{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:08:28Z","timestamp":1771553308116,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T00:00:00Z","timestamp":1553904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["2016"],"award-info":[{"award-number":["2016"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["ex60% 2017"],"award-info":[{"award-number":["ex60% 2017"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Dipartimenti di Eccellenza 2018 \u2013 2022"],"award-info":[{"award-number":["Dipartimenti di Eccellenza 2018 \u2013 2022"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LANZAVECCHIA-LASTRETTI Foundation","award":["-"],"award-info":[{"award-number":["-"]}]},{"name":"RETE ONCOLOGICA PIEMONTE VALLE D'AOSTA","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Survival predictions are currently determined on the basis of NRAS\/BRAF mutations, even though TERT promoter mutations have been recently associated with a poor prognosis in stage I-II melanomas. Usually, it is not recommended to perform a mutational test on primary melanoma, as the results do not always reflect the mutational status of metastases. In particular, trunk melanomas have been reported to have an unfavourable prognosis. A series of 105 advanced melanoma patients were analysed by TERT promoter Sanger sequencing. Univariate\/multivariate binary logistic regression models were performed using progression to a visceral site as the dependent variable and patient\/tumour characteristics as covariates. Performance of the model was assessed in an external independent primary melanoma patients\u2019 dataset. Male gender (odds ratio (OR), 344; 95% CI, 1.12\u201310.6; p = 0.031), AJCC (American Joint Committee on Cancer) classification (OR, 022; 95% CI, 0.07\u20130.67; p = 0.008), SLNB (Sentinel Lymph Node Biopsy) status (OR, 3.05; 95% CI, 1.06\u20138.78; p = 0.039) and TERT-mutated trunk lesions (OR, 3.78; 95% CI, 1.35\u201310.6; p =\u2009 0.011) were significantly associated with the risk of developing a visceral spreading as first site of progression using multivariate logistic regression analysis. These results were confirmed in the external validation control group. Therefore, in trunk primary melanomas, due to their high risk of progression to visceral sites, we encourage somatic TERT mutation analysis at diagnosis to identify those patients who would potentially benefit from a more intensive follow-up protocol and a prompt initiation of therapy.<\/jats:p>","DOI":"10.3390\/cancers11040452","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T03:21:26Z","timestamp":1554175286000},"page":"452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["TERT Promoter Mutations are Associated with Visceral Spreading in Melanoma of the Trunk"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-7694","authenticated-orcid":false,"given":"Simona","family":"Osella-Abate","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-7668","authenticated-orcid":false,"given":"Luca","family":"Bertero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Senetta","sequence":"additional","affiliation":[{"name":"Pathology Division, \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d University Hospital, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lisa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Dermatology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-1747","authenticated-orcid":false,"given":"Jasna","family":"Metovic","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-1212","authenticated-orcid":false,"given":"Barbara","family":"Pasini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Medical Genetics Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Puig S","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona &amp; Institut d\u2019investigacions biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Fierro","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Dermatology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"Manrique-Silva","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologia, Instituto Valenciano de Oncolog\u00eda, 46009 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-0395","authenticated-orcid":false,"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-8707","authenticated-orcid":false,"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologia, Instituto Valenciano de Oncolog\u00eda, 46009 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cassoni","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Pathology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Dermatology Unit, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/annonc\/mdv297","article-title":"Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Dummer","year":"2015","journal-title":"Ann. 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