{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:10:17Z","timestamp":1780524617500,"version":"3.54.1"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Autologous hematopoietic stem cell transplantation (AHCT) is an accepted strategy for various hematologic malignancies that can lead to functional impairment, fatigue, muscle wasting, and reduced quality of life (QOL). In cancer cachexia, these symptoms are associated with inflammation, hypermetabolism, and decreased anabolic hormones. The relative significance of these factors soon after AHCT setting is unclear. The purpose of this study was to characterize the acute effects of AHCT on physical function, body composition, QOL, energy expenditure, cytokines, and testosterone. Outcomes were assessed before (PRE) and 30 \u00b1 10 days after (FU) AHCT in patients with multiple myeloma (n = 15) and non-Hodgkin lymphoma (n = 6). Six-minute walk test (6MWT; p = 0.014), lean mass (p = 0.002), and fat mass (p = 0.02) decreased; nausea and fatigue increased at FU (both p = 0.039). Recent weight change and steroid exposure were predictors of reduced aerobic capacity (p &lt; 0.001). There were no significant changes in interleukin (IL)-1\u03b2, IL-6, tumor necrosis factor (TNF), energy expenditure, or bioavailable testosterone. Alterations in cytokines, energy expenditure, and testosterone were not associated with functional impairment acutely following AHCT. Recent history of weight loss and steroid exposure were predictors of worse physical function after AHCT, suggesting that targeting nutritional status and myopathy may be viable strategies to mitigate these effects.<\/jats:p>","DOI":"10.3390\/cancers11091300","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T08:28:13Z","timestamp":1567585693000},"page":"1300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Assessing Cachexia Acutely after Autologous Stem Cell Transplant"],"prefix":"10.3390","volume":"11","author":[{"given":"Lindsey J.","family":"Anderson","sequence":"first","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Yin","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Burciaga","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lee","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Migula","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Geiss-Wessel","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming M.","family":"Liu","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"},{"name":"Gerontology and Geriatric Medicine, University of Washington Department of Medicine, Seattle, 98195 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon A.","family":"Graf","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"},{"name":"Oncology, University of Washington Department of Medicine, Seattle, 98195 WA, USA"},{"name":"Fred Hutchinson Cancer Research Center, Seattle, 98109 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Chauncey","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"},{"name":"Oncology, University of Washington Department of Medicine, Seattle, 98195 WA, USA"},{"name":"Fred Hutchinson Cancer Research Center, Seattle, 98109 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, 98108 WA, USA"},{"name":"Gerontology and Geriatric Medicine, University of Washington Department of Medicine, Seattle, 98195 WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/bmt.2016.18","article-title":"Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey","volume":"51","author":"Niederwieser","year":"2016","journal-title":"Bone Marrow Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1188\/06.ONF.614-624","article-title":"Fatigue and physical activity in patients undergoing hematopoietic stem cell transplant","volume":"33","author":"Danaher","year":"2006","journal-title":"Oncol. 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