{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:42:23Z","timestamp":1785404543996,"version":"3.56.0"},"reference-count":102,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Scientists Fund (Category C), National Natural Science Foundation of China","award":["82505784"],"award-info":[{"award-number":["82505784"]}]},{"award":["82505784"],"award-info":[{"award-number":["82505784"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Multidisciplinary Innovative Team of Traditional Chinese Medicine, National Administration of Traditional Chinese Medicine","award":["ZYYCXTD-D-202409"],"award-info":[{"award-number":["ZYYCXTD-D-202409"]}]},{"name":"Special Project for Cultivating Outstanding Young Scientific and Technological Talents, Basic Scientific Research Fund, China Academy of Chinese Medical Sciences","award":["ZZ19-YQ-036"],"award-info":[{"award-number":["ZZ19-YQ-036"]}]},{"award":["ZZ19-YQ-036"],"award-info":[{"award-number":["ZZ19-YQ-036"]}],"id":[{"id":"https:\/\/ror.org\/042pgcv68","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Traditional Chinese Medicine Science and Technology Development Fund Youth Project","award":["BJZYQN-2025-07"],"award-info":[{"award-number":["BJZYQN-2025-07"]}]},{"name":"Qihuang Scholar of the National TCM Leading Talents Support Program","award":["ZZ202219005"],"award-info":[{"award-number":["ZZ202219005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The global obesity epidemic has become one of the most severe public health challenges of the 21st century, and existing treatment strategies have limitations such as poor long-term adherence, significant side effects, or high invasiveness. Dysregulation of feeding behavior is the core driver of obesity, and its precise regulation depends on the complete transmission of gut\u2013brain axis signals. The nucleus of the solitary tract (NTS), as the first central relay station for visceral afferent signals, is a key hub for the regulation of feeding homeostasis. This article reviews the peripheral signal transduction mechanisms of hunger and satiety, the core afferent pathway of the vagus nerve, and the functional heterogeneity of neuron subpopulations within the NTS, focusing on the anatomical basis, neuroimaging evidence, and preclinical and clinical research progress of transcutaneous auricular vagus nerve stimulation (taVNS) targeting the NTS to exert anti-obesity effects. Accumulating evidence suggests that taVNS may modulate the activity of satiety-promoting neurons and attenuate aberrant hyperactivity of TH+ catecholaminergic neurons in obesity via the auricular branch of the vagus nerve\u2013NTS pathway, which may in turn bidirectionally suppress homeostatic and hedonic feeding, reduce energy intake, and ameliorate metabolic dysregulation. Current research still has key gaps such as unstandardized stimulation parameters, lack of large-sample long-term randomized controlled trials, and unclear interaction mechanisms between the NTS and higher brain regions. This article provides a theoretical basis for in-depth understanding of the feeding regulatory network of the NTS and the translational application of taVNS in obesity management.<\/jats:p>","DOI":"10.3390\/brainsci16070755","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:44:02Z","timestamp":1784544242000},"page":"755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NTS Neural Subtypes and Satiety Pathways: taVNS as a Novel Neuromodulatory Intervention"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0347-9026","authenticated-orcid":false,"given":"Hanyu","family":"Deng","sequence":"first","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijing","family":"Rong","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1016\/j.cub.2020.07.084","article-title":"A Vagal-NTS Neural Pathway that Stimulates Feeding","volume":"30","author":"Chen","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990\u20132021, with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"Collaborators","year":"2025","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.7326\/ANNALS-24-02547","article-title":"Implications of the European Association for the Study of Obesity\u2019s New Framework Definition of Obesity: Prevalence and Association with All-Cause Mortality","volume":"178","author":"Dicker","year":"2025","journal-title":"Ann. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health Effects of Overweight and Obesity in 195 Countries over 25 Years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/oby.22165","article-title":"Neural Food Reward Processing in Successful and Unsuccessful Weight Maintenance","volume":"26","author":"Simon","year":"2018","journal-title":"Obesity"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/oby.23952","article-title":"Early- and later-stage persistence with antiobesity medications: A retrospective cohort study","volume":"32","author":"Gasoyan","year":"2024","journal-title":"Obesity"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1001\/jama.2023.19897","article-title":"Obesity Management in Adults: A Review","volume":"330","author":"Schwartz","year":"2023","journal-title":"Jama"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: Shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3724\/SP.J.1042.2020.02040","article-title":"Attention bias to food cues and its neural mechanisms","volume":"28","author":"Li","year":"2020","journal-title":"Adv. Psychol. Sci."},{"key":"ref_10","first-page":"501","article-title":"Neural and endocrine regulation of food intake","volume":"34","author":"Sun","year":"2016","journal-title":"J. Pharm. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3724\/SP.J.1042.2019.00322","article-title":"Why do people get fatter on a diet? Psychological mechanisms of overeating among restrained eaters","volume":"27","author":"Wang","year":"2019","journal-title":"Adv. Psychol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1249\/00005768-199103000-00003","article-title":"Diet composition, energy intake, and nutritional status in relation to obesity in men and women","volume":"23","author":"Miller","year":"1991","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-physiol-021115-104948","article-title":"Three Pillars for the Neural Control of Appetite","volume":"79","author":"Sternson","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41583-021-00544-7","article-title":"Neural signalling of gut mechanosensation in ingestive and digestive processes","volume":"23","author":"Kim","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1016\/j.cell.2025.06.010","article-title":"Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy","volume":"188","author":"Johansen","year":"2025","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.280.5368.1378","article-title":"Signals that regulate food intake and energy homeostasis","volume":"280","author":"Woods","year":"1998","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kola, J.B., Docsa, T., and Uray, K. (2022). Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010177"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2013.29","article-title":"Extrinsic primary afferent signalling in the gut","volume":"10","author":"Brookes","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.7233218","article-title":"Vagotomy abolishes cues of satiety produced by gastric distension","volume":"212","author":"Gonzalez","year":"1981","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/ijo.2009.9","article-title":"Gut peptides in the control of food intake","volume":"33","author":"Moran","year":"2009","journal-title":"Int. J. Obes."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e70457","DOI":"10.1096\/fj.202403239R","article-title":"Prebiotics pectin and resistant starch-type 4 stimulate peptide YY and cholecystokinin to promote satiety, and improve gut microbiota composition","volume":"39","author":"Patra","year":"2025","journal-title":"FASEB J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.physbeh.2006.06.017","article-title":"Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin","volume":"89","author":"Peters","year":"2006","journal-title":"Physiol. Behav."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/379069a0","article-title":"A role for glucagon-like peptide-1 in the central regulation of feeding","volume":"379","author":"Turton","year":"1996","journal-title":"Nature"},{"key":"ref_24","first-page":"R1223","article-title":"Brain glucose sensing and body energy homeostasis: Role in obesity and diabetes","volume":"276","author":"Levin","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1126\/science.1241812","article-title":"The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding","volume":"341","author":"Jennings","year":"2013","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yfrne.2009.10.005","article-title":"Leptin and the systems neuroscience of meal size control","volume":"31","author":"Grill","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2013.09.009","article-title":"Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP","volume":"18","author":"Krashes","year":"2013","journal-title":"Cell Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: Structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"ref_31","first-page":"R1623","article-title":"Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression","volume":"276","author":"Schwartz","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2019.10.031","article-title":"Genetic Identification of Vagal Sensory Neurons That Control Feeding","volume":"179","author":"Bai","year":"2019","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrgastro.2016.76","article-title":"Vagal neurocircuitry and its influence on gastric motility","volume":"13","author":"Travagli","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1113\/jphysiol.2013.253732","article-title":"Vagal afferent fibres determine the oxytocin-induced modulation of gastric tone","volume":"591","author":"Holmes","year":"2013","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1002\/cne.25398","article-title":"Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats","volume":"530","author":"Bassi","year":"2022","journal-title":"J. Comp. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1365-2982.2010.01592.x","article-title":"Plasticity of vagal brainstem circuits in the control of gastric function","volume":"22","author":"Browning","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_38","first-page":"27","article-title":"Influence of vagal nerve stimulation on food intake and body weight--results of experimental studies","volume":"56","author":"Sobocki","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.physiol.68.040504.094635","article-title":"Brainstem circuits regulating gastric function","volume":"68","author":"Travagli","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"de Lartigue, G., Barbier de la Serre, C., Espero, E., Lee, J., and Raybould, H.E. (2012). Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032967"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molmet.2018.03.016","article-title":"Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms","volume":"12","author":"Egerod","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.7268408","article-title":"Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat","volume":"213","author":"Smith","year":"1981","journal-title":"Science"},{"key":"ref_43","first-page":"R638","article-title":"Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats","volume":"249","author":"Smith","year":"1985","journal-title":"Am. J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.peptides.2007.11.003","article-title":"PYY(3-36) induces Fos in the arcuate nucleus and in both catecholaminergic and non-catecholaminergic neurons in the nucleus tractus solitarius of rats","volume":"29","author":"Blevins","year":"2008","journal-title":"Peptides"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1210\/jcem.86.12.8111","article-title":"Ghrelin enhances appetite and increases food intake in humans","volume":"86","author":"Wren","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1016\/j.cub.2020.08.069","article-title":"Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve","volume":"30","author":"Davis","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1985.sp015658","article-title":"Effects of subdiaphragmatic vagotomy on energy balance and thermogenesis in the rat","volume":"362","author":"Andrews","year":"1985","journal-title":"J. Physiol."},{"key":"ref_48","first-page":"R1626","article-title":"Gastric volume detection after selective vagotomies in rats","volume":"274","author":"Phillips","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e143770","DOI":"10.1172\/JCI143770","article-title":"Gut-brain communication and obesity: Understanding functions of the vagus nerve","volume":"131","author":"Berthoud","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_50","first-page":"193","article-title":"Long-term clinical and metabolic effects of vagotomy with either gastrojejunostomy or pyloroplasty","volume":"45","author":"Wastell","year":"1969","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e14447","DOI":"10.7717\/peerj.14447","article-title":"Ear your heart: Transcutaneous auricular vagus nerve stimulation on heart rate variability in healthy young participants","volume":"10","author":"Forte","year":"2022","journal-title":"PeerJ"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/sj.ijo.0803181","article-title":"Cardiac parasympathetic regulation in obese women with binge eating disorder","volume":"30","author":"Friederich","year":"2006","journal-title":"Int. J. Obes."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Tomasi, D., Wang, G.J., Wang, R., Backus, W., Geliebter, A., Telang, F., Jayne, M.C., Wong, C., Fowler, J.S., and Volkow, N.D. (2009). Association of body mass and brain activation during gastric distention: Implications for obesity. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006847"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bonaz, B., Bazin, T., and Pellissier, S. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00049"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/en.2011-1443","article-title":"GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake","volume":"153","author":"Alhadeff","year":"2012","journal-title":"Endocrinology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1038\/ijo.2009.10","article-title":"The nucleus tractus solitarius: A portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake","volume":"33","author":"Grill","year":"2009","journal-title":"Int. J. Obes."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/cne.24927","article-title":"Central afferents to the nucleus of the solitary tract in rats and mice","volume":"528","author":"Gasparini","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s12264-024-01335-7","article-title":"Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem","volume":"41","author":"Chen","year":"2025","journal-title":"Neurosci. Bull."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/npp.2016.246","article-title":"Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control","volume":"42","author":"Alhadeff","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"C812","DOI":"10.1152\/ajpcell.00484.2025","article-title":"Cholecystokinin receptor expression and signaling remain constant across time of day in rat vagal afferent neurons","volume":"329","author":"Arnold","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1152\/ajpregu.00280.2023","article-title":"CCK-expressing neurons in the NTS are directly activated by CCK-sensitive C-type vagal afferents","volume":"328","author":"Winzenried","year":"2025","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cmet.2019.11.016","article-title":"NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways","volume":"31","author":"Aklan","year":"2020","journal-title":"Cell Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2010.03.059","article-title":"Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure","volume":"1350","author":"Rinaman","year":"2010","journal-title":"Brain Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e13132","DOI":"10.1111\/jne.13132","article-title":"The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections","volume":"34","author":"Holt","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Maniscalco, J.W., Kreisler, A.D., and Rinaman, L. (2012). Satiation and stress-induced hypophagia: Examining the role of hindbrain neurons expressing prolactin-releasing Peptide or glucagon-like Peptide 1. Front. Neurosci., 6.","DOI":"10.3389\/fnins.2012.00199"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1210\/en.2008-1479","article-title":"Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling","volume":"150","author":"Hayes","year":"2009","journal-title":"Endocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/npp.2017.225","article-title":"Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance","volume":"43","author":"Reiner","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Richard, J.E., Anderberg, R.H., G\u00f6teson, A., Gribble, F.M., Reimann, F., and Skibicka, K.P. (2015). Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119034"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e12225","DOI":"10.7554\/eLife.12225","article-title":"Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit","volume":"5","author":"Lyons","year":"2016","journal-title":"eLife"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"11905","DOI":"10.1038\/ncomms11905","article-title":"Genetically and functionally defined NTS to PBN brain circuits mediating anorexia","volume":"7","author":"Roman","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14563","DOI":"10.1074\/jbc.275.19.14563","article-title":"Activation of downstream signals by the long form of the leptin receptor","volume":"275","author":"Banks","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/en.2007-0633","article-title":"Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats","volume":"149","author":"Huo","year":"2008","journal-title":"Endocrinology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1152\/ajpregu.00604.2003","article-title":"Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size","volume":"287","author":"Blevins","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Sabatier, N., Leng, G., and Menzies, J. (2013). Oxytocin, feeding, and satiety. Front. Endocrinol., 4.","DOI":"10.3389\/fendo.2013.00035"},{"key":"ref_76","first-page":"68","article-title":"Interacting appetite-regulating pathways in the hypothalamic regulation of body weight","volume":"20","author":"Kalra","year":"1999","journal-title":"Endocr. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102074","DOI":"10.1016\/j.molmet.2024.102074","article-title":"Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss","volume":"95","author":"Wean","year":"2025","journal-title":"Mol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12264-020-00619-y","article-title":"Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application","volume":"37","author":"Wang","year":"2021","journal-title":"Neurosci. Bull."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.brs.2018.06.003","article-title":"Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS)","volume":"11","author":"Badran","year":"2018","journal-title":"Brain Stimul."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3174\/ajnr.A6808","article-title":"Secondary Otalgia: Referred Pain Pathways and Pathologies","volume":"41","author":"Norris","year":"2020","journal-title":"Am. J. Neuroradiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/joa.13122","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J. Anat."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ca.1089","article-title":"The nerve supply of the human auricle","volume":"15","author":"Peuker","year":"2002","journal-title":"Clin. Anat."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuron.2021.12.020","article-title":"Internal senses of the vagus nerve","volume":"110","author":"Prescott","year":"2022","journal-title":"Neuron"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Paciorek, A., and Skora, L. (2020). Vagus Nerve Stimulation as a Gateway to Interoception. Front. Psychol., 11.","DOI":"10.3389\/fpsyg.2020.01659"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.brs.2022.09.003","article-title":"The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial","volume":"15","author":"Wang","year":"2022","journal-title":"Brain Stimul."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"118566","DOI":"10.1016\/j.neuroimage.2021.118566","article-title":"Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation","volume":"244","author":"Borgmann","year":"2021","journal-title":"Neuroimage"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00702-007-0755-z","article-title":"BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation","volume":"114","author":"Kraus","year":"2007","journal-title":"J. Neural Transm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2015.03.025","article-title":"Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder","volume":"79","author":"Fang","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s11695-019-04365-7","article-title":"Effects and Mechanisms of Vagal Nerve Stimulation on Body Weight in Diet-Induced Obese Rats","volume":"30","author":"Dai","year":"2020","journal-title":"Obes. Surg."},{"key":"ref_90","first-page":"637","article-title":"Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet","volume":"62","author":"Gil","year":"2011","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1038\/s41467-018-07764-z","article-title":"Effective weight control via an implanted self-powered vagus nerve stimulation device","volume":"9","author":"Yao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0361-9230(92)90021-O","article-title":"Activation of the satiety center by auricular acupuncture point stimulation","volume":"29","author":"Asamoto","year":"1992","journal-title":"Brain Res. Bull."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0361-9230(94)00179-5","article-title":"Effects of auricular stimulation on feeding-related hypothalamic neuronal activity in normal and obese rats","volume":"36","author":"Shiraishi","year":"1995","journal-title":"Brain Res. Bull."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e14735","DOI":"10.1111\/psyp.14735","article-title":"Investigating the modulation of gastric sensations and disposition toward food with taVNS","volume":"62","author":"Salaris","year":"2025","journal-title":"Psychophysiology"},{"key":"ref_95","first-page":"2954","article-title":"Analysis of Clinical Efficacy and Central Response Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Overweight\/Obesity Patients Based on Regional Homogeneity","volume":"41","author":"Fan","year":"2024","journal-title":"J. Guangzhou Univ. Chin. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.brs.2014.11.018","article-title":"Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans","volume":"8","author":"Frangos","year":"2015","journal-title":"Brain Stimul."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"521","DOI":"10.14309\/ajg.0000000000002548","article-title":"Transcutaneous Auricular Vagal Nerve Stimulation Is Effective for the Treatment of Functional Dyspepsia: A Multicenter, Randomized Controlled Study","volume":"119","author":"Shi","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Farmer, A.D., Strzelczyk, A., Finisguerra, A., Gourine, A.V., Gharabaghi, A., Hasan, A., Burger, A.M., Jaramillo, A.M., Mertens, A., and Majid, A. (2020). International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020). Front. Hum. Neurosci., 14.","DOI":"10.3389\/fnhum.2020.568051"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1080\/09638288.2024.2313123","article-title":"Clinical application of transcutaneous auricular vagus nerve stimulation: A scoping review","volume":"46","author":"Gerges","year":"2024","journal-title":"Disabil. Rehabil."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"24391","DOI":"10.1038\/s41598-024-72179-4","article-title":"Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: The importance of stimulation intensity and sensory perception","volume":"14","author":"Ludwig","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"105813","DOI":"10.1016\/j.appet.2021.105813","article-title":"Acute vagus nerve stimulation does not affect liking or wanting ratings of food in healthy participants","volume":"169","author":"Teckentrup","year":"2022","journal-title":"Appetite"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"22055","DOI":"10.1038\/s41598-022-25864-1","article-title":"Safety of transcutaneous auricular vagus nerve stimulation (taVNS): A systematic review and meta-analysis","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/7\/755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:22:52Z","timestamp":1784546572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/7\/755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":102,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["brainsci16070755"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16070755","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}