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Sci.","Behavioral Sciences"],"abstract":"<jats:p>Background: This study aimed to investigate the association between educational attainment and depressive symptoms among young-old adults aged 60\u201374 years, and to examine the mediating effect of self-reported memory function between them, so as to provide a reference for the early screening and intervention of depressive symptom severity in this population. Methods: This was a cross-sectional study, and data were derived from the 2022 China Family Panel Studies (CFPS). After data cleaning, 3666 valid samples were included. Depressive symptom severity was assessed using the 8-item Center for Epidemiologic Studies Depression Scale (CES-D 8) (Cronbach\u2019s \u03b1 = 0.771, Guttman Split-Half Coefficient = 0.742), with a total score \u2265 9 defined as probable depression. Self-reported memory function was measured using a single item (scored 0\u20134), with higher scores indicating better perceived memory, and was treated as a continuous variable for analysis. Descriptive statistics and Pearson correlation analysis were performed using R software (version 4.2.3). The mediation effect was tested using the product-of-coefficients method combined with the bootstrap method (5000 resamples), supplemented by a quasi-Bayesian model and multiple sensitivity analyses (including outcome variable substitution and model diagnostic corrections) for robustness testing. Results: Among the study participants, the prevalence of probable depression was 25.18%. Correlation analyses showed that educational attainment was significantly negatively correlated with depressive symptom severity (r = \u22120.177, p &lt; 0.001) and significantly positively correlated with self-reported memory function (r = 0.241, p &lt; 0.001). Self-reported memory function was significantly negatively correlated with depressive symptom severity (r = \u22120.223, p &lt; 0.001). After adjusting for age, gender, place of residence, subjective income, self-rated health, and chronic disease status, mediation analysis showed that the direct effect of educational attainment on depressive symptom severity was \u22120.297 (95% CI: \u22120.424 to \u22120.174), while the indirect effect via self-reported memory function was \u22120.109 (95% CI: \u22120.139 to \u22120.082). The direct and indirect effects accounted for 73.20% and 26.80% of the total effect, respectively; the results of the quasi-Bayesian analysis and multiple sensitivity analyses were consistent in direction, further validating the stability of this mediation effect. Conclusions: Among young-old adults aged 60\u201374 years, self-reported memory function plays a partial statistical mediating role in the association between educational attainment and depressive symptom severity. This suggests that strengthening attention to memory status and early screening among individuals with lower educational attainment may offer a potential intervention approach for alleviating depressive symptom severity in this population in the future.<\/jats:p>","DOI":"10.3390\/bs16081264","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:05:42Z","timestamp":1784819142000},"page":"1264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Educational Attainment and Depressive Symptom Severity Among Young-Old Adults Aged 60\u201374 Years: The Mediating Role of Self-Reported Memory Function"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7837-3373","authenticated-orcid":false,"given":"Beifen","family":"Pan","sequence":"first","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-6389","authenticated-orcid":false,"given":"Pu","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruge","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyun","family":"Ou","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3897-8723","authenticated-orcid":false,"given":"Junchen","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Dong","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Cui","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-398X","authenticated-orcid":false,"given":"Rongjuan","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Beijing University of Chinese Medicine, Beijing 100078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/geronb\/gbx183","article-title":"Memory deficits precede increases in depressive symptoms in later adulthood","volume":"74","author":"Aichele","year":"2019","journal-title":"The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2307\/2094981","article-title":"Pearson\u2019s R and coarsely categorized measures","volume":"46","author":"Bollen","year":"1981","journal-title":"American Sociological Review"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.2174\/1871527313666141130203823","article-title":"Cognitive dysfunction in major depressive disorder: A state-of-the-art clinical review","volume":"13","author":"Bortolato","year":"2014","journal-title":"CNS & Neurological Disorders Drug Targets"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpsychires.2018.12.005","article-title":"Are subjective memory complaints indicative of objective cognitive decline or depressive symptoms? 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late life depression: A meta-analysis of published literature","volume":"40","year":"2010","journal-title":"The International Journal of Psychiatry in Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1093\/geronb\/gbz053","article-title":"Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging","volume":"75","author":"Clouston","year":"2020","journal-title":"The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"16m11371","DOI":"10.4088\/JCP.16m11371","article-title":"Executive function predicts antidepressant treatment noncompletion in late-life depression","volume":"79","author":"Cristancho","year":"2018","journal-title":"The Journal of Clinical Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/aje\/kwad157","article-title":"Childhood and life-course socioeconomic position and cognitive function in the adult population of the hispanic community health study\/study of latinos","volume":"192","author":"Filigrana","year":"2023","journal-title":"American Journal of Epidemiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/jech.2004.023531","article-title":"Indicators of socioeconomic position (part 1)","volume":"60","author":"Galobardes","year":"2006","journal-title":"Journal of Epidemiology and Community Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1177\/1073191117741188","article-title":"Validity of self-rated memory among middle-aged and older Chinese adults: Results from the China health and retirement longitudinal study (CHARLS)","volume":"26","author":"Huang","year":"2019","journal-title":"Assessment"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1037\/bul0000344","article-title":"Depression and episodic memory across the adult lifespan: A meta-analytic review","volume":"147","author":"James","year":"2021","journal-title":"Psychological Bulletin"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1017\/gmh.2023.90","article-title":"Changes in depression trends during and after the COVID-19 pandemic among older adults in Korea","volume":"11","author":"Jeong","year":"2024","journal-title":"Global Mental Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer\u2019s disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1207\/S15326942DN2303_1","article-title":"The effect of education on cognitive performances and its implication for the constitution of the cognitive reserve","volume":"23","author":"Lafont","year":"2003","journal-title":"Developmental Neuropsychology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7704205100","DOI":"10.5014\/ajot.2023.050151","article-title":"Subjective memory complaints predict decline in memory, instrumental activities of daily living, and social participation in older adults: A fixed-effects model","volume":"77","author":"Lee","year":"2023","journal-title":"American Journal of Occupational Therapy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10823-011-9142-1","article-title":"Pathways from education to depression","volume":"26","author":"Lee","year":"2011","journal-title":"Journal of Cross-Cultural Gerontology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4306\/pi.2018.15.1.70","article-title":"Education as a protective factor moderating the effect of depression on memory impairment in elderly women","volume":"15","author":"Lee","year":"2018","journal-title":"Psychiatry Investig"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jad.2024.11.058","article-title":"Association between cognitive decline and depression in middle-aged and older adults: Findings from six large cohorts in different countries","volume":"371","author":"Li","year":"2025a","journal-title":"Journal of Affective Disorders"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Li, J., Pennington, A., Zhang, X., Dong, Z., and Barr, B. (2026). What are the socioeconomic risk factors of depression among the elderly in China: A systematic review. BMC Public Health, 26, (1).","DOI":"10.1186\/s12889-026-26199-6"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.genhosppsych.2025.10.016","article-title":"The relationship between cognitive function and depressive symptoms in Chinese older adults: A cross-lagged panel network analysis","volume":"97","author":"Li","year":"2025b","journal-title":"General Hospital Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119741","DOI":"10.1016\/j.jad.2025.119741","article-title":"Bidirectional relationships between cognitive decline and depression: A study of middle-aged and older adults using cross-lagged panel network analysis","volume":"389","author":"Ma","year":"2025","journal-title":"Journal of Affective Disorders"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"The Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20230395","DOI":"10.1098\/rstb.2023.0395","article-title":"Elements of episodic memory: Lessons from 40 years of research","volume":"379","author":"Easton","year":"2024","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.neubiorev.2013.01.008","article-title":"Depressive disorders and suicide: Epidemiology, risk factors, and burden","volume":"37","author":"Miret","year":"2013","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1017\/S2045796023000239","article-title":"Transition to retirement impact on risk of depression and suicidality: Results from a longitudinal analysis of the survey of health, ageing and retirement in Europe (SHARE)","volume":"32","author":"Mosconi","year":"2023","journal-title":"Epidemiology and Psychiatric Sciences"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.nlm.2011.06.006","article-title":"Cognitive dysfunction in depression: Neurocircuitry and new therapeutic strategies","volume":"96","author":"Murrough","year":"2011","journal-title":"Neurobiology of Learning and Memory"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1037\/a0029315","article-title":"When can categorical variables be treated as continuous? A comparison of robust continuous and categorical SEM estimation methods under suboptimal conditions","volume":"17","author":"Rhemtulla","year":"2012","journal-title":"Psychological Methods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12062-014-9108-5","article-title":"Awareness of memory ability and change: (In)accuracy of memory self-assessments in relation to performance","volume":"8","author":"Rickenbach","year":"2015","journal-title":"Journal of Population Ageing"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/j.0022-0337.2002.66.1.tb03506.x","article-title":"Memory and the brain","volume":"66","author":"Robertson","year":"2002","journal-title":"Journal of Dental Education"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/gps.5613","article-title":"The role of education and income for cognitive functioning in old age: A cross-country comparison","volume":"36","author":"Rodriguez","year":"2021","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neurobiolaging.2008.09.023","article-title":"When does age-related cognitive decline begin?","volume":"30","author":"Salthouse","year":"2009","journal-title":"Neurobiology of Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer\u2019s disease","volume":"11","author":"Stern","year":"2012","journal-title":"The Lancet Neurology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"b2393","DOI":"10.1136\/bmj.b2393","article-title":"Multiple imputation for missing data in epidemiological and clinical research: Potential and pitfalls","volume":"338","author":"Sterne","year":"2009","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.archger.2018.11.004","article-title":"The role of education on the association between disability and depressive symptoms among community-dwelling older adults: Evidence from frailty in Brazilian older people (Fibra) study","volume":"80","author":"Torres","year":"2019","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S1041610299005694","article-title":"A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly","volume":"11","author":"Turvey","year":"1999","journal-title":"International Psychogeriatrics"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Umucu, E., Lee, B., Wyman, M., Gooding, D. C., Van Hulle, C. A., Johnson, A., Ferrer Simo, C. A., Carter, F., Salazar, H., James, T. T., Bouges, S., Lambrou, N. H., Johnson, S. C., Asthana, S., and Gleason, C. E. (2022). Racial differences in associations of cognitive health status with happiness, helplessness, and hopelessness among older adults: An exploratory study. Frontiers in Aging Neuroscience, 14.","DOI":"10.3389\/fnagi.2022.890404"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cortex.2021.11.022","article-title":"The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study","volume":"148","author":"Vonk","year":"2022","journal-title":"Cortex"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1111\/jocn.14156","article-title":"Verbal responses, depressive symptoms, reminiscence functions and cognitive emotion regulation in older women receiving individual reminiscence therapy","volume":"27","author":"Wu","year":"2018","journal-title":"Journal of Clinical Nursing"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wu, Y. T., Lee, H. Y., Norton, S., Chen, C., Chen, H., He, C., Fleming, J., Matthews, F. E., and Brayne, C. (2013). Prevalence studies of dementia in mainland china, Hong Kong and taiwan: A systematic review and meta-analysis. PLoS ONE, 8, (6).","DOI":"10.1371\/journal.pone.0066252"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Xin, Y., and Ren, X. (2020). Social capital as a mediator through the effect of education on depression and obesity among the elderly in China. International Journal of Environmental Research and Public Health, 17, (11).","DOI":"10.3390\/ijerph17113977"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yang, F., Fu, M., Hu, Q., and Guo, J. (2023). The associations between cognitive function and depressive symptoms among older Chinese population: A cohort study. Frontiers in Psychiatry, 14.","DOI":"10.3389\/fpsyt.2023.1081209"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zhang, T., Li, S., Zhu, Z., Sha, K., and Liu, Y. (2025). The effect of cognitive function heterogeneity on depression risk in older adults: A stratified analysis based on functional status. Frontiers in Public Health, 13.","DOI":"10.3389\/fpubh.2025.1624599"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zhao, R., Wang, J., Lou, J., Liu, M., Deng, J., Huang, D., and Fang, H. (2024a). The effect of education level on depressive symptoms in Chinese older adults-parallel mediating effects of economic security level and subjective memory ability. BMC Geriatrics, 24, (1).","DOI":"10.1186\/s12877-024-05233-5"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104253","DOI":"10.1016\/j.ajp.2024.104253","article-title":"Prevalence of subthreshold depression in older adults: A systematic review and meta-analysis","volume":"102","author":"Zhao","year":"2024b","journal-title":"Asian Journal of Psychiatry"}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/16\/8\/1264\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:28:22Z","timestamp":1784953702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/16\/8\/1264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["bs16081264"],"URL":"https:\/\/doi.org\/10.3390\/bs16081264","relation":{},"ISSN":["2076-328X"],"issn-type":[{"value":"2076-328X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]}}}