{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:44:14Z","timestamp":1793371454373,"version":"4.5.0"},"reference-count":119,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The prevalence of neuropsychiatric disorders following traumatic brain injury (TBI) is 20%\u201350%, and disorders of mood and cognition may remain even after recovery of neurologic function is achieved. Selective serotonin reuptake inhibitors (SSRI) block the reuptake of serotonin in presynaptic cells to lead to increased serotonergic activity in the synaptic cleft, constituting first-line treatment for a variety of neurocognitive and neuropsychiatric disorders. This review investigates the utility of SSRIs in treating post-TBI disorders. In total, 37 unique reports were consolidated from the Cochrane Central Register and PubMed (eight randomized-controlled trials (RCTs), nine open-label studies, 11 case reports, nine review articles). SSRIs are associated with improvement of depressive but not cognitive symptoms. Pooled analysis using the Hamilton Depression Rating Scale demonstrate a significant mean decrease of depression severity following sertraline compared to placebo\u2014a result supported by several other RCTs with similar endpoints. Evidence from smaller studies demonstrates mood improvement following SSRI administration with absent or negative effects on cognitive and functional recovery. Notably, studies on SSRI treatment effects for post-traumatic stress disorder after TBI remain absent, and this represents an important direction of future research. Furthermore, placebo-controlled studies with extended follow-up periods and concurrent biomarker, neuroimaging and behavioral data are necessary to delineate the attributable pharmacological effects of SSRIs in the TBI population.<\/jats:p>","DOI":"10.3390\/brainsci7080093","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T10:04:36Z","timestamp":1500977076000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Selective Serotonin Reuptake Inhibitors for Treating Neurocognitive and Neuropsychiatric Disorders Following Traumatic Brain Injury: An Evaluation of Current Evidence"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-7722","authenticated-orcid":false,"given":"John","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-6965","authenticated-orcid":false,"given":"Pavan","family":"Upadhyayula","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Department of Psychiatry, University of California, San Diego, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-8390","authenticated-orcid":false,"given":"Hansen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Pirracchio","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Suen","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourabh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60660, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"},{"name":"San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ngwenya","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Cincinnati, Cincinnati, OH 45220, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California, San Diego, CA 92093, USA"},{"name":"Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Manley","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phiroz","family":"Tarapore","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA"},{"name":"Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, San Francisco, CA 94110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/NRE-2007-22502","article-title":"The impact of traumatic brain injuries: A global perspective","volume":"22","author":"Hyder","year":"2007","journal-title":"NeuroRehabilitation"},{"key":"ref_2","unstructured":"Centers for Disease Control and Prevention (2015). Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/HTR.0b013e3181ccc8b4","article-title":"The Epidemiology of Traumatic Brain Injury","volume":"25","author":"Corrigan","year":"2010","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1528-1157.44.s10.3.x","article-title":"The epidemiology of traumatic brain injury: A review","volume":"44","author":"Bruns","year":"2003","journal-title":"Epilepsia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00001199-199309000-00009","article-title":"Definition of mild traumatic brain injury","volume":"8","author":"Kay","year":"1993","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00701-006-1082-0","article-title":"Mild traumatic brain injuries: The impact of early intervention on late sequelae. A randomized controlled trial","volume":"149","author":"Emanuelson","year":"2007","journal-title":"Acta Neurochir."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0020-1383(79)90015-9","article-title":"Symptoms at one year following concussion from minor head injuries","volume":"10","author":"Rutherford","year":"1979","journal-title":"Injury"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/01.HTR.0000341435.52004.ac","article-title":"Prevalence of long-term disability from traumatic brain injury in the civilian population of the United States, 2005","volume":"23","author":"Zaloshnja","year":"2008","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1176\/appi.ajp.159.8.1315","article-title":"Axis I and II psychiatric disorders after traumatic brain injury: A 30-year follow-up study","volume":"159","author":"Koponen","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3109\/02699052.2011.607783","article-title":"Axis I and II psychiatric disorders in patients with traumatic brain injury: A 12-month follow-up study","volume":"25","author":"Koponen","year":"2011","journal-title":"Brain Inj."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jacobs, B.L., and Fornal, C.A. (2010). Activity of Brain Serotonergic Neurons in Relation to Physiology and Behavior. Handbook of Behavioral Neuroscience, Academic Press.","DOI":"10.1016\/S1569-7339(10)70076-X"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1001\/archneur.58.9.1425","article-title":"The 5-HTTPR*S\/*L polymorphism and aggressive behavior in Alzheimer disease","volume":"58","author":"Sukonick","year":"2001","journal-title":"Arch. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0006-3223(01)01118-0","article-title":"Factors affecting fluvoxamine antidepressant activity: Influence of pindolol and 5-HTTLPR in delusional and nondelusional depression","volume":"50","author":"Zanardi","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF01411725","article-title":"CSF neurotransmitter metabolites in comatose head injury patients during changes in their clinical state","volume":"138","author":"Markianos","year":"1996","journal-title":"Acta Neurochir."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1471-4159.1995.65010250.x","article-title":"Effect of acute fluoxetine treatment on the brain serotonin synthesis as measured by the alpha-methyl-L-tryptophan autoradiographic method","volume":"65","author":"Tsuiki","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1046\/j.1471-4159.1995.64031319.x","article-title":"Synthesis of Serotonin in Traumatized Rat Brain","volume":"64","author":"Tsuiki","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0306-4522(01)00300-1","article-title":"The selective 5-HT(1A) receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats","volume":"106","author":"Kline","year":"2001","journal-title":"Neuroscience"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/sj.npp.1300488","article-title":"Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades","volume":"29","author":"Tiraboschi","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tins.2004.08.001","article-title":"BDNF and 5-HT: A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders","volume":"27","author":"Mattson","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1014862808126","article-title":"Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration","volume":"27","author":"Kong","year":"2002","journal-title":"Neurochem. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1016\/j.febslet.2005.08.020","article-title":"Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death","volume":"579","author":"Nahon","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0028-3908(99)00206-3","article-title":"Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells","volume":"39","author":"Pacher","year":"2000","journal-title":"Neuropharmacology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00001199-200208000-00006","article-title":"Serotonin agents in the treatment of acquired brain injury","volume":"17","author":"Zafonte","year":"2002","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1527-3458.2008.00040.x","article-title":"Therapeutic potential of fluoxetine in neurological disorders","volume":"14","author":"Mostert","year":"2008","journal-title":"CNS Neurosci. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/1793-5482.146597","article-title":"Role of sertraline in posttraumatic brain injury depression and quality-of-life in TBI","volume":"9","author":"Ansari","year":"2014","journal-title":"Asian J. Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.apmr.2008.11.005","article-title":"A randomized controlled trial of sertraline for the treatment of depression in persons with traumatic brain injury","volume":"90","author":"Ashman","year":"2009","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/HTR.0b013e3181d6c715","article-title":"Impact of early administration of sertraline on cognitive and behavioral recovery in the first year after moderate to severe traumatic brain injury","volume":"25","author":"Novack","year":"2010","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1001\/jamapsychiatry.2016.2189","article-title":"Sertraline for Preventing Mood Disorders Following Traumatic Brain Injury: A Randomized Clinical Trial","volume":"73","author":"Jorge","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hup.668","article-title":"Comparing effects of methylphenidate, sertraline and placebo on neuropsychiatric sequelae in patients with traumatic brain injury","volume":"20","author":"Lee","year":"2005","journal-title":"Hum. Psychopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/026990501750111274","article-title":"Sertraline to improve arousal and alertness in severe traumatic brain injury secondary to motor vehicle crashes","volume":"15","author":"Meythaler","year":"2001","journal-title":"Brain Inj."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1089\/neu.2009.0895","article-title":"Impact of early administration of sertraline on depressive symptoms in the first year after traumatic brain injury","volume":"26","author":"Novack","year":"2009","journal-title":"J. Neurotrauma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.4088\/JCP.09m05086blu","article-title":"A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury","volume":"71","author":"Rapoport","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00213-002-1097-z","article-title":"Relief of serotonin selective reuptake inhibitor induced sexual dysfunction with low-dose mianserin in patients with traumatic brain injury","volume":"161","author":"Dolberg","year":"2002","journal-title":"Psychopharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1176\/jnp.12.2.226","article-title":"Sertraline in the treatment of major depression following mild traumatic brain injury","volume":"12","author":"Fann","year":"2000","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2190\/KQ48-XT0L-2H14-5UMV","article-title":"Fluoxetine\u2019s effects on cognitive performance in patients with traumatic brain injury","volume":"32","author":"Horsfield","year":"2002","journal-title":"Int. J. Psychiatry Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3109\/02699051003789229","article-title":"Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury","volume":"24","author":"Rapoport","year":"2010","journal-title":"Brain Inj."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.14336\/AD.2015.0507","article-title":"Cortisol Supplement Combined with Psychotherapy and Citalopram Improves Depression Outcomes in Patients with Hypocortisolism after Traumatic Brain Injury","volume":"6","author":"Luo","year":"2015","journal-title":"Aging Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/026990599121197","article-title":"Paroxetine versus citalopram treatment for pathological crying after brain injury","volume":"13","author":"Muller","year":"1999","journal-title":"Brain Inj."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/026990501458371","article-title":"Mood and behavioural disorders following traumatic brain injury: Clinical evaluation and pharmacological management","volume":"15","author":"Perino","year":"2001","journal-title":"Brain Inj."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1177\/0269881107083845","article-title":"An open-label study of citalopram for major depression following traumatic brain injury","volume":"22","author":"Rapoport","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1191\/0269215502cr523oa","article-title":"Managing depression in brain injury rehabilitation: The use of an integrated care pathway and preliminary report of response to sertraline","volume":"16","author":"Hassan","year":"2002","journal-title":"Clin. Rehabil."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00001199-200106000-00009","article-title":"A case of antidepressant-induced akathisia in a patient with traumatic brain injury","volume":"16","author":"Hensley","year":"2001","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1176\/jnp.10.4.453","article-title":"Rapid response of emotional incontinence to selective serotonin reuptake inhibitors","volume":"10","author":"Nahas","year":"1998","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/026990597123593","article-title":"Speech dysfunction due to trazodone--fluoxetine combination in traumatic brain injury","volume":"11","author":"Patterson","year":"1997","journal-title":"Brain Inj."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/026990599121250","article-title":"Panic disorder in a patient with traumatic brain injury: A case report and discussion","volume":"13","author":"Scheutzow","year":"1999","journal-title":"Brain Inj."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/026990599121890","article-title":"Selective serotonin reuptake inhibitor treatment of post-traumatic Kl\u00fcver-Bucy syndrome","volume":"13","author":"Slaughter","year":"1999","journal-title":"Brain Inj."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/02699059209034945","article-title":"Fluoxetine as a treatment for emotional lability after brain injury","volume":"6","author":"Sloan","year":"1992","journal-title":"Brain Inj."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/02699050110103319","article-title":"Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury","volume":"16","author":"Spinella","year":"2002","journal-title":"Brain Inj."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00004714-199902000-00018","article-title":"Dystonia associated with sertraline","volume":"19","author":"Stanislav","year":"1999","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1176\/appi.ajp.159.5.872","article-title":"Fluoxetine for OCD after brain injury","volume":"159","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0033-3182(92)71960-4","article-title":"Sertraline-augmented lithium therapy of organic mood syndrome","volume":"33","author":"Workman","year":"1992","journal-title":"Psychosomatics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1176\/ajp.149.2.273","article-title":"Control of depression with fluoxetine and antiseizure medication in a brain-injured patient","volume":"149","author":"Wroblewski","year":"1992","journal-title":"Am. J. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1089\/neu.2009.1091","article-title":"Treatment for depression after traumatic brain injury: A systematic review","volume":"26","author":"Fann","year":"2009","journal-title":"J. Neurotrauma"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/09602010244000354","article-title":"The neuropsychiatry of depression after brain injury","volume":"13","author":"Fleminger","year":"2003","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/09540260310001606700","article-title":"Mood disorders following traumatic brain injury","volume":"15","author":"Jorge","year":"2003","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/09540260310001606746","article-title":"Pharmacological management of the psychiatric aspects of traumatic brain injury","volume":"15","author":"Lee","year":"2003","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S0265021507003316","article-title":"Pharmacological treatment of neurobehavioural sequelae of traumatic brain injury","volume":"42","author":"Lombardi","year":"2008","journal-title":"Eur. J. Anaesthesiol. Suppl."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1176\/appi.ajp.2009.08111676","article-title":"Depression and Cognitive Complaints Following Mild Traumatic Brain Injury","volume":"166","author":"Silver","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/WCO.0b013e328010944f","article-title":"Pharmacological enhancement of cognitive and behavioral deficits after traumatic brain injury","volume":"19","author":"Tenovuo","year":"2006","journal-title":"Curr. Opin. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/JCP.0b013e318235f4ac","article-title":"Impact of pharmacological treatments on cognitive and behavioral outcome in the postacute stages of adult traumatic brain injury: A meta-analysis","volume":"31","author":"Wheaton","year":"2011","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_62","unstructured":"Hamilton, W.K., Aydin, B., and Mizumoto, A. (2015). MAVIS: Meta Analysis via Shiny, Comprehensive R Archive Network (CRAN). v1.1.1."},{"key":"ref_63","unstructured":"Cooper, H., Hedges, L.V., and Valentine, J.C. (2009). The Handbook of Research Synthesis and Meta-Analysis, Russell Sage Foundation."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Albert, P.R., and Benkelfat, C. (2013). The neurobiology of depression\u2014Revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies. Philos. Trans. R. Soc. Lond B Biol. Sci.","DOI":"10.1098\/rstb.2012.0535"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"287","DOI":"10.31887\/DCNS.2011.13.2\/tmcallister","article-title":"Neurobiological consequences of traumatic brain injury","volume":"13","author":"McAllister","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1001\/jama.2010.599","article-title":"Rates of major depressive disorder and clinical outcomes following traumatic brain injury","volume":"303","author":"Bombardier","year":"2010","journal-title":"JAMA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1001\/jama.280.19.1665","article-title":"Maintenance phase efficacy of sertraline for chronic depression: A randomized controlled trial","volume":"280","author":"Keller","year":"1998","journal-title":"JAMA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/archpsyc.59.8.723","article-title":"Psychosocial outcomes following long-term, double-blind treatment of chronic depression with sertraline vs. placebo","volume":"59","author":"Kocsis","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: Review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0733-8619(18)30185-3","article-title":"Cognitive impairment following closed head injury","volume":"10","author":"Capruso","year":"1992","journal-title":"Neurol. Clin."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11910-015-0591-8","article-title":"Update on TBI and Cognitive Impairment in Military Veterans","volume":"15","author":"Elder","year":"2015","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/jnnp.2006.095414","article-title":"A review of screening tests for cognitive impairment","volume":"78","author":"Cullen","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.apmr.2003.08.116","article-title":"Relationship between depression and psychosocial functioning after traumatic brain injury","volume":"85","author":"Hibbard","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1037\/a0015051","article-title":"Trajectories of life satisfaction in the first 5 years following traumatic brain injury","volume":"54","author":"Resch","year":"2009","journal-title":"Rehabil. Psychol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1176\/appi.psy.42.1.48","article-title":"Cognitive improvement with treatment of depression following mild traumatic brain injury","volume":"42","author":"Fann","year":"2001","journal-title":"Psychosomatics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1523\/JNEUROSCI.3632-07.2008","article-title":"Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00213-006-0660-4","article-title":"Effects of acute and chronic antidepressant treatments on memory performance: A comparison between paroxetine and imipramine","volume":"191","author":"Naudon","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopsych.2004.04.002","article-title":"Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment","volume":"56","author":"Vythilingam","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1023\/B:NERV.0000005945.58251.c0","article-title":"Postconcussion symptoms","volume":"7","author":"Gasquione","year":"1997","journal-title":"Neuropsychol. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0733-8619(18)30182-8","article-title":"The postconcussion syndrome and the sequelae of mild head injury","volume":"10","author":"Evans","year":"1992","journal-title":"Neurol. Clin."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/09540260310001606692","article-title":"Post concussion syndrome","volume":"15","author":"Ryan","year":"2003","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_84","first-page":"311","article-title":"Mild traumatic brain injury: A neuropsychiatric approach to diagnosis, evaluation, and treatment","volume":"1","author":"Arciniegas","year":"2005","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_85","first-page":"21","article-title":"Traumatic brain injury: Pharmacotherapy options for cognitive deficits","volume":"10","author":"Scher","year":"2011","journal-title":"Curr. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF00868811","article-title":"The Rivermead Post Concussion Symptoms Questionnaire: A measure of symptoms commonly experienced after head injury and its reliability","volume":"242","author":"King","year":"1995","journal-title":"J. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jamapediatrics.2013.434","article-title":"Predicting postconcussion syndrome after mild traumatic brain injury in children and adolescents who present to the emergency department","volume":"167","author":"Babcock","year":"2013","journal-title":"JAMA Pediatr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s004150050254","article-title":"Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients","volume":"245","author":"Ingebrigtsen","year":"1998","journal-title":"J. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00415-006-0275-z","article-title":"The Rivermead Post Concussion Symptoms Questionnaire: A confirmatory factor analysis","volume":"253","author":"Potter","year":"2006","journal-title":"J. Neurol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1191\/0269215505cr905oa","article-title":"Construct validity and reliability of the Rivermead Post-Concussion Symptoms Questionnaire","volume":"19","author":"Eyres","year":"2005","journal-title":"Clin. Rehabil."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1176\/ajp.153.4.466","article-title":"Serotonin-dopamine interaction and its relevance to schizophrenia","volume":"153","author":"Kapur","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/1545968304271405","article-title":"Book Review: Insomnia following Traumatic Brain Injury: A Review","volume":"18","author":"Ouellet","year":"2004","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.ncl.2012.08.008","article-title":"Traumatic brain injury and sleep disorders","volume":"30","author":"Watson","year":"2012","journal-title":"Neurol. Clin."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/00207450802328607","article-title":"Melatonin and melatonergic drugs on sleep: Possible mechanisms of action","volume":"119","author":"Srinivasan","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0149-2918(00)83028-3","article-title":"Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder: An updated meta-analysis","volume":"22","author":"Beasley","year":"2000","journal-title":"Clin. Ther."},{"key":"ref_96","first-page":"194","article-title":"Mechanism of actions of antidepressants: Beyond the receptors","volume":"12","author":"Tamam","year":"2002","journal-title":"Bull. Clin. Psychopharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0301-0082(98)00097-5","article-title":"Serotonin and the sleep\/wake cycle: Special emphasis on microdialysis studies","volume":"60","author":"Portas","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1744-6171.2004.00085.x","article-title":"Methylphenidate: Mechanism of action and clinical update","volume":"17","author":"Scahill","year":"2004","journal-title":"J. Child Adolesc. Psychiatr. Nurs."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/sleep\/31.3.375","article-title":"Sleep in adults with attention deficit hyperactivity disorder (ADHD) before and during treatment with methylphenidate: A controlled polysomnographic study","volume":"31","author":"Sobanski","year":"2008","journal-title":"Sleep"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.apmr.2003.08.117","article-title":"Psychiatric challenges in the first 6 years after traumatic brain injury: Cross-sequential analyses of Axis I disorders","volume":"85","author":"Ashman","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1176\/ajp.156.3.374","article-title":"Rate of psychiatric illness 1 year after traumatic brain injury","volume":"156","author":"Deb","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1176\/appi.ajp.2009.09050617","article-title":"The psychiatric sequelae of traumatic injury","volume":"167","author":"Bryant","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Soomro, G.M., Altman, D., Rajagopal, S., and Oakley-Browne, M. (2008). Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD). Cochrane Database Syst. Rev., CD001765.","DOI":"10.1002\/14651858.CD001765.pub3"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1007\/s007870070021","article-title":"Obsessive-compulsive disorder: Pharmacological treatment","volume":"9","author":"Thomsen","year":"2000","journal-title":"Eur. Child Adolesc. Psychiatry 9"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1176\/appi.neuropsych.12.3.316","article-title":"Can traumatic brain injury cause psychiatric disorders?","volume":"12","author":"Cohen","year":"2000","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1272\/jnms.70.313","article-title":"Therapeutic effects of milnacipran (serotonin noradrenalin reuptake inhibitor) on depression following mild and moderate traumatic brain injury","volume":"70","author":"Kanetani","year":"2003","journal-title":"J. Nippon Med. Sch."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/026988119801200212","article-title":"SSRI-induced extrapyramidal side-effects and akathisia: Implications for treatment","volume":"12","author":"Lane","year":"1998","journal-title":"J. Psychopharmacol."},{"key":"ref_108","first-page":"30","article-title":"How do SSRIs cause sexual dysfunction? Understanding key mechanisms can help improve patient adherence, prognosis","volume":"9","author":"Prabhakar","year":"2010","journal-title":"Curr. Psychiatry"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Laskowitz, D., and Grant, G. (2015). Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment. Translational Research in Traumatic Brain Injury, CRC Press\/Taylor and Francis Group.","DOI":"10.1201\/b18959"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1176\/appi.ajp.2009.08101604","article-title":"Exploring the Convergence of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury","volume":"166","author":"Stein","year":"2009","journal-title":"Am. J. Psychiatry"},{"key":"ref_111","first-page":"xi","article-title":"Overlap of mild TBI and mental health conditions in returning OIF\/OEF service members and veterans","volume":"45","author":"Lew","year":"2008","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1176\/appi.ajp.158.12.1982","article-title":"Efficacy and safety of paroxetine treatment for chronic PTSD: A fixed-dose, placebo-controlled study","volume":"158","author":"Marshall","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1001\/jama.283.14.1837","article-title":"Efficacy and safety of sertraline treatment of posttraumatic stress disorder: A randomized controlled trial","volume":"283","author":"Brady","year":"2000","journal-title":"JAMA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1192\/bjp.175.1.17","article-title":"Fluoxetine in post-traumatic stress disorder. Randomised, double-blind study","volume":"175","author":"Connor","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.biopsych.2006.06.032","article-title":"A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder","volume":"61","author":"Raskind","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00001199-200208000-00003","article-title":"Psychostimulant use in the rehabilitation of individuals with traumatic brain injury","volume":"17","author":"Whyte","year":"2002","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00001199-200208000-00004","article-title":"Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: A pilot double-blind randomized trial","volume":"17","author":"Meythaler","year":"2002","journal-title":"J. Head Trauma Rehabil."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0003-9993(96)90225-7","article-title":"Improved arousal and initiation following tricyclic antidepressant use in severe brain injury","volume":"77","author":"Reinhard","year":"1996","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1460-9568.2010.07294.x","article-title":"Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum","volume":"32","author":"Beverley","year":"2010","journal-title":"Eur. J. Neurosci."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/7\/8\/93\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:43:59Z","timestamp":1760208239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/7\/8\/93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":119,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8]]}},"alternative-id":["brainsci7080093"],"URL":"https:\/\/doi.org\/10.3390\/brainsci7080093","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]}}}