{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:27:42Z","timestamp":1787902062516,"version":"build-2784847793"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA214960-01A1"],"award-info":[{"award-number":["1R01CA214960-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA225701-01A1"],"award-info":[{"award-number":["1R01CA225701-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["1R21NR016736-01"],"award-info":[{"award-number":["1R21NR016736-01"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In this prospective study, we examined the prevalence and management of CNMP in cancer patients seen at our supportive care clinic for consultation. We systematically characterized each pain type with the Brief Pain Inventory (BPI) and documented current treatments. The attending physician made the pain diagnoses according to the International Association for the Study of Pain (IASP) task force classification. Among 200 patients (mean age 60 years, 69% metastatic disease, 1-year survival of 77%), the median number of pain diagnosis was 2 (IQR 1\u20132); 67 (34%, 95% CI 28\u201341%) had a diagnosis of CNMP; 133 (67%) had cancer-related pain; and 52 (26%) had treatment-related pain. In total, 12\/31 (39%) patients with only CNMP and 21\/36 (58%) patients with CNMP and other pain diagnoses were on opioids. There was a total of 94 CNMP diagnoses among 67 patients, including 37 (39%) osteoarthritis and 20 (21%) lower back pain; 30 (32%) were treated with opioids. In summary, CNMP was common in the timely palliative care setting and many patients were on opioids. Our findings highlight the need to develop clinical guidelines for CNMP in cancer patients to standardize its management.<\/jats:p>","DOI":"10.3390\/cancers12010214","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T04:14:41Z","timestamp":1579234481000},"page":"214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chronic Non-Malignant Pain in Patients with Cancer Seen at a Timely Outpatient Palliative Care Clinic"],"prefix":"10.3390","volume":"12","author":[{"given":"David","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abdelghani","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2790-2832","authenticated-orcid":false,"given":"Joseph","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Dibaj","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-3151","authenticated-orcid":false,"given":"Donna","family":"Zhukovsky","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberson","family":"Tanco","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-8250","authenticated-orcid":false,"given":"Ahsan","family":"Azhar","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhila","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Epner","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-6108","authenticated-orcid":false,"given":"Joseph","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-9021","authenticated-orcid":false,"given":"Yvonne","family":"Heung","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"De La Cruz","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Rehabilitation and Integrative Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jpainsymman.2005.06.007","article-title":"A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease","volume":"31","author":"Solano","year":"2006","journal-title":"J. Pain Symptom Manag."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpainsymman.2006.10.015","article-title":"Symptom prevalence in patients with incurable cancer: A systematic review","volume":"34","author":"Teunissen","year":"2007","journal-title":"J. Pain Symptom Manag."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nrn1914","article-title":"Cancer pain and its impact on diagnosis, survival and quality of life","volume":"7","author":"Mantyh","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1200\/JCO.2013.52.2508","article-title":"A personalized approach to assessing and managing pain in patients with cancer","volume":"32","author":"Hui","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3322\/caac.21490","article-title":"Improving patient and caregiver outcomes in oncology: Team-based, timely, and targeted palliative care","volume":"68","author":"Hui","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00520-019-04811-3","article-title":"Examination of referral criteria for outpatient palliative care among patients with advanced cancer","volume":"28","author":"Hui","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dowell, D., Haegerich, T.M., and Chou, R. (2016). CDC Guideline for Prescribing Opioids for Chronic Pain-United States, 2016. JAMA.","DOI":"10.1001\/jama.2016.1464"},{"key":"ref_8","first-page":"38","article-title":"Opioid prescribing: A systematic review and critical appraisal of guidelines for chronic pain","volume":"160","author":"Nuckols","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.36076\/ppj.2012\/15\/E1","article-title":"American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part I\u2014Evidence assessment","volume":"15","author":"Manchikanti","year":"2012","journal-title":"Pain Phys."},{"key":"ref_10","first-page":"S67","article-title":"American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part 2\u2014Guidance","volume":"15","author":"Manchikanti","year":"2012","journal-title":"Pain Phys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"992","DOI":"10.6004\/jnccn.2013.0119","article-title":"Adult cancer pain","volume":"11","author":"Swarm","year":"2013","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.2016.68.5206","article-title":"Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline","volume":"34","author":"Paice","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpainsymman.2003.06.011","article-title":"Pain characteristics and treatment outcome for advanced cancer patients during the first week of specialized palliative care","volume":"27","author":"Stromgren","year":"2004","journal-title":"J. Pain Symptom Manag."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/AJP.0b013e31827eb5e6","article-title":"Incidence and management of noncancer pain in cancer patients referred to a radiotherapy center","volume":"29","author":"Massaccesi","year":"2013","journal-title":"Clin. J. Pain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1200\/JCO.2013.49.8311","article-title":"Frequency of non-cancer-related pain in patients with cancer","volume":"31","author":"Barbera","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/1049909114531445","article-title":"Chronic Pain and Risk Factors for Opioid Misuse in a Palliative Care Clinic","volume":"32","author":"Childers","year":"2015","journal-title":"Am. J. Hosp. Palliat. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pain.2009.02.009","article-title":"Acceptance of pain: A study in patients with advanced cancer","volume":"143","author":"Gauthier","year":"2009","journal-title":"Pain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0304-3959(95)00076-3","article-title":"Assessment of cancer pain: A prospective evaluation in 2266 cancer patients referred to a pain service","volume":"64","author":"Grond","year":"1996","journal-title":"Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1200\/JCO.2010.29.5618","article-title":"Integrating supportive and palliative care in the trajectory of cancer: Establishing goals and models of care","volume":"28","author":"Bruera","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1634\/theoncologist.2015-0234","article-title":"Use of Palliative Care Services in a Tertiary Cancer Center","volume":"21","author":"Dalal","year":"2016","journal-title":"Oncologist"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gaertner, J., Boehlke, C., Simone, C.B., and Hui, D. (2019). Early palliative care and the opioid crisis: Ten pragmatic steps towards a more rational use of opioids. Ann. Palliat. Med.","DOI":"10.21037\/apm.2019.08.01"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"iv166","DOI":"10.1093\/annonc\/mdy152","article-title":"Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ejp.1346","article-title":"Standards for the management of cancer-related pain across Europe-A position paper from the EFIC Task Force on Cancer Pain","volume":"23","author":"Bennett","year":"2019","journal-title":"Eur. J. Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E659","DOI":"10.1503\/cmaj.170363","article-title":"Guideline for opioid therapy and chronic noncancer pain","volume":"189","author":"Busse","year":"2017","journal-title":"CMAJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Inoue, S., Kobayashi, F., Nishihara, M., Arai, Y.C., Ikemoto, T., Kawai, T., Inoue, M., Hasegawa, T., and Ushida, T. (2015). Chronic Pain in the Japanese Community\u2014Prevalence, Characteristics and Impact on Quality of Life. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129262"},{"key":"ref_26","first-page":"135","article-title":"Conjoint screening questionnaires for alcohol and other drug abuse: Criterion validity in a primary care practice","volume":"94","author":"Brown","year":"1995","journal-title":"Wis. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jpainsymman.2006.03.010","article-title":"Validation and clinical application of the Screener and Opioid Assessment for Patients with Pain (SOAPP)","volume":"32","author":"Akbik","year":"2006","journal-title":"J. Pain Symptom Manag."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pain.2004.07.026","article-title":"Validation of a screener and opioid assessment measure for patients with chronic pain","volume":"112","author":"Butler","year":"2004","journal-title":"Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/082585979100700202","article-title":"The Edmonton Symptom Assessment System (ESAS): A simple method for the assessment of palliative care patients","volume":"7","author":"Bruera","year":"1991","journal-title":"J. Palliat. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jpainsymman.2016.10.370","article-title":"The Edmonton Symptom Assessment System 25 Years Later: Past, Present and Future Developments","volume":"53","author":"Hui","year":"2017","journal-title":"J. Pain Symptom Manag."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J. Clin. Epidemiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jclinepi.2014.09.010","article-title":"A systematic review identifies valid comorbidity indices derived from administrative health data","volume":"68","author":"Yurkovich","year":"2015","journal-title":"J. Clin. Epidemiol."},{"key":"ref_34","first-page":"129","article-title":"Pain assessment: Global use of the Brief Pain Inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0304-3959(99)00073-1","article-title":"An international survey of cancer pain characteristics and syndromes. IASP Task Force on Cancer Pain. International Association for the Study of Pain","volume":"82","author":"Caraceni","year":"1999","journal-title":"Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: Redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/add.12551","article-title":"The global epidemiology and burden of opioid dependence: Results from the global burden of disease 2010 study","volume":"109","author":"Degenhardt","year":"2014","journal-title":"Addiction"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1097\/j.pain.0000000000000892","article-title":"Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data","volume":"158","author":"Morley","year":"2017","journal-title":"Pain"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/1\/214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:05:10Z","timestamp":1760364310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/1\/214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["cancers12010214"],"URL":"https:\/\/doi.org\/10.3390\/cancers12010214","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}