{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:37:09Z","timestamp":1760240229373,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Preservation of the sciatic nerve is difficult in cases of highly malignant soft tissuetumors closely surrounding the nerve. Herein, we present the first case of preservation of thisnerve by combining an in-situ preparation technique (ISP; a technique enabling the preparation ofneurovascular bundles without contamination by tumor cells) with intensive concurrent neoadjuvantchemo-radiotherapy with hyperthermia (RHC; radio-hyperthermo-chemotherapy). A 62-year-oldman presented with a soft tissue mass in the right thigh and was diagnosed with undifferentiatedpleomorphic sarcoma. The tumor arose in the multi-compartment areas of the posterior thigh musclesand was closely intertwined with the sciatic nerve. As preoperative therapy, RHC was performedfor surgical down-staging and the tumor partially responded. Afterwards, wide resection of thetumor with preservation of the sciatic nerve using ISP was performed. Following the surgery, therehas not been recurrence in the affected site and the functional outcomes of the lower extremityachieved 80% in the Musculoskeletal Tumor Society score. The patient is still alive with disease fiveyears postoperatively. This is the first case in which ISP and RHC procedures were combined forthe preservation of the neurovascular structure. Further study is needed for the validation of thefeasibility of this method.<\/jats:p>","DOI":"10.3390\/cancers11040506","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T11:25:08Z","timestamp":1554895508000},"page":"506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of a Malignant Soft Tissue Tumor Arising in the Vicinity of the Sciatic Nerve with an In-Situ Preparation Technique and Intensive Multidisciplinary Therapy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-9814","authenticated-orcid":false,"given":"Hisaki","family":"Aiba","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-2154","authenticated-orcid":false,"given":"Katsuhiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"name":"Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"name":"Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"name":"Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Inatani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"name":"Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan"},{"name":"Department of Orthopaedic Surgery, Fukui-ken Saiseikai Hospital, Fukui 918-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"},{"name":"Department of Education, Tokai Gakuen University, Nagoya 468-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s101470200006","article-title":"\u201cIn situ preparation\u201d: New surgical procedure indicated for soft-tissue sarcoma of a lower limb in close proximity to major neurovascular structures","volume":"7","author":"Matsumoto","year":"2002","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1080\/02656736.2018.1518545","article-title":"Efficacy of radio-hyperthermo-chemotherapy as salvage therapy for recurrent or residual malignant soft tissue tumors","volume":"35","author":"Aiba","year":"2018","journal-title":"Int. J. Hyperthermia."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Aiba, H., Yamada, S., Mizutani, J., Yamamoto, N., Okamoto, H., Hayashi, K., Kimura, H., Takeuchi, A., Miwa, S., and Higuchi, T. (2018). Preoperative evaluation of the efficacy of radio-hyperthermo-chemotherapy for soft tissue sarcoma in a case series. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195289"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/cam4.1366","article-title":"Clinical outcomes of radio-hyperthermo-chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: A retrospective matched-pair cohort study","volume":"4","author":"Aiba","year":"2018","journal-title":"Cancer Med."},{"key":"ref_5","first-page":"1444","article-title":"Thallium-201 scintigraphy to assess effect of chemotherapy in osteosarcoma","volume":"37","author":"Ohtomo","year":"1996","journal-title":"J. Nucl. 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Orthopaedics, 61, 859\u2013863."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/11\/4\/506\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:44:21Z","timestamp":1760186661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/11\/4\/506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["cancers11040506"],"URL":"https:\/\/doi.org\/10.3390\/cancers11040506","relation":{},"ISSN":["2072-6694"],"issn-type":[{"type":"electronic","value":"2072-6694"}],"subject":[],"published":{"date-parts":[[2019,4,10]]}}}