{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:11:20Z","timestamp":1780099880742,"version":"3.54.0"},"reference-count":138,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This is an overview of the sensorimotor impairments in dystonia, a syndrome characterized by sustained or intermittent aberrant movement patterns leading to abnormal movements and\/or postures with or without a tremulous component. Dystonia can affect the entire body or specific body regions and results from a plethora of etiologies, including subtle changes in gray and white matter in several brain regions. Research over the last 25 years addressing topics of sensorimotor control has shown functional sensorimotor impairments related to sensorimotor integration, timing, oculomotor and head control, as well as upper and lower limb control. In the context of efforts to update the classification of dystonia, sensorimotor research is highly relevant for a better understanding of the underlying pathology, and potential mechanisms contributing to global and regional dysfunction within the central nervous system. This overview of relevant research regarding sensorimotor control in humans with idiopathic dystonia attempts to frame the dysfunction with respect to what is known regarding motor control in patients and healthy individuals. We also highlight promising avenues for the future study of neuromotor control that may help to further elucidate dystonia etiology, pathology, and functional characteristics.<\/jats:p>","DOI":"10.3390\/brainsci9040079","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T03:46:37Z","timestamp":1555040797000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Sensorimotor Control in Dystonia"],"prefix":"10.3390","volume":"9","author":[{"given":"Phillip","family":"Desrochers","sequence":"first","affiliation":[{"name":"Dept. of Kinesiology, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Brunfeldt","sequence":"additional","affiliation":[{"name":"Dept. of Kinesiology, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Sidiropoulos","sequence":"additional","affiliation":[{"name":"Dept. of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-9179","authenticated-orcid":false,"given":"Florian","family":"Kagerer","sequence":"additional","affiliation":[{"name":"Dept. of Kinesiology, Michigan State University, East Lansing, MI 48824, USA"},{"name":"Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: A consensus update","volume":"28","author":"Albanese","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/mds.22490","article-title":"Sensory functions in dystonia: Insights from behavioral studies","volume":"24","author":"Tinazzi","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/mds.10398","article-title":"Role of the somatosensory system in primary dystonia","volume":"18","author":"Tinazzi","year":"2003","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41582-019-0137-9","article-title":"The role of sensory information in the pathophysiology of focal dystonias","volume":"15","author":"Conte","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1212\/WNL.47.2.508","article-title":"A primate genesis model of focal dystonia and repetitive strain injury: I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys","volume":"47","author":"Byl","year":"1996","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/ana.410440520","article-title":"Abnormal somatosensory homunculus in dystonia of the hand","volume":"44","author":"Catalan","year":"1998","journal-title":"Ann. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1097\/00001756-199811160-00006","article-title":"Alteration of digital representations in somatosensory cortex in focal hand dystonia","volume":"9","author":"Elbert","year":"1998","journal-title":"Neuroreport"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/brain\/121.5.977","article-title":"The corticomotor representation of upper limb muscles in writer\u2019s cramp and changes following botulinum toxin injection","volume":"121","author":"Byrnes","year":"1998","journal-title":"Brain A J. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1212\/01.WNL.0000046528.24693.5B","article-title":"Temporal discrimination of cross-modal and unimodal stimuli in generalized dystonia","volume":"60","author":"Aglioti","year":"2003","journal-title":"Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1212\/WNL.55.12.1869","article-title":"Spatial discrimination is abnormal in focal hand dystonia","volume":"55","author":"Shelton","year":"2000","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.10525","article-title":"Temporal processing of visuotactile and tactile stimuli in writer\u2019s cramp","volume":"53","author":"Fiorio","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/brain\/awg219","article-title":"Abnormalities of spatial discrimination in focal and generalized dystonia","volume":"126","author":"Molloy","year":"2003","journal-title":"Brain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/1531-8257(200101)16:1<94::AID-MDS1020>3.0.CO;2-O","article-title":"Abnormalities of spatial and temporal sensory discrimination in writer\u2019s cramp","volume":"16","author":"Sanger","year":"2001","journal-title":"Mov. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00415-004-0282-x","article-title":"Timing of tactile and visuo-tactile events is impaired in patients with cervical dystonia","volume":"251","author":"Tinazzi","year":"2004","journal-title":"J. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/brain\/123.1.42","article-title":"Abnormal central integration of a dual somatosensory input in dystonia Evidence for sensory overflow","volume":"123","author":"Tinazzi","year":"2000","journal-title":"Brain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mds.26804","article-title":"Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia","volume":"32","author":"Antelmi","year":"2016","journal-title":"Mov. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2018.00584","article-title":"Actual and Illusory Perception in Parkinson\u2019s Disease and Dystonia: A Narrative Review","volume":"9","author":"Avanzino","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0304-3940(92)90447-F","article-title":"Role of ia muscle spindle afferents in post-contraction and post-vibration motor effect genesis","volume":"135","author":"Gilhodes","year":"1992","journal-title":"Neurosci. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/brain\/120.12.2179","article-title":"Idiopathic focal dystonia: A disorder of muscle spindle afferent processing?","volume":"120","author":"Yoneda","year":"1997","journal-title":"Brain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1212\/WNL.53.8.1794","article-title":"Abnormal perception of vibration-induced illusion of movement in dystonia","volume":"53","author":"Rome","year":"1999","journal-title":"Neurology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1468-1331.2000.t01-1-00102.x","article-title":"Abnormal perception of the tonic vibration reflex in idiopathic focal dystonia","volume":"7","author":"Yoneda","year":"2000","journal-title":"Eur. J. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/brain\/120.4.583","article-title":"Postural responses to vibration of neck muscles in patients with idiopathic torticollis","volume":"120","author":"Lekhel","year":"1997","journal-title":"Brain"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Brugger, F., Peters, A., Georgiev, D., K\u00e4gi, G., Balint, B., Bhatia, K.P., and Day, B.L. (2018). Sensory trick efficacy in cervical dystonia is linked to processing of neck proprioception. Parkinsonism Relat. Disord.","DOI":"10.1016\/j.parkreldis.2018.11.029"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/jnnp.74.8.1154","article-title":"The effect of fatigue on abnormal vibration induced illusion of movement in idiopathic focal dystonia","volume":"74","author":"Frima","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mds.21838","article-title":"Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker?","volume":"23","author":"Frima","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/mds.20799","article-title":"Kinesthesia is impaired in focal dystonia","volume":"21","author":"Putzki","year":"2006","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/brain\/124.3.537","article-title":"Abnormalities of sensorimotor integration in focal dystonia","volume":"124","author":"Abbruzzese","year":"2001","journal-title":"Brain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00878528","article-title":"Impairment of visuospatial function in idiopathic spasmodic torticollis","volume":"243","author":"Hinse","year":"1995","journal-title":"J. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/brain\/121.1.91","article-title":"What is straight ahead to a patient with torticollis?","volume":"121","author":"Anastasopoulos","year":"1998","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1152\/jn.00198.2002","article-title":"Neck Muscle Vibration and Spatial Orientation During Stepping in Place in Humans","volume":"88","author":"Bove","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.clinph.2007.01.013","article-title":"Postural control and sensory integration in cervical dystonia","volume":"118","author":"Vacherot","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"ref_32","first-page":"58","article-title":"Disturbed egocentric space representation in cervical dystonia","volume":"20","author":"Dengler","year":"2004","journal-title":"Mov. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1212\/01.WNL.0000161869.83783.05","article-title":"Egocentric and allocentric spatial memory in idiopathic cervical dystonia","volume":"64","author":"Ploner","year":"2005","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/brain\/awh630","article-title":"Selective impairment of hand mental rotation in patients with focal hand dystonia","volume":"129","author":"Fiorio","year":"2006","journal-title":"Brain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1016\/j.neuropsychologia.2007.02.005","article-title":"Mental rotation of body parts and non-corporeal objects in patients with idiopathic cervical dystonia","volume":"45","author":"Fiorio","year":"2007","journal-title":"Neuropsychologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00702-015-1488-z","article-title":"The clinical phenomenology and associations of trick maneuvers in cervical dystonia","volume":"123","author":"Filip","year":"2015","journal-title":"J. Neural Transm."},{"key":"ref_37","first-page":"47","article-title":"Sensory tricks in cervical dystonia: Perceptual dysbalance of parietal cortex modulates frontal motor programming","volume":"322","author":"Naumann","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/mds.25305","article-title":"Sensory tricks in primary cervical dystonia depend on visuotactile temporal discrimination","volume":"28","author":"Katschnig","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/mds.25888","article-title":"Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study","volume":"29","author":"Amadio","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.expneurol.2007.01.010","article-title":"Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia","volume":"204","author":"Tang","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/908741","article-title":"The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients","volume":"2013","author":"Filip","year":"2013","journal-title":"Neural Plast."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., and Koibuchi, N. (2013). Cerebellum and Timing. Handbook of the Cerebellum and Cerebellar Disorders, Springer Netherlands.","DOI":"10.1007\/978-94-007-1333-8"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00221-007-0857-8","article-title":"Impaired predictive motor timing in patients with cerebellar disorders","volume":"180","author":"Bares","year":"2007","journal-title":"Exp. Brain Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/mds.26930","article-title":"Disruption in cerebellar and basal ganglia networks during a visuospatial task in cervical dystonia","volume":"32","author":"Filip","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/brain\/aws328","article-title":"Temporal expectation in focal hand dystonia","volume":"136","author":"Avanzino","year":"2013","journal-title":"Brain"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"van der Steen, M.C., van Vugt, F.T., Keller, P.E., and Altenm\u00fcller, E. (2014). Basic Timing Abilities Stay Intact in Patients with Musician\u2019s Dystonia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092906"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0894-4105.12.1.3","article-title":"Temporal processing in the basal ganglia","volume":"12","author":"Harrington","year":"1998","journal-title":"Neuropsychology"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Meck, W. (2003). Cerebellar and Basal Ganglia Contributions to Interval Timing. Functional and Neural Mechanisms of Interval Timing, CRC Press.","DOI":"10.1201\/9780203009574"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuroscience.2013.11.062","article-title":"Dystonia as a network disorder: What is the role of the cerebellum?","volume":"260","author":"Prudente","year":"2014","journal-title":"Neuroscience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00415-013-6937-8","article-title":"Trunk bradykinesia and foveation delays during whole-body turns in spasmodic torticollis","volume":"260","author":"Anastasopoulos","year":"2013","journal-title":"J. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/jnnp.2010.232793","article-title":"Impaired saccadic adaptation in DYT11 dystonia","volume":"82","author":"Hubsch","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.nbd.2019.01.011","article-title":"The role of pallidum in the neural integrator model of cervical dystonia","volume":"125","author":"Sedov","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1093\/brain\/aww141","article-title":"Cervical dystonia: A neural integrator disorder","volume":"139","author":"Shaikh","year":"2016","journal-title":"Brain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/jnnp.2008.144626","article-title":"Neurophysiological evidence for cerebellar dysfunction in primary focal dystonia","volume":"80","author":"Teo","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1111\/ejn.12186","article-title":"van de Cerebellum-dependent associative learning deficits in primary dystonia are normalized by rTMS and practice","volume":"38","author":"Hoffland","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00041327-200303000-00003","article-title":"A Functional Magnetic Resonance Imaging Study in Patients with Benign Essential Blepharospasm","volume":"23","author":"Baker","year":"2003","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_57","first-page":"1","article-title":"Cervical sensorimotor control in idiopathic cervical dystonia: A cross-sectional study","volume":"7","author":"Mercelis","year":"2017","journal-title":"Brain Behav."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s00415-003-1034-z","article-title":"Idiopathic spasmodic torticollis is not associated with abnormal kinesthetic perception from neck proprioceptive and vestibular afferences","volume":"250","author":"Anastasopoulos","year":"2003","journal-title":"J. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/brain\/124.1.47","article-title":"Abnormal interaction between vestibular and voluntary head control in patients with spasmodic torticollis","volume":"124","author":"Corna","year":"2001","journal-title":"Brain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.clinph.2007.10.007","article-title":"Fast voluntary neck movements in patients with cervical dystonia: A kinematic study before and after therapy with botulinum toxin type A","volume":"119","author":"Gregori","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.parkreldis.2015.03.005","article-title":"Why are voluntary head movements in cervical dystonia slow?","volume":"21","author":"Shaikh","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1007\/BF01960120","article-title":"Postural effects of neck muscle vibration in man","volume":"36","author":"Lund","year":"1980","journal-title":"Experientia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1136\/jnnp.69.5.658","article-title":"Effect of prolonged neck muscle vibration on lateral head tilt in severe spasmodic torticollis","volume":"69","author":"Karnath","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.parkreldis.2014.08.008","article-title":"Interactions between voluntary head control and neck proprioceptive reflexes in cervical dystonia","volume":"20","author":"Anastasopoulos","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1067300","article-title":"Midbrain Control of Three-Dimensional Head Orientation","volume":"295","author":"Klier","year":"2002","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.7569931","article-title":"An internal model for sensorimotor integration","volume":"269","author":"Wolpert","year":"1995","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/jnnp.58.3.312","article-title":"Kinematic properties of upper limb trajectories in idiopathic torsion dystonia","volume":"58","author":"Inzelberg","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/brain\/119.2.661","article-title":"Single\u2013joint rapid arm movements in normal subjects and in patients with motor disorders","volume":"119","author":"Berardelli","year":"1996","journal-title":"Brain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jocn.2013.08.019","article-title":"Motor sequence learning and motor adaptation in primary cervical dystonia","volume":"21","author":"Schwingenschuh","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1136\/jnnp.52.9.1043","article-title":"Rapid elbow movements in patients with torsion dystonia","volume":"52","author":"Berardelli","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.14802\/jmd.17046","article-title":"Quantitative Assessment of Hand Dysfunction in Patients with Early Parkinson\u2019s Disease and Focal Hand Dystonia","volume":"11","author":"Kandaswamy","year":"2018","journal-title":"J. Mov. Disord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/mds.22693","article-title":"Cervical dystonia affects aimed movements of nondystonic segments","volume":"24","author":"Pelosin","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.clinph.2004.06.006","article-title":"Neuronal activity in the basal ganglia and thalamus in patients with dystonia","volume":"115","author":"Zhuang","year":"2004","journal-title":"Clin. Neurophysiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nbd.2010.08.025","article-title":"Neurophysiology of dystonia: The role of inhibition","volume":"42","author":"Hallett","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1523\/JNEUROSCI.3860-11.2012","article-title":"Scaling of Movement Is Related to Pallidal \u03b3 Oscillations in Patients with Dystonia","volume":"32","author":"Huebl","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/brain\/awv109","article-title":"Cortico-pallidal oscillatory connectivity in patients with dystonia","volume":"138","author":"Neumann","year":"2015","journal-title":"Brain"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1474-4422(14)70143-7","article-title":"Pallidal neurostimulation in patients with medication-refractory cervical dystonia: A randomised, sham-controlled trial","volume":"13","author":"Volkmann","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ana.20108","article-title":"Basal ganglia activity remains elevated after movement in focal hand dystonia","volume":"55","author":"Blood","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/ana.410380606","article-title":"Movement-related cortical potentials in writer\u2019s cramp","volume":"38","author":"Deuschl","year":"1995","journal-title":"Ann. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mds.870100516","article-title":"The movement-related cortical potential is abnormal in patients with idiopathic torsion dystonia","volume":"10","author":"Kamp","year":"1995","journal-title":"Mov. Disord."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00221-004-1891-4","article-title":"Impaired inhibition of a pre-planned response in focal hand dystonia","volume":"158","author":"Stinear","year":"2004","journal-title":"Exp. Brain Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.clinph.2013.01.003","article-title":"Dystonia and the cerebellum: A new field of interest in movement disorders?","volume":"124","author":"Filip","year":"2013","journal-title":"Clin. Neurophysiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/brain\/awt147","article-title":"Defective cerebellar control of cortical plasticity in writer\u2019s cramp","volume":"136","author":"Hubsch","year":"2013","journal-title":"Brain"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1038\/s41598-018-21545-0","article-title":"High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation","volume":"8","author":"Sadnicka","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.clinph.2017.08.020","article-title":"Adaptation of feedforward movement control is abnormal in patients with cervical dystonia and tremor","volume":"129","author":"Avanzino","year":"2018","journal-title":"Clin. Neurophysiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s12311-014-0569-0","article-title":"Normal Motor Adaptation in Cervical Dystonia: A Fundamental Cerebellar Computation is Intact","volume":"13","author":"Sadnicka","year":"2014","journal-title":"Cerebellum"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1002\/mds.27517","article-title":"Delineating cerebellar mechanisms in DYT11 myoclonus-dystonia","volume":"33","author":"Sadnicka","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1046\/j.1460-9568.2002.02212.x","article-title":"The roles of the cerebellum and basal ganglia in timing and error prediction","volume":"16","author":"Dreher","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11610","DOI":"10.1523\/JNEUROSCI.1609-12.2012","article-title":"Dynamic Modulation of Cerebellar Excitability for Abrupt, But Not Gradual, Visuomotor Adaptation","volume":"32","author":"Schlerf","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.humov.2010.08.020","article-title":"Parkinson\u2019s disease differentially affects adaptation to gradual as compared to sudden visuomotor distortions","volume":"30","author":"Venkatakrishnan","year":"2011","journal-title":"Hum. Mov. Sci."},{"key":"ref_91","first-page":"168","article-title":"Learned Dynamics of Reaching Movements Generalize From Dominant to Nondominant Arm","volume":"89","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00221-014-3824-1","article-title":"Neural correlates of adaptation to gradual and to sudden visuomotor distortions in humans","volume":"232","author":"Werner","year":"2014","journal-title":"Exp. Brain Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1097-0193(1998)6:1<59::AID-HBM5>3.0.CO;2-K","article-title":"Robot-aided functional imaging: Application to a motor learning study","volume":"6","author":"Krebs","year":"1998","journal-title":"Hum. Brain Mapp."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0893-6080(99)00046-5","article-title":"What are the computations of the cerebellum, the basal ganglia and the cerebral cortex?","volume":"12","author":"Doya","year":"1999","journal-title":"Neural Netw."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0959-4388(00)00153-7","article-title":"Complementary roles of basal ganglia and cerebellum in learning and motor control","volume":"10","author":"Doya","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbr.2008.11.012","article-title":"Contributions of the basal ganglia and functionally related brain structures to motor learning","volume":"199","author":"Doyon","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s12311-014-0594-z","article-title":"A Gait Paradigm Reveals Different Patterns of Abnormal Cerebellar Motor Learning in Primary Focal Dystonias","volume":"13","author":"Hoffland","year":"2014","journal-title":"Cerebellum"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/brain\/awg188","article-title":"Abnormalities of motor cortex excitability preceding movement in patients with dystonia","volume":"126","author":"Gilio","year":"2003","journal-title":"Brain"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/jnnp.59.5.493","article-title":"Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia","volume":"59","author":"Ridding","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/cercor\/bhh017","article-title":"Impaired Modulation of Intracortical Inhibition in Focal Hand Dystonia","volume":"14","author":"Stinear","year":"2004","journal-title":"Cereb Cortex"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/mds.20160","article-title":"Elevated threshold for intracortical inhibition in focal hand dystonia","volume":"19","author":"Stinear","year":"2004","journal-title":"Mov. Disord."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mds.20514","article-title":"Task-dependent modulation of silent period duration in focal hand dystonia","volume":"20","author":"Stinear","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/mds.22814","article-title":"Restoration of motor inhibition through an abnormal premotor-motor connection in dystonia","volume":"25","author":"Huang","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/brain\/awf030","article-title":"Inhibitory control of acquired motor programmes in the human brain","volume":"125","author":"Hummel","year":"2002","journal-title":"Brain"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jns.2007.08.024","article-title":"Focal hand dystonia, mirror dystonia and motor overflow","volume":"266","author":"Sitburana","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.parkreldis.2009.05.003","article-title":"Motor overflow and mirror dystonia","volume":"15","author":"Sitburana","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10363","DOI":"10.1523\/JNEUROSCI.3564-08.2008","article-title":"Short intracortical and surround inhibition are selectively reduced during movement initiation in focal hand dystonia","volume":"28","author":"Beck","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4135708","article-title":"Spatial Integration of Somatosensory Inputs during Sensory-Motor Plasticity Phenomena Is Normal in Focal Hand Dystonia","volume":"2018","author":"Terranova","year":"2018","journal-title":"Neural Plast."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1460-9568.2009.06710.x","article-title":"Inter-hemispheric inhibition is impaired in mirror dystonia","volume":"29","author":"Beck","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/mds.25768","article-title":"Does abnormal interhemispheric inhibition play a role in mirror dystonia?","volume":"29","author":"Sattler","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/brain\/121.5.801","article-title":"Abnormal motor unit synchronization of antagonist muscles underlies pathological co-contraction in upper limb dystonia","volume":"121","author":"Farmer","year":"1998","journal-title":"Brain"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lunardini, F., Casellato, C., Bertucco, M., Sanger, T.D., and Pedrocchi, A. (2015, January 25\u201329). Muscle synergies in children with dystonia capture \u201chealthy\u201d patterns regardless the altered motor performance. Proceedings of the 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy.","DOI":"10.1109\/EMBC.2015.7318802"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s10439-017-1838-0","article-title":"Children With and Without Dystonia Share Common Muscle Synergies While Performing Writing Tasks","volume":"45","author":"Lunardini","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1093\/brain\/awh291","article-title":"Neck proprioception and spatial orientation in cervical dystonia","volume":"127","author":"Bove","year":"2004","journal-title":"Brain"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.gaitpost.2017.04.004","article-title":"Impairments of balance, stepping reactions and gait in people with cervical dystonia","volume":"55","author":"Barr","year":"2017","journal-title":"Gait Posture"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00221-018-5174-x","article-title":"Postural control and the relation with cervical sensorimotor control in patients with idiopathic adult-onset cervical dystonia","volume":"236","author":"Mercelis","year":"2018","journal-title":"Exp. Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1212\/WNL.0b013e318227b19e","article-title":"GPi-DBS may induce a hypokinetic gait disorder with freezing of gait in patients with dystonia","volume":"77","author":"Schrader","year":"2011","journal-title":"Neurology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000195718","article-title":"Induction of Bradykinesia with Pallidal Deep Brain Stimulation in Patients with Cranial-Cervical Dystonia","volume":"87","author":"Berman","year":"2009","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00702-010-0544-y","article-title":"Micrographia induced by pallidal DBS for segmental dystonia: A subtle sign of hypokinesia?","volume":"118","author":"Blahak","year":"2011","journal-title":"J. Neural Transm."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/mds.26009","article-title":"Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1 muscarinic receptors","volume":"29","author":"Maltese","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-510X(97)00151-2","article-title":"The mechanism of action of Botulinum toxin type A in focal dystonia is most probably through its dual effect on efferent (motor) and afferent pathways at the injected site","volume":"152","author":"Giladi","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Weise, D., Weise, C.M., and Naumann, M. (2019). Central Effects of Botulinum Neurotoxin\u2014Evidence from Human Studies. Toxins, 11.","DOI":"10.3390\/toxins11010021"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/jnnp.61.2.172","article-title":"Botulinum toxin in writer\u2019s cramp: Objective response evaluation in 31 patients","volume":"61","author":"Wissel","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/jnnp.52.3.355","article-title":"Treatment of focal dystonias of the hand with botulinum toxin injections","volume":"52","author":"Cohen","year":"1989","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.baga.2018.05.001","article-title":"Alterations in vestibular function in individuals with cervical dystonia and the effects of botulinum toxin treatment","volume":"13","author":"Andrzejewski","year":"2018","journal-title":"Basal Ganglia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/mds.20801","article-title":"Botulinum toxin changes intrafusal feedback in dystonia: A study with the tonic vibration reflex","volume":"21","author":"Trompetto","year":"2006","journal-title":"Mov. Disord."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/brain\/120.3.409","article-title":"Long-latency reflexes of hand muscles in idiopathic focal dystonia and their modification by botulinum toxin","volume":"120","author":"Naumann","year":"1997","journal-title":"Brain"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/mds.10383","article-title":"Reversible reorganisation of the motor cortical representation of the hand in cervical dystonia","volume":"18","author":"Thickbroom","year":"2003","journal-title":"Mov. Disord."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00221-018-5322-3","article-title":"Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: A functional MRI study","volume":"236","author":"Hok","year":"2018","journal-title":"Exp. Brain Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jns.2011.03.040","article-title":"Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: A functional MRI study","volume":"306","author":"Otruba","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/mds.21759","article-title":"Molding the sensory cortex: Spatial acuity improves after botulinum toxin treatment for cervical dystonia","volume":"22","author":"Walsh","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1093\/cercor\/bhq246","article-title":"Dissociating the Roles of the Cerebellum and Motor Cortex during Adaptive Learning: The Motor Cortex Retains What the Cerebellum Learns","volume":"21","author":"Galea","year":"2011","journal-title":"Cereb Cortex"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0959-4388(99)00028-8","article-title":"Internal models for motor control and trajectory planning","volume":"9","author":"Kawato","year":"1999","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1364-6613(98)01221-2","article-title":"Internal models in the cerebellum","volume":"2","author":"Wolpert","year":"1998","journal-title":"Trends Cogn. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"506","DOI":"10.5334\/tohm.383","article-title":"The Anatomical Basis for Dystonia: The Motor Network Model","volume":"7","author":"Jinnah","year":"2017","journal-title":"Tremor Other Hyperkinetic Mov."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/jnnp.2007.126599","article-title":"Neural correlates of dual task performance in patients with Parkinson\u2019s disease","volume":"79","author":"Wu","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuropsychologia.2008.08.001","article-title":"The effect of Parkinson\u2019s disease on interference control during action selection","volume":"47","author":"Wylie","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00221-005-0073-3","article-title":"Control of aperture closure during reach-to-grasp movements in parkinson\u2019s disease","volume":"168","author":"Rand","year":"2005","journal-title":"Exp. Brain Res."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/9\/4\/79\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:44:47Z","timestamp":1760186687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/9\/4\/79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":138,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["brainsci9040079"],"URL":"https:\/\/doi.org\/10.3390\/brainsci9040079","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]}}}