{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:39:24Z","timestamp":1773211164387,"version":"3.50.1"},"reference-count":73,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","award":["POR FESR 2014-2020-Obiettivo specifico 1.2 \"Manifestazione di Interesse per la Realizzazione di Technology Platform nell\u2019ambito della Lotta alle Patologie Oncologiche\u201d Project SATIN"],"award-info":[{"award-number":["POR FESR 2014-2020-Obiettivo specifico 1.2 \"Manifestazione di Interesse per la Realizzazione di Technology Platform nell\u2019ambito della Lotta alle Patologie Oncologiche\u201d Project SATIN"]}],"id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["InterOmics Flagship Project coordinated by the CNR, Italy"],"award-info":[{"award-number":["InterOmics Flagship Project coordinated by the CNR, Italy"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["International INCIPIT program co-funded by Marie Sklodowska Curie Actions"],"award-info":[{"award-number":["International INCIPIT program co-funded by Marie Sklodowska Curie Actions"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>High-Grade Serous Ovarian Carcinoma (HGSC) is the most incidental and lethal subtype of epithelial ovarian cancer (EOC) with a high mortality rate of nearly 65%. Recent findings aimed at understanding the pathogenesis of HGSC have attributed its principal source as the Fallopian Tube (FT). To further comprehend the exact mechanism of carcinogenesis, which is still less known, we performed a transcriptome analysis comparing FT and HGSC. Our study aims at exploring new players involved in the development of HGSC from FT, along with their signaling network, and we chose to focus on non-coding RNAs. Non-coding RNAs (ncRNAs) are increasingly observed to be the major regulators of several cellular processes and could have key functions as biological markers, as well as even a therapeutic approach. The most physiologically relevant and significantly dysregulated non-coding RNAs were identified bioinformatically. After analyzing the trend in HGSC and other cancers, MAGI2-AS3 was observed to be an important player in EOC. We assessed its tumor-suppressive role in EOC by means of various assays. Further, we mapped its signaling pathway using its role as a miRNA sponge to predict the miRNAs binding to MAGI2AS3 and showed it experimentally. We conclude that MAGI2-AS3 acts as a tumor suppressor in EOC, specifically in HGSC by sponging miR-15-5p, miR-374a-5p and miR-374b-5p, and altering downstream signaling of certain mRNAs through a ceRNA network.<\/jats:p>","DOI":"10.3390\/cancers11122008","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T11:06:41Z","timestamp":1576148801000},"page":"2008","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Long Non-Coding RNA MAGI2-AS3 is a New Player with a Tumor Suppressive Role in High Grade Serous Ovarian Carcinoma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-330X","authenticated-orcid":false,"given":"Priyanka","family":"Gokulnath","sequence":"first","affiliation":[{"name":"IEOS - Institute of Experimental Endocrinology and Oncology \u2018G. Salvatore\u2019, National Research Council, via S. Pansini 5, 80131 Napoli, Italy"},{"name":"Dpt. Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-0002","authenticated-orcid":false,"given":"Tiziana","family":"de Cristofaro","sequence":"additional","affiliation":[{"name":"IEOS - Institute of Experimental Endocrinology and Oncology \u2018G. Salvatore\u2019, National Research Council, via S. Pansini 5, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-8378","authenticated-orcid":false,"given":"Ichcha","family":"Manipur","sequence":"additional","affiliation":[{"name":"High Performance Computing and Networking Institute, National Research Council, via P. Castellino 111, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Di Palma","sequence":"additional","affiliation":[{"name":"IEOS - Institute of Experimental Endocrinology and Oncology \u2018G. Salvatore\u2019, National Research Council, via S. Pansini 5, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amata Amy","family":"Soriano","sequence":"additional","affiliation":[{"name":"IEOS - Institute of Experimental Endocrinology and Oncology \u2018G. Salvatore\u2019, National Research Council, via S. Pansini 5, 80131 Napoli, Italy"},{"name":"Present affiliation: IRCCS Casa Sollievo della Sofferenza, Cancer Stem Cells Unit, ISReMIT, 71013 San Giovanni Rotondo FG, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-8134","authenticated-orcid":false,"given":"Mario Rosario","family":"Guarracino","sequence":"additional","affiliation":[{"name":"Dpt. Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9769","authenticated-orcid":false,"given":"Mariastella","family":"Zannini","sequence":"additional","affiliation":[{"name":"IEOS - Institute of Experimental Endocrinology and Oncology \u2018G. Salvatore\u2019, National Research Council, via S. 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