{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:51:35Z","timestamp":1789573895795,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU2665\/1-2"],"award-info":[{"award-number":["KU2665\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum\/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial\/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum\/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential.<\/jats:p>","DOI":"10.3390\/brainsci9100264","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:12:52Z","timestamp":1570162372000},"page":"264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Weight Change after Striatal\/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus"],"prefix":"10.3390","volume":"9","author":[{"given":"Juan","family":"Baldermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hahn","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine, Brain &amp; Behaviour (INM-7), Research Centre J\u00fclich, 52428 J\u00fclich, Germany"},{"name":"Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-146X","authenticated-orcid":false,"given":"Till","family":"Dembek","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Kohl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany"},{"name":"Johanniter Hospital Oberhausen, Department of Psychiatry, Psychotherapy and Psychosomatics, 46145 Oberhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Visser-Vandewalle","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-6025","authenticated-orcid":false,"given":"Andreas","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9-University Medicine (CVK), 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Huys","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1474-4422(08)70291-6","article-title":"Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson\u2019s disease","volume":"8","author":"Benabid","year":"2009","journal-title":"Lancet. 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