{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:25:09Z","timestamp":1787649909507,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Degen Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sci.","Brain Sciences"],"abstract":"<jats:p>Objectives: Non-pharmacological therapies are a cornerstone of Parkinson\u2019s disease (PD) treatment, but there is not enough evidence of their benefit when delivered altogether online. Our objective was to analyze the efficacy and safety of an online comprehensive care therapy program (OL-CCTP) in people with PD (PwP). Material and methods: This was a proof-of-concept experimental, prospective, 6-month interventional study comparing a PD treatment group (PwP-T) with a control group (PwP-C). The OL-CCTP included group sessions of physical therapy\/therapeutic exercise, nutrition, speech therapy, cognitive stimulation, and psychological support (126 sessions over 6 months). The primary outcome was the change in quality of life at 6 months, as measured by the PDQ-39 questionnaire. Mood (Beck Depression Inventory-II [BDI-II]), the non-motor symptom burden (Non-Motor Symptoms Scale [NMSS]), and disability (Schwab and England Activities of Daily Living Scale [ADLS]) were also assessed. Results: Sixty patients (36 PwP-T and 24 PwP-C) completed the assessments. A reduction of 12.9% (from 78.4 \u00b1 17.9 to 68.3 \u00b1 18.7; p &lt; 0.0001) was observed in the PDQ-39 total score in the PwP-T group (p &lt; 0.0001), compared to 1.5% (from 77.8 \u00b1 22.2 to 76.6 \u00b1 27.9; p = 0.438) in the PwP-C group (p = 0.009). The BDI-II and NMSS scores decreased significantly by 13.1% (p = 0.001) and 20.3% (p = 0.046), respectively, in the PwP-T group but not in the PwP-C group. There were no significant changes in ADLS in either group. No adverse events were reported. Conclusions: After 6 months of OL-CCTP, an improvement of 12.9% was observed in the quality of life of patients with PD.<\/jats:p>","DOI":"10.3390\/brainsci16090906","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:04:30Z","timestamp":1787648670000},"page":"906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Online Comprehensive Care Therapy Complementary Program Improves Quality of Life in People with Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-5111","authenticated-orcid":false,"given":"Diego","family":"Santos Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario de A Coru\u00f1a (HUAC), Complejo Hospitalario Universitario de A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"},{"name":"Grupo de Investigaci\u00f3n en Enfermedad de Parkinson y otros Trastornos del Movimiento, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"},{"name":"Department of Neurology, Hospital San Rafael, 15006 A Coru\u00f1a, Spain"},{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-5639","authenticated-orcid":false,"given":"Pablo","family":"Campo Prieto","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"},{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Facultade de Fisioterapia, Universidade de Vigo, 36310 Pontevedra, Spain"},{"name":"Grupo de Investigaci\u00f3n HealthyFit, Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IISGS), SERGAS-UVIGO, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Breijo Garc\u00eda","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"},{"name":"Centro de Psicolog\u00eda Carmen Breijo, 15160 Sada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda Dafonte","family":"Gil","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Pereiro Nogueira","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Blanco L\u00f3pez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Doblas","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Degen, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and Treatment of Parkinson Disease: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0140-6736(23)01429-0","article-title":"Medical, surgical, and physical treatments for Parkinson\u2019s disease","volume":"403","author":"Foltynie","year":"2024","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"zab302","DOI":"10.1093\/ptj\/pzab302","article-title":"Physical Therapist Management of Parkinson Disease: A Clinical Practice Guideline From the American Physical Therapy Association","volume":"102","author":"Osborne","year":"2022","journal-title":"Phys. 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