{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:48:17Z","timestamp":1782294497261,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objectives: This study aimed to evaluate the utility of MRI-based morphometric and qualitative parameters in identifying patients with suspected normal pressure hydrocephalus (NPH) associated with shunt surgery selection following clinical and lumbar puncture evaluation. Methods: We retrospectively analyzed 134 participants: 84 symptomatic patients evaluated for suspected NPH and 50 age-matched controls with normal brain MRI findings. Symptomatic patients were categorized according to subsequent clinical management following lumbar puncture evaluation into those who underwent shunt surgery (Shunt group) and those who received conservative management (Conservative group). The Evans index, fronto-occipital horn ratio (FOHR), bicaudate index, callosal angle, ventricular measurements, and disproportionately enlarged subarachnoid space hydrocephalus (DESH) components were analyzed. The discriminatory performance of MRI parameters for shunt surgery selection was assessed using ROC analysis; independent predictors of shunt surgery selection were determined using logistic regression. Results: Although conventional ventricular indices and ventricular dimensions were significantly greater in symptomatic patients than in the control group (p &lt; 0.001), baseline continuous MRI measurements did not significantly differ between the Shunt and Conservative groups (p &gt; 0.05). Callosal angle demonstrated no discriminatory value for shunt surgery selection. In univariate analyses, an Evans Index &gt; 0.36, a bicaudate index &gt; 0.23, and a DESH score &gt; 2 were associated with shunt surgery selection. High-convexity tightness and an Evans Index &gt; 0.36 differed significantly between groups and remained independently associated with shunt surgery selection in multivariable analysis. Conclusions: Ventricular width-based indices alone appear insufficient for identifying patients selected for shunt surgery among individuals evaluated for suspected NPH. Both qualitative and quantitative MRI features, particularly high-convexity tightness and an Evans Index &gt; 0.36, were independently associated with shunt surgery selection following routine clinical assessment. Integrating multimodal imaging parameters with clinical evaluation may provide a more reliable approach for identifying patients who are ultimately selected for shunt surgery following lumbar puncture assessment.<\/jats:p>","DOI":"10.3390\/brainsci16060654","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:57:24Z","timestamp":1782287844000},"page":"654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Ventricular Enlargement: Multimodal MRI Assessment Improves Surgical Decision-Making in Normal Pressure Hydrocephalus"],"prefix":"10.3390","volume":"16","author":[{"given":"Duygu","family":"Baykal","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Bursa City Hospital, Bursa 16250, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-4274","authenticated-orcid":false,"given":"Mustafa Umut","family":"Etli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Antalya City Hospital, Antalya 07080, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1082-7719","authenticated-orcid":false,"given":"Muhammed Enes","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u00dcmraniye Training and Research Hospital, \u0130stanbul 34764, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7971-1199","authenticated-orcid":false,"given":"Zekeriya","family":"Gedikli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u00dcmraniye Training and Research Hospital, \u0130stanbul 34764, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ziya","family":"\u00c7etiner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bursa City Hospital, Bursa 16250, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet K\u00fcr\u015fat","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Antalya City Hospital, Antalya 07080, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-7135","authenticated-orcid":false,"given":"Semra","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u00dcmraniye Training and Research Hospital, \u0130stanbul 34764, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1590\/1980-57642018dn13-020001","article-title":"Normal-pressure hydrocephalus: A critical review","volume":"13","author":"Oliveira","year":"2019","journal-title":"Dement. 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