"Embodied Hyperscanning for Studying Social Interaction: A Scoping Review of Simultaneous Brain and Body Measurements","volume":"20","author":"Vilina","year":"2025","journal-title":"Soc. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Kaiser, N., and Avendano-Diaz, J.C. (2025). The ConNECT Approach: Toward a Comprehensive Understanding of Meaningful Interpersonal Moments in Psychotherapy and Beyond. Front. Hum. Neurosci., 19.","DOI":"10.3389\/fnhum.2025.1549203"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/6\/627\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:57:43Z","timestamp":1781261863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/6\/627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":112,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["brainsci16060627"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16060627","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}