{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:26:14Z","timestamp":1787307974232,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sci.","Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: The aim of this study was to apply data-driven clustering techniques for the subtyping of tinnitus severity to a retrospective cross-sectional cohort of 564 subjects. Additionally, the response of the resulting phenotypes to an enriched acoustic environment (EAE) treatment was investigated. Methods: A hierarchical decision cascade was applied to classify the measured audiograms of participants into six hearing loss (HL) patterns. K-clustering techniques were applied to demographic (gender), hearing (average audiometric threshold, HL pattern), tinnitus (tinnitus onset age, duration, severity, lateralisation, type of sound, aetiology) and emotional variables. Subjects received customised EAE stimulus to be listened to for one hour daily over four months. Results: Five phenotypes were found by applying K-clustering techniques to numerical and categorical variables. EAE provided an average tinnitus severity reduction of 24.3 points, which was clinically relevant and statistically significant, in 78% of subjects who completed the four-month treatment. Conclusions: Analysis of the performance of EAE treatment in the different phenotypes afforded clear differences in the composition of excluded, dropped out, and not improved subjects. Absolute mean improvement of both severity and emotional scores was larger in phenotypes PH3 and PH4, as they had higher tinnitus distress and emotional symptoms at baseline. Nevertheless, relative change of severity score was notably smaller in PH4.<\/jats:p>","DOI":"10.3390\/brainsci16080894","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:31:59Z","timestamp":1787304719000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tinnitus Phenotypes and Their Response to the Enriched Acoustic Environment (EAE) Treatment"],"prefix":"10.3390","volume":"16","author":[{"given":"Charles","family":"Bouzou","sequence":"first","affiliation":[{"name":"Ecole Centrale Mediterran\u00e9e, 38 Rue Fr\u00e9d\u00e9ric Joliot-Curie, 13013 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3541-1178","authenticated-orcid":false,"given":"Marta","family":"Fern\u00e1ndez-Ledesma","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Campus de Villaviciosa, Calle Tajo s\/n, Villaviciosa de Od\u00f3n, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-8568","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Institute of Physical and Information Technologies (ITEFI), CSIC, Serrano 144, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-1122","authenticated-orcid":false,"given":"Pedro","family":"Cobo","sequence":"additional","affiliation":[{"name":"Institute of Physical and Information Technologies (ITEFI), CSIC, Serrano 144, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Eggermont, J.J., and Tass, P.A. (2012). Maladaptive neural synchrony in tinnitus: Origin and restoration. Front. Neurol., 6.","DOI":"10.3389\/fneur.2015.00029"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Eggermont, J.J. (2012). The Neuroscience of Tinnitus, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199605606.001.0001"},{"key":"ref_3","first-page":"1","article-title":"Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal)","volume":"Volume 260","author":"Schlee","year":"2021","journal-title":"Progress in Brain Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00106-019-0633-7","article-title":"A multidisciplinary European guideline for tinnitus: Diagnostics, assessment, and treatment","volume":"67","author":"Cima","year":"2019","journal-title":"HNO"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3389\/fnins.2019.00802","article-title":"Why is there no cure for tinnitus?","volume":"13","author":"McFerran","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cuesta, M., and Cobo, P. (2023). A heterogeneous sample of a spanish tinnitus cohort. Brain Sci., 13.","DOI":"10.3390\/brainsci13040652"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cederroth, C.R., Gallus, S., Hall, D.A., Kleinjung, T., Langguth, B., Maruotti, A., Meyer, M., Norena, A., Probst, T., and Pryss, R. (2019). Editorial: Towards an Understanding of Tinnitus Heterogeneity. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00053"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Al-Rawashdeh, B.M., Qaswal, A.B., Suleiman, A., Zayed, F.M., Al-Rawashdeh, S.M., Tawalbeh, M., Khreesha, L., Alzubaidi, A., Al-Zubidi, E., and Ghala, Z. (2022). The quantum tunneling of ions model can explain the pathophysiology of tinnitus. Brain Sci., 12.","DOI":"10.3390\/brainsci12040426"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1038\/s41467-025-59445-3","article-title":"Tinnitus risk factors and its evolution over time","volume":"16","author":"Hobeika","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Genitsaridi, E., Hoare, D.J., Kypraios, T., and Hall, D.A. (2020). A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes. Brain Sci., 10.","DOI":"10.3390\/brainsci10120938"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Biehl, R., Boecking, B., Brueggemann, P., Grosse, R., and Mazurek, B. (2020). Personality Traits, Perceived Stress, and Tinnitus-Related Distress in Patients with Chronic Tinnitus: Support for a Vulnerability-Stress Model. Front. Psychol., 10.","DOI":"10.3389\/fpsyg.2019.03093"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Boecking, B., Biehl, R., Brueggemann, P., and Mazurek, B. (2021). Health-Related Quality of Life, Depressive Symptoms, Anxiety, and Somatization Symptoms in Male and Female Patients with Chronic Tinnitus. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132798"},{"key":"ref_13","first-page":"S50","article-title":"Tinnitus and influencing comorbidities","volume":"102","author":"Mazurek","year":"2023","journal-title":"Laryngorhinootologie"},{"key":"ref_14","first-page":"153","article-title":"Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome","volume":"9","author":"Newman","year":"1998","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","article-title":"Guidelines for the grading of tinnitus severity: The results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999","volume":"26","author":"McCombe","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_16","first-page":"22","article-title":"Cognitive behavioral therapy for tinnitus","volume":"31","author":"Woods","year":"2019","journal-title":"Audiol. Today"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00106-014-2979-1","article-title":"25 years of tinnitus retraining therapy","volume":"63","author":"Jastreboff","year":"2015","journal-title":"HNO"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.joto.2024.01.003","article-title":"Enriched Acoustic Environment as a customized treatment for tinnitus: A non-controlled longitudinal study","volume":"19","author":"Cuesta","year":"2024","journal-title":"J. Otol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ward, J., Vella, C., Hoare, D.J., and Hall, D.A. (2015). Subtyping somatic tinnitus: A cross-sectional UK cohort study of demographic, clinical and audiological characteristics. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126254"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/bs.pbr.2020.05.022","article-title":"Exploring tinnitus heterogeneity","volume":"260","author":"Beukes","year":"2021","journal-title":"Prog. Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wallh\u00e4usser-Franke, E., Brade, J., Balkenhol, T., D\u2019Amelio, R., Seegm\u00fcller, A., and Delb, W. (2012). Tinnitus: Distinguishing between subjectively perceived loudness and tinnitus-related distress. PLoS ONE, 7.","DOI":"10.1371\/annotation\/96f457f9-3f48-4f88-a7f0-1d5e6067e7a5"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Smith, P.F., and Zheng, Y. (2021). Applications of multivariate statistical and data mining analyses to the search for biomarkers of sensorineural hearing loss, tinnitus, and vestibular dysfunction. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.627294"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/s41598-024-52651-x","article-title":"Heterogeneity in response to treatment across tinnitus phenotypes","volume":"14","author":"Niemann","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2018.09.012","article-title":"Rationale and Efficacy of Sound Therapies for Tinnitus and Hyperacusis","volume":"407","author":"Pienkowkski","year":"2019","journal-title":"Neuroscience"},{"key":"ref_25","first-page":"1","article-title":"Preliminary results of the enriched acoustic environment as personalized sound-therapy for tinnitus","volume":"5","author":"Cobo","year":"2021","journal-title":"Auditio"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1051\/aacus\/2021028","article-title":"Customised enriched acoustic environment for sound therapy of tinnitus","volume":"5","author":"Cobo","year":"2021","journal-title":"Acta Acust."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cuesta, M., Garz\u00f3n, C., and Cobo, P. (2022). Efficacy of Sound Therapy for Tinnitus Using an Enriched Acoustic Environment with Hearing-Loss Matched Broadband Noise. Brain Sci., 12.","DOI":"10.3390\/brainsci12010082"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Ledesma, M., Sanz-Fern\u00e1ndez, R., Cuesta, M., and Cobo, P. (2025). Enriched Acoustic Environment Therapy (EAE): A Cost-Effective and Feasible Alternative to Tinnitus Retraining Therapy (TRT). Healthcare, 13.","DOI":"10.3390\/healthcare13243248"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Brueggemann, P., Mebus, W., Boecking, B., Amarjargal, N., Niemann, U., Spiliopoulou, M., Dobel, C., Rose, M., and Mazurek, B. (2022). Dimensions of Tinnitus-Related Distress. Brain Sci., 12.","DOI":"10.3390\/brainsci12020275"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16411","DOI":"10.1038\/s41598-020-73402-8","article-title":"Phenotyping chronic tinnitus patients using self-report questionnaire data: Cluster analysis and visual comparison","volume":"10","author":"Niemann","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/AUD.0b013e31822f67c0","article-title":"The Tinnitus Functional Index: Development of a New Clinical Measure for Chronic, Intrusive Tinnitus","volume":"33","author":"Meikle","year":"2012","journal-title":"Ear Hear."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.heares.2015.06.004","article-title":"Tinnitus Functional Index: Development, Validation, Outcomes Research, and Clinical Application","volume":"334","author":"Henry","year":"2016","journal-title":"Hear. Res."},{"key":"ref_33","first-page":"142","article-title":"Evaluaci\u00f3n de la incapacidad en los pacientes con ac\u00fafenos (Evaluation of handicap in tinnitus patients)","volume":"52","author":"Plaza","year":"2001","journal-title":"Acta Otorrinolaringol. Esp."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Engelke, M., Simoes, J.P., Langguth, B., Schlee, W., and Basso, L. (2026). The 83 symptoms of tinnitus: Content overlap of commonly used scales for tinnitus burden. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0340468"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mazurek, B., Rose, M., Schulze, H., and Dobel, C. (2022). Systems Medicine Approach for Tinnitus with Comorbid Disorders. Nutrients, 14.","DOI":"10.3390\/nu14204320"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hackenberg, B., D\u00f6ge, J., O\u2019Brien, K., Bohnert, A., Lackner, K.J., Beutel, M.E., Michal, M., M\u00fcnzel, T., Wild, P.S., and Pfeiffer, N. (2023). Tinnitus and Its Relation to Depression, Anxiety, and Stress\u2014A Population-Based Cohort Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12031169"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jeong, H., Kim, I., Kim, S.H., Lee, J.B., and Kim, H. (2024). Effects of Personality Traits on the Severity of Chronic Subjective Tinnitus: A Cross-Sectional Analysis. Medicina, 60.","DOI":"10.3390\/medicina60081259"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_39","first-page":"127","article-title":"Ansiedad y depresi\u00f3n. Validaci\u00f3n de la escala HADS en pacientes oncol\u00f3gicos","volume":"12","year":"2000","journal-title":"Rev. Psicol. Salud"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1523\/JNEUROSCI.2226-04.2005","article-title":"Enriched acoustic environment alter noise trauma reduces hearing loss and prevents cortical map reorganization","volume":"25","author":"Eggermont","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/WNR.0b013e3282202c35","article-title":"Enriched acoustic environment rescales auditory sensitivity","volume":"18","year":"2007","journal-title":"NeuroReport"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1111\/j.1460-9568.2006.04774.x","article-title":"Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: A computational model","volume":"23","author":"Schaette","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.26599\/JOTO.2026.9540051","article-title":"Cross-sectional analysis of hearing loss, age and tinnitus severity in a web-recruited cohort of 610 subjects","volume":"21","author":"Cuesta","year":"2026","journal-title":"J. Otol."},{"key":"ref_44","first-page":"23","article-title":"Comparison of Tinnitus Handicap Inventory and Tinnitus Functional Index as treatment outcomes","volume":"13","author":"Cuesta","year":"2023","journal-title":"Audiol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.26599\/JOTO.2025.9540009","article-title":"Exploring the interaction between emotional states and tinnitus severity before and after a sound therapy intervention","volume":"20","author":"Cuesta","year":"2025","journal-title":"J. Otol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chemolab.2015.02.016","article-title":"Multivariate Exploratory Data Analysis (MEDA) Toolbox for Matlab","volume":"143","author":"Camacho","year":"2015","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global Prevalence and Incidence of Tinnitus. A Systematic Review and Meta-analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2016.05.009","article-title":"A systematic review of the reporting of tinnitus prevalence and severity","volume":"337","author":"McCormack","year":"2016","journal-title":"Hear. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: Causes and clinical management","volume":"12","author":"Langguth","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Fioretti, A., Natalini, E., Riedl, D., Moschen, R., and Eibenstein, A. (2020). Gender comparison of psychological comorbidities in tinnitus patients\u2014Results of a cross-sectional study. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00704"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12070-024-05175-9","article-title":"Pattern of tinnitus and its risk factors among individuals with tinnitus in South India","volume":"77","author":"Joseph","year":"2025","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tang, D., Lu, X., Huang, R., Yu, H., and Li, W. (2022). Phenotypic profiling of people with subjective tinnitus and without a clinical hearing loss. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.804745"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Langguth, B., Landgrebe, M., Schlee, W., Schecklmann, M., Vielsmeier, V., Steffens, T., Staudinger, S., Frick, H., and Frick, U. (2017). Different Patterns of Hearing Loss among Tinnitus Patients: A Latent Class Analysis of a Large Sample. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00046"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14203","DOI":"10.1038\/s41598-024-64310-2","article-title":"Automated hearing loss type classification based on pure tone audiometry data","volume":"14","author":"Kulawiak","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mazurek, B., Olze, H., and Szczepek, A.J. (2012). Stress and tinnitus\u2014From bed side to bench and back. Front. Syst. Neurosci., 6.","DOI":"10.3389\/fnsys.2012.00047"},{"key":"ref_56","first-page":"589644","article-title":"Psychiatric comorbidity in chronic tinnitus: Depression and anxiety in an otolaryngology outpatient cohort","volume":"22","author":"Dedeoglu","year":"2026","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0168-0102(90)90031-9","article-title":"Phantom auditory perception (tinnitus): Mechanisms of generation and perception","volume":"8","author":"Jastreboff","year":"1990","journal-title":"Neurosci. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.neuron.2010.04.032","article-title":"Tuning out the noise: Limbic-auditory interactions in tinnitus","volume":"66","author":"Rauschecker","year":"2010","journal-title":"Neuron"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Simoes, J., Bulla, J., Neff, P., Pryss, R., Marcrum, S.C., Langguth, B., and Schlee, W. (2022). Daily contributors of tinnitus loudness and distress: An ecological momentary assessment study. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.883665"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10162-025-00995-0","article-title":"Tinnitus measured in everyday life: A literature review of ecological momentary assessment studies","volume":"26","author":"Engelke","year":"2025","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1007\/s00405-024-08844-1","article-title":"The impact of tinnitus on speech perception in noise: A systematic review and meta-analysis","volume":"281","author":"Madhukesh","year":"2024","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3349\/ymj.2025.0088","article-title":"Tinnitus subtyping and personalized treatment via audiometric and psychometric clustering","volume":"66","author":"Kim","year":"2025","journal-title":"Yonsei Med. J."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/8\/894\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:51:05Z","timestamp":1787305865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/8\/894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["brainsci16080894"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16080894","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}