{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:16:31Z","timestamp":1790691391272,"version":"4.1.0"},"reference-count":166,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Few movement disorders seem to make a straightforward approach to diagnosis and treatment more difficult and frustrating than myoclonus, due to its plethora of causes and its variable classifications. Nevertheless, in recent years, exciting advances have been made in the elucidation of the pathophysiology and genetic basis of many disorders presenting with myoclonus. Here, we provide a review of all of the important types of myoclonus encountered in pediatric and adult neurology, with an emphasis on the recent developments that have led to a deeper understanding of this intriguing phenomenon. An up-to-date list of the genetic basis of all major myoclonic disorders is presented. Randomized studies are scarce in myoclonus therapy, but helpful pragmatic approaches at diagnosis as well as treatment have been recently suggested.<\/jats:p>","DOI":"10.3390\/brainsci7080103","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T10:23:12Z","timestamp":1502706192000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Myoclonic Disorders"],"prefix":"10.3390","volume":"7","author":[{"given":"Olaf","family":"Eberhardt","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Klinikum Bogenhausen, St\u00e4dt. Klinikum M\u00fcnchen GmbH, Englschalkinger Str. 77, 81925 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Topka","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Klinikum Bogenhausen, St\u00e4dt. Klinikum M\u00fcnchen GmbH, Englschalkinger Str. 77, 81925 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0025-6196(11)63006-1","article-title":"Myoclonus","volume":"71","author":"Caviness","year":"1996","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neucli.2006.11.004","article-title":"Neurophysiological classification of myoclonus","volume":"36","author":"Shibasaki","year":"2006","journal-title":"Neurophysiol. 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