{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:13:55Z","timestamp":1791137635974,"version":"4.1.0"},"reference-count":237,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.<\/jats:p>","DOI":"10.3390\/bs4020125","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T11:12:51Z","timestamp":1402657971000},"page":"125-153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders"],"prefix":"10.3390","volume":"4","author":[{"given":"Mona","family":"Boules","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fredrickson","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Muehlmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Richelson","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0196-9781(80)90082-0","article-title":"Isolation, structure and biologic activity of chicken intestinal neurotensin","volume":"1","author":"Carraway","year":"1980","journal-title":"Peptides"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0163-7258(98)00009-6","article-title":"Mechanisms of regulation of neurotensin receptors","volume":"79","author":"Hermans","year":"1998","journal-title":"Pharmacol. 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