{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:09:51Z","timestamp":1790831391142,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014808","name":"GEFLUC","doi-asserted-by":"publisher","award":["R18114DD"],"award-info":[{"award-number":["R18114DD"]}],"id":[{"id":"10.13039\/501100014808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Breast adiposity is correlated with body mass index, menopausal status and mammary density. We here wish to establish how these factors influence the cross-talk between breast adipocytes and normal or malignant breast cells. Adipocyte-derived stem cells (ASCs) were obtained from healthy women and classified into six distinct groups based on body mass index, menopausal status and mammary density. The ASCs were induced to differentiate, and the influence of their conditioned media (ACM) was determined. Unexpectedly, there were no detectable differences in adipogenic differentiation and secretion between the six ASC groups, while their corresponding ACMs had no detectable influence on normal breast cells. In clear contrast, all ACMs profoundly influenced the proliferation, migration and invasiveness of malignant breast cells and increased the number of lipid droplets in their cytoplasm via increased expression of the fatty acid receptor CD36, thereby increasing fatty acid uptake. Importantly, inhibition of CD36 reduced lipid droplet accumulation and attenuated the migration and invasion of the breast cancer cells. These findings suggest that breast-associated adipocytes potentiate the invasiveness of breast cancer cells which, at least in part, is mediated by metabolic reprogramming via CD36-mediated fatty acid uptake.<\/jats:p>","DOI":"10.3390\/cancers11122012","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T11:27:22Z","timestamp":1576236442000},"page":"2012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density"],"prefix":"10.3390","volume":"11","author":[{"given":"Maurice","family":"Zaoui","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Cancer Biology and Therapeutics, Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Morel","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Cancer Biology and Therapeutics, Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ferrand","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Cancer Biology and Therapeutics, Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Fellahi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology, Tenon Hospital, AP-HP, F-75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bastard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hormonology, Tenon Hospital, AP-HP, F-75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Lamazi\u00e8re","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR 70203, Laboratory of Biomolecules, \u00c9cole Normale Sup\u00e9rieure, AP-HP, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette Kragh","family":"Larsen","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Cancer Biology and Therapeutics, Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-549X","authenticated-orcid":false,"given":"V\u00e9ronique","family":"B\u00e9r\u00e9ziat","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Genetic and Acquired Lipodystrophies, Institut Hospitalo-Universitaire de Cardiom\u00e9tabolisme et Nutrition, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9529-2648","authenticated-orcid":false,"given":"Michael","family":"Atlan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Reconstructive, Aesthetic, Microsurgery and Tissue Regeneration, Tenon Hospital, Institut Universitaire de Canc\u00e9rologie, AP-HP, F-75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-9022","authenticated-orcid":false,"given":"Mich\u00e8le","family":"Sabbah","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), UMR_S 938, Centre de Recherche Saint-Antoine, Team Cancer Biology and Therapeutics, Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, F-75012 Paris, 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J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s40471-018-0144-1","article-title":"Mendelian randomization studies of cancer risk: A literature review","volume":"5","author":"Pierce","year":"2018","journal-title":"Curr. Epidemiol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"Sorlie","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11912-018-0688-8","article-title":"The Impact of Obesity on Breast Cancer","volume":"20","author":"Argolo","year":"2018","journal-title":"Curr. Oncol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/annonc\/mdu042","article-title":"Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies","volume":"25","author":"Chan","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3390\/cancers7040883","article-title":"The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer","volume":"7","author":"Rose","year":"2015","journal-title":"Cancers"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.plipres.2017.11.002","article-title":"Adipocyte biology in breast cancer: From silent bystander to active facilitator","volume":"69","author":"Choi","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2015.04.012","article-title":"Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity","volume":"140","author":"Delort","year":"2015","journal-title":"Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/onc.2009.130","article-title":"Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells","volume":"28","author":"Walter","year":"2009","journal-title":"Oncogene"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/epirev\/mxt010","article-title":"Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status","volume":"36","author":"Munsell","year":"2014","journal-title":"Epidemiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1054\/brst.2000.0209","article-title":"Importance of local aromatase activity in hormone-dependent breast cancer: A review","volume":"10","author":"Blankenstein","year":"2001","journal-title":"Breast"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"75389","DOI":"10.18632\/oncotarget.17853","article-title":"The association between obesity related adipokines and risk of breast cancer: A meta-analysis","volume":"8","author":"Gui","year":"2017","journal-title":"Oncotarget"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ijc.23943","article-title":"Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis","volume":"124","author":"Suzuki","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/aje\/152.6.514","article-title":"Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk","volume":"152","author":"Spiegelman","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ije\/dyw129","article-title":"Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer","volume":"45","author":"Gao","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Guo, Y., Warren Andersen, S., Shu, X.O., Michailidou, K., Bolla, M.K., Wang, Q., Garcia-Closas, M., Milne, R.L., Schmidt, M.K., and Chang-Claude, J. (2016). Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002105"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10911-010-9187-8","article-title":"Diverse and active roles for adipocytes during mammary gland growth and function","volume":"15","author":"Hovey","year":"2010","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/jnci\/87.21.1622","article-title":"Mammographic features and breast cancer risk: Effects with time, age, and menopause status","volume":"87","author":"Byrne","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/dji056","article-title":"Are breast density and bone mineral density independent risk factors for breast cancer?","volume":"97","author":"Kerlikowske","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1200\/JCO.2015.60.8869","article-title":"Breast Density and Benign Breast Disease: Risk Assessment to Identify Women at High Risk of Breast Cancer","volume":"33","author":"Tice","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pettersson, A., Graff, R.E., Ursin, G., Santos Silva, I.D., McCormack, V., Baglietto, L., Vachon, C., Bakker, M.F., Giles, G.G., and Chia, K.S. (2014). Mammographic density phenotypes and risk of breast cancer: A meta-analysis. J. Natl. Cancer Inst., 106.","DOI":"10.1093\/jnci\/dju078"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1158\/1055-9965.EPI-04-0717","article-title":"Mammographic features and subsequent risk of breast cancer: A comparison of qualitative and quantitative evaluations in the Guernsey prospective studies","volume":"14","author":"Allen","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/org.24279","article-title":"Adipose-derived stromal\/stem cells: A primer","volume":"9","author":"Gimble","year":"2013","journal-title":"Organogenesis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J. Orthop. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1387\/ijdb.113365jt","article-title":"Adipocyte is a non-trivial, dynamic partner of breast cancer cells","volume":"55","author":"Tan","year":"2011","journal-title":"Int. J. Dev. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81574-3","article-title":"Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma","volume":"93","author":"Nagy","year":"1998","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","article-title":"mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer","volume":"8","author":"Tontonoz","year":"1994","journal-title":"Genes Dev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/ERC-06-0068","article-title":"Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression","volume":"14","author":"Rose","year":"2007","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/JOE-13-0339","article-title":"Adipocytokines in obesity and metabolic disease","volume":"220","author":"Cao","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1467-789X.2004.00142.x","article-title":"Obesity, adipocytokines, and insulin resistance in breast cancer","volume":"5","author":"Rose","year":"2004","journal-title":"Obes Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/17477166.2011.604326","article-title":"Is adipose tissue metabolically different at different sites?","volume":"6","author":"Gil","year":"2011","journal-title":"Int. J. Pediatr. Obes"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/IGC.0b013e3182510496","article-title":"Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer","volume":"22","author":"Modesitt","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.4081\/ejh.2010.e48","article-title":"Subcutaneous adipose tissue classification","volume":"54","author":"Sbarbati","year":"2010","journal-title":"Eur. J. Histochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"47239","DOI":"10.18632\/oncotarget.17592","article-title":"Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth","volume":"8","author":"Lapeire","year":"2017","journal-title":"Oncotarget"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.ijo.0803427","article-title":"Sex-specific determinants of serum adiponectin in older adults: The role of endogenous sex hormones","volume":"31","author":"Laughlin","year":"2007","journal-title":"Int. J. Obes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"109417","DOI":"10.18632\/oncotarget.22684","article-title":"Estrogen receptor signaling mediates leptin-induced growth of breast cancer cells via autophagy induction","volume":"8","author":"Raut","year":"2017","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Van Sinderen, M.L., Steinberg, G.R., Jorgensen, S.B., Honeyman, J., Chow, J.D., Herridge, K.A., Winship, A.L., Dimitriadis, E., Jones, M.E., and Simpson, E.R. (2015). Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136143"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"57622","DOI":"10.18632\/oncotarget.18038","article-title":"The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance","volume":"8","author":"Duong","year":"2017","journal-title":"Oncotarget"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13058-018-1078-8","article-title":"Adjusting for BMI in analyses of volumetric mammographic density and breast cancer risk","volume":"20","author":"Hudson","year":"2018","journal-title":"Breast Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1158\/0008-5472.CAN-14-0160","article-title":"Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak\/STAT3 signaling","volume":"74","author":"Lapeire","year":"2014","journal-title":"Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1158\/0008-5472.CAN-15-0927","article-title":"Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src\/Sox2\/miR-302b-Mediated Malignant Progression","volume":"76","author":"Pan","year":"2016","journal-title":"Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/0008-5472.CAN-10-3323","article-title":"Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion","volume":"71","author":"Dirat","year":"2011","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e87489","DOI":"10.1172\/jci.insight.87489","article-title":"Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells","volume":"2","author":"Wang","year":"2017","journal-title":"JCI Insight"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular fatty acid metabolism and cancer","volume":"18","author":"Currie","year":"2013","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/s41388-017-0093-z","article-title":"Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis","volume":"37","author":"Ladanyi","year":"2018","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"14752","DOI":"10.1038\/srep14752","article-title":"Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"5","author":"Nath","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2011.07.026","article-title":"Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells","volume":"146","author":"Gupta","year":"2011","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"21268","DOI":"10.18632\/oncotarget.25066","article-title":"STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells","volume":"9","author":"Rozovski","year":"2018","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2337\/db11-0425","article-title":"Fatty acids, obesity, and insulin resistance: Time for a reevaluation","volume":"60","author":"Karpe","year":"2011","journal-title":"Diabetes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1020539932353","article-title":"Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT\/CD36)-mediated cellular fatty acid uptake","volume":"239","author":"Coort","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-nutr-071812-161220","article-title":"Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism","volume":"34","author":"Pepino","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/jwh.2015.5556","article-title":"Perimenopause: From Research to Practice","volume":"25","author":"Santoro","year":"2016","journal-title":"J. Womens Health"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12282-018-0857-5","article-title":"An overview of mammographic density and its association with breast cancer","volume":"25","author":"Nazari","year":"2018","journal-title":"Breast Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3851\/IMP1988","article-title":"Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes","volume":"17","author":"Capel","year":"2012","journal-title":"Antivir. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/s41598-017-01866-2","article-title":"WISP1\/CCN4 inhibits adipocyte differentiation through repression of PPARgamma activity","volume":"7","author":"Ferrand","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1677\/joe.1.07009","article-title":"Molecular cloning and characterization of the human WISP-2\/CCN5 gene promoter reveal its upregulation by oestrogens","volume":"191","author":"Fritah","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.plipres.2007.09.001","article-title":"Lipidomics: Practical aspects and applications","volume":"47","author":"Wolf","year":"2008","journal-title":"Prog. 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