{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:07:09Z","timestamp":1760242029786,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Huntington\u2019s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to mimic HD symptomatology. Apparently, GABA receptors activity may protect striatal medium spiny neurons (MSNs) from excitotoxic damage. This study evaluates whether mitochondrial inhibition with 3-NP that mimics the early stages of HD, modifies the kinetics and pharmacology of GABA receptors in patch clamp recorded dissociated MSNs cells. The results show that MSNs from mice treated with 3-NP exhibited differences in GABA-induced dose-response currents and pharmacological responses that suggests the presence of GABAC receptors in MSNs. Furthermore, there was a reduction in the effect of the GABAC antagonist that demonstrates a lessening of this GABA receptor subtype activity as a result of mitochondria inhibition.<\/jats:p>","DOI":"10.3390\/brainsci8120217","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T03:46:14Z","timestamp":1544154374000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Striatal Neurodegeneration that Mimics Huntington\u2019s Disease Modifies GABA-induced Currents"],"prefix":"10.3390","volume":"8","author":[{"given":"Jorge","family":"Flores-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla C.P.72570, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette A.","family":"Garz\u00f3n-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla C.P.72570, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Hern\u00e1ndez-Carballo","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla C.P.72570, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Nieto-Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, UBIMED, FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, FES-Iztacala, Av. de Los Barrios #1, Los Reyes Iztacala, Tlalnepantla C.P.54090, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn A.","family":"Ru\u00edz-Luna","sequence":"additional","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla C.P.72570, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-9248","authenticated-orcid":false,"given":"Elizabeth","family":"Hern\u00e1ndez-Echeagaray","sequence":"additional","affiliation":[{"name":"Laboratorio de neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, UBIMED, FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, FES-Iztacala, Av. de Los Barrios #1, Los Reyes Iztacala, Tlalnepantla C.P.54090, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington\u2019s disease: Selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann. 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