{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:02:17Z","timestamp":1785438137880,"version":"3.56.0"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"publisher","award":["S-MIP-21-355"],"award-info":[{"award-number":["S-MIP-21-355"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]},{"award":["S-MIP-21-355"],"award-info":[{"award-number":["S-MIP-21-355"]}],"id":[{"id":"https:\/\/ror.org\/02gs16m83","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sci.","Brain Sciences"],"abstract":"<jats:p>Objectives: While longitudinal studies have linked parietal lobe structure and muscle mass, no resistance exercise studies have evaluated whether interventions can have a positive impact on parietal lobe structure. Therefore, we investigated the effects of high-intensity resistance training (HIRT) and blood-flow restriction training (BFRT) on cortical thickness and white matter integrity in the parietal region, as well as in other regions, in an exploratory manner. Methods: A total of 63 older men were assigned to BFRT, HIRT or control groups for 12 weeks of intervention. A total of 48 participants completed brain and thigh magnetic resonance imaging before and after intervention. Cortical thickness was assessed using FreeSurfer, fractional anisotropy (FA) values were calculated using ExploreDTI, thigh muscle anatomical cross-sectional area was measured from MRI. Results: A significant difference in cortical thickness was observed only in HIRT group in the left parietal cortex\u2014inferior parietal, supramarginal and posterior cingulate. Exploratory analyses revealed cortical thickness changes in other left-hemisphere regions, including the temporal (bankssts, inferior temporal), frontal (medial orbitofrontal, precentral, rostral middle frontal), and occipital (lateral occipital) cortices. In contrast, the BFRT group showed significant FA value change in parietal region \u2013 in left inferior parietal, left precuneus and right superior parietal. Exploratory analyses showed FA value change in additional regions in the BFRT group, including the left frontal (caudal middle frontal and superior frontal), left temporal (fusiform), right occipital (lateral occipital), and in the HIRT group, in the left frontal region (pars opercularis). Conclusions: HIRT and BFRT were associated with beneficial brain structural changes, although through distinct neurobiological mechanisms, with HIRT primarily influencing cortical thickness and BFRT predominantly affecting white matter microstructure.<\/jats:p>","DOI":"10.3390\/brainsci16080797","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:57:28Z","timestamp":1785254248000},"page":"797","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Effects of Blood-Flow Restriction and High-Intensity Resistance Training on Cortical Thickness and White Matter Integrity in Older Men: A Three-Group Randomized Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Milda","family":"Butkien\u0117","sequence":"first","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urt\u0117","family":"Luko\u0161evi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilt\u0117","family":"Pa\u017e\u0117rait\u0117","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Valatkevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rymant\u0117","family":"Gleiznien\u0117","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Musneckien\u0117","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulius","family":"Luko\u0161evi\u010dius","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Mickevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertas","family":"Petrolis","sequence":"additional","affiliation":[{"name":"Department of Physics, Mathematics and Biophysics, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"},{"name":"Neuroscience Institute, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-0449","authenticated-orcid":false,"given":"Vida J.","family":"\u010cesnaitien\u0117","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-5122","authenticated-orcid":false,"given":"Oron","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-4226","authenticated-orcid":false,"given":"Nerijus","family":"Masiulis","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Rehabilitation, Lithuanian Sports University, LT-44221 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-4949","authenticated-orcid":false,"given":"Wouter A. 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Normal aging induces changes in the brain and neurodegeneration progress: Review of the structural, biochemical, metabolic, cellular, and molecular changes. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.931536"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Blinkouskaya, Y., and Weickenmeier, J. (2021). Brain shape changes associated with cerebral atrophy in healthy aging and Alzheimer\u2019s disease. Front. Mech. Eng., 7.","DOI":"10.3389\/fmech.2021.705653"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wu, X., Tang, Y., He, Y., Wang, Q., Wang, Y., and Qin, X. (2024). Prevalence of cognitive impairment and its related factors among Chinese older adults: An analysis based on the 2018 CHARLS data. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1500172"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41392-022-01233-2","article-title":"Molecular Mechanisms of Exercise Contributing to Tissue Regeneration","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/ars.2013.5773","article-title":"Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy","volume":"21","author":"Ferraro","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neurobiolaging.2015.12.009","article-title":"Age-related cortical thinning in cognitively healthy individuals in their 60s: The PATH Through Life study","volume":"39","author":"Shaw","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cercor\/bhh032","article-title":"Thinning of the cerebral cortex in aging","volume":"14","author":"Salat","year":"2004","journal-title":"Cereb. Cortex"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/archneur.1994.00540210046012","article-title":"A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood","volume":"51","author":"Pfefferbaum","year":"1994","journal-title":"Arch. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106306","DOI":"10.1016\/j.bandc.2025.106306","article-title":"Age-related cortical changes and cognitive performance in healthy adults","volume":"187","author":"Singh","year":"2025","journal-title":"Brain Cogn."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/cercor\/7.3.268","article-title":"Selective Aging of the Human Cerebral Cortex Observed In Vivo: Differential Vulnerability of the Prefrontal Gray Matter","volume":"7","author":"Raz","year":"1997","journal-title":"Cereb. Cortex"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/WNL.57.4.632","article-title":"Evidence for Cortical \u201cDisconnection\u201d as a Mechanism of Age-Related Cognitive Decline","volume":"57","author":"Jones","year":"2001","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/cercor\/bhj045","article-title":"Selective Age-Related Degradation of Anterior Callosal Fiber Bundles Quantified In Vivo with Fiber Tracking","volume":"16","author":"Sullivan","year":"2006","journal-title":"Cereb. Cortex"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neubiorev.2006.07.001","article-title":"Differential aging of the brain: Patterns, cognitive correlates and modifiers","volume":"30","author":"Raz","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e4564","DOI":"10.1002\/nbm.4564","article-title":"MRI of healthy brain aging: A review","volume":"34","author":"MacDonald","year":"2021","journal-title":"NMR Biomed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/gerona\/glaa294","article-title":"Association between brain volumes and patterns of physical activity in community-dwelling older adults","volume":"76","author":"Wanigatunga","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105412","DOI":"10.1016\/j.archger.2024.105412","article-title":"Unveiling the muscle-brain axis: A bidirectional Mendelian randomization study investigating the causal relationship between sarcopenia-related traits and brain aging","volume":"123","author":"Li","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yu, J.H., Roh, E., Hong, S.H., Lee, Y.B., Kim, H.J., Kim, N.H., Seo, J.A., Kim, S.G., Kim, H.Y., and Baik, S.H. (2021). Sarcopenia is associated with decreased gray matter volume in the parietal lobe: A longitudinal cohort study. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02581-4"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2219926","DOI":"10.1001\/jamanetworkopen.2022.19926","article-title":"Association of Low Muscle Mass with Cognitive Function During a 3-Year Follow-Up Among Adults Aged 65 to 86 Years in the Canadian Longitudinal Study on Aging","volume":"5","author":"Tessier","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuroimage.2012.09.005","article-title":"Fat-free body mass but not fat mass is associated with reduced gray matter volume of cortical brain regions implicated in autonomic and homeostatic regulation","volume":"64","author":"Weise","year":"2013","journal-title":"NeuroImage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.aehs.2024.11.001","article-title":"Exercise-mediated circulating metabolites for brain health","volume":"1","author":"Wang","year":"2024","journal-title":"Adv. Exerc. Health Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"lnaf001","DOI":"10.1093\/lifemedi\/lnaf001","article-title":"A framework of biomarkers for skeletal muscle aging: A consensus statement by the Aging Biomarker Consortium","volume":"3","author":"Huang","year":"2024","journal-title":"Life Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/PSY.0000000000000526","article-title":"Role of brain structure in predicting adherence to a physical activity regimen","volume":"80","author":"Gujral","year":"2018","journal-title":"Psychosom. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuroimage.2015.09.050","article-title":"Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment","volume":"131","author":"Witte","year":"2016","journal-title":"NeuroImage"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-190875","article-title":"Cerebral white matter integrity in amnestic mild cognitive impairment: A 1-year randomized controlled trial of aerobic exercise training","volume":"73","author":"Tarumi","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/sms.13632","article-title":"Effect of blood-flow restricted vs heavy-load strength training on muscle strength: Systematic review and meta-analysis","volume":"30","author":"Mieritz","year":"2020","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Patterson, S.D., Hughes, L., Head, P., Warmington, S., Brandner, C., Bloodworth, A., Beaven, C.M., Burr, J., Scott, B.R., and Owens, J. (2019). Blood flow restriction exercise: Considerations of methodology, application, and safety. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00533"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhu, H., Tan, Z., Zhang, N., Li, Y., and Qi, H. (2025). Acute effects of blood flow restriction training at various arterial occlusion pressures on muscle activation, blood lactate responses, and RPE in healthy adult males. Front. Physiol., 16.","DOI":"10.3389\/fphys.2025.1620294"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5960\/dzsm.2018.351","article-title":"Comparison of an acute resistance training on the lactate concentration with and without blood flow restriction at different loads","volume":"69","author":"Nitzsche","year":"2018","journal-title":"Dtsch. Z. Sportmed."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Delezie, J., and Handschin, C. (2018). Endocrine crosstalk between skeletal muscle and the brain. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00698"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Landers, J.B., Landers, K.R., and Young, N.G. (2025). The effects of blood flow restriction exercise on muscle\u2013brain crosstalk: A systematic review. Muscles, 4.","DOI":"10.3390\/muscles4020019"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111402","DOI":"10.1016\/j.exger.2021.111402","article-title":"Sarcopenia is independently associated with parietal atrophy in older adults","volume":"151","author":"Hsu","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1748-1716.2008.01850.x","article-title":"Spinal and supraspinal adaptations associated with balance training and their functional relevance","volume":"193","author":"Taube","year":"2008","journal-title":"Acta Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Naito, E., and Hirose, S. (2014). Efficient Foot Motor Control by Neymar\u2019s Brain. Front. Hum. Neurosci., 8.","DOI":"10.3389\/fnhum.2014.00594"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111249","DOI":"10.1016\/j.brainresbull.2025.111249","article-title":"Cognitive gains and cortical thickness changes after 12 weeks of resistance training in older adults with low and high risk of mild cognitive impairment: Findings from a randomized controlled trial","volume":"222","author":"Ziv","year":"2025","journal-title":"Brain Res. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2014.09.033","article-title":"Exercise-induced changes in basal ganglia volume and cognition in older adults","volume":"281","author":"Niemann","year":"2014","journal-title":"Neuroscience"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/cpt1974155443","article-title":"Minimization: A new method of assigning patients to treatment and control groups","volume":"15","author":"Taves","year":"1974","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1038\/s41598-020-67251-8","article-title":"Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men","volume":"10","author":"Sui","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101185","DOI":"10.1016\/j.arr.2020.101185","article-title":"Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis","volume":"64","author":"Tuttle","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2023.02.011","article-title":"Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults","volume":"127","author":"Vints","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref_44","unstructured":"Sj\u00f6str\u00f6m, M., Ainsworth, B., Bauman, A., Bull, F., Craig, C., and Sallis, J. (2005). Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ): Short and Long Forms, IPAQ Research Committee."},{"key":"ref_45","unstructured":"Haff, G.G., and Triplett, N.T. (2016). Essentials of Strength Training and Conditioning, Human Kinetics. [4th ed.]."},{"key":"ref_46","unstructured":"Swain, D.P. (2014). ACSM\u2019s Resource Manual for Guidelines for Exercise Testing and Prescription, Wolters Kluwer Health\/Lippincott Williams & Wilkins. [7th ed.]."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature","volume":"53","author":"Destrieux","year":"2010","journal-title":"NeuroImage"},{"key":"ref_48","unstructured":"Leemans, A. (2009, January 18\u201324). ExploreDTI: A graphical toolbox for processing, analyzing, and visualizing diffusion MR data. Proceedings of the 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Honolulu, HI, USA."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1748-1716.1993.tb09573.x","article-title":"Changes in lower limb muscle cross-sectional area and tissue fluid volume after transition from standing to supine","volume":"148","author":"Berg","year":"1993","journal-title":"Acta Physiol. Scand."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e12648","DOI":"10.14814\/phy2.12648","article-title":"Muscle damage and inflammation after eccentric exercise: Can the repeated bout effect be removed?","volume":"3","author":"Margaritelis","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/14779072.2019.1561278","article-title":"Rating of perceived exertion on resistance training in elderly subjects","volume":"17","author":"Morishita","year":"2019","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/2245","article-title":"Maintaining internal representations: The role of the human superior parietal lobe","volume":"1","author":"Wolpert","year":"1998","journal-title":"Nat. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11556-019-0217-2","article-title":"Functional and\/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements\u2014A systematic review","volume":"16","author":"Herold","year":"2019","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Serna-Orozco, M.F., Pitto-Bedoya, S., Salazar-Goyes, J.S., Figueroa-Z\u00fa\u00f1iga, S., Mart\u00ednez-Mu\u00f1oz, L.M., and Jaramillo-Losada, J. (2025). Effects of resistance training on motor and cognitive function in older adults with Alzheimer\u2019s disease: A systematic review. Healthcare, 13.","DOI":"10.3390\/healthcare13233079"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Robertson, A.D., Marzolini, S., Middleton, L.E., Basile, V.S., Oh, P.I., and MacIntosh, B.J. (2017). Exercise training increases parietal lobe cerebral blood flow in chronic stroke: An observational study. Front. Aging Neurosci., 9.","DOI":"10.3389\/fnagi.2017.00318"},{"key":"ref_57","first-page":"7375","article-title":"Physical exercise and cortical thickness in healthy controls: A pilot study","volume":"25","author":"Bashir","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Xu, J., Yu, J., Li, G., and Wang, Y. (2024). Exercise Intervention on the Brain Structure and Function of Patients with Mild Cognitive Impairment: Systematic Review Based on Magnetic Resonance Imaging Studies. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1464159"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3233\/ADR-220113","article-title":"Resistance Training Maintains White Matter and Physical Function in Older Women with Cerebral Small Vessel Disease: An Exploratory Analysis of a Randomized Controlled Trial","volume":"7","author":"Oh","year":"2023","journal-title":"J. Alzheimers Dis. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-200423","article-title":"White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial","volume":"78","author":"Stephen","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"fcaf379","DOI":"10.1093\/braincomms\/fcaf379","article-title":"Proprioception as a Sensory Root for Body and Motor Awareness","volume":"7","author":"Salvato","year":"2025","journal-title":"Brain Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s42452-025-06521-4","article-title":"Unlocking the Full Potential of Resistance Training: A Comparative Analysis of Low- and High-Intensity Effects on Neurotrophic Growth Factors and Homocysteine","volume":"7","author":"Zuo","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zunner, B.E.M., Wachsmuth, N.B., Eckstein, M.L., Scherl, L., Schierbauer, J.R., Haupt, S., Stumpf, C., Reusch, L., and Moser, O. (2022). Myokines and Resistance Training: A Narrative Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073501"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/8\/797\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:33:31Z","timestamp":1785386011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/8\/797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["brainsci16080797"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16080797","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}