{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:10:57Z","timestamp":1789985457654,"version":"4.0.1"},"reference-count":101,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inha University Research Grant","award":["54680"],"award-info":[{"award-number":["54680"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Kr\u00fcppel-like factor 10 (KLF10), originally named TGF-\u03b2 (Transforming growth factor beta) inducible early gene 1 (TIEG1), is a DNA-binding transcriptional regulator containing a triple C2H2 zinc finger domain. By binding to Sp1 (specificity protein 1) sites on the DNA and interactions with other regulatory transcription factors, KLF10 encourages and suppresses the expression of multiple genes in many cell types. Many studies have investigated its signaling cascade, but other than the TGF-\u03b2\/Smad signaling pathway, these are still not clear. KLF10 plays a role in proliferation, differentiation as well as apoptosis, just like other members of the SP (specificity proteins)\/KLF (Kr\u00fcppel-like Factors). Recently, several studies reported that KLF10 KO (Knock out) is associated with defects in cell and organs such as osteopenia, abnormal tendon or cardiac hypertrophy. Since KLF10 was first discovered, several studies have defined its role in cancer as a tumor suppressor. KLF10 demonstrate anti-proliferative effects and induce apoptosis in various carcinoma cells including pancreatic cancer, leukemia, and osteoporosis. Collectively, these data indicate that KLF10 plays a significant role in various biological processes and diseases, but its role in cancer is still unclear. Therefore, this review was conducted to describe and discuss the role and function of KLF10 in diseases, including cancer, with a special emphasis on its signaling with TGF-\u03b2.<\/jats:p>","DOI":"10.3390\/cancers10060161","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T03:54:21Z","timestamp":1527479661000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["KLF10 as a Tumor Suppressor Gene and Its TGF-\u03b2 Signaling"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-6283","authenticated-orcid":false,"given":"Azra","family":"Memon","sequence":"first","affiliation":[{"name":"Laboratory of Developmental Genetics, Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Genetics, Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0968-0004(99)01406-1","article-title":"Mammalian Kruppel-like transcription factors: More than just a pretty finger","volume":"24","author":"Turner","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(83)90210-6","article-title":"The promoter-specific transcription factor sp1 binds to upstream sequences in the SV40 early promoter","volume":"35","author":"Dynan","year":"1983","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pei, J., and Grishin, N.V. (2013). A new family of predicted Kruppel-like factor genes and pseudogenes in placental mammals. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081109"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2003-4-2-206","article-title":"Sp1- and Kruppel-like transcription factors","volume":"4","author":"Kaczynski","year":"2003","journal-title":"Genome Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biocel.2007.07.018","article-title":"Kruppel-like transcription factors: A functional family","volume":"40","author":"Pearson","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_6","first-page":"2776","article-title":"A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins","volume":"13","author":"Miller","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2000.9878","article-title":"Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury","volume":"227","author":"Harrison","year":"2000","journal-title":"Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1093\/nar\/23.23.4907","article-title":"Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts","volume":"23","author":"Subramaniam","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25929","DOI":"10.1074\/jbc.273.40.25929","article-title":"Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible sp1-like zinc finger-encoding genes involved in the regulation of cell growth","volume":"273","author":"Cook","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1128\/MCB.15.11.5957","article-title":"Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: Identification of a new multigene family","volume":"15","author":"Anderson","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/MCB.16.4.1695","article-title":"Isolation and characterization of the CDNA encoding BKLF\/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells","volume":"16","author":"Crossley","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1074\/jbc.271.33.20009","article-title":"Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest","volume":"271","author":"Shields","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1002\/j.1460-2075.1992.tb05451.x","article-title":"Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene","volume":"11","author":"Imataka","year":"1992","journal-title":"EMBO J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/nar\/27.5.1263","article-title":"A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells","volume":"27","author":"Conkright","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ygeno.2005.01.005","article-title":"Mammalian SP\/KLF transcription factors: Bring in the family","volume":"85","author":"Suske","year":"2005","journal-title":"Genomics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0925-4773(02)00258-7","article-title":"Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein","volume":"118","author":"Yan","year":"2002","journal-title":"Mech. Dev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kruppel-like factors in health and diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1006\/geno.1997.4979","article-title":"Guidelines for human gene nomenclature (1997). Hugo nomenclature committee","volume":"45","author":"White","year":"1997","journal-title":"Genomics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jcp.1111","article-title":"Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer","volume":"188","author":"Black","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/gbe\/evv141","article-title":"KLF\/SP transcription factor family evolution: Expansion, diversification, and innovation in eukaryotes","volume":"7","author":"Presnell","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jacbts.2017.09.001","article-title":"Kr\u00fcppel-like factors: Crippling and uncrippling metabolic pathways","volume":"3","author":"Pollak","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.1999.tb09513.x","article-title":"Sp1 and its likes: Biochemical and functional predictions for a growing family of zinc finger transcription factors","volume":"880","author":"Cook","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1357-2725(00)00059-5","article-title":"The biology of the mammalian Kruppel-like family of transcription factors","volume":"32","author":"Dang","year":"2000","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1093\/nar\/27.15.2991","article-title":"A tale of three fingers: The family of mammalian Sp\/XKLF transcription factors","volume":"27","author":"Philipsen","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S1357-2725(99)00067-9","article-title":"Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors","volume":"31","author":"Turner","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nrm2297","article-title":"TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility","volume":"8","author":"Schmierer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/cr.2008.327","article-title":"Phospho-control of TGF-beta superfamily signaling","volume":"19","author":"Wrighton","year":"2009","journal-title":"Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","article-title":"Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta\/ALK5 signaling","volume":"12","author":"Goumans","year":"2003","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1046\/j.1523-1755.2000.07708.x","article-title":"SMAD proteins and transforming growth factor-\u03b2 signaling","volume":"58","author":"Schiffer","year":"2000","journal-title":"Kidney Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1172\/JCI119418","article-title":"Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells","volume":"99","author":"Tachibana","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/j.febslet.2007.07.008","article-title":"TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade","volume":"581","author":"Jin","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/hep.510300620","article-title":"The transforming growth factor beta(1)-inducible transcription factor tieg1, mediates apoptosis through oxidative stress","volume":"30","author":"Ribeiro","year":"1999","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1038\/sj.onc.1205681","article-title":"TGFbeta inducible early gene enhances TGFbeta\/SMAD-dependent transcriptional responses","volume":"21","author":"Johnsen","year":"2002","journal-title":"Oncogene"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jcb.21492","article-title":"Role of TIEG1 in biological processes and disease states","volume":"102","author":"Subramaniam","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hawse, J.R., Cicek, M., Grygo, S.B., Bruinsma, E.S., Rajamannan, N.M., van Wijnen, A.J., Lian, J.B., Stein, G.S., Oursler, M.J., and Subramaniam, M. (2011). TIEG1\/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019429"},{"key":"ref_36","first-page":"372","article-title":"Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes","volume":"33","author":"Benmezroua","year":"2007","journal-title":"Diabetes Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jcb.21049","article-title":"TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway","volume":"100","author":"Rajamannan","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24914","DOI":"10.1074\/jbc.M109.000059","article-title":"Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(\u2212) T cells and T regulatory cells","volume":"284","author":"Cao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1524-475X.2012.00773.x","article-title":"Impaired cutaneous wound healing in transforming growth factor-beta inducible early gene1 knockout mice","volume":"20","author":"Hori","year":"2012","journal-title":"Wound Repair Regen."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1479-5876-12-186","article-title":"Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of Kruppel-like-factor 10 in mice","volume":"12","author":"Kim","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"G900","DOI":"10.1152\/ajpgi.00309.2015","article-title":"Kruppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation","volume":"309","author":"Papadakis","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2975","DOI":"10.1038\/cddis.2017.358","article-title":"LncRNA OIP5-AS1 loss-induced microRNA-410 accumulation regulates cell proliferation and apoptosis by targeting KLF10 via activating PTEN\/PI3K\/AKT pathway in multiple myeloma","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2011.08.016","article-title":"Kruppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes","volume":"412","author":"Iizuka","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1128\/MCB.01141-09","article-title":"Kruppel-like factor kLF10 is a link between the circadian clock and metabolism in liver","volume":"30","author":"Guillaumond","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bcmd.2004.08.027","article-title":"Functional study of transcription factor KLF11 by targeted gene inactivation","volume":"34","author":"Song","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1128\/MCB.25.3.1191-1199.2005","article-title":"TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro","volume":"25","author":"Subramaniam","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1475-2840-13-8","article-title":"Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment","volume":"13","author":"Green","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1210\/er.2004-0001","article-title":"Transforming growth factor-beta1 to the bone","volume":"26","author":"Janssens","year":"2005","journal-title":"Endocr. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ydbio.2014.02.015","article-title":"Microarray meta-analysis identifies evolutionarily conserved bmp signaling targets in developing long bones","volume":"389","author":"Prashar","year":"2014","journal-title":"Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cicek, M., Vrabel, A., Sturchio, C., Pederson, L., Hawse, J.R., Subramaniam, M., Spelsberg, T.C., and Oursler, M.J. (2011). TGF-beta inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, Akt, and MEK\/ERK signaling pathways. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017522"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/FJC.0000000000000265","article-title":"TIEG1 inhibits angiotensin II-induced cardiomyocyte hypertrophy by inhibiting transcription factor GATA4","volume":"66","author":"Li","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/15275","article-title":"Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis","volume":"5","author":"Heaney","year":"1999","journal-title":"Nat. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"R608","DOI":"10.1152\/ajpregu.00085.2014","article-title":"Differential coupling of kLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene","volume":"307","author":"Xiong","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34372","DOI":"10.1074\/jbc.M111.325332","article-title":"Polycomb antagonizes p300\/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner","volume":"287","author":"Xiong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s00125-017-4412-2","article-title":"KLF10 transcription factor regulates hepatic glucose metabolism in mice","volume":"60","author":"Yang","year":"2017","journal-title":"Diabetologia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1750-1172-7-29","article-title":"Kruppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency","volume":"7","author":"Koczulla","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jor.20101","article-title":"Effect of TGF-beta inducible early gene deficiency on flexor tendon healing","volume":"24","author":"Tsubone","year":"2006","journal-title":"J. Orthop. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Koltsova, S.V., Shilov, B., Birulina, J.G., Akimova, O.A., Haloui, M., Kapilevich, L.V., Gusakova, S.V., Tremblay, J., Hamet, P., and Orlov, S.N. (2014). Transcriptomic changes triggered by hypoxia: Evidence for HIF-1alpha-independent, [Na+]i\/[K+]i-mediated, excitation-transcription coupling. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110597"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1152\/japplphysiol.00800.2005","article-title":"Age-dependent changes in the mechanical properties of tail tendons in TGF-beta inducible early gene-1 knockout mice","volume":"101","author":"Bensamoun","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bone.2006.05.021","article-title":"TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture","volume":"39","author":"Bensamoun","year":"2006","journal-title":"Bone"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1142\/S0218957709002304","article-title":"TIEG1-null osteocytes display defects in their morphology, density and surrounding bone matrix","volume":"12","author":"Haddad","year":"2009","journal-title":"J. Musculoskelet. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1152\/japplphysiol.00356.2010","article-title":"Molecular structure of tail tendon fibers in TIEG1 knockout mice using synchrotron diffraction technology","volume":"108","author":"Gumez","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bone.2008.02.004","article-title":"TIEG-null mice display an osteopenic gender-specific phenotype","volume":"42","author":"Hawse","year":"2008","journal-title":"Bone"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/jbmr.2142","article-title":"TGFbeta inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton","volume":"29","author":"Hawse","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/mus.25252","article-title":"Impact of tieg1 on the structural properties of fast- and slow-twitch skeletal muscle","volume":"55","author":"Kammoun","year":"2017","journal-title":"Muscle Nerve"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1128\/MCB.17.2.1010","article-title":"Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C","volume":"17","author":"Sartorelli","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1182\/blood-2011-06-363713","article-title":"TGF-beta1 signaling and Kruppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization","volume":"118","author":"Wara","year":"2011","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1161\/ATVBAHA.112.300655","article-title":"Bone marrow-derived Kruppel-like factor 10 controls reendothelialization in response to arterial injury","volume":"33","author":"Wara","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"20255","DOI":"10.1074\/jbc.C000135200","article-title":"Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells","volume":"275","author":"Hefferan","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00018-009-0222-0","article-title":"Functional interplay between E2F1 and chemotherapeutic drugs defines immediate E2F1 target genes crucial for cancer cell death","volume":"67","author":"Engelmann","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/sj.bjc.6600961","article-title":"Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction","volume":"88","author":"Partin","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ijc.11447","article-title":"15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway","volume":"107","author":"Chen","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/B:BREA.0000032926.74216.7d","article-title":"Differential gene expression of TGF beta inducible early gene (TIEG), SMAD7, SMAD2 and Bard1 in normal and malignant breast tissue","volume":"86","author":"Reinholz","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cyto.2005.01.013","article-title":"SMAD signal and TGFbeta induced apoptosis in human lymphoma cells","volume":"30","author":"Sebestyen","year":"2005","journal-title":"Cytokine"},{"key":"ref_75","first-page":"321","article-title":"Gene expression profiling of metastatic brain cancer","volume":"18","author":"Zohrabian","year":"2007","journal-title":"Oncol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bbrc.2008.03.066","article-title":"Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors","volume":"370","author":"Ivanov","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/CBI20100896","article-title":"Lentivirus-mediated overexpression of TGF-beta inducible early gene 1 inhibits SW1990 pancreatic cancer cell growth","volume":"35","author":"Jiang","year":"2011","journal-title":"Cell Biol. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3835(01)00802-3","article-title":"Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer","volume":"183","author":"Antonello","year":"2002","journal-title":"Cancer Lett."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3748\/wjg.v18.i17.2035","article-title":"Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-beta-susceptible hepatocellular carcinoma cells","volume":"18","author":"Jiang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3892\/or.2015.3801","article-title":"Kruppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis","volume":"33","author":"Heo","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"17","DOI":"10.23937\/2378-3648\/1410017","article-title":"Common genetic variation in circadian rhythm genes and risk of Epithelial Ovarian Cancer (EOC)","volume":"2","author":"Jim","year":"2015","journal-title":"J. Genet. Genome Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1158\/0008-5472.CAN-16-2589","article-title":"Kruppel-like transcription factor KLF10 suppresses TGFbeta-induced epithelial-to-mesenchymal transition via a negative feedback mechanism","volume":"77","author":"Mishra","year":"2017","journal-title":"Cancer Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bbrc.2012.02.032","article-title":"KLF10, transforming growth factor-beta-inducible early gene 1, acts as a tumor suppressor","volume":"419","author":"Song","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/hep.22743","article-title":"CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis","volume":"49","author":"Ding","year":"2009","journal-title":"Hepatology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.0705395105","article-title":"Progenitor\/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling","volume":"105","author":"Tang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1248\/bpb.25.970","article-title":"Functional analysis of zinc finger proteins that bind to the silencer element in the glutathione transferase P gene","volume":"25","author":"Tanabe","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ajpath.2012.04.025","article-title":"Kruppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma","volume":"181","author":"Chang","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.biocel.2014.12.021","article-title":"KLF10 affects pancreatic function via the SEI-1\/p21Cip1 pathway","volume":"60","author":"Wu","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2008.09.017","article-title":"Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cells","volume":"274","author":"Jiang","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jso.1032","article-title":"Instability of chromosome 8 as an indicator of aggressive tumor phenotype in pancreatic cancer","volume":"76","author":"Sato","year":"2001","journal-title":"J. Surg. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Venkov, C., Plieth, D., Ni, T., Karmaker, A., Bian, A., George, A.L., and Neilson, E.G. (2011). Transcriptional networks in epithelial-mesenchymal transition. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025354"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/jcmm.12811","article-title":"Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells","volume":"20","author":"Hung","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MCB.06152-11","article-title":"TIEG1 inhibits breast cancer invasion and metastasis by inhibition of epidermal growth factor receptor (EGFR) transcription and the EGFR signaling pathway","volume":"32","author":"Jin","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biocel.2011.01.010","article-title":"KLF10 induces cell apoptosis through modulation of BI-1 expression and Ca2+ homeostasis in estrogen-responding adenocarcinoma cells","volume":"43","author":"Hsu","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81574-3","article-title":"Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma","volume":"93","author":"Nagy","year":"1998","journal-title":"Cell"},{"key":"ref_96","first-page":"2461","article-title":"Expression of early growth response genes in human prostate cancer","volume":"58","author":"Eid","year":"1998","journal-title":"Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.lfs.2008.06.006","article-title":"Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats","volume":"83","author":"Yono","year":"2008","journal-title":"Life Sci."},{"key":"ref_98","first-page":"3867","article-title":"TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8","volume":"22","author":"Barna","year":"2002","journal-title":"Anticancer Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s00262-005-0074-x","article-title":"Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma","volume":"55","author":"Zhou","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"26948","DOI":"10.1074\/jbc.M310634200","article-title":"The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter","volume":"279","author":"Noti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1074\/jbc.M412627200","article-title":"The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells","volume":"280","author":"Noti","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/10\/6\/161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:05:57Z","timestamp":1760195157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/10\/6\/161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":101,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["cancers10060161"],"URL":"https:\/\/doi.org\/10.3390\/cancers10060161","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,25]]}}}