{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:18:15Z","timestamp":1778199495613,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Projects and Funding Administration Office","award":["PN305LH013-53"],"award-info":[{"award-number":["PN305LH013-53"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Ictal semiology and brain single-photon emission computed tomography have been performed in approaching the epileptogenic zone in drug-resistant focal epilepsies. The authors aim to describe the brain structures involved in the ictal and interictal epileptogenic network from sequential semiology and brain perfusion quantitative patterns analysis. A sequential representation of seizures was performed (n = 15). A two-level analysis (individual and global) was carried out for the analysis of brain perfusion quantification and estimating network structures from the perfusion indexes. Most of the subjects started with focal seizures without impaired consciousness, followed by staring, automatisms, language impairments and evolution to a bilateral tonic-clonic seizure (temporal lobe and posterior quadrant epilepsy). Frontal lobe epilepsy seizures continued with upper limb clonus and evolution to bilateral tonic-clonic. The perfusion index of the epileptogenic zone ranged between 0.439\u20131.362 (mesial and lateral structures), 0.826\u20131.266 in dorsolateral frontal structures and 0.678\u20131.507 in the occipital gyrus. The interictal epileptogenic network proposed involved the brainstem and other subcortical structures. For the ictal state, it included the rectus gyrus, putamen and cuneus. The proposed methodology provides information about the brain structures in the neural networks in patients with drug-resistant focal epilepsies.<\/jats:p>","DOI":"10.3390\/bs12040107","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:44:06Z","timestamp":1649972646000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sequential Semiology of Seizures and Brain Perfusion Patterns in Patients with Drug-Resistant Focal Epilepsies: A Perspective from Neural Networks"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-8829","authenticated-orcid":false,"given":"Jorge L.","family":"Arocha P\u00e9rez","sequence":"first","affiliation":[{"name":"International Center for Neurological Restoration, 25th Ave, No 15805, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-0733","authenticated-orcid":false,"given":"Lilia M.","family":"Morales Chac\u00f3n","sequence":"additional","affiliation":[{"name":"International Center for Neurological Restoration, 25th Ave, No 15805, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-7369","authenticated-orcid":false,"given":"Karla","family":"Batista Garc\u00eda Ramo","sequence":"additional","affiliation":[{"name":"International Center for Neurological Restoration, 25th Ave, No 15805, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00eddice","family":"Gal\u00e1n Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cuban Neurosciences Center, 25th Ave, No 15202, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fnins.2019.00417","article-title":"Functional Brain Mapping of Epilepsy Networks: Methods and Applications","volume":"13","author":"Abbott","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_2","first-page":"1","article-title":"Epilepsy, a burden health problem","volume":"17","author":"Bender","year":"2018","journal-title":"Rev. Haban Cienc. M\u00e9d."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.eplepsyres.2016.11.020","article-title":"The promise of subtraction ictal SPECT co-registered to MRI for improved seizure localization in pediatric epilepsies: Affecting factors and relationship to the surgical outcome","volume":"129","author":"Stamoulis","year":"2017","journal-title":"Epilepsy Res."},{"key":"ref_4","unstructured":"Begueria, R. (2018). Manual de Pr\u00e1cticas M\u00e9dicas, CEDISAP. [7th ed.]."},{"key":"ref_5","first-page":"e323","article-title":"Epileptogenic zone surgery located in an eloquent area of the frontal lobe in an adolescent with epilepsy","volume":"10","author":"Santos","year":"2020","journal-title":"Rev. Cubana Neurol. Neurocir."},{"key":"ref_6","first-page":"10623","article-title":"Precursors of seizures due to specific spatial-temporal modifications of evolving large-scale epileptic brain networks","volume":"9","author":"Rings","year":"2019","journal-title":"Nature"},{"key":"ref_7","first-page":"1","article-title":"Estereoelectroencefalograf\u00eda en la evaluaci\u00f3n prequir\u00fargica de epilepsias focales refractarias: Experiencia de un centro de epilepsia","volume":"95","author":"Toledano","year":"2019","journal-title":"Neurolog\u00eda"},{"key":"ref_8","unstructured":"Morales, L.M., B\u00e1ez, M.M., Bender, J.E., Gonz\u00e1lez, J., Garc\u00eda, M.E., Lorigados, L., Gonz\u00e1lez, M.E., D\u00edaz, M.L., Estupi\u00f1\u00e1n, B.O., and Pav\u00f3n, N. (2018). Drug-resistant epilepsies. Treatment in Cuba, Medical Sciencies. [1st ed.]."},{"key":"ref_9","unstructured":"Andalusian Epilepsy Society (2020). Clinical Practice Guideline 2020. Diagnostic and Treatment of Epilepsy, Andalusian Epilepsy Society. 2020 ed."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/epi.15612","article-title":"Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League against Epilepsy Neuroimaging Task Force","volume":"60","author":"Bernasconi","year":"2019","journal-title":"Epilepsia"},{"key":"ref_11","first-page":"42","article-title":"Multimodal imaging in nonlesional medically intractable focal epilepsy","volume":"7","author":"Catasus","year":"2015","journal-title":"Front. Biosci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Morales Chac\u00f3n, L.M., Garcia Maeso, I., Baez Martin, M.M., Bender del Busto, J.E., Garc\u00eda Navarro, M.E., Quintanal Cordero, N., Estupi\u00f1an D\u00edaz, B., Lorigados Pedre, L., Vald\u00e9s Yerena, R., and Gonzalez, J. (2018). Long-Term Electroclinical and Employment Follow up in Temporal Lobe Epilepsy Surgery. A Cuban Comprehensive Epilepsy Surgery Program. Behav. Sci., 8.","DOI":"10.3390\/bs8020019"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1212\/WNL.0000000000005733","article-title":"Relating structural and functional brainstem connectivity to disease measures in epilepsy","volume":"91","author":"Englot","year":"2018","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102254","DOI":"10.1016\/j.nicl.2020.102254","article-title":"Temporal lobe epilepsy alters spatio-temporal dynamics of the hippocampal functional network","volume":"26","author":"Morgana","year":"2020","journal-title":"NeuroImage Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4172\/Neuropsychiatry.1000429","article-title":"Abnormal Brain Network in Epilepsy and Associated Comorbidites","volume":"8","author":"Yang","year":"2018","journal-title":"Neuropsychiatry"},{"key":"ref_16","unstructured":"Maest\u00fa, F., Pereda, E., and del Pozo, F. (2015). Conectividad funcional y anat\u00f3mica en el cerebro humano. An\u00e1lisis de Se\u00f1ales y Aplicaciones en Ciencias de la Salud, Elsevier. [1st ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.seizure.2008.06.015","article-title":"Reduced interhemispheric hippocampal BOLD signal coupling related to early epilepsy onset","volume":"18","author":"Frings","year":"2009","journal-title":"Seizure"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00415-009-5187-2","article-title":"Impaired perceptual networks in temporal lobe epilepsy revealed by resting fMRI","volume":"256","author":"Zhang","year":"2009","journal-title":"J. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.yebeh.2009.12.030","article-title":"The neurobiological substrates of behavioral manifestation during temporal lobe seizures: A neuroethological and ictal SPECT correlation study","volume":"17","author":"Bertti","year":"2010","journal-title":"Epilepsy Behav."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yebeh.2014.07.025","article-title":"Looking for complexity in quantitative semiology of frontal and temporal lobe seizures using neuroethology and graph theory","volume":"38","author":"Bertti","year":"2014","journal-title":"Epilepsy Behav."},{"key":"ref_21","first-page":"149","article-title":"Neuroethology application for the study of human temporal lobe epilepsy: From basic to applied sciences","volume":"8","author":"Terra","year":"2005","journal-title":"Epilepsy Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"NeuroImage"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2009.01.002","article-title":"Atlas-Based Whole Brain White Matter Analysis Using Large Deformation Diffeomorphic Metric Mapping: Application to Normal Elderly and Alzheimer\u2019s Disease Participants","volume":"46","author":"Oishi","year":"2009","journal-title":"NeuroImage"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2006.04.072","article-title":"An improved method for voxel-based partial volume correction in PET and SPECT","volume":"31","author":"Erlandsson","year":"2006","journal-title":"NeuroImage"},{"key":"ref_25","first-page":"130","article-title":"Electroclinical Profile and Outcomes in Extratemporal Lobe Epilepsy Surgery Based on Intraoperative Electrocorticography","volume":"3","author":"Batista","year":"2020","journal-title":"Neurol Disord. Epilepsy J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.22379\/24224022159","article-title":"Clinical, electroencephalographic e imagenological features in adults with temporal lobe epilepsy of Epilepsy program of Antioquia University: Descriptive-retrospective study in Medellin 2008\u20132012","volume":"33","author":"Ortiz","year":"2017","journal-title":"Acta Neurol. Colomb."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chac\u00f3n, L.M., Gonz\u00e1lez, J.G., Castillo, M.R., Batista, S.B., Garc\u00eda-Ramo, K.B., Santos, A.S., Cordero, N.Q., Berm\u00fadez, M.Z., Fern\u00e1ndez, R.G., and D\u00edaz, B.E. (2021). Surgical Outcome in Extratemporal Epilepsies Based on Multimodal Pre-Surgical Evaluation and Sequential Intraoperative Electrocorticography. Behav. Sci., 11.","DOI":"10.3390\/bs11030030"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.nicl.2017.12.020","article-title":"Structural and effective connectivity in focal epilepsy","volume":"17","author":"Parker","year":"2018","journal-title":"NeuroImage Clin."},{"key":"ref_29","first-page":"39","article-title":"Is dystonic posturing during temporal lobe epileptic seizures the expression of an endogenous anticonvulsant system?","volume":"1","author":"Bertti","year":"2007","journal-title":"Epilepsy Behav."},{"key":"ref_30","first-page":"1","article-title":"Orbitofrontal epilepsy: Distinct neuronal networks underlying electroclinical subtypes and surgical outcomes","volume":"1","author":"Zhao","year":"2020","journal-title":"J. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nicl.2016.05.020","article-title":"The effective connectivity of the seizure onset zone and ictal perfusion changes in amygala kindled rhesus monkeys","volume":"12","author":"Cleeren","year":"2016","journal-title":"NeuroImage Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/j.semnuclmed.2016.09.008","article-title":"Presurgical Focus Localization in Epilepsy: PET and SPECT","volume":"47","author":"Theodore","year":"2017","journal-title":"Semin. Nucl. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1046\/j.1528-1157.2001.41900.x","article-title":"Typical and atypical perfusion patterns in periictal SPECT of patients with unilateral temporal lobe epilepsy","volume":"42","author":"Velasco","year":"2001","journal-title":"Epilepsia"},{"key":"ref_34","unstructured":"Blanco, M. (2020). Alteraciones Neuropsicol\u00f3gicas en Epilepsia del L\u00f3bulo Frontal en Ni\u00f1os, Universidad Complutense de Madrid."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102060","DOI":"10.1016\/j.nicl.2019.102060","article-title":"Altered brain connectivity in sudden unexpected death in epilepsy (SUDEP) revealed using resting-state fMRI","volume":"24","author":"Allen","year":"2019","journal-title":"NeuroImage Clin."},{"key":"ref_36","first-page":"258","article-title":"SUDEP in Spain: First case series and epidemiological analysis","volume":"69","author":"Sanchez","year":"2019","journal-title":"Seizure"},{"key":"ref_37","first-page":"e1694","article-title":"Postictal brainstem hypoperfusion and risk factors for sudden unexpected death in epilepsy","volume":"12","author":"Liu","year":"2020","journal-title":"Neurology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/brain\/awx341","article-title":"Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study","volume":"1","author":"Whelan","year":"2018","journal-title":"Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1684\/epd.2020.1230","article-title":"Electroclinical features of lateral and medial orbitofrontal epilepsy: A case series","volume":"1","author":"Liu","year":"2020","journal-title":"Epileptic Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/jnnp.59.1.26","article-title":"SPECT in the localisation of extratemporal and temporal seizure foci","volume":"59","author":"Newton","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/12\/4\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:54:18Z","timestamp":1760136858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/12\/4\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["bs12040107"],"URL":"https:\/\/doi.org\/10.3390\/bs12040107","relation":{},"ISSN":["2076-328X"],"issn-type":[{"value":"2076-328X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}