{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:03:24Z","timestamp":1788897804735,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Catatonia is a psychomotor syndrome which has historically been associated with schizophrenia. Many clinicians have thought that the prevalence of this condition has been decreasing over the past few decades. This review reminds clinicians that catatonia is not exclusively associated with schizophrenia, and is still common in clinical practice. Many cases are related to affective disorders or are of an idiopathic nature. The illusion of reduced prevalence has been due to evolving diagnostic systems that failed to capture catatonic syndromes. This systemic error has remained unchallenged, and potentiated by the failure to perform adequate neurological evaluations and catatonia screening exams on psychiatric patients. We find that current data supports catatonic syndromes are still common, often severe and of modern clinical importance. Effective treatment is relatively easy and can greatly reduce organ failure associated with prolonged psychomotor symptoms. Prompt identification and treatment can produce a robust improvement in most cases. The ongoing prevalence of this syndrome requires that psychiatrists recognize catatonia and its presentations, the range of associated etiologies, and the import of timely treatment.<\/jats:p>","DOI":"10.3390\/bs5040576","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T15:21:41Z","timestamp":1449674501000},"page":"576-588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The Syndrome of Catatonia"],"prefix":"10.3390","volume":"5","author":[{"given":"James","family":"Wilcox","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Arizona, 1401 E University, Tucson, AZ 85721, USA"},{"name":"Tucson VA Medical Center, 3601 South 6th Avenue, Tucson, AZ 85723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pam","family":"Reid Duffy","sequence":"additional","affiliation":[{"name":"Tucson VA Medical Center, 3601 South 6th Avenue, Tucson, AZ 85723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"ref_1","unstructured":"Bellak, L. (1947). Dementia Praecox, Grune and Stratton."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1176\/ajp.120.8.817","article-title":"A historical footnote to the term catatonia","volume":"120","author":"Papathomopoulos","year":"1964","journal-title":"Am. J. Psychiatr."},{"key":"ref_3","unstructured":"(2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.]."},{"key":"ref_4","unstructured":"Kahlbaum, K. (1874). Die katatonie oder das spannungsirresein, Klinische Abhandlugen uber psychische Kranekhieten."},{"key":"ref_5","unstructured":"Barclay, R.M. (1919). Dementia Praecox and Paraphrenia, E. & S. Livingston."},{"key":"ref_6","unstructured":"Zink, J. (1950). Dementia Praecox or The Group of Schizophrenias, International Universities Press."},{"key":"ref_7","unstructured":"Fink, M., and Taylor, M. (2006). Catatonia: A Clinician\u2019s Guide to Diagnosis and Treatment, Cambridge University Press."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/00005053-191311000-00002","article-title":"Catatonic syndrome and its relations to manic-depressive illness","volume":"40","author":"Kirby","year":"1913","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF02881925","article-title":"Catatonia revealed by follow-up studies: Part I, degeneration psychosis which were mistaken for catatonias","volume":"157","author":"Kleist","year":"1937","journal-title":"Z. Ges. Neurol. Psychiat."},{"key":"ref_10","unstructured":"Hamilton, M. (1962). Fish\u2019s Schizophrenia, John Wright & Sons. [2nd ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hoch, A.A. (1921). Benign Stupors: A Study of a New Manic\u00adDepressive Reaction Type, Cambridge University Press.","DOI":"10.1037\/14013-000"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1192\/bjp.112.491.967","article-title":"The clinical features and outcome of stupor","volume":"112","year":"1966","journal-title":"Br. J. Psychiatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1465-5922.1957.00137.x","article-title":"Acute catatonic schizophrenia","volume":"2","author":"Perry","year":"1957","journal-title":"J. Anal. Psychol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000099841","article-title":"How does our brain constitute defense mechanisms? First person neuroscience and psychoanalysis","volume":"76","author":"Northoff","year":"2007","journal-title":"Psychother. Psychosom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/archpsyc.1973.04200040066011","article-title":"The phenomenology of mania: A new look at some old patients","volume":"33","author":"Taylor","year":"1973","journal-title":"Arch. Gen. Psychiatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1440-1819.2001.00887.x","article-title":"Kahlbaum\u2019s catatonia revisited","volume":"55","author":"Carroll","year":"2001","journal-title":"Psychiatr. Clin. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF02064336","article-title":"Beitrage zur Kenntnis der Pathophysiologie des katatonen Stupors. I Mitteilung. Uber periodisch rezidivierend katatonen stupor, mit kristischem Began und Abschluss","volume":"96","author":"Gjessing","year":"1932","journal-title":"Arch Psychiat. Nervenkr."},{"key":"ref_18","first-page":"392","article-title":"Beitrage zur Kenntnis der Pathophysiologie des katatonen Stupors. II Mitteilung. Uber periodisch rezidivierend verlaufenden katatonen stupor, mit lytischem Began und Abschluss","volume":"96","author":"Gjessing","year":"1932","journal-title":"Arch Psychiat. Nervenkr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/PL00014197","article-title":"Towards the genetic basis of periodic catatonia: Pedigree sample for genome scan I and II","volume":"251","author":"Stober","year":"2001","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1086\/321183","article-title":"Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15","volume":"67","author":"Stober","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1001\/archpsyc.1978.01770300115013","article-title":"Research diagnostic criteria: Rationale and reliability","volume":"35","author":"Spitzer","year":"1978","journal-title":"Arch. Gen. Psychiatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1192\/bjp.141.6.567","article-title":"The evolution of symptoms in institutionalized hebephrenic\/catatonic schizophrenics","volume":"141","author":"Pfohl","year":"1982","journal-title":"Br. J. Psychiatr."},{"key":"ref_23","unstructured":"Winokur, G., and Tsuang, M.T. (1996). The Natural History of Mania, Depression and Schizophrenia, American Psychiatric Association Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/archpsyc.1973.01750310023005","article-title":"Catatonia. Retarded and excited types","volume":"28","author":"Morrison","year":"1973","journal-title":"Arch. Gen. Psychiatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0010-440X(74)90053-4","article-title":"Catatonia: Prediction of outcome","volume":"15","author":"Morrison","year":"1974","journal-title":"Compr. Psychiatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1176\/ajp.131.6.674","article-title":"Changes in schizophrenia 1920\u20131966","volume":"131","author":"Morrison","year":"1974","journal-title":"Am. J. Psychiatr."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Leonard, K. (1999). Classification of Endogenous Psychoses and Their Differentiated Etiology, Springer. [2nd ed.].","DOI":"10.1007\/978-3-7091-6371-9"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1053\/comp.2002.32352","article-title":"Are we witnessing the disappearance of catatonic schizophrenia?","volume":"43","author":"Stompe","year":"2002","journal-title":"Compr. Psychiatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.pnpbp.2006.11.012","article-title":"Schizophrenia with prominent catatonic features (catatonic schizophrenia). II. Factor analysis if the catatonic syndrome","volume":"31","author":"Ungvari","year":"2007","journal-title":"Progress in Neuro\u00adPsychopharmacology & Biological Psychiatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/schbul\/sbq087","article-title":"Catatonic schizophrenia: A cohort study","volume":"38","author":"Kleinhaus","year":"2012","journal-title":"Schizophr. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/archpsyc.1976.01770050043006","article-title":"Catatonia, a prospective clinical study","volume":"33","author":"Abrams","year":"1976","journal-title":"Arch. Gen. Psychiatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/schbul\/sbp059","article-title":"Catatonia is not schizophrenia: Kraepelin error and the need to recognize catatonia as an independent syndrome in medical nomenclature","volume":"36","author":"Fink","year":"2010","journal-title":"Schizophrenia Bulletin"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00005053-197404000-00007","article-title":"Catatonic schizophrenia: Epidemiology and clinical Course. A 7 year register of 798 cases","volume":"158","author":"Guggenheim","year":"1974","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_34","unstructured":"Freedman, A., Kaplan, H., and Sadock, B. (1975). Comprehensive Textbook of Psychiatry, Williams and Wilkins."},{"key":"ref_35","unstructured":"Brain, R. (1962). Disease of the Nervous System, Oxford University Press."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s00702-002-0762-z","article-title":"Catatonia and neuroleptic malignant syndrome: Psychopathology and pathophysiology","volume":"109","author":"Northoff","year":"2002","journal-title":"J. Neural Transm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/NMD.0b013e31827ab24b","article-title":"Catatonia and neuroleptic malignant syndrome: Two disorders of the same spectrum? Four case reports","volume":"201","author":"Luchini","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0920-9964(00)00035-9","article-title":"Motor features in psychotic disorders. II: Development of diagnostic criteria for catatonia","volume":"47","author":"Peralta","year":"2001","journal-title":"Schizophr. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(76)92669-6","article-title":"The catatonic syndrome","volume":"1","author":"Gelenberg","year":"1976","journal-title":"Lancet"},{"key":"ref_40","first-page":"880","article-title":"Catatonic syndrome associated with diabetes, mellitus","volume":"31","author":"Katz","year":"1934","journal-title":"Arch. Neurol. Psychiatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1176\/ajp.132.2.129","article-title":"Mental changes associated with hyperparathyroidism","volume":"132","author":"Gatewood","year":"1975","journal-title":"Am. J. Psychiatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM197503062921001","article-title":"Folate-responsive homocystinuria and \u201cschizophrenia\u201d","volume":"292","author":"Freeman","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"ref_43","first-page":"606","article-title":"Catatonia and hepatic dysfunction","volume":"28","author":"Jaffe","year":"1976","journal-title":"Dis. Nerv. Syst."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1176\/ajp.119.5.451","article-title":"Akinetic mutism simulating catatonic schizophrenia","volume":"119","author":"Sours","year":"1962","journal-title":"Am. J. Psychiatr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/archgenpsychiatry.2009.141","article-title":"The catatonia syndrome: Forgotten, but not gone","volume":"66","author":"Fink","year":"2009","journal-title":"Arch. Gen. Psychiatr."},{"key":"ref_46","first-page":"79","article-title":"The neuroleptic malignant syndrome","volume":"41","author":"Caroff","year":"1980","journal-title":"J. Clin. Psychiatr."},{"key":"ref_47","first-page":"189","article-title":"Fatal hyperpyrexia during chlorpromazine therapy","volume":"17","author":"Ayd","year":"1956","journal-title":"J. Clin. Exp. Psychopathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/jnnp.58.3.271","article-title":"Neuroleptic malignant syndrome","volume":"58","author":"Buckley","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1176\/ajp.2007.164.6.870","article-title":"Neuroleptic malignant syndrome","volume":"164","author":"Strawn","year":"2007","journal-title":"Am. J. Psychiatr."},{"key":"ref_50","first-page":"117","article-title":"Neuroleptic-resistant schizophrenia treated with clozapine and ECT","volume":"12","author":"Benatov","year":"1996","journal-title":"Convuls. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E42","DOI":"10.1176\/appi.neuropsych.13050102","article-title":"Repetitive transcranial magnetic stimulation for the treatment of catatonia: An alternative treatment to electroconvulsive therapy?","volume":"26","author":"Trojak","year":"2014","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_52","first-page":"471","article-title":"Drug resistant neuroleptic malignant syndrome and the role of electroconvulsive therapy","volume":"64","author":"Hashim","year":"2014","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1176\/appi.ajp.160.7.1233","article-title":"Catatonia in psychiatric classification: A home of its own","volume":"160","author":"Taylor","year":"2003","journal-title":"Am. J. Psychiatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/070674370905400704","article-title":"Catatonia: A syndrome appears, disappears and is rediscovered","volume":"54","author":"Fink","year":"2009","journal-title":"Can. J. Psychiatr."}],"container-title":["Behavioral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-328X\/5\/4\/576\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:53:42Z","timestamp":1760216022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-328X\/5\/4\/576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,9]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["bs5040576"],"URL":"https:\/\/doi.org\/10.3390\/bs5040576","relation":{},"ISSN":["2076-328X"],"issn-type":[{"value":"2076-328X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,9]]}}}