{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:19:05Z","timestamp":1777958345325,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1U01NS082074"],"award-info":[{"award-number":["1U01NS082074"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R01NS040068"],"award-info":[{"award-number":["5R01NS040068"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R01NS054893"],"award-info":[{"award-number":["5R01NS054893"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1U01NS082086"],"award-info":[{"award-number":["1U01NS082086"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1U01NS082083"],"award-info":[{"award-number":["1U01NS082083"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1U01NS082085"],"award-info":[{"award-number":["1U01NS082085"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","award":["A3917"],"award-info":[{"award-number":["A3917"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","award":["A6266"],"award-info":[{"award-number":["A6266"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This study assessed how BDNF (brain-derived neurotrophic factor) and other genes involved in its signaling influence brain structure and clinical functioning in pre-diagnosis Huntington\u2019s disease (HD). Parallel independent component analysis (pICA), a multivariate method for identifying correlated patterns in multimodal datasets, was applied to gray matter concentration (GMC) and genomic data from a sizeable PREDICT-HD prodromal cohort (N = 715). pICA identified a genetic component highlighting NTRK2, which encodes BDNF\u2019s TrkB receptor, that correlated with a GMC component including supplementary motor, precentral\/premotor cortex, and other frontal areas (p &lt; 0.001); this association appeared to be driven by participants with high or low levels of the genetic profile. The frontal GMC profile correlated with cognitive and motor variables (Trail Making Test A (p = 0.03); Stroop Color (p = 0.017); Stroop Interference (p = 0.04); Symbol Digit Modalities Test (p = 0.031); Total Motor Score (p = 0.01)). A top-weighted NTRK2 variant (rs2277193) was protectively associated with Trail Making Test B (p = 0.007); greater minor allele numbers were linked to a better performance. These results support the idea of a protective role of NTRK2 in prodromal HD, particularly in individuals with certain genotypes, and suggest that this gene may influence the preservation of frontal gray matter that is important for clinical functioning.<\/jats:p>","DOI":"10.3390\/brainsci8070116","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T10:56:28Z","timestamp":1529664988000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High and Low Levels of an NTRK2-Driven Genetic Profile Affect Motor- and Cognition-Associated Frontal Gray Matter in Prodromal Huntington\u2019s Disease"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6312-7901","authenticated-orcid":false,"given":"Jennifer","family":"Ciarochi","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Liu","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vince","family":"Calhoun","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"},{"name":"Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-2660","authenticated-orcid":false,"given":"Hans","family":"Johnson","sequence":"additional","affiliation":[{"name":"Iowa Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Misiura","sequence":"additional","affiliation":[{"name":"Department of Psychology, Georgia State University, Atlanta, GA 30302, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bockholt","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor","family":"Espinoza","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Caprihan","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Plis","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Turner","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA"},{"name":"Department of Psychology, Georgia State University, Atlanta, GA 30302, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0983-228X","authenticated-orcid":false,"given":"Jane","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Iowa Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Neurology, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Psychology, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The PREDICT-HD Investigators and Coordinators of the Huntington Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnagi.2014.00078","article-title":"Clinical and biomarker changes in premanifest huntington disease show trial feasibility: A decade of the predict-hd study","volume":"6","author":"Paulsen","year":"2014","journal-title":"Front. 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