{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:11:08Z","timestamp":1774044668072,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Introduction. Insomnia is an important symptom associated with major depressive disorder (MDD). In addition, it is one of the risk factors for suicide. Studies have shown the relationship be-tween insomnia and suicidal behavior in patients with MDD. However, this association has not been evaluated in a large sample of hospitalized patients. Objectives. To evaluate the suicidal be-havior in MDD patients with insomnia compared to those without insomnia. Methods. From the National Inpatient Sample (NIS 2006\u20132015) database using the ICD-9 code, patients\u2019 data were obtained with the primary diagnosis of MDD and comorbid diagnosis of insomnia disorders (MDD+I). These patients were compared with MDD patients without insomnia disorders (MDD\u2013I) by performing a 1:2 match for the primary diagnosis code. Suicidal ideation\/attempt da-ta were compared between the groups by multivariate logistic regression analysis. Results. After the diagnostic code matching, 139061 patients were included in the MDD+I group and 276496 patients in the MDD\u2013I group. MDD+I patients were older (47 years vs. 45 years, p &lt; 0.001) com-pared to the MDD\u2013I group. The rate of suicidal ideation\/attempt was 56.0% in the MDD+I group and 42.0% in the MDD\u2013I group (p &lt; 0.001). After adjusting for age, sex, race, borderline personal-ity disorders, anxiety disorders, and substance use disorders, \u2018insomnia\u2019 was associated with 1.71 times higher odds of suicidal behavior among MDD patients admitted to the hospital. (Odds ratio: 1.71, 95% confidence interval 1.60\u20131.82, p &lt; 0.001). Conclusions. Insomnia among MDD patients is significantly associated with the risk of suicide. MDD patients with insomnia need to be closely monitored for suicidal behavior.<\/jats:p>","DOI":"10.3390\/bs12050117","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T22:07:26Z","timestamp":1650406046000},"page":"117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does Insomnia Increase the Risk of Suicide in Hospitalized Patients with Major Depressive Disorder? A Nationwide Inpatient Analysis from 2006 to 2015"],"prefix":"10.3390","volume":"12","author":[{"given":"Zeeshan","family":"Mansuri","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-1465","authenticated-orcid":false,"given":"Abhishek","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramu","family":"Vadukapuram","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounica","family":"Thootkur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chintan","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Science Center at Permian Basin, Odessa, TX 79763, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref_1","unstructured":"(2021, May 27). 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