{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:16:53Z","timestamp":1771456613169,"version":"3.50.1"},"reference-count":158,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Junta de Extremadura co-financed by European Regional Development Funds \u201cUna manera de hacer Europa\u201d","award":["GR18085 to INPATT (CTS040) research group"],"award-info":[{"award-number":["GR18085 to INPATT (CTS040) research group"]}]},{"name":"Ministry of Economy and Competitiveness of Spain","award":["SAF2017-87538-R"],"award-info":[{"award-number":["SAF2017-87538-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Schizophrenia is a severe, chronic mental disorder characterized by delusions and hallucinations. Several evidences support the link of schizophrenia with accelerated telomeres shortening and accelerated aging. Thus, schizophrenia patients show higher mortality compared to age-matched healthy donors. The etiology of schizophrenia is multifactorial, involving genetic and environmental factors. Telomere erosion has been shown to be accelerated by different factors including environmental factors such as cigarette smoking and chronic alcohol consumption or by psychosocial stress such as childhood maltreatment. In humans, telomere studies have mainly relied on measurements of leukocyte telomere length and it is generally accepted that individuals with short leukocyte telomere length are considered biologically older than those with longer ones. A dysregulation of both innate and adaptive immune systems has been described in schizophrenia patients and other mental diseases supporting the contribution of the immune system to disease symptoms. Thus, it has been suggested that abnormal immune activation with high pro-inflammatory cytokine production in response to still undefined environmental agents such as herpesviruses infections can be involved in the pathogenesis and pathophysiology of schizophrenia. It has been proposed that chronic inflammation and oxidative stress are involved in the course of schizophrenia illness, early onset of cardiovascular disease, accelerated aging, and premature mortality in schizophrenia. Prenatal or neonatal exposures to neurotropic pathogens such as Cytomegalovirus or Toxoplasma gondii have been proposed as environmental risk factors for schizophrenia in individuals with a risk genetic background. Thus, pro-inflammatory cytokines and microglia activation, together with genetic vulnerability, are considered etiological factors for schizophrenia, and support that inflammation status is involved in the course of illness in schizophrenia.<\/jats:p>","DOI":"10.3390\/brainsci8100188","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T10:55:41Z","timestamp":1539860141000},"page":"188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?"],"prefix":"10.3390","volume":"8","author":[{"given":"Corona","family":"Solana","sequence":"first","affiliation":[{"name":"Centro Hospitalar Psiquiatrico de Lisboa, 1700-063 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Psiquiatrico de Lisboa, 1700-063 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-6377","authenticated-orcid":false,"given":"Raquel","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Immunology Unit, University of Extremadura, 10003 Caceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1056\/NEJMra1801490","article-title":"Psychotic Disorders","volume":"379","author":"Lieberman","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15067","DOI":"10.1038\/nrdp.2015.67","article-title":"Schizophrenia","volume":"1","author":"Kahn","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","first-page":"11","article-title":"Psychotic and Bipolar Disorders: Schizophrenia","volume":"455","author":"Edmunds","year":"2017","journal-title":"FP Essent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(15)01121-6","article-title":"Schizophrenia","volume":"388","author":"Owen","year":"2016","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11920-017-0807-5","article-title":"Genetics of Schizophrenia: Ready to Translate?","volume":"19","author":"Foley","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ajmg.b.32550","article-title":"Shifting the focus toward rare variants in schizophrenia to close the gap from genotype to phenotype","volume":"174","author":"Bustamante","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12264-014-1494-4","article-title":"Genetic studies of schizophrenia: An update","volume":"31","author":"Chen","year":"2015","journal-title":"Neurosci. Bull."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1017\/S0033291715000537","article-title":"What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review","volume":"45","author":"Gurung","year":"2015","journal-title":"Psychol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ng.3725","article-title":"Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects","volume":"49","author":"Marshall","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","volume":"45","author":"Ripke","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pnpbp.2017.06.018","article-title":"Imaging genetics of schizophrenia in the post-GWAS era","volume":"80","author":"Arslan","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/17460441.2017.1324419","article-title":"The impact of genetics on future drug discovery in schizophrenia","volume":"12","author":"Matsumoto","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ajmg.b.32581","article-title":"A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains","volume":"177","author":"Ranlund","year":"2018","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.4088\/JCP.15m10133","article-title":"Effects of Cumulative Herpesviridae and Toxoplasma gondii Infections on Cognitive Function in Healthy, Bipolar, and Schizophrenia Subjects","volume":"78","author":"Hamdani","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.17219\/acem\/61435","article-title":"Relationship between toxoplasmosis and schizophrenia: A review","volume":"26","author":"Fuglewicz","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E1177","DOI":"10.1503\/cmaj.161351","article-title":"Trends in standardized mortality among individuals with schizophrenia, 1993\u20132012: A population-based, repeated cross-sectional study","volume":"189","author":"Gatov","year":"2017","journal-title":"CMAJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2015.1737","article-title":"Premature Mortality among Adults with Schizophrenia in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.24869\/psyd.2017.108","article-title":"Causes of mortality in schizophrenia: An updated review of European studies","volume":"29","author":"Piotrowski","year":"2017","journal-title":"Psychiatr. Danub."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/eurpub\/ckv245","article-title":"Mortality trends in cardiovascular causes in schizophrenia, bipolar and unipolar mood disorder in Sweden 1987\u20132010","volume":"26","author":"Osby","year":"2016","journal-title":"Eur. J. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jagp.2015.09.003","article-title":"Mortality and Its Determinants in Late-Life Schizophrenia: A 5-Year Prospective Study in a Dutch Catchment Area","volume":"24","author":"Meesters","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2215-0366(17)30078-0","article-title":"Years of potential life lost and life expectancy in schizophrenia: A systematic review and meta-analysis","volume":"4","author":"Hjorthoj","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11920-017-0794-6","article-title":"Brain-Derived Neurotrophic Factor Expression in Individuals with Schizophrenia and Healthy Aging: Testing the Accelerated Aging Hypothesis of Schizophrenia","volume":"19","author":"Islam","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.schres.2017.06.034","article-title":"Accelerated aging in schizophrenia and related disorders: Future research","volume":"196","author":"Kirkpatrick","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4933-9-23","article-title":"CMV and Immunosenescence: From basics to clinics","volume":"9","author":"Solana","year":"2012","journal-title":"Immun. Ageing"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1196\/annals.1396.043","article-title":"Cytomegalovirus infection: A driving force in human T cell immunosenescence","volume":"1114","author":"Koch","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0105-2896.2005.00271.x","article-title":"Human immunosenescence: Is it infectious?","volume":"205","author":"Pawelec","year":"2005","journal-title":"Immunol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hassouneh, F., Lopez-Sejas, N., Campos, C., Sanchez-Correa, B., Tarazona, R., Pera, A., and Solana, R. (2017). Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071391"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1189\/jlb.4A0316-112R","article-title":"CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154","volume":"101","author":"Pera","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mad.2015.12.003","article-title":"Effect of age and latent CMV infection on CD8+ CD56+ T cells (NKT-like) frequency and functionality","volume":"158","author":"Hassouneh","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"ref_31","first-page":"476","article-title":"Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets","volume":"7","author":"Campos","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pera, A., Campos, C., Corona, A., Sanchez-Correa, B., Tarazona, R., Larbi, A., and Solana, R. (2014). CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088538"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coi.2014.04.002","article-title":"Shaping of NK cell subsets by aging","volume":"29","author":"Solana","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/imm.12409","article-title":"Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults","volume":"144","author":"Riddell","year":"2015","journal-title":"Immunology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000167816","article-title":"Telomeres, histone code, and DNA damage response","volume":"122","author":"Misri","year":"2008","journal-title":"Cytogenet. Genome Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.gde.2014.06.009","article-title":"Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing","volume":"26","author":"Rossiello","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mad.2017.08.004","article-title":"Is DNA damage indispensable for stress-induced senescence?","volume":"170","author":"Mosieniak","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ceb.2006.03.003","article-title":"Telomerase regulation and stem cell behaviour","volume":"18","author":"Flores","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1101\/gad.451008","article-title":"The longest telomeres: A general signature of adult stem cell compartments","volume":"22","author":"Flores","year":"2008","journal-title":"Genes Dev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/j.febslet.2010.07.042","article-title":"The role of telomeres and telomerase in stem cell aging","volume":"584","author":"Flores","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bar, C., and Blasco, M.A. (2016). Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. F1000 Res., 5.","DOI":"10.12688\/f1000research.7020.1"},{"key":"ref_43","first-page":"160","article-title":"Mouse models for the study of telomerase","volume":"211","author":"Blasco","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/S0959-8049(02)00450-1","article-title":"Mouse models to study the role of telomeres in cancer, aging and DNA repair","volume":"38","author":"Blasco","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrc862","article-title":"Telomerase beyond telomeres","volume":"2","author":"Blasco","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"14398","DOI":"10.1073\/pnas.0504161102","article-title":"Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells","volume":"102","author":"Wang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections","volume":"8","author":"Appay","year":"2002","journal-title":"Nat. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nri1440","article-title":"Will telomere erosion lead to a loss of T-cell memory?","volume":"4","author":"Akbar","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arr.2015.11.006","article-title":"Ageing and the telomere connection: An intimate relationship with inflammation","volume":"25","author":"Zhang","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.201610111","article-title":"Telomere-driven diseases and telomere-targeting therapies","volume":"216","author":"Martinez","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.mayocp.2018.03.020","article-title":"Short Telomere Syndromes in Clinical Practice: Bridging Bench and Bedside","volume":"93","author":"Mangaonkar","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20160436","DOI":"10.1098\/rstb.2016.0436","article-title":"Reflections on telomere dynamics and ageing-related diseases in humans","volume":"373","author":"Aviv","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fimmu.2017.00649","article-title":"Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations","volume":"8","author":"Hassouneh","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10522-015-9563-2","article-title":"Impact of age, sex and CMV-infection on peripheral T cell phenotypes: Results from the Berlin BASE-II Study","volume":"16","author":"Derhovanessian","year":"2015","journal-title":"Biogerontology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.maturitas.2015.05.004","article-title":"Immunosenescence: Implications for response to infection and vaccination in older people","volume":"82","author":"Pera","year":"2015","journal-title":"Maturitas"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-4933-9-15","article-title":"Hallmarks of human \u201cimmunosenescence\u201d: Adaptation or dysregulation?","volume":"9","author":"Pawelec","year":"2012","journal-title":"Immun. Ageing"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0047-6374(00)00199-8","article-title":"Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector\/senescent T cells","volume":"121","author":"Tarazona","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"ref_58","first-page":"537","article-title":"Aging, immunity, and cancer","volume":"11","author":"Hakim","year":"2011","journal-title":"Discov. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.jcpa.2009.09.005","article-title":"Senescence of the human immune system","volume":"142","author":"Pawelec","year":"2010","journal-title":"J. Comp. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.4049\/jimmunol.0903442","article-title":"Cytomegalovirus infection reduces telomere length of the circulating T cell pool","volume":"184","author":"Griffiths","year":"2010","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.exger.2013.01.016","article-title":"Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort","volume":"48","author":"Dowd","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1017\/S0950268817001881","article-title":"The impact of pathogen burden on leukocyte telomere length in the Multi-Ethnic Study of Atherosclerosis","volume":"145","author":"Aiello","year":"2017","journal-title":"Epidemiol. Infect."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/infdis\/jix255","article-title":"Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort","volume":"216","author":"Dowd","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3389\/fimmu.2017.01027","article-title":"Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans","volume":"8","author":"Lustig","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_65","first-page":"1680","article-title":"T cell replicative senescence in human aging","volume":"19","author":"Chou","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.mad.2012.05.005","article-title":"Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study","volume":"133","author":"Collerton","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exger.2010.08.027","article-title":"Telomere\/telomerase dynamics within the human immune system: Effect of chronic infection and stress","volume":"46","author":"Effros","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.4049\/jimmunol.175.12.8218","article-title":"Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion","volume":"175","author":"Fletcher","year":"2005","journal-title":"J. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2013.11.010","article-title":"Immunosenenescence: Role of cytomegalovirus","volume":"54","author":"Pawelec","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fimmu.2013.00271","article-title":"Human T cell aging and the impact of persistent viral infections","volume":"4","author":"Fulop","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.vaccine.2012.01.015","article-title":"The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines","volume":"30","author":"McElhaney","year":"2012","journal-title":"Vaccine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virusres.2010.09.010","article-title":"Role of CMV in immune senescence","volume":"157","author":"Pawelec","year":"2011","journal-title":"Virus Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Thomasini, R.L., Pereira, D.S., Pereira, F.S.M., Mateo, E.C., Mota, T.N., Guimar\u00e3es, G.G., Pereira, L.S.M., Lima, C.X., Teixeira, M.M., and Teixeira, A.L. (2017). Junior. Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180841"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Cao-Dinh, H., Bautmans, I., Beyer, I., Mets, T., Onyema, O.O., Forti, L.N., Renmans, W., Vander Meeren, S., Jochmans, K., and Vermeiren, S. (2018). Association between Immunosenescence Phenotypes and pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role?. J. Gerontol. A Biol. Sci. Med. Sci.","DOI":"10.1093\/gerona\/gly135"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3389\/fimmu.2017.01263","article-title":"T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection","volume":"8","author":"Elwenspoek","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1474-9726.2007.00340.x","article-title":"Telomere length predicts survival independent of genetic influences","volume":"6","author":"SBakaysa","year":"2007","journal-title":"Aging Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.jacc.2016.03.530","article-title":"Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study","volume":"67","author":"Fuster","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/EDE.0000000000000299","article-title":"Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999\u20132002","volume":"26","author":"Needham","year":"2015","journal-title":"Epidemiology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.psyneuen.2018.06.020","article-title":"In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study","volume":"96","author":"Lin","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/CS20100385","article-title":"Healthy aging and disease: Role for telomere biology?","volume":"120","author":"Zhu","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00294-017-0746-z","article-title":"Do long telomeres affect cellular fitness?","volume":"64","author":"Harari","year":"2018","journal-title":"Curr. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.arr.2016.05.009","article-title":"Telomere-associated aging disorders","volume":"33","author":"Opresko","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.aab3389","article-title":"Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection","volume":"350","author":"Blackburn","year":"2015","journal-title":"Science"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.envres.2017.06.038","article-title":"Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis","volume":"158","author":"Astuti","year":"2017","journal-title":"Environ. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4162\/nrp.2017.11.4.334","article-title":"Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults","volume":"11","author":"Wang","year":"2017","journal-title":"Nutr. Res. Pract."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.psyneuen.2017.05.024","article-title":"Telomere length in alcohol dependence: A role for impulsive choice and childhood maltreatment","volume":"83","author":"Kang","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jacc.2018.06.014","article-title":"Telomere Length as Cardiovascular Aging Biomarker: JACC Review Topic of the Week","volume":"72","author":"Nawrot","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1515\/cclm-2017-0870","article-title":"Telomere biology and age-related diseases","volume":"56","author":"Herrmann","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glw240","article-title":"Chronic Inflammation: Accelerator of Biological Aging","volume":"72","author":"Fougere","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Yeh, J.K., and Wang, C.Y. (2016). Telomeres and Telomerase in Cardiovascular Diseases. Genes, 7.","DOI":"10.3390\/genes7090058"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/aje\/kww210","article-title":"Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results from Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies","volume":"185","author":"Mons","year":"2017","journal-title":"Am. J. Epidemiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jad.2015.10.037","article-title":"Association of dimensional psychological health measures with telomere length in male war veterans","volume":"190","author":"Bersani","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/PSY.0000000000000356","article-title":"The Association between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons","volume":"78","author":"Darrow","year":"2016","journal-title":"Psychosom. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neubiorev.2015.05.007","article-title":"Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging","volume":"55","author":"Lindqvist","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0140-6736(07)60071-3","article-title":"Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study","volume":"369","author":"Brouilette","year":"2007","journal-title":"Lancet"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/ATVBAHA.108.167049","article-title":"Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: Data from the Heart and Soul Study","volume":"28","author":"Cawthon","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"g4373","DOI":"10.1136\/bmj.g4373","article-title":"Telomere length predicts cardiovascular disease","volume":"349","author":"Spyridopoulos","year":"2014","journal-title":"BMJ"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"414","DOI":"10.18632\/aging.100671","article-title":"Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: The Strong Heart Family Study","volume":"6","author":"Chen","year":"2014","journal-title":"Aging"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Goglin, S.E., Farzaneh-Far, R., Epel, E.S., Lin, J., Blackburn, E.H., and Whooley, M.A. (2016). Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168868"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCRESAHA.116.304393","article-title":"Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients","volume":"116","author":"Hoffmann","year":"2015","journal-title":"Circ. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"380","DOI":"10.18632\/aging.100664","article-title":"Short leukocyte telomere length is associated with obesity in American Indians: The Strong Heart Family study","volume":"6","author":"Chen","year":"2014","journal-title":"Aging"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"176","DOI":"10.18632\/aging.100644","article-title":"Metabolic profiles of biological aging in American Indians: The Strong Heart Family Study","volume":"6","author":"Zhao","year":"2014","journal-title":"Aging"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/j.1464-5491.2011.03370.x","article-title":"Leukocyte telomere length is associated with complications of type 2 diabetes mellitus","volume":"28","author":"Testa","year":"2011","journal-title":"Diabet. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ekir.2017.12.005","article-title":"Short Leukocyte Telomere Length Predicts Albuminuria Progression in Individuals with Type 2 Diabetes","volume":"3","author":"Gurung","year":"2018","journal-title":"Kidney Int. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.diabres.2017.10.020","article-title":"Leukocyte telomere length correlates with glucose control in adults with recently diagnosed type 2 diabetes","volume":"135","author":"Rosa","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.diabres.2016.10.015","article-title":"Role of telomeres and associated maintenance genes in Type 2 Diabetes Mellitus: A review","volume":"122","author":"Sethi","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"50835","DOI":"10.18632\/oncotarget.10615","article-title":"Leukocyte telomere length and mortality risk in patients with type 2 diabetes","volume":"7","author":"Bonfigli","year":"2016","journal-title":"Oncotarget"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00592-016-0857-x","article-title":"Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: A cross-sectional study","volume":"53","author":"Spigoni","year":"2016","journal-title":"Acta Diabetol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/ggi.12738","article-title":"Telomere attrition and diabetes mellitus","volume":"16","author":"Tamura","year":"2016","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Gurung, R.L., Yiamunaa, M., Liu, S., Liu, J.J., Chan, S.M., Moh, M.C., Ang, K., Tang, W.E., Sum, C.F., and Subramaniam, T. (2018). Ethnic disparities in relationship of obesity indices and telomere length in Asians with type 2 diabetes. J. Diabetes.","DOI":"10.1111\/1753-0407.12864"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/mp.2013.151","article-title":"Major depressive disorder and accelerated cellular aging: Results from a large psychiatric cohort study","volume":"19","author":"Verhoeven","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1192\/bjp.bp.114.151027","article-title":"Anxiety disorders and accelerated cellular ageing","volume":"206","author":"Verhoeven","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpsychires.2016.10.015","article-title":"Leukocyte telomere length: Effects of schizophrenia, age, and gender","volume":"85","author":"Wolkowitz","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wolkowitz, O.M., Mellon, S.H., Epel, E.S., Lin, J., Dhabhar, F.S., Su, Y., Reus, V.I., Rosser, R., Burke, H.M., and Kupferman, E. (2011). Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress\u2014Preliminary findings. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017837"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2015.11.052","article-title":"Depression and telomere length: A meta-analysis","volume":"191","author":"Ridout","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1192\/bjp.bp.115.178798","article-title":"Telomere length and depression: Prospective cohort study and Mendelian randomisation study in 67 306 individuals","volume":"210","author":"Orsted","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.psyneuen.2018.02.015","article-title":"Prospective association between major depressive disorder and leukocyte telomere length over two years","volume":"90","author":"Vance","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/mp.2014.89","article-title":"Depression, anxiety and telomere length in young adults: Evidence from the National Health and Nutrition Examination Survey","volume":"20","author":"Needham","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_119","first-page":"88","article-title":"Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report","volume":"2","author":"Hough","year":"2016","journal-title":"Mol. Neuropsychiatry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1017\/S0033291716000891","article-title":"Depressive and anxiety disorders and short leukocyte telomere length: Mediating effects of metabolic stress and lifestyle factors","volume":"46","author":"Revesz","year":"2016","journal-title":"Psychol. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e502","DOI":"10.1038\/tp.2014.142","article-title":"Influence of maternal infections on neonatal acute phase proteins and their interaction in the development of non-affective psychosis","volume":"5","author":"Blomstrom","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.schres.2013.10.004","article-title":"Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel","volume":"151","author":"Li","year":"2013","journal-title":"Schizophr. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/HAB-170325","article-title":"Determining the IgM and IgG antibodies titer against HSV1, HSV2 and CMV in the serum of schizophrenia patients","volume":"26","author":"Mohagheghi","year":"2018","journal-title":"Hum. Antibodies"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"15041","DOI":"10.1038\/npjschz.2015.41","article-title":"The association between antibodies to neurotropic pathogens and schizophrenia: A case-control study","volume":"1","author":"Litjens","year":"2015","journal-title":"NPJ Schizophr."},{"key":"ref_125","first-page":"132","article-title":"Seropositivity of neurotropic infectious agents in first-episode schizophrenia patients and the relationship with positive and negative symptoms","volume":"28","author":"Bolu","year":"2016","journal-title":"Psychiatr. Danub."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pnpbp.2013.09.003","article-title":"Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder","volume":"48","author":"Houenou","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpsychires.2016.11.011","article-title":"Suicide attempts and markers of immune response in individuals with serious mental illness","volume":"87","author":"Dickerson","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/NMD.0000000000000772","article-title":"Clinical and Serological Predictors of Suicide in Schizophrenia and Major Mood Disorders","volume":"206","author":"Dickerson","year":"2018","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"256","DOI":"10.14336\/AD.2014.0500256","article-title":"Accelerated aging in schizophrenia patients: The potential role of oxidative stress","volume":"5","author":"Okusaga","year":"2014","journal-title":"Aging Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.biopsych.2013.06.010","article-title":"Immune system disturbances in schizophrenia","volume":"75","author":"Horvath","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref_131","first-page":"19","article-title":"Cytokines dysregulation in schizophrenia: A systematic review of psychoneuroimmune relationship","volume":"197","author":"Spuch","year":"2017","journal-title":"Schizophr. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","article-title":"The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia","volume":"48","author":"Na","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fpsyt.2017.00203","article-title":"Inflammation, Stress Response, and Redox Dysregulation Biomarkers: Clinical Outcomes and Pharmacological Implications for Psychosis","volume":"8","author":"Schiavone","year":"2017","journal-title":"Front Psychiatry"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ijnp\/pyx015","article-title":"Oxidative Stress and Inflammation in Early Onset First Episode Psychosis: A Systematic Review and Meta-Analysis","volume":"20","author":"Fraguas","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.schres.2015.04.025","article-title":"Leukocyte telomere length in patients with schizophrenia: A meta-analysis","volume":"165","author":"Polho","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2016.04.010","article-title":"Accelerated leukocyte telomere erosion in schizophrenia: Evidence from the present study and a meta-analysis","volume":"79","author":"Rao","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ajmg.b.32403","article-title":"Variants in TERT influencing telomere length are associated with paranoid schizophrenia risk","volume":"171","author":"Rao","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.schres.2017.03.007","article-title":"Shorter telomere length in people with schizophrenia: A preliminary study from Australia","volume":"190","author":"Galletly","year":"2017","journal-title":"Schizophr. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.schres.2015.03.011","article-title":"Telomere length variability is related to symptoms and cognition in schizophrenia","volume":"164","author":"Ruby","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.psychres.2011.01.010","article-title":"Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?","volume":"188","author":"Mansour","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.schres.2013.06.043","article-title":"Longer telomere length in pattiens with schizophrenia","volume":"149","author":"Nieratschker","year":"2013","journal-title":"Schizophr. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jpsychires.2017.10.016","article-title":"Leukocyte telomere length variation in different stages of schizophrenia","volume":"96","author":"Maurya","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.euroneuro.2017.02.008","article-title":"Shorter leukocyte telomere length in patients at ultra high risk for psychosis","volume":"27","author":"Maurya","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajmg.b.32351","article-title":"Parental age effects on odor sensitivity in healthy subjects and schizophrenia patients","volume":"171","author":"Malaspina","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1093\/hmg\/ddw070","article-title":"Shorter telomere length in Europeans than in Africans due to polygenetic adaptation","volume":"25","author":"Hansen","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/schbul\/sbx015","article-title":"Telomere Length and CCL11 Levels are Associated with Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging","volume":"44","author":"Czepielewski","year":"2018","journal-title":"Schizophr. Bull."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jamaneurol.2014.1926","article-title":"Effect of leukocyte telomere length on total and regional brain volumes in a large population-based cohort","volume":"71","author":"King","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Russo, P., Prinzi, G., Proietti, S., Lamonaca, P., Frustaci, A., Boccia, S., Amore, R., Lorenzi, M., Onder, G., and Marzetti, E. (2018). Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of most recent literature. Schizophr. Res., in press.","DOI":"10.1016\/j.schres.2018.07.015"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.schres.2008.08.028","article-title":"Telomerase levels in schizophrenia: A preliminary study","volume":"106","author":"Porton","year":"2008","journal-title":"Schizophr. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/humu.22397","article-title":"Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene","volume":"34","author":"Alder","year":"2013","journal-title":"Hum. Mutat."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gde.2015.06.004","article-title":"The short and long telomere syndromes: Paired paradigms for molecular medicine","volume":"33","author":"Stanley","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.3109\/07853890.2012.660497","article-title":"Telomere length and cardiovascular aging","volume":"44","author":"Fyhrquist","year":"2012","journal-title":"Ann. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.schres.2018.02.059","article-title":"Telomere length and early trauma in schizophrenia","volume":"199","author":"Riley","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.schres.2018.02.039","article-title":"Shorter telomere length in people with schizophrenia who live alone?","volume":"199","author":"Balzan","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1176\/appi.ajp.2016.16050610","article-title":"Accelerated Gray and White Matter Deterioration with Age in Schizophrenia","volume":"174","author":"Cropley","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jpsychires.2017.09.006","article-title":"Telomere quantification in frontal and temporal brain tissue of patients with schizophrenia","volume":"95","author":"Wichers","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1176\/appi.ajp.2015.15070922","article-title":"Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study","volume":"173","author":"Schnack","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-12-387718-5.00007-9","article-title":"Immune and neuroimmune alterations in mood disorders and schizophrenia","volume":"101","author":"Drexhage","year":"2011","journal-title":"Int. Rev. 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