{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:45:16Z","timestamp":1790516716922,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) acts as a co-activator of EBNA-2, a transcriptional activator essential for Epstein-Barr virus (EBV)-induced B-cell transformation. Burkitt\u2019s lymphoma (BL) cells harboring a mutant EBV strain that lacks both the EBNA-2 gene and 3\u2032 exons of EBNA-LP express Y1Y2-truncated isoforms of EBNA-LP (tEBNA-LP) and better resist apoptosis than if infected with the wild-type virus. In such BL cells, tEBNA-LP interacts with the protein phosphatase 2A (PP2A) catalytic subunit (PP2A C), and this interaction likely plays a role in resistance to apoptosis. Here, 28 cellular and four viral proteins have been identified by mass spectrometry as further possible interactors of tEBNA-LP. Three interactions were confirmed by immunoprecipitation and Western blotting, namely with the A structural subunit of PP2A (PP2A A), the structure-specific recognition protein 1 (SSRP1, a component of the facilitate chromatin transcription (FACT) complex), and a new form of the transcription factor EC (TFEC). Thus, tEBNA-LP appears to be involved not only in cell resistance to apoptosis through its interaction with two PP2A subunits, but also in other processes where its ability to co-activate transcriptional regulators could be important.<\/jats:p>","DOI":"10.3390\/cancers10010012","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T04:21:21Z","timestamp":1515385281000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New Interactors of the Truncated EBNA-LP Protein Identified by Mass Spectrometry in P3HR1 Burkitt\u2019s Lymphoma Cells"],"prefix":"10.3390","volume":"10","author":[{"given":"Sonia","family":"Chelouah","sequence":"first","affiliation":[{"name":"UMR 8126 CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Cochet","sequence":"additional","affiliation":[{"name":"Proteomic Platform, Institut Gustave Roussy, Villejuif F-94805, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Couv\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Oncologique, Ecole Pratique des Hautes Etudes, F-75014 Paris, France"},{"name":"UMR 1186 Inserm, Univ. Paris-Sud, EPHE, Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Balkaran","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-4190","authenticated-orcid":false,"given":"Aude","family":"Robert","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"May","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, F-94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily","family":"Ogryzko","sequence":"additional","affiliation":[{"name":"UMR 8126 CNRS, Univ. 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