{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:40:58Z","timestamp":1781322058202,"version":"3.54.1"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"E-015 institutional program (ISSSTE)","award":["056.2014"],"award-info":[{"award-number":["056.2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Background: Major depressive disorder (MDD) is a mood disorder with a high prevalence worldwide that causes disability and, in some cases, suicide. Although environmental factors play a crucial role in this disease, other biological factors may predispose individuals to MDD. Genetic and environmental factors influence mental disorders; therefore, a potential combined effect of MAO-A\/MAO-B gene variants may be a target for the study of susceptibility to MDD. This study aimed to evaluate the effects of MAO-A and -B gene variants when combined with adverse childhood experiences (ACEs) on the susceptibility and severity of symptoms in MDD. Methods: A case-control study was performed, including 345 individuals, 175 MDD cases and 170 controls. Genotyping was performed using real-time PCR with hydrolysis probes. The analysis of the rs1465107 and rs1799836 gene variants of MAO-A and -B, respectively, was performed either alone or in combination with ACEs on the severity of depression, as determined through specific questionnaires, including DSM-IV diagnostic criteria for MDD. Results: According to individual effects, the presence of ACEs, as well as the allele G of the rs1465107 of MAO-A, is associated with a higher severity of depression, more significantly in females. Furthermore, the allele rs1799836 G of MAO-B was associated with the severity of depression, even after being adjusted by gene variants and ACEs (IRR = 1.67, p = 0.01). In males, the allele rs1799836 G of MAO-B was shown to interact with SNP with ACEs (IRR = 1.70, p &lt; 0.001). According to combined effect analyses, the severity of depression was associated with ACEs when combined with either allele rs1465107 of MAO-A or allele rs17993836 of MAO-B, whereas SNP risk association was influenced by gender. Conclusions: The severity of depression is related to either individual or combined effects of temperamental traits and genetic susceptibility of specific genes such as MAO-A and MAO-B.<\/jats:p>","DOI":"10.3390\/bs13100795","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:45:23Z","timestamp":1695699923000},"page":"795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Individual and Combined Effect of MAO-A\/MAO-B Gene Variants and Adverse Childhood Experiences on the Severity of Major Depressive Disorder"],"prefix":"10.3390","volume":"13","author":[{"given":"Christian Gabriel","family":"Toledo-Lozano","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-6754","authenticated-orcid":false,"given":"Luz Berenice","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Life Cycle Department, Autonomous University of Guadalajara, Zapopan 45129, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Su\u00e1rez-Cuenca","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-025X","authenticated-orcid":false,"given":"Luis","family":"Villalobos-Gallegos","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Psicolog\u00eda, Universidad Aut\u00f3noma de Baja California, Tijuana 22390, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce Ade\u00ed","family":"Jim\u00e9nez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda Lizeth","family":"Alcaraz-Estrada","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mondrag\u00f3n-Ter\u00e1n","sequence":"additional","affiliation":[{"name":"Coordination of Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Joya-Laureano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n Mauricio","family":"Coral-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Teaching and Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"},{"name":"Postgraduate Section, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-3150","authenticated-orcid":false,"given":"Silvia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuron.2019.03.022","article-title":"Uncovering the Genetic Architecture of Major Depression","volume":"102","author":"McIntosh","year":"2019","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lung, F.-W., Tzeng, D.-S., Huang, M.-F., and Lee, M.-B. (2011). Association of the MAOA Promoter UVNTR Polymorphism with Suicide Attempts in Patients with Major Depressive Disorder. BMC Med. Genet., 12.","DOI":"10.1186\/1471-2350-12-74"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jad.2022.01.103","article-title":"Predictors of Suicidal Ideation, Suicide Attempt and Suicide Death among People with Major Depressive Disorder: A Systematic Review and Meta-Analysis of Cohort Studies","volume":"302","author":"Li","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/da.22499","article-title":"Glucocorticoid Receptor-Related Genes: Genotype and Brain Gene Expression Relationships to Suicide and Major Depressive Disorder","volume":"33","author":"Yin","year":"2016","journal-title":"Depress. Anxiety"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Castro Gon\u00e7alves, A.B., Ferreira Fratelli, C., Saraiva Siqueira, J.W., Canongia de Abreu Cardoso Duarte, L., Ribeiro Barros, A., Possatti, I., Lima dos Santos, M., de Souza Silva, C.M., and Rodrigues da Silva, I.C. (2022). MAOA UVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review. Cells, 11.","DOI":"10.3390\/cells11203267"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fernandez-Pujals, A.M., Adams, M.J., Thomson, P., McKechanie, A.G., Blackwood, D.H.R., Smith, B.H., Dominiczak, A.F., Morris, A.D., Matthews, K., and Campbell, A. (2015). Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS). PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142197"},{"key":"ref_7","first-page":"354","article-title":"Psychosocial Aspects of Resistance in Complex Treatment of Depressive Disorder","volume":"36","author":"Sedlackova","year":"2015","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ortiz-S\u00e1nchez, F.A., Brambila-Tapia, A.J.L., C\u00e1rdenas-Fujita, L.S., Toledo-Lozano, C.G., Samudio-Cruz, M.A., G\u00f3mez-D\u00edaz, B., Garc\u00eda, S., Rodr\u00edguez-Arellano, M.E., Zamora-Gonz\u00e1lez, E.O., and L\u00f3pez-Hern\u00e1ndez, L.B. (2023). Family Functioning and Suicide Attempts in Mexican Adolescents. Behav. Sci., 13.","DOI":"10.3390\/bs13020120"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fpsyt.2015.00042","article-title":"Childhood Maltreatment, Depression, and Suicidal Ideation: Critical Importance of Parental and Peer Emotional Abuse during Developmental Sensitive Periods in Males and Females","volume":"6","author":"Khan","year":"2015","journal-title":"Front. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neubiorev.2019.04.010","article-title":"Stress, Epigenetics and Depression: A Systematic Review","volume":"102","author":"Park","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/archpsyc.63.11.1209","article-title":"Elevated Monoamine Oxidase A Levels in the Brain","volume":"63","author":"Meyer","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41398-023-02506-2","article-title":"Impact of Genetic Variants within Serotonin Turnover Enzymes on Human Cerebral Monoamine Oxidase A in Vivo","volume":"13","author":"Spies","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1086\/302562","article-title":"Monoamine Oxidase in Neuropsychiatry and Behavior","volume":"65","author":"Shih","year":"1999","journal-title":"Am. J. Human. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00702-014-1362-4","article-title":"Modulation of Monoamine Oxidase (MAO) Expression in Neuropsychiatric Disorders: Genetic and Environmental Factors Involved in Type A MAO Expression","volume":"123","author":"Naoi","year":"2016","journal-title":"J. Neural Transm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3389\/fphar.2016.00340","article-title":"Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology","volume":"7","author":"Finberg","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2014.06.005","article-title":"Life without Brain Serotonin: Reevaluation of Serotonin Function with Mice Deficient in Brain Serotonin Synthesis","volume":"277","author":"Mosienko","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine Oxidase Inactivation: From Pathophysiology to Therapeutics","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/B978-0-12-386467-3.00002-9","article-title":"Behavioral Outcomes of Monoamine Oxidase Deficiency: Preclinical and Clinical Evidence","volume":"100","author":"Bortolato","year":"2011","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"112476","DOI":"10.1016\/j.bbr.2020.112476","article-title":"Monoamine Oxidase A Genotype and Methylation Moderate the Association of Maltreatment and Aggressive Behaviour","volume":"382","author":"Checknita","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.biopsych.2010.06.004","article-title":"A Cis-Phase Interaction Study of Genetic Variants Within the MAOA Gene in Major Depressive Disorder","volume":"68","author":"Zhang","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3390\/cimb43020045","article-title":"The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia","volume":"43","author":"Madzarac","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Konjevod, M., Sreter, K.B., Popovic-Grle, S., Lampalo, M., Tudor, L., Jukic, I., Nedic Erjavec, G., Bingulac-Popovic, J., Safic Stanic, H., and Nikolac Perkovic, M. (2023). Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13.","DOI":"10.3390\/biom13050800"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"852949","DOI":"10.5402\/2012\/852949","article-title":"Monoamine Oxidase A and B Gene Polymorphisms and Negative and Positive Symptoms in Schizophrenia","volume":"2012","author":"Camarena","year":"2012","journal-title":"ISRN Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/YCO.0b013e32833ad79b","article-title":"Childhood Adversities of Populations Living in Low-Income Countries: Prevalence, Characteristics, and Mental Health Consequences","volume":"23","author":"Benjet","year":"2010","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bja.2023.03.008","article-title":"The Effect of Adverse Childhood Experiences on Chronic Pain and Major Depression in Adulthood: A Systematic Review and Meta-Analysis","volume":"130","author":"Antoniou","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archgenpsychiatry.2009.186","article-title":"Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I","volume":"67","author":"Green","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/YPG.0b013e32834f3577","article-title":"Association of Serotonin Transporter Gene Polymorphism 5-HTTLPR and Depressive Disorder in a Mexican Population","volume":"22","author":"Gonzales","year":"2012","journal-title":"Psychiatr. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/brb3.220","article-title":"BDNF Met66 Modulates the Cumulative Effect of Psychosocial Childhood Adversities on Major Depression in Adolescents","volume":"4","author":"Benjet","year":"2014","journal-title":"Brain Behav."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2011.12.040","article-title":"Depression, Gender, and the Treatment Gap in Mexico","volume":"138","author":"Rafful","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_30","first-page":"975","article-title":"Apolipoprotein E Polymorphism in the Indian and Mestizo Populations of Mexico","volume":"72","author":"Gamboa","year":"2000","journal-title":"Hum. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0025-7753(02)72429-9","article-title":"Validaci\u00f3n de Las Versiones En Espa\u00f1ol de La Montgomery-Asberg Depression Rating Scale y La Hamilton Anxiety Rating Scale Para La Evaluaci\u00f3n de La Depresi\u00f3n y de La Ansiedad","volume":"118","author":"Lobo","year":"2002","journal-title":"Med. Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/0706743718772516","article-title":"Cross-Cultural Psychometric Properties of the Hamilton Depression Rating Scale","volume":"64","author":"Vindbjerg","year":"2019","journal-title":"Can. J. Psychiatry"},{"key":"ref_33","first-page":"298","article-title":"A Fast Method for High-Quality Genomic DNA Extraction from Whole Human Blood","volume":"11","author":"Gustincich","year":"1991","journal-title":"Biotechniques"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fpsyt.2020.00038","article-title":"Association between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients","volume":"11","author":"Losenkov","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2830","DOI":"10.1002\/hup.2830","article-title":"Role of Serotonin Transporter and Receptor Gene Polymorphisms in Treatment Response to Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder","volume":"37","author":"Ramesh","year":"2022","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fphar.2019.01462","article-title":"Limited Associations between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression","volume":"10","author":"Ochi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/13651501.2014.894073","article-title":"Lack of Influence of Rs4680 (COMT) and Rs6276 (DRD2) on Diagnosis and Clinical Outcomes in Patients with Major Depression","volume":"18","author":"Chiesa","year":"2014","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1192\/bjp.bp.111.093328","article-title":"Moderating Role of the MAOA Genotype in Antisocial Behaviour","volume":"200","author":"Fergusson","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"ref_39","first-page":"582","article-title":"The Long Reach of Early Adversity: Parenting, Stress, and Neural Pathways to Antisocial Behavior in Adulthood","volume":"2","author":"Gard","year":"2017","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1017\/S0954579407000600","article-title":"Interactions of Child Maltreatment and Serotonin Transporter and Monoamine Oxidase A Polymorphisms: Depressive Symptomatology among Adolescents from Low Socioeconomic Status Backgrounds","volume":"19","author":"Cicchetti","year":"2007","journal-title":"Dev. Psychopathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1037\/a0018074","article-title":"Child Maltreatment Moderates the Association of MAOA with Symptoms of Depression and Antisocial Personality Disorder","volume":"24","author":"Beach","year":"2010","journal-title":"J. Fam. Psychol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41398-020-0706-0","article-title":"Genomic Influences on Self-Reported Childhood Maltreatment","volume":"10","author":"Dalvie","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s007020070075","article-title":"Platelet Monoamine Oxidase Activity Is Related to MAOB Intron 13 Genotype","volume":"107","author":"Garpenstrand","year":"2000","journal-title":"J. Neural Transm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1600-0447.1987.tb02818.x","article-title":"Le Platelet MAO Activity in Clinical Subtypes of Depression and DST Suppression","volume":"75","author":"Poirier","year":"1987","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00422413","article-title":"Increased Platelet Monoamine Oxidase Activity in Affective Disorders","volume":"73","author":"Reveley","year":"1981","journal-title":"Psychopharmacology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-0447.2000.101003226.x","article-title":"Decreased Platelet Monoamine Oxidase Activity in Female Anorexia Nervosa","volume":"101","author":"Carrasco","year":"2000","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00702-017-1709-8","article-title":"Type A Monoamine Oxidase and Serotonin Are Coordinately Involved in Depressive Disorders: From Neurotransmitter Imbalance to Impaired Neurogenesis","volume":"125","author":"Naoi","year":"2018","journal-title":"J. Neural Transm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1567205018666210917162843","article-title":"Association of the MAOB Rs1799836 Single Nucleotide Polymorphism and APOE \u03954 Allele in Alzheimer\u2019s Disease","volume":"18","author":"Leko","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/00207454.2015.1028057","article-title":"A Meta-Analysis on Relationship of MAOB Intron 13 Polymorphisms, Interactions with Smoking\/COMT H158L Polymorphisms with the Risk of PD","volume":"126","author":"Zhang","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ajhg.2013.03.017","article-title":"EXclusion: Toward Integrating the X Chromosome in Genome-Wide Association Analyses","volume":"92","author":"Wise","year":"2013","journal-title":"Am. J. Hum. Genet."}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/13\/10\/795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:58:08Z","timestamp":1760129888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/13\/10\/795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["bs13100795"],"URL":"https:\/\/doi.org\/10.3390\/bs13100795","relation":{},"ISSN":["2076-328X"],"issn-type":[{"value":"2076-328X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]}}}