{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:53:50Z","timestamp":1773309230638,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed  (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 \u00b1 13 mmHg; DBP: 58 \u00b1 13 mmHg) vs. AB (SBP:  121 \u00b1 12 mmHg; DBP: 74 \u00b1 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% \u00b1 6%) vs. AB (29% \u00b1 12%, P &lt; 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.<\/jats:p>","DOI":"10.3390\/brainsci3020781","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T11:26:23Z","timestamp":1368012383000},"page":"781-789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study"],"prefix":"10.3390","volume":"3","author":[{"given":"Aaron","family":"Phillips","sequence":"first","affiliation":[{"name":"Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver V6T 1Z1, Canada"},{"name":"Experimental Medicine Program, Faculty of Medicine, University of British Columbia,  Vancouver V6T 1Z1, Canada"},{"name":"International Collaboration of Repair Discoveries, University of British Columbia,  Vancouver V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration of Repair Discoveries, University of British Columbia,  Vancouver V6T 1Z1, Canada"},{"name":"Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Warburton","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver V6T 1Z1, Canada"},{"name":"Experimental Medicine Program, Faculty of Medicine, University of British Columbia,  Vancouver V6T 1Z1, Canada"},{"name":"International Collaboration of Repair Discoveries, University of British Columbia,  Vancouver V6T 1Z1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"ref_1","unstructured":"Eng, J.J., Teasell, R.W., Miller, W.C., Wolfe, D.L., Townson, A.F., Aubut, J., Abramson, C., Hsieh, J.T.C., and Connolly, S. 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