{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:27:51Z","timestamp":1777598871776,"version":"3.51.4"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Complex regional pain syndrome type I (CRPS-I) is a chronic painful condition. We investigated whether manual therapy (MT), in a chronic post-ischemia pain (CPIP) model, is capable of reducing pain behavior and oxidative stress. Male Swiss mice were subjected to ischemia-reperfusion (IR) to mimic CRPS-I. Animals received ankle joint mobilization 48h after the IR procedure, and response to mechanical stimuli was evaluated. For biochemical analyses, mitochondrial function as well as oxidative stress thiobarbituric acid reactive substances (TBARS), protein carbonyls, antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) levels were determined. IR induced mechanical hyperalgesia which was subsequently reduced by acute MT treatment. The concentrations of oxidative stress parameters were increased following IR with MT treatment preventing these increases in malondialdehyde (MDA) and carbonyls protein. IR diminished the levels of SOD and CAT activity and MT treatment prevented this decrease in CAT but not in SOD activity. IR also diminished mitochondrial complex activity, and MT treatment was ineffective in preventing this decrease. In conclusion, repeated sessions of MT resulted in antihyperalgesic effects mediated, at least partially, through the prevention of an increase of MDA and protein carbonyls levels and an improvement in the antioxidant defense system.<\/jats:p>","DOI":"10.3390\/brainsci9080197","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:38:02Z","timestamp":1565591882000},"page":"197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Manual Therapy Reduces Pain Behavior and Oxidative Stress in a Murine Model of Complex Regional Pain Syndrome Type I"],"prefix":"10.3390","volume":"9","author":[{"given":"Afonso S. I.","family":"Salgado","sequence":"first","affiliation":[{"name":"Coordinator of Integrative Physical Therapy Residency\u2013Philadelphia University Center, Londrina 86020-000, Paran\u00e1, Brazil"},{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Stramosk","sequence":"additional","affiliation":[{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela D.","family":"Ludtke","sequence":"additional","affiliation":[{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"},{"name":"Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C. C.","family":"Kuci","sequence":"additional","affiliation":[{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana C.","family":"Salm","sequence":"additional","affiliation":[{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"},{"name":"Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandro A.","family":"Ceci","sequence":"additional","affiliation":[{"name":"Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"},{"name":"Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palho\u00e7a 88137-270, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubar\u00e3o 88704-900, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drielly","family":"Florentino","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubar\u00e3o 88704-900, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucineia G.","family":"Danielski","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubar\u00e3o 88704-900, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Gassenferth","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Centre of Biological Sciences, University Federal of Santa Catarina, Florian\u00f3polis 88040-900, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana R.","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine T.","family":"Rezin","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294-1212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-4698","authenticated-orcid":false,"given":"Adair R. 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