{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:03:46Z","timestamp":1760241826802,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioral Sciences"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To treat neurodegenerative diseases, stem cell transplants with bone marrow (BM) have been performed for several decades. In this work we determine the effect of mononuclear bone marrow cell (mBMC) transplantation on the rotational behavior and neurochemical activity in a model of Huntington\u2019s disease in rats. Four experimental groups were organized: Group I: Control animals (n = 5); Group II: Lesion with quinolinic acid (QA) in the striatum (n = 5); Group III: Lesion with QA and transplant with mBMC (n = 5); Group IV: Lesion with QA and transplant with culture medium (Dulbecco\u2019s modified Eagle\u2019s medium (DMEM) injection) (n = 5). The rotational activity induced by D-amphetamine was evaluated and the concentration of the neurotransmitter amino acids (glutamate and GABA) was studied. The striatal cell transplantation decreases the rotations induced by D-amphetamine (p &lt; 0.04, Wilcoxon matched pairs test) and improves the changes produced in the levels of neurotransmitters studied. This work suggests that the loss of GABAergic neurons in the brain of rats lesioned with AQ produces behavioral and neurochemical alterations that can be reversed with the use of bone marrow mononuclear cell transplants.<\/jats:p>","DOI":"10.3390\/bs8100087","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T03:46:35Z","timestamp":1537501595000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-2400","authenticated-orcid":false,"given":"Teresa","family":"Serrano S\u00e1nchez","sequence":"first","affiliation":[{"name":"Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, Havana PC 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elena","family":"Gonz\u00e1lez Fraguela","sequence":"additional","affiliation":[{"name":"Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, Havana PC 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"Blanco Lezcano","sequence":"additional","affiliation":[{"name":"Experimental Neurophysiology Department, International Center of Neurological Restoration (CIREN) Ave. 25 No. 15805 e\/158 and 160, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Alberti Amador","sequence":"additional","affiliation":[{"name":"Molecular biology Department, International Center of Neurological Restoration (CIREN) Ave. 25 No. 15805 e\/158 and 160, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Caballero Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Policl\u00ednico 26 de Julio, Calle 72 #1313. A. Almendares, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los \u00c1ngeles","family":"Robinson Agramonte","sequence":"additional","affiliation":[{"name":"Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, Havana PC 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-0706","authenticated-orcid":false,"given":"Lourdes","family":"Lorigados Pedre","sequence":"additional","affiliation":[{"name":"Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, Havana PC 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A","family":"Bergado Rosado","sequence":"additional","affiliation":[{"name":"Experimental Neurophysiology Department, International Center of Neurological Restoration (CIREN) Ave. 25 No. 15805 e\/158 and 160, Playa, Havana 11300, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ncl.2014.09.003","article-title":"Huntington disease: Pathogenesis and treatment","volume":"33","author":"Dayalu","year":"2015","journal-title":"Neurol. 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