{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:03:54Z","timestamp":1789578234693,"version":"build-2803163510"},"reference-count":87,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3-0154"],"award-info":[{"award-number":["P3-0154"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"award":["P3-0154"],"award-info":[{"award-number":["P3-0154"]}],"id":[{"id":"https:\/\/ror.org\/059bp8k51","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sci.","Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Intracranial aneurysm (IA) management has evolved from surgical treatment of ruptured lesions into a multidisciplinary field integrating diagnostics, neurocritical care, endovascular techniques, and individualized risk assessment. As the literature has grown beyond the scope of traditional narrative synthesis, bibliometric methods are needed to characterize the field\u2019s development. We used co-word analysis to map the conceptual structure and thematic evolution of IA research over nearly eight decades. Methods: We analyzed 22,061 publications indexed in PubMed between 1946 and 2023. Co-word analysis of Medical Subject Headings tracked thematic development across six subperiods grouped into eras. Within each thematic network, topics were classified by centrality and density as motor, niche (highly developed but isolated), emerging or declining, or basic themes. Results: Four historical eras were delineated as an interpretative synthesis of the six subperiods. The open-surgery era (1946\u20131980) centered on ruptured aneurysms and refinement of operative techniques. The transitional era (1981\u20131990) was marked by proactive vasospasm management and emerging neurocritical care. The endovascular era (1991\u20132010) reflected the rise of evidence-based medicine and endovascular therapy. The multidisciplinary era (2011\u20132023) shifted toward unruptured aneurysms, molecular research, biomechanics, and individualized risk stratification. Recent themes, including hemodynamics, flow diversion, and precision medicine, reflect a growing research emphasis on predictive and personalized approaches to aneurysm management. Conclusions: IA research has evolved from descriptive, technique-oriented studies toward a data-driven landscape increasingly focused on predictive assessment and management of unruptured lesions. Its thematic evolution highlights the growing prominence of molecular and computational approaches, although their clinical and translational impact cannot be directly inferred from the present analysis.<\/jats:p>","DOI":"10.3390\/brainsci16090984","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:07:29Z","timestamp":1789574849000},"page":"984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Clipping to Coiling and Beyond: Mapping the Evolution and Future Directions of Intracranial Aneurysm Research"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7910-0839","authenticated-orcid":false,"given":"Jure","family":"Pe\u0161ak","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Interdisciplinary Doctoral Programme in Biomedicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-0165","authenticated-orcid":false,"given":"Andrej","family":"Kastrin","sequence":"additional","affiliation":[{"name":"Institute for Biostatistics and Medical Informatics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: A systematic review","volume":"29","author":"Rinkel","year":"1998","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1161\/01.STR.0000140636.30204.da","article-title":"Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: Histological analysis of 24 unruptured and 42 ruptured cases","volume":"35","author":"Piippo","year":"2004","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1161\/01.STR.0000144648.89172.0f","article-title":"Magnitude and role of wall shear stress on cerebral aneurysm: Computational fluid dynamic study of 20 middle cerebral artery aneurysms","volume":"35","author":"Shojima","year":"2004","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","article-title":"Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: A pooled analysis of six prospective cohort studies","volume":"13","author":"Greving","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s12975-020-00867-0","article-title":"Aneurysmal subarachnoid hemorrhage: The last decade","volume":"12","author":"Neifert","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","article-title":"Surgical risk as related to time of intervention in the repair of intracranial aneurysms","volume":"28","author":"Hunt","year":"1968","journal-title":"J. Neurosurg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.wneu.2015.10.093","article-title":"Historical landmarks in the management of aneurysms and arteriovenous malformations of the central nervous system","volume":"88","author":"Peschillo","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3171\/jns.2006.104.4.626","article-title":"Historical vignette. Dominique Anel: Father of the Hunterian ligation?","volume":"104","author":"Sloffer","year":"2006","journal-title":"J. Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00000658-193805000-00003","article-title":"Intracranial aneurysm of the internal carotid artery: Cured by operation","volume":"107","author":"Dandy","year":"1938","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3171\/jns.1976.44.3.0298","article-title":"Anatomical observations of the subarachnoid cisterns of the brain during surgery","volume":"44","author":"Yasargil","year":"1976","journal-title":"J. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00006123-199911000-00014","article-title":"A legacy of microneurosurgery: Memoirs, lessons, and axioms","volume":"45","year":"1999","journal-title":"Neurosurgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/19714009211012358","article-title":"An international bibliometric study of scientific articles on intracranial aneurysms","volume":"34","author":"Kiraz","year":"2021","journal-title":"Neuroradiol. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: An overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J. Bus. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02019280","article-title":"Co-word analysis as a tool for describing the network of interactions between basic and technological research: The case of polymer chemistry","volume":"22","author":"Callon","year":"1991","journal-title":"Scientometrics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/neurintsurg-2020-016238","article-title":"Nature, content and shifts over time of the most impactful unruptured intracranial aneurysms articles: A bibliometric analysis","volume":"13","author":"Lu","year":"2021","journal-title":"J. Neurointerv. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Weng, L., and Li, J. (2022). The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.953285"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e808","DOI":"10.1016\/j.wneu.2023.03.020","article-title":"Knowledge mapping of intracranial aneurysm clipping: A bibliometric and visualized study (2001\u20132021)","volume":"173","author":"Qin","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.wneu.2023.06.020","article-title":"Trends in global research for treating intracranial aneurysms: A bibliometric analysis","volume":"177","author":"Fu","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chen, J., Liu, J., Liu, X., Zeng, C., Chen, Z., Li, S., and Zhang, Q. (2022). Animal model contributes to the development of intracranial aneurysm: A bibliometric analysis. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.1027453"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s10143-023-02022-3","article-title":"A review of the top 100 most influential articles on basilar artery aneurysms","volume":"46","author":"Lei","year":"2023","journal-title":"Neurosurg. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2147\/DDDT.S503226","article-title":"The clinical research landscape of intracranial nicardipine for aneurysmal subarachnoid hemorrhage: Insights from bibliometric analysis","volume":"19","author":"Chen","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chen, B., Huang, S., Zhang, L., Yang, L., Liu, Y., and Li, C. (2023). Global tendencies and frontier topics in hemodynamics research of intracranial aneurysms: A bibliometric analysis from 1999 to 2022. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1157787"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.21037\/qims-23-793","article-title":"Global trend in research of intracranial aneurysm management with artificial intelligence technology: A bibliometric analysis","volume":"14","author":"Zhang","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_24","first-page":"959","article-title":"bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Inf."},{"key":"ref_25","unstructured":"Kottwitz, S. (2023). LATEX Graphics with TikZ, Packt Publishing."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"Blondel","year":"2008","journal-title":"J. Stat. Mech."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers","year":"2003","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: A randomised trial","volume":"360","author":"Molyneux","year":"2002","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(00)02237-6","article-title":"Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score","volume":"355","author":"Barber","year":"2000","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3171\/jns.1990.73.1.0018","article-title":"The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results","volume":"73","author":"Kassell","year":"1990","journal-title":"J. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"(1998). International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms\u2013risk of rupture and risks of surgical intervention. N. Engl. J. Med., 339, 1725\u20131733.","DOI":"10.1056\/NEJM199812103392401"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","article-title":"Subarachnoid haemorrhage","volume":"369","author":"Kerr","year":"2007","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis","volume":"10","author":"Vlak","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/01.STR.0000073841.88563.E9","article-title":"Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils","volume":"34","author":"Raymond","year":"2003","journal-title":"Stroke"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1148\/radiol.13120099","article-title":"Pipeline for uncoilable or failed aneurysms: Results from a multicenter clinical trial","volume":"267","author":"Becske","year":"2013","journal-title":"Radiology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3171\/jns.1966.25.5.0503","article-title":"Effect of common carotid ligation on size of internal carotid aneurysms and distal intracarotid and retinal artery pressures","volume":"25","author":"Tindall","year":"1966","journal-title":"J. Neurosurg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1956.13.1.0001","article-title":"Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms","volume":"13","author":"Botterell","year":"1956","journal-title":"J. Neurosurg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3171\/jns.1961.18.1.0034","article-title":"Intrasellar aneurysms simulating hypophyseal tumours","volume":"18","author":"White","year":"1961","journal-title":"J. Neurosurg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3171\/jns.1978.48.2.0173","article-title":"Time course of vasospasm in man","volume":"48","author":"Weir","year":"1978","journal-title":"J. Neurosurg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/00006123-198001000-00001","article-title":"Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning","volume":"6","author":"Fisher","year":"1980","journal-title":"Neurosurgery"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3171\/jns.1976.45.2.0148","article-title":"Postoperative hypertension in the management of patients with intracranial arterial aneurysms","volume":"45","author":"Kosnik","year":"1976","journal-title":"J. Neurosurg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3171\/jns.1972.37.6.0666","article-title":"Physical factors in the initiation, growth, and rupture of human intracranial saccular aneurysms","volume":"37","author":"Ferguson","year":"1972","journal-title":"J. Neurosurg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/ana.410010407","article-title":"The long-term prognosis in untreated cerebral aneurysms: I. The incidence of late hemorrhage in cerebral aneurysm: A 10-year evaluation of 364 patients","volume":"1","author":"Winn","year":"1977","journal-title":"Ann. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJM198103193041203","article-title":"The natural history of unruptured intracranial aneurysms","volume":"304","author":"Wiebers","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1227\/00006123-198804000-00006","article-title":"The critical first minutes after subarachnoid hemorrhage","volume":"22","author":"Grote","year":"1988","journal-title":"Neurosurgery"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ana.410180208","article-title":"Volume depletion and natriuresis in patients with a ruptured intracranial aneurysm","volume":"18","author":"Wijdicks","year":"1985","journal-title":"Ann. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3171\/jns.1985.62.1.0059","article-title":"Cerebrovascular reactivity in patients with ruptured intracranial aneurysms","volume":"62","author":"Voldby","year":"1985","journal-title":"J. Neurosurg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1227\/00006123-198209000-00001","article-title":"Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension","volume":"11","author":"Kassell","year":"1982","journal-title":"Neurosurgery"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF01406044","article-title":"Balloon catheter technique for dilatation of constricted cerebral arteries after aneurysmal SAH","volume":"70","author":"Zubkov","year":"1984","journal-title":"Acta Neurochir."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3171\/jns.1988.68.4.0505","article-title":"Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled trial","volume":"68","author":"Petruk","year":"1988","journal-title":"J. Neurosurg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3171\/jns.1985.63.6.0857","article-title":"Transpetrosal approach for aneurysms of the lower basilar artery","volume":"63","author":"Kawase","year":"1985","journal-title":"J. Neurosurg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3171\/jns.1985.62.5.0667","article-title":"A combined epi- and subdural direct approach to carotid-ophthalmic artery aneurysms","volume":"62","author":"Dolenc","year":"1985","journal-title":"J. Neurosurg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3171\/jns.2000.93.3.0379","article-title":"Natural history of unruptured intracranial aneurysms: Probability of and risk factors for aneurysm rupture","volume":"93","author":"Juvela","year":"2000","journal-title":"J. Neurosurg."},{"key":"ref_54","first-page":"119","article-title":"Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: A possible index for surgical treatment of intracranial aneurysms","volume":"45","author":"Ujiie","year":"1999","journal-title":"Neurosurgery"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/01.STR.30.7.1396","article-title":"Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms","volume":"30","author":"Kataoka","year":"1999","journal-title":"Stroke"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(96)08093-2","article-title":"Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage","volume":"349","author":"Berendes","year":"1997","journal-title":"Lancet"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1991.75.1.0001","article-title":"Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: Electrochemical basis, technique, and experimental results","volume":"75","author":"Guglielmi","year":"1991","journal-title":"J. Neurosurg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3171\/jns.1991.75.1.0008","article-title":"Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: Preliminary clinical experience","volume":"75","author":"Guglielmi","year":"1991","journal-title":"J. Neurosurg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/BF02684187","article-title":"Alteration of hemodynamics in aneurysm models by stenting: Influence of stent porosity","volume":"25","author":"Lieber","year":"1997","journal-title":"Ann. Biomed. Eng."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/STROKEAHA.110.585059","article-title":"Small unruptured intracranial aneurysm verification study: SUAVe study, Japan","volume":"41","author":"Sonobe","year":"2010","journal-title":"Stroke"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1227\/01.NEU.0000339109.98070.65","article-title":"Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: The Buenos Aires experience","volume":"64","author":"Lylyk","year":"2009","journal-title":"Neurosurgery"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3174\/ajnr.A2023","article-title":"Treatment of intracranial aneurysms by functional reconstruction of the parent artery: The Budapest experience with the pipeline embolization device","volume":"31","author":"Szikora","year":"2010","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/STROKEAHA.109.558114","article-title":"Stent-assisted coiling of intracranial aneurysms: Clinical and angiographic results in 216 consecutive aneurysms","volume":"41","author":"Piotin","year":"2010","journal-title":"Stroke"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/01.STR.0000260955.51401.cd","article-title":"Risk of rupture of unruptured intracranial aneurysms in relation to patient and aneurysm characteristics: An updated meta-analysis","volume":"38","author":"Wermer","year":"2007","journal-title":"Stroke"},{"key":"ref_65","first-page":"2550","article-title":"Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models","volume":"26","author":"Cebral","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_66","first-page":"132","article-title":"Near-infrared indocyanine green video angiography: A new method for intraoperative assessment of vascular flow","volume":"52","author":"Raabe","year":"2003","journal-title":"Neurosurgery"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1109\/TMI.2005.844159","article-title":"Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: Technique and sensitivity","volume":"24","author":"Cebral","year":"2005","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng.72","article-title":"The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm","volume":"40","author":"Helgadottir","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1212\/WNL.0000000000003865","article-title":"ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms","volume":"88","author":"Backes","year":"2017","journal-title":"Neurology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","article-title":"The natural course of unruptured cerebral aneurysms in a Japanese cohort","volume":"366","author":"Morita","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1161\/STROKEAHA.110.592923","article-title":"Hemodynamic-morphologic discriminants for intracranial aneurysm rupture","volume":"42","author":"Xiang","year":"2011","journal-title":"Stroke"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3174\/ajnr.A3558","article-title":"High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: Toward a unifying hypothesis","volume":"35","author":"Meng","year":"2014","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/jcbfm.2012.84","article-title":"Biology of intracranial aneurysms: Role of inflammation","volume":"32","author":"Chalouhi","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000346087","article-title":"European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage","volume":"35","author":"Steiner","year":"2013","journal-title":"Cerebrovasc. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0140-6736(14)60975-2","article-title":"The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT)","volume":"385","author":"Molyneux","year":"2015","journal-title":"Lancet"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3171\/2014.9.JNS141749","article-title":"The Barrow Ruptured Aneurysm Trial: 6-year results","volume":"123","author":"Spetzler","year":"2015","journal-title":"J. Neurosurg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3171\/2011.8.JNS101767","article-title":"The Barrow Ruptured Aneurysm Trial","volume":"116","author":"McDougall","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Hong, Y., Wang, Y.J., Deng, Z., Wu, Q., and Zhang, J.M. (2014). Stent-assisted coiling versus coiling in treatment of intracranial aneurysm: A systematic review and meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0082311"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3174\/ajnr.A2421","article-title":"The pipeline embolization device for the intracranial treatment of aneurysms trial","volume":"32","author":"Nelson","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3174\/ajnr.A4111","article-title":"International retrospective study of the pipeline embolization device: A multicenter aneurysm treatment study","volume":"36","author":"Kallmes","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3174\/ajnr.A2398","article-title":"Aneurysm rupture following treatment with flow-diverting stents: Computational hemodynamics analysis of treatment","volume":"32","author":"Cebral","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/STROKEAHA.112.678151","article-title":"Endovascular treatment of intracranial aneurysms with flow diverters: A meta-analysis","volume":"44","author":"Brinjikji","year":"2013","journal-title":"Stroke"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1161\/STROKEAHA.111.000641","article-title":"Stent-assisted coiling of intracranial aneurysms: Predictors of complications, recanalization, and outcome in 508 cases","volume":"44","author":"Chalouhi","year":"2013","journal-title":"Stroke"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/neurintsurg-2017-013688","article-title":"The 100 most cited articles in the endovascular management of intracranial aneurysms","volume":"10","author":"Maingard","year":"2018","journal-title":"J. Neurointerv. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.21037\/qims-20-729","article-title":"Knowledge framework and emerging trends in intracranial aneurysm magnetic resonance angiography: A scientometric analysis from 2004 to 2020","volume":"11","author":"Zheng","year":"2021","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10143-023-02056-7","article-title":"Research trends within aneurysmal subarachnoid hemorrhage from 2017 to 2021: A bibliometric study","volume":"46","year":"2023","journal-title":"Neurosurg. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41586-023-06221-2","article-title":"Scientific discovery in the age of artificial intelligence","volume":"620","author":"Wang","year":"2023","journal-title":"Nature"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/9\/984\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:28:26Z","timestamp":1789576106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/16\/9\/984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":87,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["brainsci16090984"],"URL":"https:\/\/doi.org\/10.3390\/brainsci16090984","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}