{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:41:55Z","timestamp":1783086115565,"version":"3.54.6"},"reference-count":140,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Killam Postdoctoral Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Eating disorders (EDs) remain challenging to treat, with high dropout and low remission rates in cognitive-behavioral therapy for EDs (CBT-ED). Psilocybin treatment (PT) demonstrates therapeutic potential to enhance CBT-ED by exerting several neurobiological, psychological, and experiential effects (e.g., antidepressant, neuroplasticity, emotional openness) that are hypothesized to increase psychotherapeutic engagement, reduce dropout, and improve clinical outcomes. This narrative review provides the first consolidation of theoretical evidence for PT\/CBT-ED, proposes considerations for a concurrent intervention protocol, and presents clinical and research considerations to empirically test its feasibility, safety, and efficacy. This line of inquiry is expected to advance the development of approaches that improve ED treatment outcomes and, more broadly, advance the study of psychedelics as tools to enhance evidence-based psychotherapy models.<\/jats:p>","DOI":"10.3390\/bs16030376","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:22:14Z","timestamp":1772788934000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psilocybin Treatment as an Adjunct to Cognitive Behavioral Therapy for Eating Disorders: Therapeutic Rationale &amp; Considerations for Protocol Development"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-0288","authenticated-orcid":false,"given":"Elena","family":"Koning","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS B3H 2E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gamberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS B3H 2E2, Canada"},{"name":"Eating Disorders Program, Nova Scotia Health, Halifax, NS B3H 2E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Keshen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS B3H 2E2, Canada"},{"name":"Eating Disorders Program, Nova Scotia Health, Halifax, NS B3H 2E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1037\/ccp0000021","article-title":"Therapeutic alliance in a randomized clinical trial for bulimia nervosa","volume":"83","author":"Accurso","year":"2015","journal-title":"Journal of Consulting and Clinical Psychology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e70038","DOI":"10.1111\/fcp.70038","article-title":"Psilocybin as transformative fast-acting antidepressant: Pharmacological properties and molecular mechanisms","volume":"39","author":"Adebo","year":"2025","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1176\/appi.ajp.157.8.1302","article-title":"Outcome predictors for the cognitive behavior treatment of bulimia nervosa: Data from a multisite study","volume":"157","author":"Agras","year":"2000","journal-title":"The American Journal of Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Amianto, F., Ottone, L., Abbate Daga, G., and Fassino, S. 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