{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:59:39Z","timestamp":1790755179768,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studies, melatonin was shown to have antioxidant activity and, possibly, to affect the development of Alzheimer\u2019s disease (AD). In addition, melatonin has neuroprotective effects and affects neuroplasticity, thus indicating potential antidepressant properties. In the present review, the new functions of melatonin are summarized and a therapeutic target for the development of new drugs based on the mechanism of action of melatonin is proposed.<\/jats:p>","DOI":"10.3390\/brainsci9100285","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T11:37:55Z","timestamp":1571657875000},"page":"285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-2667","authenticated-orcid":false,"given":"Jung Goo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan 47392, Korea"},{"name":"Paik Institute for Clinical Research, Department of Health Science and Technology, Graduate School, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sup","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Paik Institute for Clinical Research, Department of Health Science and Technology, Graduate School, Inje University, Busan 47392, Korea"},{"name":"Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyun","family":"Seog","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-4950","authenticated-orcid":false,"given":"Mi Kyoung","family":"Seo","sequence":"additional","affiliation":[{"name":"Paik Institute for Clinical Research, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Myong","family":"Bahk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.20945\/2359-3997000000066","article-title":"A brief review about melatonin, a pineal hormone","volume":"62","author":"Amaral","year":"2018","journal-title":"Arch. 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