{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:31:58Z","timestamp":1760243518681,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology","award":["UIDB\/04527\/2020","UIDP\/04527\/2020","SFRH\/BD\/44515\/2008"],"award-info":[{"award-number":["UIDB\/04527\/2020","UIDP\/04527\/2020","SFRH\/BD\/44515\/2008"]}]},{"name":"the Portuguese Foundation for Science and Technology (FCT)","award":["UIDB\/04527\/2020","UIDP\/04527\/2020","SFRH\/BD\/44515\/2008"],"award-info":[{"award-number":["UIDB\/04527\/2020","UIDP\/04527\/2020","SFRH\/BD\/44515\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>The advances in knowledge about the association between personality and neuropathology in Alzheimer\u2019s disease have been highlighted. This research is oriented to the evaluation of personality changes in the screening of axis II personality disorders in Alzheimer\u2019s disease. The investigation was managed with four groups to whom were applied the PDQ-4+ in individual interviews. Some results are in line with the state-of-the-art review and we also provide new research data. A higher global personality disorder index and greater incidence of clusters C (anxious) and A (odd\/eccentric) are confirmed as personality changes. Interpretive possibilities of the data and their implications for the study of psychopathology changes in Alzheimer\u2019s disease are discussed.<\/jats:p>","DOI":"10.3390\/bs12110418","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T23:45:00Z","timestamp":1667087100000},"page":"418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychopathology Changes in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Joana","family":"Henriques-Calado","sequence":"first","affiliation":[{"name":"Faculdade de Psicologia, Universidade de Lisboa, Alameda da Universidade, 1649-013 Lisboa, Portugal"},{"name":"CICPSI, Faculdade de Psicologia, Universidade de Lisboa, Alameda da Universidade, 1649-013 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopsych.2021.08.021","article-title":"Personality associations with amyloid and tau: Results from the baltimore longitudinal study of aging and meta-analysis","volume":"15","author":"Terracciano","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref_2","first-page":"410","article-title":"Behavioural problems and personality change related to cerebral amyloid angiopathy","volume":"39","author":"Gahr","year":"2012","journal-title":"Psychiatr. Prax."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.paid.2012.08.035","article-title":"Personality features and cognitive level in patients at an early stage of Alzheimer\u00b4s disease","volume":"54","author":"Pocnet","year":"2013","journal-title":"Pers. Individ. Differ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpsychires.2016.12.024","article-title":"Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer\u2019s disease pathology","volume":"90","author":"Antonietti","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1212\/WNL.0000000000001777","article-title":"Midlife personality and risk of Alzheimer disease and distress: A 38-year follow-up","volume":"85","author":"Caselli","year":"2015","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/NMD.0000000000000264","article-title":"Personality and dementia","volume":"203","author":"Cipriani","year":"2015","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1037\/a0021377","article-title":"Personality and risk for Alzheimer\u2019s disease in adults 72 years of age and older: A 6-year follow-up","volume":"26","author":"Duberstein","year":"2010","journal-title":"Psychol. Aging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/geronb\/62.6.P353","article-title":"The power of personality in discriminating between healthy aging and early-stage Alzheimer\u2019s disease","volume":"62","author":"Duchek","year":"2007","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jad.2018.08.004","article-title":"Depressive vulnerability in women with Alzheimer\u2019s disease: Relationship with personality traits and abnormal personality dimensions","volume":"241","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.paid.2017.01.001","article-title":"Anaclitic personality dimension in women with Alzheimer\u2019s disease: Comparison with control groups","volume":"109","year":"2017","journal-title":"Pers. Individ. Differ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.paid.2016.06.024","article-title":"Personality traits in women with Alzheimer\u2019s disease: Comparisons with control groups with the NEO-FFI","volume":"101","year":"2016","journal-title":"Pers. Individ. Differ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/13607861003713208","article-title":"The relationship between pre-morbid personality and challenging behaviour in people with dementia: A systematic review","volume":"14","author":"Osborne","year":"2010","journal-title":"Aging Ment. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/070674371105600704","article-title":"Personality changes in patients with beginning Alzheimer disease","volume":"56","author":"Pocnet","year":"2011","journal-title":"Can. J. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/gps.3822","article-title":"Personality traits and behavioral and psychological symptoms in patients at an early stage of Alzheimer\u00b4s disease","volume":"28","author":"Pocnet","year":"2012","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2012.08.008","article-title":"Personality and resilience to Alzheimer\u2019s disease neuropathology: A prospective autopsy study","volume":"34","author":"Terracciano","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jalz.2013.03.002","article-title":"Personality and risk of Alzheimer\u2019s disease: New data and meta-analysis","volume":"10","author":"Terracciano","year":"2014","journal-title":"Alzheimers Dement."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainresbull.2009.07.004","article-title":"The impact of personality characteristics on the clinical expression in neurodegenerative disorders: A review","volume":"80","author":"Pocnet","year":"2009","journal-title":"Brain Res. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/gps.2655","article-title":"Personality changes in Alzheimer\u2019s disease: A systematic review","volume":"26","author":"Wahlin","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/geronb\/60.2.P98","article-title":"Personality change precedes clinical diagnosis of dementia of the Alzheimer type","volume":"60","author":"Balsis","year":"2005","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/jnnp-2012-304479","article-title":"Alzheimer\u2019s disease: Charting the crossroads between neurology and psychology","volume":"85","author":"Gilbert","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_21","first-page":"227","article-title":"Particularit\u00e9s s\u00e9miologiques des synpt\u00f4mes comportamentaux et psycholoqiques de la d\u00e9mence en fonction de la personalit\u00e9 ant\u00e9rieure, de l\u00e9nvironnement familial et de la s\u00e9v\u00e9rit\u00e9 de la d\u00e9mence. Role of personality, familial environment, and severity of the disease on the behavioral and psychological symptoms of dementia","volume":"4","author":"Auguste","year":"2006","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"ref_22","first-page":"129","article-title":"\u00c9v\u00e9nements de vie, personnalit\u00e9 et d\u00e9mence. Life events, personality and dementia","volume":"1","author":"Clement","year":"2003","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0006-3223(02)01336-7","article-title":"Comorbid psychiatric disorders in late life","volume":"52","author":"Devenand","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jnnp-2012-302755","article-title":"Feelings of loneliness, but not social isolation, predict dementia onset: Results from the Amsterdam study of the elderly (AMSTEL)","volume":"85","author":"Holwerda","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1300\/J018v26n03_07","article-title":"Determinants of behavioral symptoms in dementia patients","volume":"26","author":"Kunik","year":"2003","journal-title":"Clin. Gerontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1192\/apt.bp.107.003897","article-title":"Personality disorder in older people: How common is it and what can be done?","volume":"14","author":"Mordekar","year":"2008","journal-title":"Adv. Psychiatr. Treat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/gps.2345","article-title":"Are abnormal premorbid personality traits associated with Alzheimer\u2019s disease?","volume":"25","author":"Nicholas","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-clinpsy-090310-120435","article-title":"Personality disorders in later life: Questions about the measurement, course, and impact of disorders","volume":"7","author":"Oltmanns","year":"2011","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_29","first-page":"12","article-title":"Psychodynamic perspectives on Alzheimer\u00b4s disease and related dementias","volume":"6","author":"Sadavoy","year":"1991","journal-title":"Am. J. Alzheimer\u2019s Care Relat. Disord. Res."},{"key":"ref_30","unstructured":"Segal, D.L., Coolidge, F.L., and Rosowsky, E. (2006). Personality Disorders and Older Adults: Diagnosis, Assessment, and Treatment, Wiley."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1192\/bjp.161.3.344","article-title":"Assessment of DSM-II-R personality disorders by self-report questionnaire: The role of informants and a screening test for co-morbid personality disorders (STCPD)","volume":"161","author":"Dowson","year":"1992","journal-title":"Br. J. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/WAD.0b013e31826e5504","article-title":"Big 5 personality changes in Greek bvFTD, AD, and MCI patients","volume":"27","author":"Lykou","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1212\/01.WNL.0000041497.07694.D2","article-title":"Double dissociation of social functioning in frontotemporal dementia","volume":"60","author":"Rankin","year":"2003","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/WAD.0000000000000030","article-title":"Personality changes in dementia: Are they disease specific and universal?","volume":"28","author":"Torrente","year":"2014","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_35","first-page":"922","article-title":"Trajectories of personality traits preceding dementia diagnosis","volume":"72","author":"Yoneda","year":"2017","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/geronb\/gby034","article-title":"Increases in neuroticism may be an early indicator of dementia: A coordinated analysis","volume":"14","author":"Yoneda","year":"2020","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Hyler, S.E. (1994). The Personality Diagnostic Questionnaire, New York State Psychiatric Institute.","DOI":"10.1037\/t07759-000"},{"key":"ref_38","unstructured":"American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [4th ed.]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1207\/S15327752JPA8101_03","article-title":"Correspondence among observer ratings of Rorschach, Big Five Model, and DSM-IV personality disorder constructs","volume":"81","author":"Mihura","year":"2003","journal-title":"J. Pers. Assess"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archpsyc.1990.01810180027005","article-title":"Diagnosing personality disorders in the community: A comparison of self-report and interview measures","volume":"47","author":"Zimmerman","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_41","unstructured":"Bagby, R.M., and Farvolden, P. (2004). The Personality Diagnostic Questionnaire-4+ (PDQ-4+). Comprehensive Handbook of Psychological Assessment: Personality Assessment, John Wiley."},{"key":"ref_42","unstructured":"Alzheimer Europe (2022, September 01). The Ethics of Dementia Research. Available online: http:\/\/www.alzheimer-europe.org\/OEN\/Ethics\/Ethical-issues-in-practice\/Ethics-of-dementia-research."},{"key":"ref_43","unstructured":"World Health Organization (2022, September 01). The ICD-10 Classification of Mental and Behavioral Disorders: Diagnostic Criteria for Research. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/37108."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Forces on Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref_45","unstructured":"Cohen, J. (1998). Statistical Power Analysis for the Behavioral Sciences, Routledge."}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/12\/11\/418\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:05:04Z","timestamp":1760144704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/12\/11\/418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["bs12110418"],"URL":"https:\/\/doi.org\/10.3390\/bs12110418","relation":{},"ISSN":["2076-328X"],"issn-type":[{"type":"electronic","value":"2076-328X"}],"subject":[],"published":{"date-parts":[[2022,10,28]]}}}