{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:49:21Z","timestamp":1789602561653,"version":"build-2803163510"},"reference-count":174,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG059103"],"award-info":[{"award-number":["AG059103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Aging-related changes have been identified at virtually every level of the central auditory system. One of the most common findings across these nuclei is a loss of synaptic inhibition with aging, which has been proposed to be at the heart of several aging-related changes in auditory cognition, including diminished speech perception in complex environments and the presence of tinnitus. Some authors have speculated that downregulation of synaptic inhibition is a consequence of peripheral deafferentation and therefore is a homeostatic mechanism to restore excitatory\/inhibitory balance. As such, disinhibition would represent a form of maladaptive plasticity. However, clinical data suggest that deafferentation-related disinhibition tends to occur primarily in the aged brain. Therefore, aging-related disinhibition may, in part, be related to the high metabolic demands of inhibitory neurons relative to their excitatory counterparts. These findings suggest that both deafferentation-related maladaptive plastic changes and aging-related metabolic factors combine to produce changes in central auditory function. Here, we explore the arguments that downregulation of inhibition may be due to homeostatic responses to diminished afferent input vs. metabolic vulnerability of inhibitory neurons in the aged brain. Understanding the relative importance of these mechanisms will be critical for the development of treatments for the underlying causes of aging-related central disinhibition.<\/jats:p>","DOI":"10.3390\/brainsci9120351","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:50:45Z","timestamp":1575283845000},"page":"351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?"],"prefix":"10.3390","volume":"9","author":[{"given":"Baher A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-1837","authenticated-orcid":false,"given":"Daniel A.","family":"Llano","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA"},{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/gerona\/glr002","article-title":"Hearing loss prevalence and risk factors among older adults in the United States","volume":"66","author":"Lin","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4419-0993-0_9","article-title":"Epidemiology of Age-Related Hearing Impairment","volume":"Volume 34","author":"Frisina","year":"2010","journal-title":"The Aging Auditory System"},{"key":"ref_3","unstructured":"Ortman, J.M., Velkoff, V.A., and Hogan, H. (2014). An Aging Nation: The Older Population in the United States."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1044\/jshr.3301.149","article-title":"Hearing loss, aging, and speech perception in reverberation and noise","volume":"33","author":"Helfer","year":"1990","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1682\/JRRD.2004.12.0164","article-title":"Some effects of aging on central auditory processing","volume":"42","author":"Martin","year":"2005","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/14992020309074638","article-title":"Effects of aging on auditory processing of speech","volume":"42","author":"Souza","year":"2003","journal-title":"Int. J. Audiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnins.2018.00125","article-title":"Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review","volume":"12","author":"Jayakody","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00441-014-2107-2","article-title":"Age-related changes in the central auditory system","volume":"361","author":"Ouda","year":"2015","journal-title":"Cell Tissue Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1749-6632.2009.03931.x","article-title":"Age-related hearing loss: Ear and brain mechanisms","volume":"1170","author":"Frisina","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kandler, K. (2019). Aging Processes in the Subcortical Auditory System. The Oxford Handbook of the Auditory Brainstem, Oxford University Press.","DOI":"10.1093\/oxfordhb\/9780190849061.001.0001"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.heares.2011.04.004","article-title":"Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity","volume":"279","author":"Wang","year":"2011","journal-title":"Hear. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actpsy.2017.04.008","article-title":"Intentional switching in auditory selective attention: Exploring age-related effects in a spatial setup requiring speech perception","volume":"177","author":"Oberem","year":"2017","journal-title":"Acta Psychol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/cercor\/7.1.63","article-title":"Prefrontal deficits in attention and inhibitory control with aging","volume":"7","author":"Chao","year":"1997","journal-title":"Cereb. Cortex"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"a005736","DOI":"10.1101\/cshperspect.a005736","article-title":"Homeostatic synaptic plasticity: Local and global mechanisms for stabilizing neuronal function","volume":"4","author":"Turrigiano","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1111\/j.1460-9568.2006.04774.x","article-title":"Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: A computational model","volume":"23","author":"Schaette","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.heares.2008.02.006","article-title":"Development of hyperactivity after hearing loss in a computational model of the dorsal cochlear nucleus depends on neuron response type","volume":"240","author":"Schaette","year":"2008","journal-title":"Hear. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Schaette, R., Turtle, C., and Munro, K.J. (2012). Reversible induction of phantom auditory sensations through simulated unilateral hearing loss. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035238"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.heares.2006.03.005","article-title":"Age-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus","volume":"216","author":"Caspary","year":"2006","journal-title":"Hear. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1523\/JNEUROSCI.2451-05.2005","article-title":"Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: Role of inhibitory inputs","volume":"25","author":"Caspary","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-4522(95)00082-T","article-title":"Age-related reduction of [3H] strychnine binding sites in the cochlear nucleus of the Fischer 344 rat","volume":"67","author":"Milbrandt","year":"1995","journal-title":"Neuroscience"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuroscience.2009.01.079","article-title":"Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus","volume":"160","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005537-199801000-00005","article-title":"Age-related glycine receptor subunit changes in the cochlear nucleus of Fischer-344 rats","volume":"108","author":"Krenning","year":"1998","journal-title":"Laryngoscope"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-5955(00)00197-0","article-title":"Bicuculline application affects discharge patterns, rate-intensity functions, and frequency tuning characteristics of bat auditory cortical neurons","volume":"150","author":"Chen","year":"2000","journal-title":"Hear. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0079-6123(08)62269-4","article-title":"Varieties of inhibition in the processing and control of processing in the mammalian cochlear nucleus","volume":"97","author":"Evans","year":"1993","journal-title":"Prog. Brain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1152\/jn.1992.68.5.1760","article-title":"GABAergic circuits sharpen tuning curves and modify response properties in the mustache bat inferior colliculus","volume":"68","author":"Yang","year":"1992","journal-title":"J. Neurophysiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1152\/jn.00301.2004","article-title":"Lateral inhibition for center-surround reorganization of the frequency map of bat auditory cortex","volume":"92","author":"Ma","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1152\/jn.1997.77.4.2098","article-title":"Sharpening of frequency tuning by inhibition in the thalamic auditory nucleus of the mustached bat","volume":"77","author":"Suga","year":"1997","journal-title":"J. Neurophysiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s003590050317","article-title":"Bicuculline application affects discharge pattern and pulse-duration tuning characteristics of bat inferior collicular neurons","volume":"184","author":"Jen","year":"1999","journal-title":"J. Comp. Physiol. A"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5955(99)00133-1","article-title":"Sound duration selectivity in the pallid bat inferior colliculus","volume":"137","author":"Fuzessery","year":"1999","journal-title":"Hear. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.8171341","article-title":"Neural tuning for sound duration: Role of inhibitory mechanisms in the inferior colliculus","volume":"264","author":"Casseday","year":"1994","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1152\/jn.00056.2005","article-title":"Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain","volume":"94","author":"Galazyuk","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10162-002-2002-5","article-title":"Auditory processing of spectral cues for sound localization in the inferior colliculus","volume":"4","author":"Davis","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuron.2008.05.011","article-title":"Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem","volume":"59","author":"Magnusson","year":"2008","journal-title":"Neuron"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fncir.2012.00077","article-title":"A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats","volume":"6","author":"Rabang","year":"2012","journal-title":"Front. Neural Circuits"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-5955(02)00363-5","article-title":"GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus","volume":"168","author":"Caspary","year":"2002","journal-title":"Hear. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1152\/jn.01084.2002","article-title":"Glutamatergic and GABAergic regulation of neural responses in inferior colliculus to amplitude-modulated sounds","volume":"90","author":"Zhang","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s004220000174","article-title":"Computational models of temporal processing in the auditory thalamus","volume":"83","author":"Llano","year":"2000","journal-title":"Biol. Cybern."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1121\/1.429607","article-title":"The effect of aging on horizontal plane sound localization","volume":"108","author":"Abel","year":"2000","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1152\/jn.00951.2010","article-title":"Influence of aging on human sound localization","volume":"105","author":"Dobreva","year":"2011","journal-title":"J. Neurophysiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3109\/00016485709126909","article-title":"Pitch discrimination and age","volume":"48","year":"1957","journal-title":"Acta Oto-laryngol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.heares.2009.11.010","article-title":"Aging alters the perception and physiological representation of frequency: Evidence from human frequency-following response recordings","volume":"264","author":"Clinard","year":"2010","journal-title":"Hear. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3758\/BF03211353","article-title":"Identification and discrimination of consonant-vowel syllables by younger and older adults","volume":"37","author":"Elliott","year":"1985","journal-title":"Percept. Psychophys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1121\/1.401659","article-title":"Aging and consonant errors in reverberation and noise","volume":"90","author":"Helfer","year":"1991","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"Zheng","year":"1999","journal-title":"Hear. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/83660","article-title":"Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D","volume":"27","author":"Holme","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neurobiolaging.2005.03.001","article-title":"Age-related changes in cochlear and brainstem auditory functions in Fischer 344 rats","volume":"27","author":"Popelar","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neurobiolaging.2017.09.034","article-title":"The FBN rat model of aging: Investigation of ABR waveforms and ribbon synapse changes","volume":"62","author":"Cai","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.heares.2017.05.002","article-title":"Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats","volume":"350","author":"Godfrey","year":"2017","journal-title":"Hear. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.neuroscience.2009.07.049","article-title":"Cochlear nucleus neurons redistribute synaptic AMPA and glycine receptors in response to monaural conductive hearing loss","volume":"163","author":"Whiting","year":"2009","journal-title":"Neuroscience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cne.903000106","article-title":"Morphology of the octopus cell area of the cochlear nucleus in young and aging C57BL\/6J and CBA\/J mice","volume":"300","author":"Willott","year":"1990","journal-title":"J. Comp. neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0306-4522(88)90322-3","article-title":"Age-related loss of synaptic terminals in the rat medial nucleus of the trapezoid body","volume":"24","author":"Casey","year":"1988","journal-title":"Neuroscience"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cne.902320311","article-title":"Aging in the rat medial nucleus of the trapezoid body. II. Electron microscopy","volume":"232","author":"Casey","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0197-4580(82)90039-2","article-title":"Aging in the rat medial nucleus of the trapezoid body. I. Light microscopy","volume":"3","author":"Casey","year":"1982","journal-title":"Neurobiol. Aging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-5955(94)90270-4","article-title":"Age-related changes in brainstem auditory neurotransmitters: Measures of GABA and acetylcholine function","volume":"77","author":"Raza","year":"1994","journal-title":"Hear. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.exger.2008.09.012","article-title":"Age-related changes in GAD levels in the central auditory system of the rat","volume":"44","author":"Burianova","year":"2009","journal-title":"Exp. Gerontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00964918","article-title":"Changes with aging in the levels of amino acids in rat CNS structural elements. I. Glutamate and related amino acids","volume":"14","author":"Lajtha","year":"1989","journal-title":"Neurochem. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00967245","article-title":"Heterogeneous distribution of functionally important amino acids in brain areas of adult and aging humans","volume":"18","author":"Palkovits","year":"1993","journal-title":"Neurochem. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0197-4580(94)90051-5","article-title":"Age-related decrease in GABAB receptor binding in the Fischer 344 rat inferior colliculus","volume":"15","author":"Milbrandt","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0306-4522(96)00050-4","article-title":"GABAA receptor binding in the aging rat inferior colliculus","volume":"73","author":"Milbrandt","year":"1996","journal-title":"Neuroscience"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/(SICI)1096-9861(19970317)379:3<455::AID-CNE10>3.0.CO;2-F","article-title":"Alterations of GABAA receptor subunit mRNA levels in the aging Fischer 344 rat inferior colliculus","volume":"379","author":"Milbrandt","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0378-5955(00)00135-0","article-title":"GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma","volume":"147","author":"Milbrandt","year":"2000","journal-title":"Hear. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(03)00394-0","article-title":"Consequences of noise- or styrene-induced cochlear damages on glutamate decarboxylase levels in the rat inferior colliculus","volume":"189","author":"Pouyatos","year":"2004","journal-title":"Hear. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1046\/j.1460-9568.2002.02302.x","article-title":"The effect of bilateral deafness on excitatory and inhibitory synaptic strength in the inferior colliculus","volume":"16","author":"Vale","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1523\/JNEUROSCI.3277-12.2013","article-title":"Reduced GABA(A) receptor-mediated tonic inhibition in aged rat auditory thalamus","volume":"33","author":"Richardson","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.exger.2008.04.001","article-title":"Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat","volume":"43","author":"Ouda","year":"2008","journal-title":"Exp. Gerontol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnana.2014.00040","article-title":"Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex","volume":"8","author":"Ouellet","year":"2014","journal-title":"Front. Neuroanat."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.heares.2012.08.017","article-title":"Parvalbumin immunoreactivity in the auditory cortex of a mouse model of presbycusis","volume":"294","author":"Measor","year":"2012","journal-title":"Hear. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fnagi.2016.00270","article-title":"Age-Related Deterioration of Perineuronal Nets in the Primary Auditory Cortex of Mice","volume":"8","author":"Brewton","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/JP271221","article-title":"Ageing-related changes in GABAergic inhibition in mouse auditory cortex, measured using in vitro flavoprotein autofluorescence imaging","volume":"594","author":"Stebbings","year":"2016","journal-title":"J. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnsys.2013.00052","article-title":"Shaping the aging brain: Role of auditory input patterns in the emergence of auditory cortical impairments","volume":"7","author":"Kamal","year":"2013","journal-title":"Front. Syst. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1093\/cercor\/bhm233","article-title":"Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex","volume":"18","author":"Kotak","year":"2008","journal-title":"Cereb. Cortex"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mad.2005.09.028","article-title":"Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice","volume":"127","author":"Yarian","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/10715760902849813","article-title":"Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production","volume":"43","author":"Lam","year":"2009","journal-title":"Free Radic. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The free radical theory of aging matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process","volume":"292","author":"Navarro","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/abbi.1999.1495","article-title":"Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse","volume":"373","author":"Kwong","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"R1244","DOI":"10.1152\/ajpregu.00226.2004","article-title":"Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging","volume":"287","author":"Navarro","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2741\/2133","article-title":"Brain mitochondrial dysfunction in aging: Conditions that improve survival, neurological performance and mitochondrial function","volume":"12","author":"Navarro","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0891-5849(03)00388-5","article-title":"Effects of age and caloric restriction on glutathione redox state in mice","volume":"35","author":"Rebrin","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2006.10.040","article-title":"Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL\/6 and DBA\/2 mice","volume":"1127","author":"Rebrin","year":"2007","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neurobiolaging.2016.03.006","article-title":"The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging","volume":"42","author":"Stebbings","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1126\/science.1174331","article-title":"Energy-efficient action potentials in hippocampal mossy fibers","volume":"325","author":"Alle","year":"2009","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000017327","article-title":"Functional energy metabolism: In vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronal activity","volume":"20","author":"Sibson","year":"1998","journal-title":"Dev. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/sj.jcbfm.9600263","article-title":"Neuronal-glial glucose oxidation and glutamatergic-GABAergic function","volume":"26","author":"Hyder","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/378075a0","article-title":"Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons","volume":"378","author":"Cobb","year":"1995","journal-title":"Nature"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1152\/jn.1996.75.6.2467","article-title":"Oscillatory firing and interneuronal correlations in squirrel monkey striate cortex","volume":"75","author":"Livingstone","year":"1996","journal-title":"J. Neurophysiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1152\/jn.1991.66.3.1059","article-title":"Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons","volume":"66","author":"Lytton","year":"1991","journal-title":"J. Neurophysiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuron.2016.06.033","article-title":"GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits","volume":"91","author":"Tremblay","year":"2016","journal-title":"Neuron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/schbul\/sbn070","article-title":"GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia","volume":"34","author":"Lewis","year":"2008","journal-title":"Schizophr. Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/jcbfm.2014.104","article-title":"Highly energized inhibitory interneurons are a central element for information processing in cortical networks","volume":"34","author":"Kann","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/cercor\/bhl030","article-title":"Hippocampal and neocortical gamma oscillations predict memory formation in humans","volume":"17","author":"Sederberg","year":"2007","journal-title":"Cereb. Cortex"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1523\/JNEUROSCI.18-01-00388.1998","article-title":"Gamma oscillations in the entorhinal cortex of the freely behaving rat","volume":"18","author":"Chrobak","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1523\/JNEUROSCI.15-01-00047.1995","article-title":"Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat","volume":"15","author":"Bragin","year":"1995","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/brain\/awq333","article-title":"Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria","volume":"134","author":"Kann","year":"2011","journal-title":"Brain"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.neuroimage.2008.06.027","article-title":"Cortical glucose metabolism positively correlates with gamma-oscillations in nonlesional focal epilepsy","volume":"42","author":"Nishida","year":"2008","journal-title":"Neuroimage"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/jcbfm.2013.94","article-title":"Cerebral energy metabolism and the brain\u2019s functional network architecture: An integrative review","volume":"33","author":"Lord","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tins.2003.10.010","article-title":"Interneuron Diversity series: Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons","volume":"27","author":"Jonas","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nn.3678","article-title":"A supercritical density of Na(+) channels ensures fast signaling in GABAergic interneuron axons","volume":"17","author":"Hu","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1523\/JNEUROSCI.20-15-05594.2000","article-title":"Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse","volume":"20","author":"Kraushaar","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1111\/j.1460-9568.2006.04814.x","article-title":"Populations of hippocampal inhibitory neurons express different levels of cytochrome c","volume":"23","author":"Freund","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Cser\u00e9p, C., P\u00f3sfai, B., Schwarcz, A.D., and D\u00e9nes, \u00c1. (2018). Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites. eNeuro, 5.","DOI":"10.1101\/216093"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10863-006-9052-z","article-title":"Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex","volume":"38","author":"Li","year":"2006","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.freeradbiomed.2012.07.021","article-title":"Cytochrome c oxidase dysfunction in oxidative stress","volume":"53","author":"Srinivasan","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuroimage.2013.05.070","article-title":"Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin","volume":"85","author":"Kolyva","year":"2014","journal-title":"Neuroimage"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.23.5.056006","article-title":"Test-retest reliability of brain mitochondrial cytochrome-c-oxidase assessed by functional near-infrared spectroscopy","volume":"23","author":"Holper","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"E026","DOI":"10.1017\/S0952523815000218","article-title":"Co-localization of glutamic acid decarboxylase and vesicular GABA transporter in cytochrome oxidase patches of macaque striate cortex","volume":"32","author":"Adams","year":"2015","journal-title":"Vis. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0165-0270(89)90129-5","article-title":"Double labeling of cytochrome oxidase and gamma-aminobutyric acid in central nervous system neurons of adult cats","volume":"30","author":"Luo","year":"1989","journal-title":"J. Neurosci. Methods"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1523\/JNEUROSCI.4134-15.2016","article-title":"Connectional Modularity of Top-Down and Bottom-Up Multimodal Inputs to the Lateral Cortex of the Mouse Inferior Colliculus","volume":"36","author":"Lesicko","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1523\/JNEUROSCI.04-01-00251.1984","article-title":"Increased glucose metabolism during long-duration recurrent inhibition of hippocampal pyramidal cells","volume":"4","author":"Ackermann","year":"1984","journal-title":"J. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1523\/JNEUROSCI.17-14-05509.1997","article-title":"GABAergic neurons in barrel cortex show strong, whisker-dependent metabolic activation during normal behavior","volume":"17","author":"McCasland","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0361-9230(03)00026-1","article-title":"Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats","volume":"60","author":"Wang","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1523\/JNEUROSCI.4105-07.2008","article-title":"Gamma oscillations and spontaneous network activity in the hippocampus are highly sensitive to decreases in pO2 and concomitant changes in mitochondrial redox state","volume":"28","author":"Huchzermeyer","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1523\/JNEUROSCI.5080-10.2011","article-title":"Changes in hippocampal neuronal activity during and after unilateral selective hippocampal ischemia in vivo","volume":"31","author":"Barth","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1093\/brain\/awr018","article-title":"Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons","volume":"134","author":"Whittaker","year":"2011","journal-title":"Brain"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1212\/WNL.55.9.1249","article-title":"Cellular factors controlling neuronal vulnerability in the brain: A lesson from the striatum","volume":"55","author":"Calabresi","year":"2000","journal-title":"Neurology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00004647-200005000-00011","article-title":"Involvement of intracellular calcium stores during oxygen\/glucose deprivation in striatal large aspiny interneurons","volume":"20","author":"Pisani","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ana.410380304","article-title":"Aging, energy, and oxidative stress in neurodegenerative diseases","volume":"38","author":"Beal","year":"1995","journal-title":"Ann. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"ref_121","first-page":"1813","article-title":"Pictorial review of glutamate excitotoxicity: Fundamental concepts for neuroimaging","volume":"22","author":"Mark","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1523\/JNEUROSCI.3857-09.2010","article-title":"Redox dysregulation affects the ventral but not dorsal hippocampus: Impairment of parvalbumin neurons, gamma oscillations, and related behaviors","volume":"30","author":"Steullet","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.21211","article-title":"Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain","volume":"502","author":"Cowell","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1167\/iovs.15-17758","article-title":"PGC-1\u03b1 Induces Human RPE Oxidative Metabolism and Antioxidant Capacity","volume":"57","author":"Iacovelli","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1242\/jcs.113662","article-title":"PGC1\u03b1 and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders","volume":"125","author":"Austin","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.biopsych.2012.12.004","article-title":"Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons","volume":"73","author":"Jiang","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.biopsych.2012.09.020","article-title":"Early-life insults impair parvalbumin interneurons via oxidative stress: Reversal by N-acetylcysteine","volume":"73","author":"Cabungcal","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1111\/j.1582-4934.2008.00675.x","article-title":"Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age","volume":"13","author":"Shetty","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nbd.2006.01.003","article-title":"Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia","volume":"22","author":"Cabungcal","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/aps.2009.24","article-title":"Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases","volume":"30","author":"Dong","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1046\/j.1471-4159.1995.65031184.x","article-title":"Selective inhibition of the tricarboxylic acid cycle of GABAergic neurons with 3-nitropropionic acid in vivo","volume":"65","author":"Hassel","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/mp.2017.47","article-title":"Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia","volume":"22","author":"Steullet","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2004.10.019","article-title":"Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains","volume":"57","author":"Torrey","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archpsyc.1995.03950160008002","article-title":"Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics","volume":"52","author":"Akbarian","year":"1995","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00401-011-0881-4","article-title":"Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin-and somatostatin-positive interneurons in the parahippocampal region","volume":"122","author":"Wang","year":"2011","journal-title":"Acta neuropathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fphar.2013.00110","article-title":"Reduced brain somatostatin in mood disorders: A common pathophysiological substrate and drug target?","volume":"4","author":"Lin","year":"2013","journal-title":"Front. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0006-3223(02)01430-0","article-title":"Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices","volume":"52","author":"Fatemi","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1523\/JNEUROSCI.19-21-09519.1999","article-title":"Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats","volume":"19","author":"Buckmaster","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/cne.10622","article-title":"Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures","volume":"459","author":"Dinocourt","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nature08002","article-title":"Driving fast-spiking cells induces gamma rhythm and controls sensory responses","volume":"459","author":"Cardin","year":"2009","journal-title":"Nature"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nbd.2012.08.012","article-title":"Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility","volume":"49","author":"Dutton","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0197-4580(02)00069-6","article-title":"Modulation of ion channels by reactive oxygen and nitrogen species: A pathophysiological role in brain aging?","volume":"23","author":"Annunziato","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1096\/fj.12-208413","article-title":"Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Rubio","year":"2012","journal-title":"FASEB J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neurobiolaging.2016.09.006","article-title":"The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy","volume":"49","author":"Soler","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_149","first-page":"269","article-title":"Parkinson\u2019s Disease and Neurodegeneration: GABA-Collapse Hypothesis","volume":"10","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5607\/en.2015.24.2.103","article-title":"Mitochondrial Dysfunction in Parkinson\u2019s Disease","volume":"24","author":"Moon","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2014.03.001","article-title":"Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson\u2019s disease","volume":"255","author":"Feng","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_152","first-page":"427","article-title":"CSF GABA levels in Parkinson\u2019s disease","volume":"40","author":"Lakke","year":"1984","journal-title":"Adv. Neurol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e675","DOI":"10.1212\/WNL.0000000000006007","article-title":"Reduced occipital GABA in Parkinson disease with visual hallucinations","volume":"91","author":"Firbank","year":"2018","journal-title":"Neurology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-5955(99)00103-3","article-title":"Age-related reductions in the activities of antioxidant enzymes in the rat inferior colliculus","volume":"135","author":"Mei","year":"1999","journal-title":"Hear. Res."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zeng, L., Yang, Y., Hu, Y., Sun, Y., Du, Z., Xie, Z., Zhou, T., and Kong, W. (2014). Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088019"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000499475","article-title":"Mitochondrial DNA 3,860-bp Deletion Increases with Aging in the Auditory Nervous System of C57BL\/6J Mice","volume":"81","author":"Du","year":"2019","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1523\/JNEUROSCI.08-02-00682.1988","article-title":"The ontogeny of inhibition and excitation in the gerbil lateral superior olive","volume":"8","author":"Sanes","year":"1988","journal-title":"J. Neurosci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5955(93)90123-I","article-title":"Response of neurons in the lateral superior olive and medial nucleus of the trapezoid body to repetitive stimulation: Intracellular and extracellular recordings from mouse brain slice","volume":"68","author":"Wu","year":"1993","journal-title":"Hear. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/ejn.13789","article-title":"An auditory brainstem nucleus as a model system for neuronal metabolic demands","volume":"47","author":"Brosel","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.heares.2016.08.009","article-title":"Auditory thalamic circuits and GABA","volume":"349","author":"Caspary","year":"2017","journal-title":"Hear. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"16141","DOI":"10.1523\/JNEUROSCI.2499-12.2012","article-title":"Diminished cortical inhibition in an aging mouse model of chronic tinnitus","volume":"32","author":"Llano","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_162","unstructured":"Snow, J. (2014). Epidemiology of tinnitus. Tinnitus: Theory and Management, BC Decker Inc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.heares.2016.12.002","article-title":"Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy","volume":"344","author":"Guest","year":"2017","journal-title":"Hear. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1808-8694(15)31194-0","article-title":"Tinnitus in normally hearing patients: Clinical aspects and repercussions","volume":"71","author":"Sanchez","year":"2005","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/00206099009081644","article-title":"Tinnitus with normal hearing sensitivity: Extended high-frequency audiometry and auditory-nerve brain-stem-evoked responses","volume":"29","author":"Barnea","year":"1990","journal-title":"Audiology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/MAO.0000000000002352","article-title":"The Influence of Metabolic Syndrome on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss","volume":"40","author":"Zhang","year":"2019","journal-title":"Otol. Neurotol."},{"key":"ref_167","first-page":"15","article-title":"Audiologic and metabolic findings in 90 patients with fluctuant hearing loss","volume":"2","author":"Gosselin","year":"1976","journal-title":"J. Am. Audiol. Soc."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Kim, H.J., Lee, H.J., An, S.Y., Sim, S., Park, B., Kim, S.W., Lee, J.S., Hong, S.K., and Choi, H.G. (2015). Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127578"},{"key":"ref_169","first-page":"736","article-title":"Treatment of hyperlipoidemia by xiaozhi capsule: A clinical efficacy research]","volume":"33","author":"Wang","year":"2013","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjoto.2009.09.004","article-title":"Simvastatin and Ginkgo biloba in the treatment of subacute tinnitus: A retrospective study of 94 patients","volume":"32","author":"Canis","year":"2011","journal-title":"Am. J. Otolaryngol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Larsson, M., Lietzau, G., Nathanson, D., \u00d6stenson, C.G., Mallard, C., Johansson, M.E., Nystr\u00f6m, T., Patrone, C., and Darsalia, V. (2016). Diabetes negatively affects cortical and striatal GABAergic neurons: An effect that is partially counteracted by exendin-4. Biosci. Rep., 36.","DOI":"10.1042\/BSR20160437"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainresbull.2015.06.002","article-title":"Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons","volume":"116","author":"Coviello","year":"2015","journal-title":"Brain Res. Bull."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.heares.2009.01.007","article-title":"Interactions of hearing loss and diabetes mellitus in the middle age CBA\/CaJ mouse model of presbycusis","volume":"249","author":"Vasilyeva","year":"2009","journal-title":"Hear. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2016.04.004","article-title":"Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability","volume":"93","author":"Inan","year":"2016","journal-title":"Neurobiol. 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