{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:06:59Z","timestamp":1790676419320,"version":"4.1.0"},"reference-count":175,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Ovarian cancer (OC) is one of the leading causes of cancer death in women, with high-grade serous ovarian cancer (HGSOC) being the most lethal gynecologic malignancy among women. This high fatality rate is the result of diagnosis of a high number of new cases when cancer implants have already spread. The poor prognosis is due to our inadequate understanding of the molecular mechanisms preceding ovarian malignancy. Knowledge about the site of origination has been improved recently by the discovery of tube intraepithelial cancer (TIC), but the potential risk factors are still obscure. Due to high tumoral heterogeneity in OC, the establishment of early stage biomarkers is still underway. Microbial infection may induce or result in chronic inflammatory infection and in the pathogenesis of cancers. Microbiome research has shed light on the relationships between the host and microbiota, as well as the direct roles of host pathogens in cancer development, progression, and drug efficacy. While controversial, the detection of viruses within ovarian malignancies and fallopian tube tissues suggests that these pathogens may play a role in the development of OC. Genomic and proteomic approaches have enhanced the methods for identifying candidates in early screening. This article summarizes the existing knowledge related to the molecular mechanisms that lead to tumorigenesis in the ovary, as well as the viruses detected in OC cases and how they may elevate this process.<\/jats:p>","DOI":"10.3390\/cancers12030561","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:35:30Z","timestamp":1583134530000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Factors in Oncogenesis: Viral Infections in Ovarian Cancer"],"prefix":"10.3390","volume":"12","author":[{"given":"Sudipta","family":"Pathak","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek R.","family":"Wilczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Surgical and Oncological Gynecology, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Paradowska","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"ref_1","unstructured":"(2019, June 17). Global Cancer Observatory. Available online: https:\/\/gco.iarc.fr\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2644","article-title":"The biology of ovarian cancer: New opportunities for translation","volume":"9","author":"Bast","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajog.2008.01.005","article-title":"Early detection and treatment of ovarian cancer: Shifting from early stage to minimal volume of disease based on a new model of carcinogenesis","volume":"198","author":"Kurman","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1158\/1055-9965.EPI-16-0459","article-title":"Is pelvic inflammatory disease a risk factor for ovarian cancer?","volume":"26","author":"Rasmussen","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10555-014-9547-8","article-title":"Proteomics of ovarian cancer: Functional insights and clinical applications","volume":"34","author":"Elzek","year":"2015","journal-title":"Cancer Metastasis Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ygyno.2016.12.002","article-title":"Genotype-matched treatment for patients with advanced type I epithelial ovarian cancer (EOC)","volume":"144","author":"Spreafico","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_8","unstructured":"(2019, July 19). Biological Agents. Available online: https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans\/Biological-Agents-2012."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/carcin\/21.3.405","article-title":"Viral carcinogenesis: Revelation of molecular mechanisms and etiology of human disease","volume":"21","author":"Butel","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.61","article-title":"Ovarian cancer","volume":"2","author":"Matulonis","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_11","unstructured":"Kurman, R. (2014). WHO Classification of Tumours of Female Reproductive Organs, Internat Agency for Research on Cancer."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lisio, M.-A., Fu, L., Goyeneche, A., Gao, Z.-H., and Telleria, C. (2019). High-grade serous ovarian cancer: Basic sciences, clinical and therapeutic standpoints. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040952"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The dualistic model of ovarian carcinogenesis","volume":"186","author":"Kurman","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2018.00654","article-title":"When is \u201cType I\u201d ovarian cancer not \u201cType I\u201d? Indications of an out-dated dichotomy","volume":"8","author":"Salazar","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-0-387-68969-2_7","article-title":"Ovarian carcinogenesis: An alternative hypothesis","volume":"622","author":"Piek","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1038\/srep06116","article-title":"Ovulation and extra-ovarian origin of ovarian cancer","volume":"4","author":"Sumi","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1073\/pnas.1117135109","article-title":"High-grade serous ovarian cancer arises from fallopian tube in a mouse model","volume":"109","author":"Kim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2006","journal-title":"J. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/path.2696","article-title":"Driver mutations in tp53 are ubiquitous in high grade serous carcinoma of the ovary","volume":"221","author":"Ahmed","year":"2010","journal-title":"J. Pathol."},{"key":"ref_21","first-page":"255","article-title":"Ovarian surface epithelium: Biology, endocrinology, and pathology","volume":"22","author":"Auersperg","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000494001","article-title":"Mechanism for the decision of ovarian surface epithelial stem cells to undergo neo-oogenesis or ovarian tumorigenesis","volume":"50","author":"Xu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/jnci\/91.17.1459","article-title":"Possible role of ovarian epithelial inflammation in ovarian cancer","volume":"91","author":"Ness","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00004347-199910000-00008","article-title":"p53, c-ErbB, and Ki-67 expression in ovaries removed prophylactically from women with a family history of ovarian cancer","volume":"18","author":"Werness","year":"1999","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/PGP.0000000000000120","article-title":"Two types of ovarian cortical inclusion cysts","volume":"34","author":"Banet","year":"2015","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12253-014-9854-y","article-title":"Immunophenotype and human papillomavirus status of serous adenocarcinoma of the uterine cervix","volume":"21","author":"Togami","year":"2014","journal-title":"Pathol. Oncol. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2014.00192","article-title":"Estrogen biosynthesis and action in ovarian cancer","volume":"5","author":"Mungenast","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8128","DOI":"10.1038\/sj.onc.1208959","article-title":"Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells","volume":"24","author":"Syed","year":"2005","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.steroids.2013.01.008","article-title":"New insights on the role of hormonal therapy in ovarian cancer","volume":"78","author":"Simpkins","year":"2013","journal-title":"Steroids"},{"key":"ref_30","first-page":"1","article-title":"Epidermal growth factor receptor blockers for the treatment of ovarian cancer","volume":"10","author":"Morrison","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-017-0134-9","article-title":"The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis","volume":"12","author":"Ingerslev","year":"2017","journal-title":"Infect. Agents Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Savant, S., Sriramkumar, S., and O\u2019Hagan, H. (2018). The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancer. Cancers, 10.","DOI":"10.3390\/cancers10080251"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-30261-8","article-title":"Inflammation is a key contributor to ovarian cancer cell seeding","volume":"8","author":"Jia","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1158\/1055-9965.EPI-10-1180","article-title":"Circulating inflammation markers and risk of epithelial ovarian cancer","volume":"20","author":"Clendenen","year":"2011","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1684\/ecn.2009.0161","article-title":"Circulating levels of TNF-\u03b1 and its soluble receptors in the plasma of patients with epithelial ovarian cancer","volume":"20","author":"Dobrzycka","year":"2009","journal-title":"Eur. Cytokine Netw."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10555-013-9456-2","article-title":"Ovarian cancer microenvironment: Implications for cancer dissemination and chemoresistance acquisition","volume":"33","author":"Thibault","year":"2013","journal-title":"Cancer Metast. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neo.2015.12.003","article-title":"Activation-induced cytidine deaminase links ovulation-induced inflammation and serous carcinogenesis","volume":"18","author":"Sapoznik","year":"2016","journal-title":"Neoplasia"},{"key":"ref_38","first-page":"1","article-title":"The crowded crosstalk between cancer cells and stromal microenvironment in gynecological malignancies: Biological pathways and therapeutic implication","volume":"20","author":"Nola","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/sji.12162","article-title":"An optimized protocol for human M2 macrophages using M-CSF and IL-4\/IL-10\/TGF-\u03b2yields a dominant immunosuppressive phenotype","volume":"79","author":"Mia","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ygyno.2016.03.008","article-title":"PD-L1 expression is associated with tumor-infiltrating T-cells and favorable prognosis in high-grade serous ovarian cancer","volume":"141","author":"Webb","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2016.06.011","article-title":"B7-H4 expression in ovarian serous carcinoma: A study of 306 cases","volume":"57","author":"Liang","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10815-008-9219-0","article-title":"The involvement of the toll-like receptor family in ovulation","volume":"25","author":"Liu","year":"2008","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00262-008-0650-y","article-title":"Toll-like receptor expression in normal ovary and ovarian tumors","volume":"58","author":"Zhou","year":"2009","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1349-7006.2010.01491.x","article-title":"Toll-like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors","volume":"101","author":"Berger","year":"2010","journal-title":"Cancer Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.20122394","article-title":"The Human Papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter","volume":"210","author":"Hasan","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11372","DOI":"10.1128\/JVI.05279-11","article-title":"High-Risk Human Papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression","volume":"85","author":"Reiser","year":"2011","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/s41598-018-38031-2","article-title":"The biodiversity composition of microbiome in ovarian carcinoma patients","volume":"9","author":"Zhou","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fimmu.2015.00500","article-title":"Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration","volume":"6","author":"Bougherara","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.4161\/onci.21650","article-title":"Tumor-infiltrating B cells and T cells: Working together to promote patient survival","volume":"1","author":"Nielsen","year":"2012","journal-title":"Oncoimmunology"},{"key":"ref_50","first-page":"1070","article-title":"Dynamics of T-Cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells","volume":"132","author":"Sojka","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/15384047.2015.1040960","article-title":"Tumor infiltrating lymphocytes in ovarian cancer","volume":"16","author":"Santoiemma","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1158\/2326-6066.CIR-17-0479","article-title":"Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg\/th17 cell imbalance in epithelial ovarian cancer","volume":"6","author":"Zhou","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1158\/1078-0432.CCR-13-1185","article-title":"A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: From bench to bedside","volume":"19","author":"Chiang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-9378-7-35","article-title":"The role of infectious agents in urogenital cancers","volume":"7","author":"Alibek","year":"2012","journal-title":"Infect. Agents Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00404-013-3122-3","article-title":"Chlamydia trachomatis infection: Implications for HPV status and cervical cancer","volume":"289","author":"Silva","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"36225","DOI":"10.18632\/oncotarget.16717","article-title":"The ovarian cancer oncobiome","volume":"8","author":"Banerjee","year":"2017","journal-title":"Oncotarget"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0090-8258(89)90158-3","article-title":"Human Papillomavirus and epithelial ovarian neoplasia","volume":"32","author":"Leake","year":"1989","journal-title":"Gynecol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00004347-199207000-00007","article-title":"Human Papillomavirus in benign and malignant ovarian and endometrial tissues","volume":"11","author":"Lai","year":"1992","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_59","first-page":"573","article-title":"Human papillomavirus integration is not associated with advanced epithelial ovarian cancer in German patients","volume":"4","author":"Runnebaum","year":"1995","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/gyno.1998.5264","article-title":"Failure to demonstrate Human Papillomavirus DNA in epithelial ovarian cancer by general primer PCR","volume":"72","author":"Anttila","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/sj.bjc.6601172","article-title":"Detection of Human Papillomavirus-16 in ovarian malignancy","volume":"89","author":"Wu","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_62","first-page":"642","article-title":"HPV and p53 expression in epithelial ovarian carcinoma","volume":"10","author":"Kuscu","year":"2005","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1447-0756.2007.00663.x","article-title":"Detection of Human Papillomavirus DNA and genotyping in patients with epithelial ovarian carcinoma","volume":"33","author":"Atalay","year":"2007","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1447-0756.2008.00759.x","article-title":"Role of Human Papillomavirus in the development of epithelial ovarian neoplasms in Italian women","volume":"34","author":"Giordano","year":"2008","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1007\/s10096-012-1570-5","article-title":"Viral and bacterial aetiologies of epithelial ovarian cancer","volume":"31","author":"Shanmughapriya","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00404-012-2367-6","article-title":"Detection and genotyping of Human Papillomaviruses and their role in the development of ovarian carcinomas","volume":"286","author":"Malisic","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_67","first-page":"1","article-title":"Human Papillomavirus genotyping and integration in ovarian cancer Saudi patients","volume":"10","author":"Hafez","year":"2013","journal-title":"Virol. J."},{"key":"ref_68","first-page":"121","article-title":"The frequency of Human Papillomavirus types 16, 18 in upper genital tract of women at high risk of developing ovarian cancer","volume":"36","author":"Bilyk","year":"2014","journal-title":"Exp. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-016-0087-4","article-title":"High-Risk HPV is not associated with epithelial ovarian cancer in a Caucasian population","volume":"11","author":"Ingerslev","year":"2016","journal-title":"Infect. Agents Cancer"},{"key":"ref_70","first-page":"169","article-title":"Human papillomavirus genotypes and methylation of CADM1, PAX1, MAL and ADCYAP1 genes in epithelial ovarian cancer patients","volume":"18","author":"Hassan","year":"2017","journal-title":"Asian Pac. J. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"19935","DOI":"10.1038\/s41598-019-56448-1","article-title":"Detection and genotyping of CMV and HPV in tumors and fallopian tubes from epithelial ovarian cancer patients","volume":"9","author":"Paradowska","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.tranon.2018.08.003","article-title":"Impact of human cytomegalovirus infection and its immune response on survival of patients with ovarian cancer","volume":"11","author":"Estekizadeh","year":"2018","journal-title":"Transl. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000009685","article-title":"Human Cytomegalovirus in high grade serous ovarian cancer possible implications for patients survival","volume":"97","author":"Carlson","year":"2018","journal-title":"Medicine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-019-0223-z","article-title":"The prevalence of EBV and CMV DNA in epithelial ovarian cancer","volume":"14","author":"Ingerslev","year":"2019","journal-title":"Infect. Agents Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1128\/JVI.00340-13","article-title":"Landscape of DNA virus associations across human malignant cancers: Analysis of 3,775 cases using RNA-Seq","volume":"87","author":"Khoury","year":"2013","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Pandya, D., Mariani, M., McHugh, M., Andreoli, M., Sieber, S., He, S., Dowell-Martino, C., Fiedler, P., Scambia, G., and Ferlini, C. (2014). Herpes virus microRNA expression and significance in serous ovarian cancer. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0114750"},{"key":"ref_77","unstructured":"US Department of Health and Human Services, and Centers for Disease Control and Prevention (2017). Prevalence of HPV in Adults Aged 18\u201369: United States, 2011\u20132014, National Center for Health Statistics."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1002\/ijc.27571","article-title":"Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies","volume":"131","author":"Zhao","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/ncomms3513","article-title":"The landscape of viral expression and host gene fusion and adaptation in human cancer","volume":"4","author":"Tang","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/aogs.12254","article-title":"Prevalence of Human Papillomavirus in epithelial ovarian cancer tissue. A meta-analysis of observational studies","volume":"93","author":"Svahn","year":"2013","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/IGC.0b013e318280f3e0","article-title":"The Prevalence of Human Papillomavirus in ovarian cancer: A systematic review","volume":"23","author":"Rosa","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Bernard, X., Robinson, P., Nomin\u00e9, Y., Masson, M., Charbonnier, S., Ramirez-Ramos, J.R., Deryckere, F., Trav\u00e9, G., and Orfanoudakis, G. (2011). Proteasomal degradation of p53 by Human Papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025981"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2008.10.006","article-title":"The Human Papillomavirus E7 oncoprotein","volume":"384","year":"2009","journal-title":"Virology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molmed.2003.11.002","article-title":"Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology","volume":"10","author":"Cinatl","year":"2004","journal-title":"Trends Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5493\/wjem.v5.i1.1","article-title":"Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options","volume":"5","year":"2015","journal-title":"World J. Exp. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.canlet.2010.08.007","article-title":"Viral hit and run-oncogenesis: Genetic and epigenetic scenarios","volume":"305","author":"Niller","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_87","first-page":"257","article-title":"Synchronous occurrence of brucellosis and ovarian cancer-a case report","volume":"6","author":"Emara","year":"2007","journal-title":"Australas. J. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1128\/IAI.71.2.973-984.2003","article-title":"Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infection","volume":"71","author":"Scidmore","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1084\/jem.191.9.1525","article-title":"Degradation of transcription factor Rfx5 during the inhibition of both constitutive and interferon \u03b3\u2013inducible major histocompatibility complex class I expression in chlamydia-infected cells","volume":"191","author":"Zhong","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.chom.2013.05.010","article-title":"Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response","volume":"13","author":"Chumduri","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_91","first-page":"1","article-title":"Chlamydia infection depends on a functional MDM2-p53 axis","volume":"5","author":"Rother","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/gyno.1996.0316","article-title":"Prevalence of mycoplasma conserved DNA in malignant ovarian cancer detected using sensitive PCR\u2013ELISA","volume":"63","author":"Chan","year":"1996","journal-title":"Gynecol. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1096\/fj.06-6675com","article-title":"Neisseria gonorrhoeae infection causes a G1 arrest in human epithelial cells","volume":"21","author":"Jones","year":"2007","journal-title":"FASEB J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2009.07.042","article-title":"Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, Human Papillomavirus, and Polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions","volume":"202","author":"Idahl","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_96","unstructured":"(2007). Human Papillomaviruses. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, IARC."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2217\/fmb.10.107","article-title":"Human Papillomavirus: Gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies","volume":"5","author":"Graham","year":"2010","journal-title":"Future Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Pyeon, D., Pearce, S., Lank, S., Ahlquist, P., and Lambert, P. (2009). Establishment of Human Papillomavirus infection requires cell cycle progression. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000318"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.trecan.2016.04.001","article-title":"Human papillomaviruses: Research priorities for the next decade","volume":"2","author":"Langsfeld","year":"2016","journal-title":"Trends Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jnci\/92.9.690","article-title":"Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis","volume":"92","author":"Hausen","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/ijc.29823","article-title":"Human Papillomavirus capsids preferentially bind and infect tumor cells","volume":"138","author":"Kines","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1128\/JVI.00057-06","article-title":"Identification of a dynein interacting domain in the papillomavirus minor capsid protein L2","volume":"80","author":"Florin","year":"2006","journal-title":"J. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00292-008-1051-x","article-title":"HPV in non-gynecological tumors","volume":"29","author":"Petersen","year":"2008","journal-title":"Pathologe"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"11291","DOI":"10.1128\/JVI.76.22.11291-11300.2002","article-title":"Human Papillomavirus type 31b infection of human keratinocytes and the onset of early transcription","volume":"76","author":"Ozbun","year":"2002","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"10559","DOI":"10.1128\/JVI.76.20.10559-10568.2002","article-title":"Inactivation of both the retinoblastoma tumor suppressor and p21 by the Human Papillomavirus Type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells","volume":"76","author":"Helt","year":"2002","journal-title":"J. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1128\/JVI.78.21.11451-11460.2004","article-title":"Mechanisms of Human Papillomavirus-induced oncogenesis","volume":"78","author":"Munger","year":"2004","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/23962","article-title":"Both Rb\/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells","volume":"396","author":"Kiyono","year":"1998","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc2050","article-title":"The natural history of cervical HPV infection: Unresolved issues","volume":"7","author":"Woodman","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mc.2940100304","article-title":"Cellular control of Human Papillomavirus oncogene transcription","volume":"10","author":"Butz","year":"1994","journal-title":"Mol. Carcinog."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00705-003-0111-z","article-title":"The biochemical and biological functions of Human Papillomavirus Type 16 E5 protein","volume":"148","author":"Tsai","year":"2003","journal-title":"Arch. Virol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1008112207824","article-title":"The Human Papillomavirus type 16 E5 protein modulates ERK1\/2 and p38 MAP kinase activation by an EGFR-independent process in stressed human keratinocytes","volume":"20","author":"Crusius","year":"2000","journal-title":"Virus Genes"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/JVI.76.1.220-231.2002","article-title":"E5 protein of Human Papillomavirus Type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis","volume":"76","author":"Zhang","year":"2002","journal-title":"J. Virol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1099\/0022-1317-80-9-2461","article-title":"Transcription-modulatory activities of differentially spliced cDNAs encoding the E2 protein of Human Papillomavirus Type 16","volume":"80","author":"Alloul","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Olmedo-Nieva, L., Mu\u00f1oz-Bello, J., Contreras-Paredes, A., and Lizano, M. (2018). The role of E6 spliced isoforms (E6*) in Human Papillomavirus-induced carcinogenesis. Viruses, 10.","DOI":"10.3390\/v10010045"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.onc.1201202","article-title":"Alternatively Spliced HPV-18 E6* Protein Inhibits E6 mediated degradation of P53 and suppresses transformed cell growth","volume":"15","author":"Pim","year":"1997","journal-title":"Oncogene"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1128\/JVI.03355-13","article-title":"Human Papillomavirus Type 16 E6* induces oxidative stress and DNA damage","volume":"88","author":"Williams","year":"2014","journal-title":"J. Virol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.02068-14","article-title":"E6^E7, A novel splice isoform protein of Human Papillomavirus 16, stabilizes viral E6 And E7 oncoproteins via HSP90 and GRP78","volume":"6","author":"Ajiro","year":"2015","journal-title":"mBio"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.1038\/srep08645","article-title":"In North America, some ovarian cancers express the oncogenes of preventable Human Papillomavirus HPV-18","volume":"5","author":"Roos","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_119","first-page":"150","article-title":"Analysis of p53, p16ink4a, pRB and cyclin D1 expression and human papillomavirus in primary ovarian serous carcinomas","volume":"33","author":"Bilyk","year":"2011","journal-title":"Exp. Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-019-5582-8","article-title":"HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: Three case reports","volume":"19","author":"Arfi","year":"2019","journal-title":"BMC Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.7314\/APJCP.2014.15.6.2719","article-title":"Methylation of Sfrps and APC genes in ovarian cancer infected with high risk Human Papillomavirus","volume":"15","author":"Hafez","year":"2014","journal-title":"Asian Pac. J. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1158\/2159-8290.CD-17-1018","article-title":"Multiple routes to oncogenesis are promoted by the Human Papillomavirus\u2013host protein network","volume":"8","author":"Eckhardt","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_123","first-page":"1","article-title":"NF-\u03baB signaling and crosstalk during carcinogenesis","volume":"2","author":"Lang","year":"2019","journal-title":"4Open"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftz048","article-title":"Association of human papillomavirus infection and inflammation in cervical cancer","volume":"77","author":"Hemmat","year":"2019","journal-title":"Pathog. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Morgan, E.L., and Macdonald, A. (2019). Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NF\u03baB-IL-6 signalling axis. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007835"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1158\/1055-9965.EPI-10-0184","article-title":"Elevated systemic levels of inflammatory cytokines in older women with persistent cervical Human Papillomavirus infection","volume":"19","author":"Kemp","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/imr.12054","article-title":"Mir-17-92: A polycistronic oncomir with pleiotropic functions","volume":"253","author":"Olive","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., S\u00fcltmann, H., Scheffner, M., Hoppe-Seyler, K., and Hoppe-Seyler, F. (2015). Dependence of intracellular and exosomal micrornas on viral E6\/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004712"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9076","DOI":"10.1073\/pnas.1712018114","article-title":"Human Papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen","volume":"114","author":"Spurgeon","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1158\/0008-5472.CAN-08-2051","article-title":"requirement for estrogen receptor in a mouse model for Human Papillomavirus-associated cervical cancer","volume":"68","author":"Chung","year":"2008","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1073\/pnas.0409883102","article-title":"Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a Human Papillomavirus-transgenic mouse model","volume":"102","author":"Brake","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.steroids.2009.07.011","article-title":"Estrogen-induced Stromal cell-Derived Factor-1 (SDF-1\/Cxcl12) expression is repressed by progesterone and by selective estrogen receptor modulators via estrogen receptor \u03b1 in rat uterine cells and tissues","volume":"74","author":"Glace","year":"2009","journal-title":"Steroids"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1677\/ERC-10-0107","article-title":"The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor","volume":"17","author":"Bolitho","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1016-8478(23)15045-X","article-title":"Immortalization and transformation of human cells","volume":"13","author":"Hahn","year":"2002","journal-title":"Mol. Cells"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ygyno.2003.09.007","article-title":"Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: Consistent loss of chromosome 13 and amplification of chromosome 20","volume":"92","author":"Jin","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0165-4608(01)00473-3","article-title":"Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes","volume":"130","author":"Tsao","year":"2001","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/gcc.20094","article-title":"Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma","volume":"42","author":"Gisselsson","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/mc.20098","article-title":"Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells","volume":"43","author":"Chung","year":"2005","journal-title":"Mol. Carcinog."},{"key":"ref_140","first-page":"4280","article-title":"Spontaneous malignant transformation of human ovarian surface epithelial cells in vitro","volume":"7","author":"Gregoire","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1159\/000356583","article-title":"Molecular and metabolic consequences following E6 transfection in an isogenic ovarian cell line (A2780) pair","volume":"32","author":"Chung","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/rmv.655","article-title":"Review of Cytomegalovirus seroprevalence and demographic characteristics associated with infection","volume":"20","author":"Cannon","year":"2010","journal-title":"Rev. Med. Virol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0140-6736(02)11524-8","article-title":"Specific localisation of Human Cytomegalovirus nucleic acids and proteins in human colorectal cancer","volume":"360","author":"Harkins","year":"2002","journal-title":"Lancet"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jcv.2012.04.007","article-title":"Human Cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis","volume":"54","author":"Chen","year":"2012","journal-title":"J. Clin. Virol."},{"key":"ref_145","first-page":"3347","article-title":"Human Cytomegalovirus infection and expression in human malignant glioma","volume":"62","author":"Cobbs","year":"2002","journal-title":"Cancer Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0022-5347(17)58194-X","article-title":"Evidence For the association of Cytomegalovirus with carcinoma of the prostate","volume":"118","author":"Sanford","year":"1977","journal-title":"J. Urol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/01.ju.0000080263.46164.97","article-title":"High prevalence of Human Cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma","volume":"170","author":"Samanta","year":"2003","journal-title":"J. Urol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/jnci\/55.4.775","article-title":"Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls 2","volume":"55","author":"Pacsa","year":"1975","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2042-4280-1-8","article-title":"Detection of Human Cytomegalovirus in normal and neoplastic breast epithelium","volume":"1","author":"Harkins","year":"2010","journal-title":"Herpesviridae"},{"key":"ref_150","first-page":"31","article-title":"Human Cytomegalovirus in neoplastic cells of Epstein-Barr Virus negative Hodgkin\u00b4s disease","volume":"21","author":"Huang","year":"2002","journal-title":"Int. J. Oncol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1593\/neo.81178","article-title":"The story of Human Cytomegalovirus and cancer: Increasing evidence and open questions","volume":"11","author":"Michaelis","year":"2009","journal-title":"Neoplasia"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.coviro.2019.08.003","article-title":"Cytomegalovirus is a tumor-associated virus: Armed and dangerous","volume":"39","author":"Cobbs","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Herbein, G. (2018). The Human Cytomegalovirus, from oncomodulation to oncogenesis. Viruses, 10.","DOI":"10.3390\/v10080408"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.1152095","article-title":"Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function","volume":"320","author":"Hume","year":"2008","journal-title":"Science"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.femsre.2003.07.005","article-title":"Oncomodulatory signals by regulatory proteins encoded by Human Cytomegalovirus: A novel role for viral infection in tumor progression","volume":"28","author":"Cinatl","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2796.2006.01618.x","article-title":"Does Cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?","volume":"259","year":"2006","journal-title":"J. Int. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.virusres.2010.09.011","article-title":"The role of Cytomegalovirus in angiogenesis","volume":"157","author":"Caposio","year":"2011","journal-title":"Virus Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1128\/jvi.69.9.5391-5400.1995","article-title":"Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105\/p50 and p65 promoters","volume":"69","author":"Yurochko","year":"1995","journal-title":"J. Virol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-S\u00e1nchez, I., and Munger, J. (2019). Meal for two: Human Cytomegalovirus-induced activation of cellular metabolism. Viruses, 11.","DOI":"10.3390\/v11030273"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ebiom.2018.03.015","article-title":"The Human Cytomegalovirus strain db activates oncogenic pathways in mammary epithelial cells","volume":"30","author":"Kumar","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"E8244","DOI":"10.1073\/pnas.1710799114","article-title":"cellular responses to Human Cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype","volume":"114","author":"Oberstein","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"20039","DOI":"10.1073\/pnas.1014509107","article-title":"Experimental Human Cytomegalovirus latency in CD14+ monocytes","volume":"107","author":"Hargett","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1128\/JVI.05878-11","article-title":"Inhibition of inflammatory Interleukin-6 activity via extracellular signal-regulated kinase-mitogen-activated protein kinase signaling antagonizes Human Cytomegalovirus reactivation from dendritic cells","volume":"85","author":"Reeves","year":"2011","journal-title":"J. Virol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"ra58","DOI":"10.1126\/scisignal.2001180","article-title":"HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6\u2013STAT3 axis","volume":"3","author":"Slinger","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cncr.27724","article-title":"Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells","volume":"119","author":"Zhao","year":"2012","journal-title":"Cancer"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1073\/pnas.1202910109","article-title":"Infection of Epstein-Barr virus in a gastric carcinoma cell line induces anchorage independence and global changes in gene expression","volume":"109","author":"Marquitz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1080\/00365540310016556","article-title":"Association between late age at infectious mononucleosis, Epstein-Barr virus antibodies, and ovarian cancer risk","volume":"35","author":"Littman","year":"2003","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e02624","DOI":"10.1016\/j.heliyon.2019.e02624","article-title":"The interplay between Epstein-Bar virus (EBV) with the p53 and its homologs during EBV associated malignancies","volume":"5","author":"Chatterjee","year":"2019","journal-title":"Heliyon"},{"key":"ref_169","first-page":"1","article-title":"Tumor evolution and chemoresistance in ovarian cancer","volume":"2","author":"Kim","year":"2018","journal-title":"NPJ Precis. Oncol."},{"key":"ref_170","first-page":"CD007287","article-title":"Antigen-specific active immunotherapy for ovarian cancer","volume":"9","author":"Paijens","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"O\u2019Cearbhaill, R.E., Ragupathi, G., Zhu, J., Wan, Q., Mironov, S., Yang, G., Spassova, M.K., Iasonos, A., Kravetz, S., and Ouerfelli, O. (2016). A phase I study of unimolecular pentavalent (Globo-H-GM2-sTn-TF-Tn) immunization of patients with epithelial ovarian, fallopian tube, or peritoneal cancer in first remission. Cancers, 8.","DOI":"10.3390\/cancers8040046"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nnano.2015.292","article-title":"In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer","volume":"11","author":"Lizotte","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1158\/0008-5472.CAN-14-0296","article-title":"Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma","volume":"74","author":"Schuessler","year":"2014","journal-title":"Cancer Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e29289","DOI":"10.4161\/onci.29289","article-title":"Immunological targeting of cytomegalovirus for glioblastoma therapy","volume":"3","author":"Nair","year":"2014","journal-title":"Oncoimmunology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13045-019-0743-4","article-title":"Immune checkpoint inhibitors in the treatment of virus-associated cancers","volume":"12","author":"Gao","year":"2019","journal-title":"J. Hematol. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/3\/561\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:02:43Z","timestamp":1760173363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/3\/561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"references-count":175,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["cancers12030561"],"URL":"https:\/\/doi.org\/10.3390\/cancers12030561","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,29]]}}}