{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:05:01Z","timestamp":1790730301158,"version":"4.1.0"},"reference-count":121,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONAHCYT","award":["4004794"],"award-info":[{"award-number":["4004794"]}]},{"name":"EPM program","award":["4004794"],"award-info":[{"award-number":["4004794"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Unsatisfactory sleep is a worldwide concern, as evidenced by the high prevalence of insomnia symptoms and diagnosis in the general population, and an issue that has also risen among adolescents. These circumstances are a cause of worry due to, among other factors, the observed bidirectional association of sleep disturbances and the risk of substance use disorder development. In this regard, across the globe, several reports indicate that substance consumption is at an all-time high, with alcohol, nicotine, and cannabis leading the charts. Additionally, the age of onset has dropped, with reports suggesting that first contact is usually during adolescence. Although the nature of the link between poor sleep and substance use disorder development is still not fully understood, it is possible that an overactive orexinergic system could play a role, as it has been observed that treatment with orexinergic antagonists improves insomnia symptoms and that postmortem studies show an increase in orexin immunoreactive neurons in sections obtained from habitual opioid consumers. We further argue that it is during adolescence that this maladaptive loop can be established, priming for the development of substance use disorders.<\/jats:p>","DOI":"10.3390\/bs15020220","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T04:40:25Z","timestamp":1739767225000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sleep Loss and Substance Use Disorders: An Issue from Adolescents to Adults"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-5278","authenticated-orcid":false,"given":"Ana Clementina","family":"Equihua-Ben\u00edtez","sequence":"first","affiliation":[{"name":"Biology Sleep Laboratory, Biomedicine Department, Health Sciences Institute, Veracruzana University, Xalapa 91190, Ver, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2580-1353","authenticated-orcid":false,"given":"Rodolfo","family":"Espinoza-Abad","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Health Sciences Institute, Veracruzana University, Xalapa 91190, Ver, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-9845","authenticated-orcid":false,"given":"Fabio","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Biology Sleep Laboratory, Biomedicine Department, Health Sciences Institute, Veracruzana University, Xalapa 91190, Ver, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"ref_1","unstructured":"American Academy of Sleep Medicine (2025, February 11). AASM sleep prioritization survey chronic insomnia, Available online: https:\/\/aasm.org\/wp-content\/uploads\/2024\/06\/sleep-prioritization-survey-2024-chronic-insomnia.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.alcohol.2020.06.003","article-title":"Adolescent alcohol exposure increases orexin-A\/hypocretin-1 in the anterior hypothalamus","volume":"88","author":"Amodeo","year":"2020","journal-title":"Alcohol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"171280","DOI":"10.1016\/j.peptides.2024.171280","article-title":"Orexin-mediated motivated arousal and reward seeking","volume":"180","author":"Bjorness","year":"2024","journal-title":"Peptides"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nn.3177","article-title":"Decision-making in the adolescent brain","volume":"15","author":"Blakemore","year":"2012","journal-title":"Nature Neuroscience"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.smrv.2009.05.002","article-title":"Hyperarousal and insomnia: State of the science","volume":"14","author":"Bonnet","year":"2010","journal-title":"Sleep Medicine Reviews"},{"key":"ref_6","first-page":"110","article-title":"Alcohol\u2019s effects on sleep in alcoholics","volume":"25","author":"Brower","year":"2001","journal-title":"Alcohol Research & Health: The Journal of the National Institute on Alcohol Abuse and Alcoholism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1087-0792(03)90005-0","article-title":"Insomnia, alcoholism and relapse","volume":"7","author":"Brower","year":"2003","journal-title":"Sleep Medicine Reviews"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.20882\/adicciones.78","article-title":"Relaciones entre el sue\u00f1o y la adicci\u00f3n","volume":"24","year":"2012","journal-title":"Adicciones"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neubiorev.2016.06.044","article-title":"Orexin, stress and central cardiovascular control. A link with hypertension?","volume":"74","author":"Carrive","year":"2017","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1196\/annals.1440.010","article-title":"The Adolescent Brain","volume":"1124","author":"Casey","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/acer.13217","article-title":"Alcohol dependence and its relationship with insomnia and other sleep disorders","volume":"40","author":"Chakravorty","year":"2016","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1073\/pnas.1418490112","article-title":"Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness","volume":"112","author":"Chang","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1556\/2006.8.2019.65","article-title":"Increase of orexin A in the peripheral blood of adolescents with Internet gaming disorder","volume":"9","author":"Choi","year":"2020","journal-title":"Journal of Behavioral Addictions"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Collier, A. D., Yasmin, N., Chang, G., Karatayev, O., Khalizova, N., Fam, M., Abdulai, A. R., Yu, B., and Leibowitz, S. F. (2022). Embryonic ethanol exposure induces ectopic Hcrt and MCH neurons outside hypothalamus in rats and zebrafish: Role in ethanol\u2014Induced behavioural disturbances. Addiction Biology, 27, (6).","DOI":"10.1111\/adb.13238"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Crowley, S. J., Van Reen, E., LeBourgeois, M. K., Acebo, C., Tarokh, L., Seifer, R., Barker, D. H., and Carskadon, M. A. (2014). A longitudinal assessment of sleep timing, circadian phase, and phase angle of entrainment across human adolescence. PLoS ONE, 9, (11).","DOI":"10.1371\/journal.pone.0112199"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.adolescence.2018.06.001","article-title":"An update on adolescent sleep: New evidence informing the perfect storm model","volume":"67","author":"Crowley","year":"2018","journal-title":"Journal of Adolescence"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.sleep.2024.11.002","article-title":"Insomnia disorder is associated with 24-h cortical hyperarousal","volume":"124","author":"Dai","year":"2024","journal-title":"Sleep Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ncl.2012.08.012","article-title":"Insomnia","volume":"30","author":"Deak","year":"2012","journal-title":"Neurologic Clinics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2011.03.029","article-title":"Aspects of the narcolepsy-cataplexy syndrome in O\/E3-null mutant mice","volume":"183","author":"Vidaltamayo","year":"2011","journal-title":"Neuroscience"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"Kilduff","year":"1998","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.smrv.2017.06.009","article-title":"Insomnia disorder in adolescence: Diagnosis, impact, and treatment","volume":"39","author":"Goldstone","year":"2018","journal-title":"Sleep Medicine Reviews"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173274","DOI":"10.1016\/j.pbb.2021.173274","article-title":"Sleep, psychiatric and socioeconomic factors associated with substance use in a large population sample: A cross-sectional study","volume":"210","author":"Fernandes","year":"2021","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"173014","DOI":"10.1016\/j.pbb.2020.173014","article-title":"Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats","volume":"197","author":"Tufik","year":"2020","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101588","DOI":"10.1016\/j.smrv.2022.101588","article-title":"HPA axis activity in patients with chronic insomnia: A systematic review and meta-analysis of case\u2013control studies","volume":"62","author":"Dressle","year":"2022","journal-title":"Sleep Medicine Reviews"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13928","DOI":"10.1111\/jsr.13928","article-title":"Hyperarousal in insomnia disorder: Current evidence and potential mechanisms","volume":"32","author":"Dressle","year":"2023","journal-title":"Journal of Sleep Research"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/16066359.2022.2074406","article-title":"Persistent sleep problems among people in recovery from substance use disorders: A mixed methods study","volume":"30","author":"Erga","year":"2022","journal-title":"Addiction Research & Theory"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001","article-title":"Fos expression in orexin neurons varies with behavioral state","volume":"21","author":"Estabrooke","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.5665\/sleep.5746","article-title":"Insomnia is associated with cortical hyperarousal as early as adolescence","volume":"39","author":"Li","year":"2016","journal-title":"Sleep"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1177\/1477153515584979","article-title":"Self-luminous devices and melatonin suppression in adolescents","volume":"48","author":"Figueiro","year":"2016","journal-title":"Lighting Research & Technology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.biopsych.2013.06.012","article-title":"The Hypocretin\/Orexin Receptor-1 as a Novel Target to Modulate Cannabinoid Reward","volume":"75","author":"Flores","year":"2014","journal-title":"Biological Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Flores-Ramirez, F. J., Illenberger, J. M., Pascasio, G. E., Matzeu, A., Mason, B. J., and Martin-Fardon, R. (2022). Alternative use of suvorexant (Belsomra\u00ae) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence. Frontiers in Behavioral Neuroscience, 16.","DOI":"10.3389\/fnbeh.2022.1085882"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e12946","DOI":"10.1111\/adb.12946","article-title":"Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system","volume":"26","author":"Fragale","year":"2021a","journal-title":"Addiction Biology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000514965","article-title":"The insomnia-addiction positive feedback loop: Role of the orexin system","volume":"45","author":"Fragale","year":"2021b","journal-title":"The Orexin System. Basic Science and Role in Sleep Pathology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.tics.2015.07.008","article-title":"Adolescence as a sensitive period of brain development","volume":"19","author":"Fuhrmann","year":"2015","journal-title":"Trends in Cognitive Sciences"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Galan-Lopez, P., Dom\u00ednguez, R., G\u00edslad\u00f3ttir, T., S\u00e1nchez-Oliver, A. J., Pihu, M., Ries, F., and Klonizakis, M. (2021). Sleep quality and duration in european adolescents (the adoleshealth study): A cross-sectional, quantitative study. Children, 8, (3).","DOI":"10.3390\/children8030188"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/ajad.12291","article-title":"Polysomnographic sleep disturbances in nicotine, caffeine, alcohol, cocaine, opioid, and cannabis use: A focused review","volume":"24","author":"Garcia","year":"2015","journal-title":"The American Journal on Addictions"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.jadohealth.2020.03.013","article-title":"How are adolescents sleeping? Adolescent sleep patterns and sociodemographic differences in 24 european and north american countries","volume":"66","author":"Gariepy","year":"2020","journal-title":"Journal of Adolescent Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41562-020-0820-2","article-title":"Interplay of chronotype and school timing predicts school performance","volume":"4","author":"Goldin","year":"2020","journal-title":"Nature Human Behaviour"},{"key":"ref_39","first-page":"1","article-title":"Differential Effects of addictive drugs on sleep and sleep stages","volume":"3","author":"Gordon","year":"2019","journal-title":"Journal of Addiction Research"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.sleep.2010.11.008","article-title":"Recent worldwide sleep patterns and problems during adolescence: A review and meta-analysis of age, region, and sleep","volume":"12","author":"Gradisar","year":"2011","journal-title":"Sleep Medicine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41386-022-01404-3","article-title":"Sleep disturbance in substance use disorders: The orexin (hypocretin) system as an emerging pharmacological target","volume":"48","author":"Gyawali","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000216538","article-title":"Adolescent changes in the homeostatic and circadian regulation of sleep","volume":"31","author":"Hagenauer","year":"2009","journal-title":"Developmental Neuroscience"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/acer.14808","article-title":"Self-reported sleep and circadian characteristics predict alcohol and cannabis use: A longitudinal analysis of the national consortium on alcohol and neurodevelopment in adolescence study","volume":"46","author":"Hasler","year":"2022","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-017-0010-2","article-title":"Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies","volume":"3","author":"Hatori","year":"2017","journal-title":"Npj Aging and Mechanisms of Disease"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"zsx202","DOI":"10.1093\/sleep\/zsx202","article-title":"Beyond sleep duration: Bidirectional associations among chronotype, social jetlag, and drinking behaviors in a longitudinal sample of US high school students","volume":"41","author":"Haynie","year":"2018","journal-title":"Sleep"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hisler, G. C., Dickinson, D. L., Bruce, S. A., and Hasler, B. P. (2023). Preliminary evidence that misalignment between sleep and circadian timing alters risk\u2014Taking preferences. Journal of Sleep Research, 32, (2).","DOI":"10.1111\/jsr.13728"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"eabn8238","DOI":"10.1126\/scitranslmed.abn8238","article-title":"Suvorexant ameliorated sleep disturbance, opioid withdrawal, and craving during a buprenorphine taper","volume":"14","author":"Huhn","year":"2022","journal-title":"Science Translational Medicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.biopsych.2022.06.027","article-title":"Orexin reserve: A mechanistic framework for the role of orexins (hypocretins) in addiction","volume":"92","author":"James","year":"2022","journal-title":"Biological Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41386-020-0619-x","article-title":"Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: Why sleep on this any longer?","volume":"45","author":"James","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.biopsych.2018.07.022","article-title":"Increased number and activity of a lateral subpopulation of hypothalamic orexin\/hypocretin neurons underlies the expression of an addicted state in rats","volume":"85","author":"James","year":"2019","journal-title":"Biological Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00429-021-02449-8","article-title":"Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens","volume":"227","author":"Omrani","year":"2022","journal-title":"Brain Structure and Function"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/sleep\/25.3.337","article-title":"Hypocretin-1 (orexin-A) levels in human lumbar csf in different age groups: Infants to elderly persons","volume":"25","author":"Kanbayashi","year":"2002","journal-title":"Sleep"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Khazaie, H., Sadeghi, M., Khazaie, S., Hirshkowitz, M., and Sharafkhaneh, A. (2022). Dual orexin receptor antagonists for treatment of insomnia: A systematic review and meta-analysis on randomized, double-blind, placebo-controlled trials of suvorexant and lemborexant. Frontiers in Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.1070522"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1183","DOI":"10.1002\/prp2.1183","article-title":"Preclinical metabolism and the disposition of vornorexant\/TS-142, a novel dual orexin 1\/2 receptor antagonist for the treatment of insomnia","volume":"12","author":"Konno","year":"2024","journal-title":"Pharmacology Research & Perspectives"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/15402002.2015.1083022","article-title":"When thinking impairs sleep: Trait, daytime and nighttime repetitive thinking in insomnia","volume":"15","author":"Lancee","year":"2017","journal-title":"Behavioral Sleep Medicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e13553","DOI":"10.1111\/jsr.13553","article-title":"Sleep, substance misuse and addictions: A nationwide observational survey on smoking, alcohol, cannabis and sleep in 12,637 adults","volume":"31","author":"Leger","year":"2022","journal-title":"Journal of Sleep Research"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/08897077.2017.1309935","article-title":"The surgeon general\u2019s facing addiction report: An historic document for health care","volume":"38","author":"Levy","year":"2017","journal-title":"Substance Abuse"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e13817","DOI":"10.1111\/jsr.13817","article-title":"The trajectories and associations of insomnia symptoms with addictive behaviours in adolescents: A two-year longitudinal study","volume":"32","author":"Liu","year":"2023","journal-title":"Journal of Sleep Research"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-neuro-071714-034054","article-title":"An integrative model of the maturation of cognitive control","volume":"38","author":"Luna","year":"2015","journal-title":"Annual Review of Neuroscience"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lund, L., S\u00f8lvh\u00f8j, I. N., Danielsen, D., and Andersen, S. (2021). Electronic media use and sleep in children and adolescents in western countries: A systematic review. BMC Public Health, 21, (1).","DOI":"10.1186\/s12889-021-11640-9"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.sleep.2024.07.034","article-title":"Heart rate variability during sleep onset in patients with insomnia with or without comorbid sleep apnea","volume":"122","author":"Ma","year":"2024","journal-title":"Sleep Medicine"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Maduabuchi, J. C., Obu, H. A., Chukwu, B. F., Ebele, A., Manyike, P. C., and Chinawa, A. T. (2014). Sleep pattern and practice among adolescents school children in Nigerian secondary schools. Pan African Medical Journal, 19.","DOI":"10.11604\/pamj.2014.19.313.4603"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jadohealth.2013.10.201","article-title":"Developmental trends in sleep duration in adolescence and young adulthood: Evidence from a national United States sample","volume":"54","author":"Maslowsky","year":"2014","journal-title":"Journal of Adolescent Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0140-6736(22)00877-7","article-title":"Circadian rhythms and disorders of the timing of sleep","volume":"400","author":"Meyer","year":"2022","journal-title":"The Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias","volume":"59","author":"Mignot","year":"2002","journal-title":"Archives of Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.drugalcdep.2016.08.009","article-title":"The hazards of bad sleep\u2014Sleep duration and quality as predictors of adolescent alcohol and cannabis use","volume":"168","author":"Mike","year":"2016","journal-title":"Drug and Alcohol Dependence"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jadohealth.2016.08.019","article-title":"The prospective association between sleep and initiation of substance use in young adolescents","volume":"60","author":"Miller","year":"2017","journal-title":"Journal of Adolescent Health"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1111\/j.1460-9568.2005.04104.x","article-title":"Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors","volume":"21","author":"Modirrousta","year":"2005","journal-title":"European Journal of Neuroscience"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1111\/bph.17325","article-title":"Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation","volume":"181","author":"Mohammadkhani","year":"2024","journal-title":"British Journal of Pharmacology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1017\/S0033291712002875","article-title":"Sleep deprivation amplifies striatal activation to monetary reward","volume":"43","author":"Mullin","year":"2013","journal-title":"Psychological Medicine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"105591","DOI":"10.1016\/j.clineuro.2019.105591","article-title":"Sleep quality and its association with substance abuse among university students","volume":"188","author":"Vlachou","year":"2020","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/adb.12519","article-title":"Effects of sleep on substance use in adolescents: A longitudinal perspective","volume":"23","author":"Brumback","year":"2018","journal-title":"Addiction Biology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1176\/appi.ajp.161.11.2126","article-title":"Functional neuroimaging evidence for hyperarousal in insomnia","volume":"161","author":"Nofzinger","year":"2004","journal-title":"The American Journal of Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17241\/smr.2011.2.1.1","article-title":"Epidemiological overview of sleep disorders in the general population","volume":"2","author":"Ohayon","year":"2011","journal-title":"Sleep Medicine Research"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e13825","DOI":"10.1111\/jsr.13825","article-title":"Current models of insomnia disorder: A theoretical review on the potential role of the orexinergic pathway with implications for insomnia treatment","volume":"32","author":"Palagini","year":"2023","journal-title":"Journal of Sleep Research"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e12795","DOI":"10.1111\/adb.12795","article-title":"The number of lateral hypothalamus orexin\/hypocretin neurons contributes to individual differences in cocaine demand","volume":"25","author":"Pantazis","year":"2020","journal-title":"Addiction Biology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101100","DOI":"10.1016\/j.dcn.2022.101100","article-title":"Contributions of dopamine-related basal ganglia neurophysiology to the developmental effects of incentives on inhibitory control","volume":"54","author":"Parr","year":"2022","journal-title":"Developmental Cognitive Neuroscience"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.5664\/jcsm.6288","article-title":"Consensus statement of the american academy of sleep medicine on the recommended amount of sleep for healthy children: Methodology and discussion","volume":"12","author":"Paruthi","year":"2016","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Chada, D., Bioch, S. A., Sch\u00f6nfeld, D., Gozal, D., and Perez-Lloret, S. (2023). Screen use, sleep duration, daytime somnolence, and academic failure in school-aged adolescents. PLoS ONE, 18, (2).","DOI":"10.1371\/journal.pone.0281379"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"zsz125","DOI":"10.1093\/sleep\/zsz125","article-title":"Reducing the use of screen electronic devices in the evening is associated with improved sleep and daytime vigilance in adolescents","volume":"42","author":"Perrault","year":"2019","journal-title":"Sleep"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Poudel, A., and Gautam, S. (2017). Age of onset of substance use and psychosocial problems among individuals with substance use disorders. BMC Psychiatry, 17, (1).","DOI":"10.1186\/s12888-016-1191-0"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"13400","DOI":"10.1523\/JNEUROSCI.4332-06.2006","article-title":"Hypocretin\/orexin overexpression induces an insomnia-like phenotype in zebrafish","volume":"26","author":"Prober","year":"2006","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000507573","article-title":"Shiftwork and alcohol consumption: A systematic review of the literature","volume":"27","author":"Richter","year":"2021","journal-title":"European Addiction Research"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Riemann, D., Dressle, R. J., Benz, F., Palagini, L., and Feige, B. (2023). The psychoneurobiology of insomnia: Hyperarousal and rem sleep instability. Clinical and Translational Neuroscience, 7, (4).","DOI":"10.3390\/ctn7040030"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"zsy091","DOI":"10.1093\/sleep\/zsy091","article-title":"Insomnia as a path to alcoholism: Tolerance development and dose escalation","volume":"41","author":"Roehrs","year":"2018","journal-title":"Sleep"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"173153","DOI":"10.1016\/j.pbb.2021.173153","article-title":"Sleep and alertness disturbance and substance use disorders: A bi-directional relation","volume":"203","author":"Roehrs","year":"2021","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41574-023-00851-2","article-title":"How can social jetlag affect health?","volume":"19","author":"Roenneberg","year":"2023","journal-title":"Nature Reviews Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.medcli.2011.07.015","article-title":"Evaluaci\u00f3n de las alteraciones del sue\u00f1o en pacientes drogodependientes hospitalizados","volume":"138","author":"Roncero","year":"2012","journal-title":"Medicina Cl\u00ednica"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"125","DOI":"10.17711\/SM.0185-3325.2022.017","article-title":"Association between screen time exposure, anxiety, and sleep quality in adolescents","volume":"45","author":"Santiago","year":"2022","journal-title":"Salud Mental"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: Hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends in Neurosciences"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.12788\/jfp.0620","article-title":"Insomnia management: A review and update","volume":"72","author":"Shaha","year":"2023","journal-title":"The Journal of Family Practice"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Shi, Y., Ren, R., Lei, F., Zhang, Y., Vitiello, M. V., and Tang, X. (2022). Elevated beta activity in the nighttime sleep and multiple sleep latency electroencephalograms of chronic insomnia patients. Frontiers in Neuroscience, 16.","DOI":"10.3389\/fnins.2022.1045934"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Silvani, M. I., Werder, R., and Perret, C. (2022). The influence of blue light on sleep, performance and wellbeing in young adults: A systematic review. Frontiers in Physiology, 13.","DOI":"10.3389\/fphys.2022.943108"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0193-953X(18)30532-X","article-title":"A behavioral perspective on insomnia treatment","volume":"10","author":"Spielman","year":"1987","journal-title":"The Psychiatric Clinics of North America"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.dr.2007.08.002","article-title":"A social neuroscience perspective on adolescent risk-taking","volume":"28","author":"Steinberg","year":"2008","journal-title":"Developmental Review"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/sleep\/11.1.54","article-title":"Daytime alertness in patients with chronic insomnia compared with asymptomatic control subjects","volume":"11","author":"Stepanski","year":"1988","journal-title":"Sleep"},{"key":"ref_99","unstructured":"Strashny, A. (2014). Age of substance use initiation among treatment admissions aged 18 to 30, Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD. The CBHSQ Report: July 17, 2014."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.peptides.2016.12.008","article-title":"Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms","volume":"88","author":"Tang","year":"2017","journal-title":"Peptides"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"eaao4953","DOI":"10.1126\/scitranslmed.aao4953","article-title":"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy","volume":"10","author":"Thannickal","year":"2018","journal-title":"Science Translational Medicine"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1523\/JNEUROSCI.2492-21.2022","article-title":"Differential dopamine dynamics in adolescents and adults","volume":"42","author":"Toth","year":"2022","journal-title":"The Journal of Neuroscience"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neubiorev.2016.07.030","article-title":"Stress and the adolescent brain","volume":"70","author":"Tottenham","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"803","DOI":"10.5664\/jcsm.7788","article-title":"The treatment of narcolepsy with amphetamine-based stimulant medications: A call for better understanding","volume":"15","author":"Turner","year":"2019","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"ref_106","unstructured":"UNODC. United Nations Office on Drugs and Crime (2023). World drug report 2023, UNODC."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neubiorev.2016.06.037","article-title":"What motivates adolescents? Neural responses to rewards and their influence on adolescents\u2019 risk taking, learning, and cognitive control","volume":"70","author":"Peters","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1037\/dev0001192","article-title":"Sleepless: The developmental significance of sleep quality and quantity among adolescents","volume":"57","author":"Vazsonyi","year":"2021","journal-title":"Developmental Psychology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/wps.21073","article-title":"Substance use disorders: A comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention","volume":"22","author":"Volkow","year":"2023","journal-title":"World Psychiatry"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Wang, Y., Sun, Q., Tang, Q., Zhang, Y., Tang, M., Wang, D., and Wang, Z. (2023). Progress of autonomic disturbances in narcolepsy type 1. Frontiers in Neurology, 14.","DOI":"10.3389\/fneur.2023.1107632"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"85","DOI":"10.15585\/mmwr.mm6703a1","article-title":"Short sleep duration among middle school and high school students\u2014United States, 2015","volume":"67","author":"Wheaton","year":"2018","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"173109","DOI":"10.1016\/j.pbb.2021.173109","article-title":"Sleep time differs among people who co-use cocaine and cannabis compared to people who only use cocaine","volume":"201","author":"Wheeler","year":"2021","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"White, A. M., Eglovitch, M., Parlier-Ahmad, A. B., Dzierzewski, J. M., James, M., Bjork, J. M., Moeller, F. G., and Martin, C. E. (2024). Insomnia symptoms and neurofunctional correlates among adults receiving buprenorphine for opioid use disorder. PLoS ONE, 19, (6).","DOI":"10.1371\/journal.pone.0304461"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.sleep.2008.06.015","article-title":"Childhood sleep problems, early onset of substance use and behavioral problems in adolescence","volume":"10","author":"Wong","year":"2009","journal-title":"Sleep Medicine"},{"key":"ref_115","unstructured":"World Health Organization (2024). Global status report on alcohol and health and treatment of substance use disorders, World Health Organization."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuron.2023.10.002","article-title":"Dopamine pathways mediating affective state transitions after sleep loss","volume":"112","author":"Wu","year":"2024","journal-title":"Neuron"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"107755","DOI":"10.1016\/j.addbeh.2023.107755","article-title":"Compositional associations of time spent in sleep, screen time, and physical activity with polysubstance use in adolescents","volume":"144","author":"Zahran","year":"2023","journal-title":"Addictive Behaviors"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"114608","DOI":"10.1016\/j.bbr.2023.114608","article-title":"The role of orexin-1 receptors within the ventral tegmental area in the extinction and reinstatement of methamphetamine place preference","volume":"453","author":"Zamanirad","year":"2023","journal-title":"Behavioural Brain Research"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1523\/JNEUROSCI.23-08-03555.2003","article-title":"Circadian and homeostatic regulation of hypocretin in a primate model: Implications for the consolidation of wakefulness","volume":"23","author":"Zeitzer","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1210\/jc.2013-3728","article-title":"A community-based study on the association between insomnia and hypothalamic-pituitary-adrenal axis: Sex and pubertal influences","volume":"99","author":"Zhang","year":"2014","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"ref_121","first-page":"379","article-title":"Insomnia in adults in the primary care clinic setting","volume":"121","author":"Zweig","year":"2024","journal-title":"Missouri Medicine"}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/15\/2\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:35:17Z","timestamp":1760027717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/15\/2\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":121,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["bs15020220"],"URL":"https:\/\/doi.org\/10.3390\/bs15020220","relation":{},"ISSN":["2076-328X"],"issn-type":[{"value":"2076-328X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]}}}