{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:02:23Z","timestamp":1789650143878,"version":"4.0.0"},"reference-count":156,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sci.","Brain Sciences"],"abstract":"<jats:p>Learning disabilities are traditionally conceptualized as domain-specific disorders arising from deficits in reading, attention, or numerical processing. Although these approaches have substantially advanced understanding of dyslexia, attention-deficit\/hyperactivity disorder (ADHD), and dyscalculia, they do not fully explain the marked heterogeneity, developmental variability, frequent comorbidity, or changing learning trajectories observed across children. This conceptual review proposes a developmental timing framework in which learning disabilities emerge, in many cases, from maturational asynchrony among interacting neural, cognitive, linguistic, sensorimotor, and executive systems rather than from isolated deficits within a single domain. Drawing on evidence from developmental neuroscience, cognitive psychology, neuroeducation, developmental systems theory, and learning sciences, we synthesize research on the developmental coordination of language, executive function, attention, motor control, working memory, symbolic learning, and numerical cognition across childhood. Within this framework, dyslexia, ADHD-related learning difficulties, dyscalculia, and mixed learning profiles are interpreted as distinct developmental expressions of differing patterns of cross-system asynchrony interacting with the increasing cognitive demands of formal education. We distinguish maturational asynchrony from related concepts, including developmental variability, developmental cascades, and multiple-deficit models, and propose measurable indicators through which the framework may be empirically evaluated. The framework further generates testable predictions concerning longitudinal developmental trajectories, educational transitions, developmental fit, and timing-sensitive intervention. Rather than replacing established cognitive accounts of learning disabilities, the developmental timing framework provides an integrative developmental architecture within which existing theories can be understood while offering a basis for future longitudinal and intervention research. This perspective highlights the importance of aligning educational expectations and instructional practices with children\u2019s evolving neurodevelopmental readiness rather than chronological age alone.<\/jats:p>","DOI":"10.3390\/brainsci16090987","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:41:35Z","timestamp":1789645295000},"page":"987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When Development Falls out of Sync: A Developmental Timing Framework for Learning Disabilities"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-7331","authenticated-orcid":false,"given":"Gerry","family":"Leisman","sequence":"first","affiliation":[{"name":"Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2022). 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