{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:41:37Z","timestamp":1773114097108,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00934"],"award-info":[{"award-number":["PI15\/00934"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01468"],"award-info":[{"award-number":["PI16\/01468"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial contribution to improv our knowledge of the pathogenesis of this disease. We show here that miRNAs represent valuable tools to identify signaling pathways involved in hepatoblastoma progression as well as useful biomarkers and novel molecular targets to develop alternative therapeutic strategies in this disease.<\/jats:p>","DOI":"10.3390\/cancers11030409","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T05:03:12Z","timestamp":1553662992000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of MicroRNAs in Hepatoblastoma Tumors"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0234-4213","authenticated-orcid":false,"given":"Ion","family":"Crist\u00f3bal","sequence":"first","affiliation":[{"name":"Cancer Unit for Research on Novel Therapeutic Targets, Oncohealth Institute, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"},{"name":"Translational Oncology Division, Oncohealth Institute, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sanz-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Pathology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melani","family":"Luque","sequence":"additional","affiliation":[{"name":"Pathology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-7628","authenticated-orcid":false,"given":"Cristina","family":"Caram\u00e9s","sequence":"additional","affiliation":[{"name":"Cancer Unit for Research on Novel Therapeutic Targets, Oncohealth Institute, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"},{"name":"Medical Oncology Department, University Hospital \u201cFundaci\u00f3n Jim\u00e9nez D\u00edaz\u201d, UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Rojo","sequence":"additional","affiliation":[{"name":"Pathology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Garc\u00eda-Foncillas","sequence":"additional","affiliation":[{"name":"Translational Oncology Division, Oncohealth Institute, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-UAM, E-28040 Madrid, Spain"},{"name":"Medical Oncology Department, University Hospital \u201cFundaci\u00f3n Jim\u00e9nez D\u00edaz\u201d, UAM, E-28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lim, I.I.P., Bondoc, A.J., Geller, J.I., and Tiao, G.M. (2018). Hepatoblastoma-The Evolution of Biology, Surgery, and Transplantation. Children, 6.","DOI":"10.3390\/children6010001"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e26888","DOI":"10.1002\/pbc.26888","article-title":"Do pregnancy characteristics contribute to rising childhood cancer incidence rates in the United States?","volume":"65","author":"Kehm","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1470-2045(16)30598-8","article-title":"Risk-stratified staging in paediatric hepatoblastoma: A unified analysis from the Children\u2019s Hepatic tumors International Collaboration","volume":"18","author":"Meyers","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3727\/105221616X693639","article-title":"Novel advances in understanding of molecular pathogenesis of hepatoblastoma: A Wnt\/beta-catenin perspective","volume":"17","author":"Bell","year":"2017","journal-title":"Gene Expr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.28888","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","volume":"65","author":"Sumazin","year":"2017","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.humpath.2017.10.007","article-title":"General paucity of genomic alteration and low tumor mutation burden in refractory and metastatic hepatoblastoma: Comprehensive genomic profiling study","volume":"70","author":"Lee","year":"2017","journal-title":"Hum. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2741\/e393","article-title":"Activation of Wnt and Myc signaling in hepatoblastoma","volume":"4","author":"Cairo","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/febs.13985","article-title":"Crosstalk between Hippo signalling and miRNAs in tumour progression","volume":"284","author":"Li","year":"2017","journal-title":"FEBS J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1016\/S1470-2045(12)70073-6","article-title":"microRNAs in cancer management","volume":"13","author":"Kong","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.canlet.2014.11.051","article-title":"MicroRNAs in colorectal cancer: Small molecules with big functions","volume":"360","author":"Xuan","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1053\/j.gastro.2015.07.011","article-title":"Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers","volume":"149","author":"Okugawa","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","first-page":"2464","article-title":"miR-15 and miR-16 induce apoptosis by targeting BCL2","volume":"103","author":"Cimmino","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.18632\/oncotarget.6390","article-title":"MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer","volume":"7","author":"Cekaite","year":"2016","journal-title":"Oncotarget"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"Wentzel","year":"2005","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0808300106","article-title":"Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation","volume":"106","author":"Chang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1677\/ERC-09-0184","article-title":"The role of let-7 in cell differentiation and cancer","volume":"17","author":"Boyerinas","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Watahiki, A., Wang, Y., Morris, J., Dennis, K., O\u00b4Dwyer, H.M., Gleave, M., Gout, P.W., and Wang, Y. (2011). MicroRNAs associated with metastatic prostate cancer. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024950"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1158\/0008-5472.CAN-08-0325","article-title":"Epigenetic silencing of microRNA-34b\/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer","volume":"68","author":"Toyota","year":"2008","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1158\/0008-5472.CAN-08-2129","article-title":"A SNP in a let-7 microRNA complementary site in the KRAS 3 untranslated region increases non-small cell lung cancer risk","volume":"68","author":"Chin","year":"2008","journal-title":"Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrclinonc.2010.196","article-title":"Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways","volume":"8","author":"Takebe","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Hua, Z., Lv, Q., Ye, W., Wong, C.K., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., and Yang, B.B. (2006). Mirna-directed regulation of VEGF and other angiogenic under hypoxia. PLoS ONE, 1.","DOI":"10.1371\/journal.pone.0000116"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20471","DOI":"10.1073\/pnas.1009009107","article-title":"Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer","volume":"107","author":"Cairo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41211","DOI":"10.18632\/oncotarget.17162","article-title":"New tumor suppressor microRNAs target glypican-3 in human liver cancer","volume":"8","author":"Cartier","year":"2017","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/hep4.1029","article-title":"MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting \u03b2-catenin and Wnt signaling","volume":"1","author":"Indersie","year":"2017","journal-title":"Hepatol. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yexcr.2015.05.023","article-title":"MicroRNA-101 overexpression by IL-6 and TNF-\u03b1 inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression","volume":"336","author":"Zhang","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1080\/00498254.2017.1390624","article-title":"MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2","volume":"48","author":"Awortwe","year":"2018","journal-title":"Xenobiotica"},{"key":"ref_29","first-page":"5635","article-title":"Serum microRNA miR-206 is decreased in hyperthyroidism and mediates thyroid hormone regulation of lipid metabolism in HepG2 human hepatoblastoma cells","volume":"17","author":"Zheng","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCRESAHA.115.306624","article-title":"miR-206 mediates YAP-induced cardiac hypertrophy and survival","volume":"117","author":"Yang","year":"2015","journal-title":"Circ. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77890","DOI":"10.18632\/oncotarget.12839","article-title":"GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3","volume":"7","author":"Pei","year":"2016","journal-title":"Oncotarget"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.24125","article-title":"MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatichepatoblastoma","volume":"53","author":"Pagel","year":"2011","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/liv.13687","article-title":"MiR-492 regulates metastatic properties of hepatoblastoma via CD44","volume":"38","author":"Hauck","year":"2018","journal-title":"Liver Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.febslet.2012.06.049","article-title":"Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3","volume":"586","author":"Zeng","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/gut.2011.239145","article-title":"The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2","volume":"61","author":"Zheng","year":"2012","journal-title":"Gut"},{"key":"ref_36","first-page":"7161","article-title":"Systematic analysis of the molecular mechanism of microRNA-124 in hepatoblastoma cells","volume":"14","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/hep4.1185","article-title":"MicroRNA-26-5p functions as a new inhibitor of hepatoblastoma by repressing lin-28 homolog B and aurora kinase a expression","volume":"2","author":"Zhang","year":"2018","journal-title":"Hepatol. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e2278","DOI":"10.1038\/cddis.2016.143","article-title":"Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma","volume":"7","author":"Dong","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_39","first-page":"5773","article-title":"Nuclear paraspeckle assembly transcript 1 promotes the metastasis and epithelial-mesenchymal transition of hepatoblastoma cells by inhibiting miR-129-5p","volume":"14","author":"Fu","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biopha.2018.02.026","article-title":"Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1","volume":"101","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.3892\/ol.2016.4312","article-title":"MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma","volume":"11","author":"Ruan","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2014.05.004","article-title":"Activation of \u03b2-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice","volume":"147","author":"Tao","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Min, Q., Molina, L., Li, J., Adebayo Michael, A.O., Russell, J.O., Preziosi, M.E., Singh, S., Poddar, M., Matz-Soja, M., and Ranganathan, S. (2019). \u03b2-Catenin and yes-associated protein 1 cooperate in hepatoblastoma pathogenesis. Am. J. Pathol., in press.","DOI":"10.1016\/j.ajpath.2019.02.002"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.18632\/oncotarget.26668","article-title":"mTOR inhibition affects Yap1-\u03b2-catenin-induced hepatoblastoma growth and development","volume":"10","author":"Molina","year":"2019","journal-title":"Oncotarget"},{"key":"ref_45","first-page":"975","article-title":"MiR-122 increases sensitivity of drug-resistant BEL-7402\/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins","volume":"66","author":"Yin","year":"2011","journal-title":"Pharmazie"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1042\/BSR20160062","article-title":"Dynamic regulation of uncoupling protein 2 expression by microRNA-214 in hepatocellular carcinoma","volume":"36","author":"Yu","year":"2016","journal-title":"Biosci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00428-014-1549-y","article-title":"MicroRNA expression might predict prognosis of epithelial hepatoblastoma","volume":"464","author":"Gyugos","year":"2014","journal-title":"Virchows Arch."},{"key":"ref_48","first-page":"4581","article-title":"miR-378a enhances the sensitivity of liver cancer to sorafenib by targeting VEGFR, PDGFR\u03b2 and c-Raf","volume":"17","author":"Fu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1159\/000487163","article-title":"Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma","volume":"45","author":"Liu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1593\/tlo.09124","article-title":"Altered microRNA Expression Patterns in Hepatoblastoma Patients","volume":"2","author":"Magrelli","year":"2009","journal-title":"Transl. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cellsig.2016.04.002","article-title":"Suppression of microRNA-125a-5p upregulates the TAZ-EGFR signaling pathway and promotes retinoblastoma proliferation","volume":"28","author":"Zhang","year":"2016","journal-title":"Cell Signal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/gcc.10307","article-title":"Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma","volume":"39","author":"Zatkova","year":"2004","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1074\/mcp.M300094-MCP200","article-title":"From proteomic analysis to clinical significance: Overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis","volume":"3","author":"Ding","year":"2004","journal-title":"Mol. Cell. Proteom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.surg.2008.04.008","article-title":"The search for cancer stem cells in hepatocellular carcinoma","volume":"144","author":"Kamohara","year":"2008","journal-title":"Surgery"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.biocel.2014.04.002","article-title":"Regulation of microRNAs and their role in liver development, regeneration and disease","volume":"54","author":"Finch","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/MPH.0000000000001234","article-title":"MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance","volume":"41","author":"Ecevit","year":"2019","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00383-016-3960-8","article-title":"Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: A Chinese population-based study","volume":"32","author":"Liu","year":"2016","journal-title":"Pediatr. Surg. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jpedsurg.2016.02.091","article-title":"Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study","volume":"51","author":"Jiao","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jpedsurg.2016.09.070","article-title":"Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma","volume":"52","author":"Jiao","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1038\/srep10438","article-title":"A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients","volume":"5","author":"Chatterjee","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13742-015-0099-9","article-title":"Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples","volume":"4","author":"Leichter","year":"2015","journal-title":"Gigascience"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/11\/3\/409\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:40:00Z","timestamp":1760186400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/11\/3\/409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["cancers11030409"],"URL":"https:\/\/doi.org\/10.3390\/cancers11030409","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]}}}